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Online Academic Libraries And Distance Learning, Merilyn Burke, Bruce Levin, Ardis Hanson 2011 University of South Florida

Online Academic Libraries And Distance Learning, Merilyn Burke, Bruce Levin, Ardis Hanson

Merilyn S Burke

Although educational institutions create courses and programs for distance learners, they often omit the support component that librarians and accrediting organizations consider critical.


Radiation Acts On The Microenvironment To Affect Breast Carcinogenesis By Distinct Mechanisms That Decrease Cancer Latency And Affect Tumor Type, Karen Dunphy, D.H. Nguyen, H.A. Oketch-Rabah, I. Illa-Bochaca, F.C. Geyer, J.S. Reis-Filho, J.H. Mao, S.A. Ravani, J. Zavadil, A.D. Borowsky, J.D. Jeryy 2011 University of Massachusetts - Amherst

Radiation Acts On The Microenvironment To Affect Breast Carcinogenesis By Distinct Mechanisms That Decrease Cancer Latency And Affect Tumor Type, Karen Dunphy, D.H. Nguyen, H.A. Oketch-Rabah, I. Illa-Bochaca, F.C. Geyer, J.S. Reis-Filho, J.H. Mao, S.A. Ravani, J. Zavadil, A.D. Borowsky, J.D. Jeryy

Karen Dunphy

Tissue microenvironment is an important determinant of carcinogenesis. We demonstrate that ionizing radiation, a known carcinogen, affects cancer frequency and characteristics by acting on the microenvironment. Using a mammary chimera model in which an irradiated host is transplanted with oncogenic Trp53 null epithelium, we show accelerated development of aggressive tumors whose molecular signatures were distinct from tumors arising in nonirradiated hosts. Molecular and genetic approaches show that TGFβ mediated tumor acceleration. Tumor molecular signatures implicated TGFβ, and genetically reducing TGFβ abrogated the effect on latency. Surprisingly, tumors from irradiated hosts were predominantly estrogen receptor negative. This effect was TGFβ independent ...


Baseline Data For Maine Pediatric And Family Practices From Arra-Funded Hit Ambulatory Practice Survey Data, Kimberley S. Fox MPA 2011 University of Southern Maine, Muskie School of Public Service

Baseline Data For Maine Pediatric And Family Practices From Arra-Funded Hit Ambulatory Practice Survey Data, Kimberley S. Fox Mpa

Population Health & Health Policy

No abstract provided.


Statistical Image Reconstruction For Quantitative Computed Tomography, Joshua Evans 2011 Virginia Commonwealth University

Statistical Image Reconstruction For Quantitative Computed Tomography, Joshua Evans

Theses and Dissertations

Statistical iterative reconstruction (SIR) algorithms for x-ray computed tomography (CT) have the potential to reconstruct images with less noise and systematic error than the conventional filtered backprojection (FBP) algorithm. More accurate reconstruction algorithms are important for reducing imaging dose and for a wide range of quantitative CT applications. The work presented herein investigates some potential advantages of one such statistically motivated algorithm called Alternating Minimization (AM). A simulation study is used to compare the tradeoff between noise and resolution in images reconstructed with the AM and FBP algorithms. The AM algorithm is employed with an edge-preserving penalty function, which is ...


Four Year Experience Of Sarcoma Of Soft Tissues And Bones In A Tertiary Care Hospital And Review Of Literature, Tayyaba Z. Ansari, Nehal Masood, Asra Parekh, Rabab Z. Jafri, Syed N. Niamatullah, Adnan A. Zaidi, Masood Umer 2011 Aga Khan University

Four Year Experience Of Sarcoma Of Soft Tissues And Bones In A Tertiary Care Hospital And Review Of Literature, Tayyaba Z. Ansari, Nehal Masood, Asra Parekh, Rabab Z. Jafri, Syed N. Niamatullah, Adnan A. Zaidi, Masood Umer

Department of Medicine

Background:

Sarcoma encompasses an uncommon group of cancer and the data is insufficient from Pakistan. We report our four years experience of Sarcoma of soft tissues and bones.

Methods:

This cross sectional study was carried out at Aga Khan University Hospital from 2004 to 2008. The Patients were divided into two groups from the outset i.e. initially diagnosed and relapsed group and separate sub group analysis was conducted.

Results:

Out of 93 newly diagnosed Patients, 58 belonged to bone sarcoma and 35 to soft tissue sarcoma group. While for relapsed Patients, 5 had soft tissue sarcoma and 9 had ...


Possible Role Of Death Receptor-Mediated Apoptosis By The E3 Ubiquitin Ligases Siah2 And Posh, Perry A. Christian, Michael V. Fiandalo, Steven R. Schwarze 2011 University of Kentucky

Possible Role Of Death Receptor-Mediated Apoptosis By The E3 Ubiquitin Ligases Siah2 And Posh, Perry A. Christian, Michael V. Fiandalo, Steven R. Schwarze

Markey Cancer Center Faculty Publications

BACKGROUND: A functioning ubiquitin proteasome system (UPS) is essential for a number of diverse cellular processes and maintenance of overall cellular homeostasis. The ability of proteasome inhibitors, such as Velcade, to promote extrinsic apoptotic effects illustrates the importance of the ubiquitin proteasome system in the regulation of death receptor signaling. Here, we set out to define the UPS machinery, particularly the E3 ubiquitin ligases, that repress apoptosis through the extrinsic pathway. A cell-based genome-wide E3 ligase siRNA screen was established to monitor caspase-8 activity following the addition of TRAIL.

RESULTS: Data from the high-throughput screen revealed that targeting the RING-finger ...


A Strategic Plan For Transitioning To A Healthcare Knowledge Services Center In New England (Poster), H. Mark Goldstein, Margaret H. Coletti 2011 University of Massachusetts Medical School

A Strategic Plan For Transitioning To A Healthcare Knowledge Services Center In New England (Poster), H. Mark Goldstein, Margaret H. Coletti

National Network of Libraries of Medicine New England Region (NNLM NER) Repository

In 2004, as part of its Regional Advisory Council (RAC), the National Network of Libraries of Medicine New England Region (NN/LM NER) formed the Hospital Library Subcommittee, with the charge to promote the value of hospital libraries throughout the region. Over its 7-year tenure, the Subcommittee has tracked a gradual decline in support for hospital libraries, as evidenced by budget cuts and library closures. The status quo had ultimately become untenable.

In 2009, the Subcommittee began to shift focus from library advocacy towards a new strategy: a 5-year plan to assist hospital libraries with the transition to healthcare knowledge ...


Recombination Phenotypes Of The Nci-60 Collection Of Human Cancer Cells, Dawn M. Stults, Michael W. Killen, Brent J. Shelton, Andrew J. Pierce 2011 Vanderbilt University

Recombination Phenotypes Of The Nci-60 Collection Of Human Cancer Cells, Dawn M. Stults, Michael W. Killen, Brent J. Shelton, Andrew J. Pierce

Microbiology, Immunology, and Molecular Genetics Faculty Publications

BACKGROUND: The NCI-60 is a collection of tumor cell lines derived from a variety of human adult cancer tissue types and is commonly used for genetic analysis and screening of potential chemotherapeutic agents. We wanted to understand the contributions of specific mechanisms of genomic instability to the etiology of cancers represented by the NCI-60.

RESULTS: We screened the NCI-60 for dysregulated homologous recombination by using the gene cluster instability (GCI) assay we pioneered, and for defects in base excision repair by sensitivity to 5-hydroxymethyl-2'-deoxyuridine (hmdUrd). We identified subsets of the NCI-60 lines that either displayed the characteristic molecular signature ...


Comparison Of Toxic Reaction Of Tripterygium Wilfordii Multiglycoside In Normal And Adjuvant Arthritic Rats, J Li, Y Lu, C Xiao, C Lu, X Niu, X He, H Zhao, Y Tan, Aiping Lu 2011 Hong Kong Baptist University

Comparison Of Toxic Reaction Of Tripterygium Wilfordii Multiglycoside In Normal And Adjuvant Arthritic Rats, J Li, Y Lu, C Xiao, C Lu, X Niu, X He, H Zhao, Y Tan, Aiping Lu

Professor LU, Aiping

No abstract provided.


A Practical Approach To Prescribe The Amount Of Used Insulin Of Diabetic Patients, Mehran Mazandarani, Ali Vahidian Kamyad 2011 Selected Works

A Practical Approach To Prescribe The Amount Of Used Insulin Of Diabetic Patients, Mehran Mazandarani, Ali Vahidian Kamyad

Mehran Mazandarani

To assess of diabetes mellitus, extensive mathematical studies have been done to date. Up to now, many crisp mathematical models have described this phenomenon, but with the aim of controlling and modelling diabetes mellitus in more realistic and practical form, the models that consider most aspects of the problem should be considered. This kind of attitude to the disease can be modelling with mathematics called fuzzy mathematics. In this paper, modelling of diabetes mellitus type 2 has been studied by using IF-Then fuzzy rules based on the medical information of diabetic patients of Parsian clinic in Mashhad-Iran who were treated ...


Toward A New Era Of Policy: Health Care Service Delivery To First Nations, Miranda D. Kelly 2011 University of British Columbia, School of Population and Public Health, Vancouver

Toward A New Era Of Policy: Health Care Service Delivery To First Nations, Miranda D. Kelly

The International Indigenous Policy Journal

The disproportionate burdens of ill health experienced by First Nations have been attributed to an uncoordinated, fragmented health care system. This system is rooted in public policies that have created jurisdictional gaps and a long-standing debate between federal, provincial and First Nations governments as to who is responsible for First Nations health care. This article examines: (1) the policies that shape First Nations health care in Canada and in the province of British Columbia (BC) specifically; (2) the interests of the actors involved in First Nations health policy; and (3) recent developments in BC that present an opportunity for change ...


Health Care And Aboriginal Seniors In Urban Canada: Helping A Neglected Class, Bonita Beulah Beatty, Loleen Berdahl 2011 University of Saskatchewan Department of Native Studies

Health Care And Aboriginal Seniors In Urban Canada: Helping A Neglected Class, Bonita Beulah Beatty, Loleen Berdahl

The International Indigenous Policy Journal

Canadian researchers and policymakers have paid limited attention to the health care needs of Aboriginal seniors. This lack of attention is problematic, as the situation of Aboriginal seniors – including both status and non-status First Nations, Métis and Inuit – is particularly bleak. Using Winnipeg, Regina and Saskatoon as examples, this paper analyses the health care challenges facing Aboriginal seniors in urban Canada. We ask, what policy approaches are needed to improve the health and wellbeing of urban Aboriginal seniors so that they can have good quality living reflective of their needs and culture? We suggest that, in thinking through present and ...


Capacity-Building And Participatory Research Development Of A Community-Based Nutrition And Exercise Lifestyle Intervention Program (Nelip) For Pregnant And Postpartum Aboriginal Women:Information Gathered From Talking Circles., Michelle F. Mottola, Maggie M. Sopper, Lindsay Doxtator, Katie Big-Canoe, Harry Prapavessis, Stewart Harris, Anthony Hanley 2011 The University of Western Ontario

Capacity-Building And Participatory Research Development Of A Community-Based Nutrition And Exercise Lifestyle Intervention Program (Nelip) For Pregnant And Postpartum Aboriginal Women:Information Gathered From Talking Circles., Michelle F. Mottola, Maggie M. Sopper, Lindsay Doxtator, Katie Big-Canoe, Harry Prapavessis, Stewart Harris, Anthony Hanley

The International Indigenous Policy Journal

Objectives were to gather information from Talking Circles of Aboriginal women who participated in a maternal Nutrition and Exercise Lifestyle Intervention Program (NELIP) to identify strategies to bring NELIP into the community. Twelve First Nations women participated. Several main themes were identified regarding health: balance, knowledge/education and time management. Benefits of the NELIP were improvement in health, stamina, stress, and a healthy baby, no gestational diabetes and a successful home birth, with social support as an important contributing factor for success. Suggestions for improvement for the NELIP included group walking, and incorporating more traditional foods into the meal plan ...


Colonialism As A Broader Social Determinant Of Health, Karina Czyzewski 2011 University of Toronto

Colonialism As A Broader Social Determinant Of Health, Karina Czyzewski

The International Indigenous Policy Journal

A proposed broader or Indigenized social determinants of health framework includes "colonialism" along with other global processes. What does it mean to understand Canadian colonialism as a distal determinant of Indigenous health? This paper reviews pertinent discourses surrounding Indigenous mental health in Canada. With an emphasis on the notion of intergenerational trauma, there are real health effects of social, political, and economic marginalization embodied within individuals, which can collectively affect entire communities. Colonialism can also be enacted and reinforced within Indigenous mental health discourse, thus influencing scholarly and popular perceptions. Addressing this distal determinant through policy work necessitates that improving ...


Preventing Obesity In Canada’S Aboriginal Children: Not Just A Matter Of Eating Right And Getting Active, Melanie A. Ferris 2011 Huntinghawk Communications

Preventing Obesity In Canada’S Aboriginal Children: Not Just A Matter Of Eating Right And Getting Active, Melanie A. Ferris

The International Indigenous Policy Journal

Obesity is a growing issue for all children. Many experts say that preventing obesity is largely a matter of eating the right foods and getting enough physical activity. This advice doesn’t recognize the fact that First Nations, Inuit, and Métis children face unique barriers to growing up healthy and strong simply because of their identity. This paper discusses how the social determinants of health impact the ability of Aboriginal children to grow up free of obesity. The paper highlights results from a community-based research project conducted amongst Aboriginal parents and service providers in Ontario who wish to prevent obesity ...


Addressing The Persistence Of Tuberculosis Among The Canadian Inuit Population: The Need For A Social Determinants Of Health Framework, Kassandra C. Kulmann MA Candidate, Chantelle AM Richmond Professor 2011 The University of Western Ontario

Addressing The Persistence Of Tuberculosis Among The Canadian Inuit Population: The Need For A Social Determinants Of Health Framework, Kassandra C. Kulmann Ma Candidate, Chantelle Am Richmond Professor

The International Indigenous Policy Journal

Canadian Aboriginal people have poorer levels of health than the general population. A serious issue is the high rate of tuberculosis (TB) among the Inuit population; rates are much higher than those of the general Canadian population. Several social determinants of health (SDOH), including household crowding and poverty, are strongly correlated with TB prevalence. In this paper, we describe the medical and social determinants of TB, and critically examine the TB literature specific to the Inuit population. The majority of studies recommend biomedical interventions for the treatment of TB. Few researchers have employed the social determinants of health theory to ...


Distinct Neuromuscular Patterns From A Single Motor Network, Rachel S. White 2011 School of Medicine

Distinct Neuromuscular Patterns From A Single Motor Network, Rachel S. White

Publicly Accessible Penn Dissertations

My thesis aimed to elucidate several aspects of motor circuit regulation and its impact on movement. It is well established that a single motor network can produce different output patterns in response to different inputs. However, in most model systems it remains challenging to identify the neurons comprising these networks and determine their role(s) in network operation, including whether each network neuron retains its role(s) when the network generates different output patterns. Also, most work on these circuits has occurred in the isolated nervous system, so little is known about how muscles respond to distinct neural outputs. I ...


Perspectives On Firm Decision Making During Risky Technology Acquisitions, Adam C. Powell 2011 University of Pennsylvania

Perspectives On Firm Decision Making During Risky Technology Acquisitions, Adam C. Powell

Publicly Accessible Penn Dissertations

A novel survey dataset on computed tomography (CT) machine acquisition is used to explore which theories best answer two questions from the decision making literature. First, what determines how much uncertainty a firm has when investing in updated technology? Second, what determines the value of the acquisition? In answering these questions, two theoretical comparisons are conducted. In the first, economic theory, behavioral theory (the Behavioral Theory of the Firm and Prospect Theory), and Bounded Rationality are tested as potential determinants of acquisition uncertainties. In the second, economic theory and Prospect Theory are tested as potential determinants of the value of ...


The Role Of Stress, Glucocorticoids & Β-Adrenergic Signaling In Aversive, Hippocampus-Dependent Memory Retrieval, Keith B. Schutsky 2011 University of Pennsylvania

The Role Of Stress, Glucocorticoids & Β-Adrenergic Signaling In Aversive, Hippocampus-Dependent Memory Retrieval, Keith B. Schutsky

Publicly Accessible Penn Dissertations

Studies in wild-type rats and mice, and mutant mice lacking norepinephrine (NE) demonstrate that NE, β1-adrenergic, cAMP/PKA and Epac signaling are required for intermediate-term hippocampus-dependent memory retrieval. Although it has been proposed that glucocorticoids (GCs) facilitate β-adrenergic signaling to impair retrieval, neither a specific requirement for NE nor a definitive mechanism as to how this interaction occurs has been established. This thesis provides compelling evidence that 1) GCs do not require (but can synergize with) the adrenergic system to impair hippocampus-dependent memory retrieval; 2) GCs and xamoterol interact with the β2 receptor to impair retrieval; 3 ...


Potency Testing For Ntd Vaccines: Determining Relative Potency For The Na-Gst-1 Human Hookworm Vaccine, Amar R. Jariwala, Brian Keegan, Pavithra Raghavendra, Jordan L. Plieskatt, Maria Elena Bottazzi, Peter J. Hotez, Jeffrey M. Bethony 2011 Albert B. Sabin Vaccine Institute

Potency Testing For Ntd Vaccines: Determining Relative Potency For The Na-Gst-1 Human Hookworm Vaccine, Amar R. Jariwala, Brian Keegan, Pavithra Raghavendra, Jordan L. Plieskatt, Maria Elena Bottazzi, Peter J. Hotez, Jeffrey M. Bethony

Microbiology, Immunology, and Tropical Medicine Posters and Presentations

Over the next decade, a new generation of vaccines will target the neglected tropical diseases (NTDs) . The goal of most NTD vaccines will be to reduce the morbidity and decrease the chronic debilitating nature of these often-forgotten infections - outcomes that are hard to measure in the traditional potency-testing paradigm . The absence of measurable correlates of protection, a lack of permissive animal models for lethal infection, and a lack of clinical indications that do not include the induction of sterilizing immunity required us to reconsider the traditional bioassay methods for determining vaccine potency . Owing to these limitations, potency assay design for ...


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