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Transcriptional Regulatory Network Analysis During Epithelial-Mesenchymal Transformation Of Retinal Pigment Epithelium., Craig H Pratt, Rajanikanth Vadigepalli, Praveen Chakravarthula, Gregory E Gonye, Nancy J Philp, Gerald B Grunwald 2012 Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University

Transcriptional Regulatory Network Analysis During Epithelial-Mesenchymal Transformation Of Retinal Pigment Epithelium., Craig H Pratt, Rajanikanth Vadigepalli, Praveen Chakravarthula, Gregory E Gonye, Nancy J Philp, Gerald B Grunwald

Rajanikanth Vadigepalli

PURPOSE: Phenotypic transformation of retinal pigment epithelial (RPE) cells contributes to the onset and progression of ocular proliferative disorders such as proliferative vitreoretinopathy (PVR). The formation of epiretinal membranes in PVR may involve an epithelial-mesenchymal transformation (EMT) of RPE cells as part of an aberrant wound healing response. While the underlying mechanism remains unclear, this likely involves changes in RPE cell gene expression under the control of specific transcription factors (TFs). Thus, the purpose of the present study was to identify TFs that may play a role in this process. METHODS: Regulatory regions of genes that are differentially regulated during ...


Robust Dynamic Balance Of Ap-1 Transcription Factors In A Neuronal Gene Regulatory Network., Gregory M Miller, Babatunde A Ogunnaike, James S Schwaber, Rajanikanth Vadigepalli 2012 Thomas Jefferson University

Robust Dynamic Balance Of Ap-1 Transcription Factors In A Neuronal Gene Regulatory Network., Gregory M Miller, Babatunde A Ogunnaike, James S Schwaber, Rajanikanth Vadigepalli

Rajanikanth Vadigepalli

BACKGROUND: The octapeptide Angiotensin II is a key hormone that acts via its receptor AT1R in the brainstem to modulate the blood pressure control circuits and thus plays a central role in the cardiac and respiratory homeostasis. This modulation occurs via activation of a complex network of signaling proteins and transcription factors, leading to changes in levels of key genes and proteins. AT1R initiated activity in the nucleus tractus solitarius (NTS), which regulates blood pressure, has been the subject of extensive molecular analysis. But the adaptive network interactions in the NTS response to AT1R, plausibly related to the development of ...


Development Of A Computer-Assisted Dietary Assessment Tool For Use In Primary Healthcare Practice: Perceptions Of Nutrition And Computers In A Sample Of Older Adults With Type 2 Diabetes Mellitus, Y. C. Probst, C. Krnavek, L. Lockyer, Linda C. Tapsell 2012 University of Wollongong

Development Of A Computer-Assisted Dietary Assessment Tool For Use In Primary Healthcare Practice: Perceptions Of Nutrition And Computers In A Sample Of Older Adults With Type 2 Diabetes Mellitus, Y. C. Probst, C. Krnavek, L. Lockyer, Linda C. Tapsell

Professor Lori Lockyer

As part of a larger study developing dietary software, this study aims to evaluate a sample of potential users for their experience and comfort with computers and assess the preferred program design and navigation features for the development of the automated diet history interview. A telephone-based questionnaire and focus groups were employed to evaluate the perceptions, beliefs and attitudes of 37 older adults with type 2 diabetes mellitus. Participants were also shown a range of existing dietary assessment programs and asked to state their perceptions of each. Data was coded and thematically analysed based on computer use, software features, dietary ...


Toward Nutrition Education For Adults: A Systematic Approach To The Interface Design Of An Online Dietary Assessment Tool, Y. Probst, L. Lockyer, Linda Tapsell, D. Steel, O. McKerrow, M. Bare 2012 University of Wollongong

Toward Nutrition Education For Adults: A Systematic Approach To The Interface Design Of An Online Dietary Assessment Tool, Y. Probst, L. Lockyer, Linda Tapsell, D. Steel, O. Mckerrow, M. Bare

Professor Lori Lockyer

To support nutrition-related behavioural change, a dietitian can offer tailored educational programmes based on patients’ specific dietary behaviours. A model has been developed to integrate learning technologies into this process. This tool allows patients to self-report their dietary intake, creating awareness, and to receive individually tailored dietary advice from their General Practitioner (GP) via a dietitian, to assist with change. This article examines how a step-wise approach to the interface design has allowed a multidisciplinary approach to automated dietary assessment to be undertaken. Concentrating on the identification of core foods and on the questionnaire format using an outline of the ...


The Life Of A ‘Digital Native’, Linda Corrin, Sue Bennett, Lori Lockyer 2012 University of Wollongong

The Life Of A ‘Digital Native’, Linda Corrin, Sue Bennett, Lori Lockyer

Professor Lori Lockyer

There have been many claims about the characteristics of the new generation of ‘digital native’ students participating in higher education. The lack of empirical evidence upon which many of these early claims were based has been highlighted in a number of studies investigating students’ technology ownership. However, very few studies to date have explored in detail students’ day-to-day interactions with technology and the impact on their academic studies. In the current project multiple case studies were compiled to provide an in-depth exploration of technology use across university students’ everyday life and academic study contexts. This paper reports on one of ...


Neighborhood Socioeconomic Status And Use Of Colonoscopy In An Insured Population--A Retrospective Cohort Study, Chyke A. Doubeni, Guruprasad D. Jambaulikar, Hassan Fouayzi, Scott B. Robinson, Margaret J. Gunter, Terry S. Field, Douglas W. Roblin, Robert H. Fletcher 2012 University of Massachusetts Medical School

Neighborhood Socioeconomic Status And Use Of Colonoscopy In An Insured Population--A Retrospective Cohort Study, Chyke A. Doubeni, Guruprasad D. Jambaulikar, Hassan Fouayzi, Scott B. Robinson, Margaret J. Gunter, Terry S. Field, Douglas W. Roblin, Robert H. Fletcher

Meyers Primary Care Institute Publications and Presentations

BACKGROUND: Low-socioeconomic status (SES) is associated with a higher colorectal cancer (CRC) incidence and mortality. Screening with colonoscopy, the most commonly used test in the US, has been shown to reduce the risk of death from CRC. This study examined if, among insured persons receiving care in integrated healthcare delivery systems, differences exist in colonoscopy use according to neighborhood SES.

METHODS: We assembled a retrospective cohort of 100,566 men and women, 50-74 years old, who had been enrolled in one of three US health plans for >/=1 year on January 1, 2000. Subjects were followed until the date of ...


Frequency And Associated Factors For Anxiety And Depression In Pregnant Women: A Hospital-Based Cross-Sectional Study., Niloufer Sultan Ali, Iqbal Azam Syed, Badar S. Ali, Ghurnata Tabbusum, Sana S. Moin 2012 Aga Khan University

Frequency And Associated Factors For Anxiety And Depression In Pregnant Women: A Hospital-Based Cross-Sectional Study., Niloufer Sultan Ali, Iqbal Azam Syed, Badar S. Ali, Ghurnata Tabbusum, Sana S. Moin

Department of Family Medicine

Antepartum anxiety and/or depression is a major public health problem globally. The aim of this study was to estimate the frequency of antepartum anxiety and/or depression among pregnant women. This was a cross-sectional study conducted in a tertiary care hospital among pregnant women. A total of 165 pregnant women were interviewed by a clinical psychologist using HADS for assessing anxiety and/or depression and also collected information regarding sociodemographic, obstetric, family relationships, and home environment. Out of the total of 165 pregnant women about 70 percent of them were either anxious and/or depressed. The increasing age of ...


Humberto Reynoso-Vallejo On Cultural Competence And Cultural Humility In Evaluation, Humberto Reynoso-Vallejo 2012 University of Massachusetts Medical School

Humberto Reynoso-Vallejo On Cultural Competence And Cultural Humility In Evaluation, Humberto Reynoso-Vallejo

Center for Health Policy and Research (CHPR) Publications

Blog post to AEA365, a blog sponsored by the American Evaluation Association (AEA) dedicated to highlighting Hot Tips, Cool Tricks, Rad Resources, and Lessons Learned for evaluators. The American Evaluation Association is an international professional association of evaluators devoted to the application and exploration of program evaluation, personnel evaluation, technology, and many other forms of evaluation. Evaluation involves assessing the strengths and weaknesses of programs, policies, personnel, products, and organizations to improve their effectiveness.


Radiation Sensitization Of Breast Cancer Cells By Vitamin D Through The Promotion Of Autophagic Cell Death, Eden Wilson 2012 Virginia Commonwealth University

Radiation Sensitization Of Breast Cancer Cells By Vitamin D Through The Promotion Of Autophagic Cell Death, Eden Wilson

Theses and Dissertations

Radiation therapy is a widely used tool in cancer therapy and is frequently offered as the first line of treatment for cancers of the breast. While radiotherapy is often initially effective in killing tumor cells or suppressing their growth, there are factors that confer tumor cell resistance to irradiation. Development of resistance may lead to disease recurrence despite the use of surgery, chemotherapy and radiation therapy. A primary goal of the studies in Dr. Gewirtz’s laboratory is to develop strategies to overcome resistance to radiation (and chemotherapy) in breast cancer, with the ultimate goal of preventing or attenuating disease ...


Pv1 Down-Regulation Via Shrna Inhibits The Growth Of Pancreatic Adenocarcinoma Xenografts, Sophie J. Deharvengt, Dan Tse, Olga Sideleva, Caitlin McGarry, Jason R. Gunn, Daniel S. Longnecker, Catherine Carriere, Radu V. Stan 2012 Dartmouth College

Pv1 Down-Regulation Via Shrna Inhibits The Growth Of Pancreatic Adenocarcinoma Xenografts, Sophie J. Deharvengt, Dan Tse, Olga Sideleva, Caitlin Mcgarry, Jason R. Gunn, Daniel S. Longnecker, Catherine Carriere, Radu V. Stan

Open Dartmouth: Faculty Open Access Articles

PV1 is an endothelial-specific protein with structural roles in the formation of diaphragms in endothelial cells of normal vessels. PV1 is also highly expressed on endothelial cells of many solid tumours. On the basis of in vitro data, PV1 is thought to actively participate in angiogenesis. To test whether or not PV1 has a function in tumour angiogenesis and in tumour growth in vivo, we have treated pancreatic tumour-bearing mice by single-dose intratumoural delivery of lentiviruses encoding for two different shRNAs targeting murine PV1. We find that PV1 down-regulation by shRNAs inhibits the growth of established tumours derived from two ...


Corneal Replication Is An Interferon Response-Independent Bottleneck For Virulence Of Herpes Simplex Virus 1 In The Absence Of Virion Host Shutoff, Tracy J. Pasieka, Vineet D. Menachery, Pamela C. Rosato, David A. Leib 2012 Washington University School of Medicine

Corneal Replication Is An Interferon Response-Independent Bottleneck For Virulence Of Herpes Simplex Virus 1 In The Absence Of Virion Host Shutoff, Tracy J. Pasieka, Vineet D. Menachery, Pamela C. Rosato, David A. Leib

Open Dartmouth: Faculty Open Access Articles

Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR−/−) mice, Δvhs remains highly attenuated via corneal infection but is fully virulent via intracranial infection. The data demonstrate that the interferon-independent inherent replication defect of Δvhs has a significant impact upon peripheral replication and neuroinvasion.


Case Report: Rapid Spontaneous Recovery From Severe Hypothyroidism In 2 Teenage Girls., Paul B. Kaplowitz 2012 George Washington University

Case Report: Rapid Spontaneous Recovery From Severe Hypothyroidism In 2 Teenage Girls., Paul B. Kaplowitz

Pediatrics Faculty Publications

Background

While it is recognized that patients sometimes recover from autoimmune hypothyroidism, little is known about how rapidly this may occur.

Case reports

Two 13 year old girls had severe primary hypothyroidism (total T4 14.2 nmol/L with TSH 468 miU/L and total T4 7.7 nmol/L with TSH 183 miU/L) accompanied by goiter and positive thyroid peroxidase antibodies. There were delays in starting thyroid hormone replacement, and complete reversal of hypothyroidism was documented within 2 months in both cases. One of the girls had recurrence of severe hypothyroidism after being euthyroid for 18 months.

Review ...


Diagnostic Patterns And Immunohistochemical Stain Usage In Extended Core Prostate Biopsies: Comparisons Between Genitourinary And Non-Genitourinary Pathologists, Anna Plourde, Zhong Jiang, Christopher L. Owens 2012 University of Massachusetts Medical School

Diagnostic Patterns And Immunohistochemical Stain Usage In Extended Core Prostate Biopsies: Comparisons Between Genitourinary And Non-Genitourinary Pathologists, Anna Plourde, Zhong Jiang, Christopher L. Owens

Senior Scholars Program

Background: Ancillary immunohistochemical (IPOX) stains are useful in clarifying diagnostically challenging pathologic specimens. In diagnostic workup of prostate needle biopsies, stains for basal cells and α-methylacyl coenzyme A racemase are routinely used to support or refute the diagnosis of prostate cancer. Although useful, these stains add cost and must be used judiciously. There is a lack of firm guidelines establishing the proper utilization of IPOX studies in prostate pathology. Therefore, differences in patterns of stain use and diagnoses may exist, related to expertise of the pathologist.

Objectives: The purpose of this study was to compare patterns of diagnoses and IPOX ...


Assessing Patient-Provider Collaboration In Subjects With Type 2 Diabetes In Jamaica And Effects On Glycemic Control, Paul E. Daniel Jr., Michael A. Godkin, Judith A. Savageau, Rosemarie Wright-Pascoe, Michael G. Lee 2012 University of Massachusetts Medical School

Assessing Patient-Provider Collaboration In Subjects With Type 2 Diabetes In Jamaica And Effects On Glycemic Control, Paul E. Daniel Jr., Michael A. Godkin, Judith A. Savageau, Rosemarie Wright-Pascoe, Michael G. Lee

Senior Scholars Program

Background: Type 2 Diabetes Mellitus is a growing health problem worldwide that places patients at increased risk of morbidity and mortality from microvascular and macrovascular complications. Research suggests that a patient-centered approach which focuses on patient-physician communication and collaboration in the management of chronic diseases such as diabetes may improve clinical outcomes in a glycemic parameter such as HbA1c. We measured the degree of this patient-centered approach in a sample population of subjects with Type 2 Diabetes in Jamaica with the use of the Patient Assessment of Care for Chronic Illness (PACIC) questionnaire and assessed the relationship between patient-centered care ...


Gestational Weight Gain Prior To Glucola And Risk Of Gestational Diabetes Mellitus, Anna BuAbbud, Katherine Callaghan, Xun Liao, Tiffany A. Moore Simas 2012 University of Massachusetts Medical School

Gestational Weight Gain Prior To Glucola And Risk Of Gestational Diabetes Mellitus, Anna Buabbud, Katherine Callaghan, Xun Liao, Tiffany A. Moore Simas

Senior Scholars Program

Background: Gestational diabetes mellitus (GDM) complicates 4–7% of U.S. pregnancies. Diabetes and obesity rates are consistently higher in Hispanics compared to non-Hispanic whites. Early-to-mid gestational weight gain (GWG) has been thought to be associated with GDM risk; however, the Institute of Medicine (IOM) found insufficient evidence when re-examining GWG guidelines in 2009.

Objective: To investigate associations of GWG adherence per 2009 IOM guidelines prior to 1-hr 50g Glucose Tolerance Test (GTT), or glucola, with GDM diagnoses in Latinas.

Methods: The study is a retrospective chart review of all Hispanic women delivered by UMass Memorial faculty between 4/1 ...


Evaluating The Efficacy Of Training Programs For Community Health Workers In Rural Uganda, Elizabeth Butler, Edward O’Neil, Zachary Tabb, Edward Mwebe, John Mukadde, Prossy Jim, Michael A. Godkin, Judith A. Savageau, Safi Ahmed, Arwen Wolfe 2012 University of Massachusetts Medical School

Evaluating The Efficacy Of Training Programs For Community Health Workers In Rural Uganda, Elizabeth Butler, Edward O’Neil, Zachary Tabb, Edward Mwebe, John Mukadde, Prossy Jim, Michael A. Godkin, Judith A. Savageau, Safi Ahmed, Arwen Wolfe

Senior Scholars Program

Background: The Ministry of Health and Omnimed, a non-profit U.S.-based organization that works with international communities to provide basic health education, have partnered to provide health training to community health workers (henceforth referred to as village health workers or VHWs) in rural villages in Uganda. The training is provided via an intensive five-day long session that introduces a wide variety of themes in basic health education taught by experts in the respective fields. The participants are selected by the local government based on their age, reliability, level of education and availability. On the first day, the participants are ...


Health Care For The Homeless: An Aging Demographic 2006 To 2010, Jennifer Aborn Russo, Carole C. Upshur 2012 University of Massachusetts Medical School

Health Care For The Homeless: An Aging Demographic 2006 To 2010, Jennifer Aborn Russo, Carole C. Upshur

Senior Scholars Program

Background: Homelessness in America is a growing problem. An estimated 1.59 million people spent at least one night in an emergency shelter or transitional housing program in 2010. Of this group, an estimated 2.8% were over the age of 62. The number of elderly homeless individuals is expected to increase by about 33% between 2010 and 2020 and more than double by 2050. Programs like the Health Care for the Homeless serve to both medically care for this growing population as well as collect data about their specific demographics and health care needs.

Objectives: We studied demographic and ...


Are Our Students Teachers?, Joel Bradley, Melissa A. Fischer 2012 University of Massachusetts Medical School

Are Our Students Teachers?, Joel Bradley, Melissa A. Fischer

Senior Scholars Program

Background: Though the practical and philosophical importance of teaching educational skills to students of medicine has been widely acknowledged, the principle accrediting bodies of resident and medical student training in the U.S. do not require medical schools to offer formal training in how to teach. Both recognize resident teaching in their competencies: the Accreditation Council for Graduate Medical Education (ACGME) requires all residencies to have a formal program in teaching; the Liaison Committee on Medical Education (LCME) mandates that all residents and faculty charged with teaching medical students “be prepared for their roles in teaching and assessment.” But many ...


Codon Optimization For Alpha 1-Antitrypsin Disease, Timothy Menz, Qiushi Tang, Lina Song, Christian Mueller, Terence R. Flotte 2012 University of Massachusetts Medical School

Codon Optimization For Alpha 1-Antitrypsin Disease, Timothy Menz, Qiushi Tang, Lina Song, Christian Mueller, Terence R. Flotte

Senior Scholars Program

Alpha 1-antitrypsin deficiency is a genetic disorder caused by defective production of alpha 1-antitrypsin (AAT). Gene therapy approaches have been conducted in patients with AAT deficiency with successful AAT expression, but not to the therapeutic levels required to reduce the risk of emphysema. Codon optimization, a somewhat new and evolving technique, is used by many scientists to maximize protein expression in living organisms by altering translational and transcriptional efficiency as well as protein refolding. The purpose of this study was to develop single stranded and double stranded AAT gene constructs, test their protein expression in vitro, and compare with those ...


Assessing Oral Health Curriculum In U.S. Family Medicine Residency Programs: A National Survey, Ronnelle King, Hugh Silk, Judith A. Savageau, Ian M. Bennett, Alexander W. Chessman 2012 University of Massachusetts Medical School

Assessing Oral Health Curriculum In U.S. Family Medicine Residency Programs: A National Survey, Ronnelle King, Hugh Silk, Judith A. Savageau, Ian M. Bennett, Alexander W. Chessman

Senior Scholars Program

Background: During the past decade, national initiatives have called for improved oral health (OH) training for physicians. However, how Family Medicine residency programs have answered this call is unknown.

Objectives: The purpose of this study was to determine how much oral health education is being provided to Family Medicine residents, if the program directors are aware of the importance of oral health, and if there are specific barriers to teaching oral health curricula in these programs.

Methods: 452 Family Medicine residency directors were surveyed about numbers of hours of OH teaching, topics covered, and perceived barriers to this education.

Results ...


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