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Plants, People, And Partnership In Madagascar: How Pharmaceutical Companies And Bioprospecting Ventures Must And May Positively Benefit The Communities Whose Resources They Use, Rebecca Slotkin 2011 SIT Study Abroad

Plants, People, And Partnership In Madagascar: How Pharmaceutical Companies And Bioprospecting Ventures Must And May Positively Benefit The Communities Whose Resources They Use, Rebecca Slotkin

Independent Study Project (ISP) Collection

For centuries, traditional medical practitioners around the world have understood the tremendous wealth of medicinal power that can be found in the natural environment. In Madagascar, traditional practitioners have both used and cared for their natural environment, which in turn has given them a wide array of medical knowledge. According to the World Health Organization (WHO), “approximately 80% of the world’s inhabitants rely predominantly on traditional medicines for their primary health care” (Cao et al. 2009). Traditional medical knowledge has relatively recently come to the attention of the international medical market. This “recent ‘rediscovery’ of medicinally useful plants” (Sheldon ...


The Benefits Of Having An Integrated Health Care System In Madagascar, Elizabeth Miller 2011 SIT Study Abroad

The Benefits Of Having An Integrated Health Care System In Madagascar, Elizabeth Miller

Independent Study Project (ISP) Collection

For my individual research, I wanted to look into all the benefits that could be offered by collaborating allopathic and traditional healthcare systems and how such a system is accomplished in Madagascar, in order to weigh and to discover the feasibility of using integrated healthcare systems as sustainable development in other parts of the world. Furthermore, as Madagascar sets the example in my research this summer, the use of traditional and modern medicine as an integrated health care system best serves the majority of the Malagasy population for several important reasons.


“Mind The Gap” Addressing The Gap Between Health Care Policy & Health Care Reality In Madagascar & The Way Forward Integrating Traditional Medicine & Ethical Reform Within Health Care, Laura Dillon 2011 SIT Study Abroad

“Mind The Gap” Addressing The Gap Between Health Care Policy & Health Care Reality In Madagascar & The Way Forward Integrating Traditional Medicine & Ethical Reform Within Health Care, Laura Dillon

Independent Study Project (ISP) Collection

At first glance the health care system in Madagascar looks pretty good. No health care system is perfect, in fact most are far from perfect, but some certainly work better than others. On paper it seems that the current system in Madagascar would be among those that “work better”. Sadly, there is oftentimes a disconnect between what a government writes on paper and what happens in reality; looking around the streets of Antananarivo it quickly became apparent that Madagascar is an example of this disconnect. You do not have to be a health care professional to see the lack of ...


Suburban Poverty: Barriers To Services And Injury Prevention Among Marginalized Women Who Use Methamphetamine, Miriam W. Boeri, Benjamin Tyndall, Denise R. Woodall 2011 Kennesaw State University

Suburban Poverty: Barriers To Services And Injury Prevention Among Marginalized Women Who Use Methamphetamine, Miriam W. Boeri, Benjamin Tyndall, Denise R. Woodall

Faculty Publications

Objective: This paper aims to identify the needed healthcare and social services barriers for women living in suburban communities who are using or have used methamphetamine. Drug users are vulnerable to injury, violence and transmission of infectious diseases, and having access to healthcare has been shown to positively influence prevention and intervention among this population. Yet little is known regarding the social context of suburban drug users, their risks behaviors, and their access to healthcare.

Methods: The data collection involved participant observation in the field, face-to-face interviews and focus groups. Audio-recorded in-depth life histories, drug use histories, and resource needs ...


Acute Arginine Supplementation Fails To Improve Muscle Endurance Or Affect Blood Pressure Responses To Resistance Training, Beau K. Greer, Brett T. Jones 2011 Sacred Heart University

Acute Arginine Supplementation Fails To Improve Muscle Endurance Or Affect Blood Pressure Responses To Resistance Training, Beau K. Greer, Brett T. Jones

All PTHMS Faculty Publications

Dietary supplement companies claim that arginine supplements acutely enhance skeletal muscular endurance. The purpose of this study was to determine whether acute arginine a-ketoglutarate supplementation (AAKG) will affect local muscle endurance of the arm and shoulder girdle or the blood pressure (BP) response to anaerobic exercise. Twelve trained college-aged men (22.6 +/- 3.8 years) performed 2 trials of exercise separated by at least 1 week. At 4 hours before, and 30 minutes before exercise, a serving of an AAKG supplement (3,700 mg arginine alpha-ketoglutarate per serving) or placebo was administered. Resting BP was assessed pre-exercise after 16 minutes ...


A System Dynamics Model Of Pharmaceutical Opioids: Medical Use, Diversion, And Nonmedical Use, Teresa Schmidt, Wayne Wakeland, J. David Haddox 2011 Portland State University

A System Dynamics Model Of Pharmaceutical Opioids: Medical Use, Diversion, And Nonmedical Use, Teresa Schmidt, Wayne Wakeland, J. David Haddox

Systems Science Faculty Publications and Presentations

A dramatic rise in the nonmedical of pharmaceutical opioids has presented the United States with a substantial public health problem. Nonmedical use of prescription pain relievers has become increasingly prevalent in the US over the last two decades, and diversion of medicines obtained by prescription is assumed to be a major source of supply for nonmedical opioid use. Policymakers striving to protect population health by ameliorating the adverse outcomes of nonmedical use of opioid analgesics could benefit from a systems-level model which reflects the complexity of the system and incorporates the full range of available data. To address this need ...


A System Dynamics Model Of Pharmaceutical Opioids: Medical Use, Diversion, And Nonmedical Use, Teresa D. Schmidt, Wayne W. Wakeland, J. David Haddox 2011 Portland State University

A System Dynamics Model Of Pharmaceutical Opioids: Medical Use, Diversion, And Nonmedical Use, Teresa D. Schmidt, Wayne W. Wakeland, J. David Haddox

Wayne W. Wakeland

Abstract: A dramatic rise in the nonmedical of pharmaceutical opioids has presented the United States with a substantial public health problem. Nonmedical use of prescription pain relievers has become increasingly prevalent in the US over the last two decades, and diversion of medicines obtained by prescription is assumed to be a major source of supply for nonmedical opioid use. Policymakers striving to protect population health by ameliorating the adverse outcomes of nonmedical use of opioid analgesics could benefit from a systems-level model which reflects the complexity of the system and incorporates the full range of available data. To address this ...


Abnormal Placental Findings Associated With Non-Reassuring Fetal Monitoring And Excellent Neonatal Outcomes, Gary Ventolini, Shanthi Ramesh, Sheela M. Barhan, Ran Neiger 2011 Wright State University

Abnormal Placental Findings Associated With Non-Reassuring Fetal Monitoring And Excellent Neonatal Outcomes, Gary Ventolini, Shanthi Ramesh, Sheela M. Barhan, Ran Neiger

Obstetrics and Gynecology Faculty Publications

Objective: Obstetricians, Neonatologists, and Pathologists have studied gross histological analysis of human placentas in search of specific alterations in placental functions that can be correlated with neonatal outcomes. Our study assessed the prevalence of abnormal placental findings associated with non-reassuring fetal monitoring in labor requiring emergent instrumental or cesarean delivery, followed by an excellent neonatal outcome. Study Design: One hundred consecutive emergency deliveries, instrumental or cesarean, performed due to non-reassuring fetal monitoring while in labor were retrospectively evaluated. All patients were low-risk for obstetric complications, and had a singleton, term pregnancy. They had a normal antenatal routine testing and a ...


'How To Contain Generalized Hiv Epidemics' Article Misconstrues The Evidence, Richard Wamai, B. Morris 2011 Northeastern University

'How To Contain Generalized Hiv Epidemics' Article Misconstrues The Evidence, Richard Wamai, B. Morris

Richard G. Wamai

No abstract provided.


Making The Move To Blended Learning: Reflections On A Faculty Development Program, Carole Myers, Sandra Mixer, Tami Wyatt, Trena Paulus, Debra Lee 2011 University of Tennessee - Knoxville

Making The Move To Blended Learning: Reflections On A Faculty Development Program, Carole Myers, Sandra Mixer, Tami Wyatt, Trena Paulus, Debra Lee

Sandra J Mixer

Lessons learned from a faculty development program that preceded the move of a traditional PhD program in nursing to a blended learning model using online and face-to-face strategies are discussed. The majority of lessons and strategies presented are universal to any faculty development program. The lessons are organized into seven topics: Situational Leadership, Adult Learners, Just in Time Teaching, Thinking About Learning and Teaching, Lifelong Learning, Transparency and Collaboration, and Community. Our far-reaching lessons are related to the contextual nature of leadership, how to effectively design and time learning experiences for adults, the importance of open and supportive communities working ...


A Challenging Case: A Dog With A Painful Red Eye, Juliet Gionfriddo, Thomas Chen 2011 University of Tennessee, Knoxville

A Challenging Case: A Dog With A Painful Red Eye, Juliet Gionfriddo, Thomas Chen

Thomas Chen DVM, DACVO

A 7-year-old 19.8-lb (9-kg) intact female Scottish terrier was presented to the Colorado State University (CSU) James L. Voss Veterinary Teaching Hospital for evaluation of redness and pain of the right eye of four days' duration.


The Prevalence Of Childhood Overweight And Obesity In A Health Maintenance Organization In Hawaii, MariaIliana Stark, Victoria Niederhauser, Janet Camacho, Lance Shirai 2011 University of Tennessee, Knoxville

The Prevalence Of Childhood Overweight And Obesity In A Health Maintenance Organization In Hawaii, Mariailiana Stark, Victoria Niederhauser, Janet Camacho, Lance Shirai

Victoria Niederhauser

In the past 20-30 years, the number of overweight children in the United States has doubled.1 Overweight children are acquiring conditions such as hypertension, type II diabetes, hypercholesterolemia, sleep apnea, and orthopedic problems. The purpose of this study was to explore the prevalence of and factors associated with at risk and overweight in children 2-10 years of age in a Health Maintenance Organization (HMO) in Hawai'i. This quantitative, retrospective cross-sectional study included a stratified random sample of 554 children ages 2-10 years who received a well child health care exam at a HMO in 2003. The prevalence of ...


Pcr Prevalence Of Ranavirus In Free-Ranging Eastern Box Turtles (Terrapene Carolina Carolina) At Rehabilitation Centers In Three Southeastern Us States, Matthew Allender, M Abd-Eldaim, Juergen Schumacher, D McRuer, L Christian, Melissa Kennedy 2011 University of Tennessee - Knoxville

Pcr Prevalence Of Ranavirus In Free-Ranging Eastern Box Turtles (Terrapene Carolina Carolina) At Rehabilitation Centers In Three Southeastern Us States, Matthew Allender, M Abd-Eldaim, Juergen Schumacher, D Mcruer, L Christian, Melissa Kennedy

Melissa A. Kennedy

Ranaviruses (genus Ranavirus) have been observed in disease epidemics and mass mortality events in free-ranging amphibian, turtle, and tortoise populations worldwide. Infection is highly fatal in turtles, and the potential impact on endangered populations could be devastating. Our objectives were to determine the prevalence of ranavirus DNA in blood and oral swabs, report associated clinical signs of infection, and determine spatial distribution of infected turtles. Blood and oral swabs were taken from 140 eastern box turtles (Terrapene carolina carolina) that were presented to the wildlife centers at the University of Tennessee (UT; n=39), Wildlife Center of Virginia (WCV; n ...


11beta-Hydroxylase Inhibitors Protect Against Seizures In Mice By Increasing Endogenous Neurosteroid Synthesis, Rafal Kaminski, Michael Rogawski 2011 University of California - Davis

11beta-Hydroxylase Inhibitors Protect Against Seizures In Mice By Increasing Endogenous Neurosteroid Synthesis, Rafal Kaminski, Michael Rogawski

Michael A. Rogawski

Steroid 11β-hydroxylase (CYP11B1; EC 1.14.15.4) is a mitochondrial enzyme located in the zona fasciculata of the adrenal cortex and also in the brain that mediates the conversion of 11-deoxycortisol to cortisol and 11-deoxycorticosterone (DOC) to corticosterone. Inhibitors of CYP11B1, such as metyrapone and etomidate, reduce glucocorticoid synthesis and raise levels of DOC providing greater availability for metabolic conversion to the GABA-A receptor modulating neurosteroid allotetrahydrodeoxycorticosterone (THDOC). Because THDOC is potent anticonvulsant, it is plausible that CYP11B1 inhibitors could protect against seizures. Here we demonstrate that metyrapone affords dose-dependent protection against 6-Hz seizures 30 min after injection (ED50 ...


Capsaicin Represses Transcriptional Activity Of Β-Catenin In Human Colorectal Cancer Cells, S. Lee, R. Richardson, R. Dashwood, Seung Baek 2011 The University of Tennessee

Capsaicin Represses Transcriptional Activity Of Β-Catenin In Human Colorectal Cancer Cells, S. Lee, R. Richardson, R. Dashwood, Seung Baek

Seung J Baek

Capsaicin is a pungent ingredient in chili red peppers and has been linked to suppression of growth in various cancer cells. However, the underlying mechanism(s) by which capsaicin induces growth arrest and apoptosis of cancer cells is not completely understood. In the present study, we investigated whether capsaicin alters β-catenin-dependent signaling in human colorectal cancer cells in vitro. Exposure of SW480, LoVo and HCT-116 cells to capsaicin suppressed cell proliferation. Transient transfection with a β-catenin/T-cell factor (TCF)-responsive reporter indicated that capsaicin suppressed the transcriptional activity of β-catenin/TCF. Capsaicin treatment resulted in a decrease of intracellular β-catenin ...


Narrative Analysis, M Murray, Sally Sargeant 2011 Bond University

Narrative Analysis, M Murray, Sally Sargeant

Sally Sargeant

No abstract provided.


Alternaria Fungal Dermatitis In A Free-Ranging Javelina (Pecari Tajacu), L Shender, Richard Gerhold Jr., S Sanchez, M Keel 2011 University of Tennessee, Knoxville

Alternaria Fungal Dermatitis In A Free-Ranging Javelina (Pecari Tajacu), L Shender, Richard Gerhold Jr., S Sanchez, M Keel

Richard W. Gerhold Jr., DVM, MS, PhD

We report a javelina from Pinal County, Arizona, USA, with severe fungal dermatitis and cellulitis. Extreme emaciation and rostral disfiguration, including left-lateral displacement of the nasal planum, justified euthanasia. A pus-filled tract within the rostrum was observed. Histopathology revealed granulomatous inflammation with hyphae morphologically consistent with Alternaria sp. isolated by culture.


Load Carriage And The Female Soldier, Rob Marc Orr, Venerina Johnston, Julia Coyle, Rodney Pope 2011 University of Queensland

Load Carriage And The Female Soldier, Rob Marc Orr, Venerina Johnston, Julia Coyle, Rodney Pope

Rob Marc Orr

This paper reviews the physiological, biomechanical and health impacts of load carriage on the female soldier and extends to include issues acknowledged as impacting on the female athlete and hence the female soldier. Physiological factors such as fat mass, strength, aerobic endurance and biomechanical factors such as stride length and forward lean have the potential to increase the energy cost of load carriage and cause injury. The female athlete triad, iron deficiency, pelvic floor muscle dysfunction and military equipment issues can likewise reduce female soldier performance and increase injury risk. Research evidence is presented to inform the development and implementation ...


Treatment Options In Asthma And Copd Overlap Syndrome, Shambhu Aryal, Enrique Diaz-Guzman, David M. Mannino 2011 University of Kentucky Medical Center

Treatment Options In Asthma And Copd Overlap Syndrome, Shambhu Aryal, Enrique Diaz-Guzman, David M. Mannino

David M. Mannino

Asthma and chronic obstructive pulmonary diseases (COPD) are the most common obstructive lung diseases and may coexist in adults. The term ‘asthma and COPD overlap syndrome’ has been used to describe patients who have clinical features of both conditions. Recognition of the overlap syndrome is key to managing these patients successfully. The goals of treatment include reducing exposure to risk factors, reducing symptoms, maintaining lung function and normal activity, preventing exacerbations, reducing mortality and minimising adverse effects of treatment. Based on our understanding of the two disease processes, the cornerstones of pharmacological treatment in the overlap syndrome include anti-inflammatory agents ...


Aldehyde Dehydrogenase 2 (Aldh2) And Glutathione S-Transferase M1 (Gstm1) Polymorphisms In Relation To Oral Cancer Risk Among Malaysians, Karen-Ng L. P., Ghani W. M. N., Vimmitra A., Yuen K. M., Tan H. S., Lim S. J., Abraham M. T., Rahman Z. A. A., Tay K. K., Mustafa W. M. W., Jalil N., Norlida A., Cheong S. C., Rosnah Binti Zain 2011 University of Malaya

Aldehyde Dehydrogenase 2 (Aldh2) And Glutathione S-Transferase M1 (Gstm1) Polymorphisms In Relation To Oral Cancer Risk Among Malaysians, Karen-Ng L. P., Ghani W. M. N., Vimmitra A., Yuen K. M., Tan H. S., Lim S. J., Abraham M. T., Rahman Z. A. A., Tay K. K., Mustafa W. M. W., Jalil N., Norlida A., Cheong S. C., Rosnah Binti Zain

Prof. Dr. Rosnah Binti Zain

Introduction: ALDH2 is an enzyme involved in major oxidative pathway of alcohol metabolism while GSTM1 is a drug-metabolizing enzyme of acetaldehyde. It has been reported that the mutant ALDH2 allele and the absence of GSTM1 contributes to increased oral cancer risk due to reduced acetaldehyde metabolism. This study aims to determine ALDH2 and GSTM1 polymorphisms and its association with oral cancer risk. Method: An unmatched case-control study was conducted using 163 oral cancer patients and 87 non-cancer subjects selected from the OCRCC database. ALDH2 and GSTM1 genotypes were determined using PCR-RFLP from peripheral blood. Multiple logistic regression was employed to ...


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