Acute Effects Of A Selective Cannabinoid-2 Receptor Agonist On Neuroinflammation In A Model Of Traumatic Brain Injury., 2011 Department of Neurological Surgery, Thomas Jefferson University
Acute Effects Of A Selective Cannabinoid-2 Receptor Agonist On Neuroinflammation In A Model Of Traumatic Brain Injury., Melanie B Elliott, Ronald F Tuma, Peter S Amenta, Mary F Barbe, Jack I Jallo
Department of Neurosurgery Faculty Papers
Proposed therapeutic strategies for attenuating secondary traumatic brain injury (TBI) include modulation of acute neuroimmune responses. The goal of this study was to examine the acute effects of cannabinoid-2 receptor (CB(2)R) modulation on behavioral deficits, cerebral edema, perivascular substance P, and macrophage/microglial activation in a murine model of TBI. Thirty male C57BL/6 mice underwent sham surgery, or cortical contusion impact injury (CCI). CCI mice received vehicle or the CB(2)R agonist 0-1966 at 1 and 24 h after injury. Performance on the rotarod, forelimb cylinder, and open-field tests were evaluated before and at 48 h ...
Role And Mechanism Of Arsenic In Regulating Angiogenesis., 2011 Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Role And Mechanism Of Arsenic In Regulating Angiogenesis., Ling-Zhi Liu, Yue Jiang, Richard L Carpenter, Yi Jing, Stephen C Peiper, Bing-Hua Jiang
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Arsenic is a wide spread carcinogen associated with several kinds of cancers including skin, lung, bladder, and liver cancers. Lung is one of the major targets of arsenic exposure. Angiogenesis is the pivotal process during carcinogenesis and chronic pulmonary diseases, but the role and mechanism of arsenic in regulating angiogenesis remain to be elucidated. In this study we show that short time exposure of arsenic induces angiogenesis in both human immortalized lung epithelial cells BEAS-2B and adenocarcinoma cells A549. To study the molecular mechanism of arsenic-inducing angiogenesis, we find that arsenic induces reactive oxygen species (ROS) generation, which activates AKT ...
Evaluation Of The Use Of Patient-Focused Simulation For Student Assessment In A Surgery Clerkship., 2011 Thomas Jefferson University
Evaluation Of The Use Of Patient-Focused Simulation For Student Assessment In A Surgery Clerkship., Gerald A Isenberg, Katherine W Berg, Judith A Veloski, Dale D Berg, J J. Veloski, Charles Yeo
Department of Surgery Faculty Papers
BACKGROUND: The purpose of this study was to evaluate the use of simulated patients in conjunction with anatomic and tissue task-training models to assess skills.
METHODS: Faculty reviewed the objectives of the clerkship to identify skills to be acquired. Three cases were developed related to rectal examination, suturing, and inserting intravenous lines and nasogastric tubes. Student scores were based on their ability to gather data from simulated patients and perform procedures on simulation models.
RESULTS: A total of 670 students were assessed between 2006 and 2009. Alpha reliability coefficients were .97 for Communication/Interpersonal Skills, .71 for Procedures, and .58 ...
Endothelial Differentiation Of Adipose-Derived Stem Cells From Elderly Patients With Cardiovascular Disease., 2011 Department of Surgery, Thomas Jefferson University
Endothelial Differentiation Of Adipose-Derived Stem Cells From Elderly Patients With Cardiovascular Disease., Ping Zhang, Neil Moudgill, Eric Hager, Nicolas Tarola, Christopher Dimatteo, Stephen Mcilhenny, Thomas Tulenko, Paul J Dimuzio
Department of Surgery Faculty Papers
Adipose-derived stem cells (ASCs) possess significant therapeutic potential for tissue engineering and regeneration. This study investigates the endothelial differentiation and functional capacity of ASCs isolated from elderly patients. Isolation of ASCs from 53 patients (50-89 years) revealed that advanced age or comorbidity did not negatively impact stem cell harvest; rather, higher numbers were observed in older donors (>70 years) than in younger. ASCs cultured in endothelial growth medium-2 for up to 3 weeks formed cords upon Matrigel and demonstrated acetylated-low-density lipoprotein and lectin uptake. Further stimulation with vascular endothelial growth factor and shear stress upregulated endothelial cell-specific markers (CD31, von ...
Mediator Influences Telomeric Silencing And Cellular Life Span, 2011 University of Gothenburg
Mediator Influences Telomeric Silencing And Cellular Life Span, Xuefeng Zhu, Beidong Liu, Jonas O. P. Carlsten, Jenny Beve, Thomas Nyström, Lawrence C. Myers, Claes M. Gustafsson
Open Dartmouth: Faculty Open Access Articles
The Mediator complex is required for the regulated transcription of nearly all RNA polymerase II-dependent genes. Here we demonstrate a new role for Mediator which appears to be separate from its function as a transcriptional coactivator. Mediator associates directly with heterochromatin at telomeres and influences the exact boundary between active and inactive chromatin. Loss of the Mediator Med5 subunit or mutations in Med7 cause a depletion of the complex from regions located near subtelomeric X elements, which leads to a change in the balance between the Sir2 and Sas2 proteins. These changes in turn result in increased levels of H4K16 ...
Comparison Of Two Commercial Ovine Campylobacter Vaccines And An Experimental Bacterin In Guinea Pigs Inoculated With Campylobacter Jejuni, Eric R. Burrough, Orhan Sahin, Paul J. Plummer, Kevin D. Diverde, Qijing Zhang, Michael J. Yaeger
Veterinary Microbiology and Preventive Medicine Publications
Objective—To compare efficacy of 2 commercial ovine Campylobacter vaccines and an experimental bacterin in guinea pigs following IP inoculation with Campylobacter jejuni IA3902.
Animals—51 female guinea pigs.
Procedures—Pregnant and nonpregnant animals were randomly assigned to 1 of 4 treatment groups and administered a commercial Campylobacter vaccine labeled for prevention of campylobacteriosis in sheep via two 5-mL doses 14 days apart (vaccine A; n = 13), another labeled for prevention of campylobacteriosis via two 2-mL doses (vaccine B; 12), an experimental bacterin prepared from the challenge strain (12), or a sham vaccine (14). Ten days later, animals were challenged ...
Pilot Evaluation Of An Internet Educational Module For Agricultural Safety, 2011 Iowa State University
Pilot Evaluation Of An Internet Educational Module For Agricultural Safety, Charles V. Schwab, Steven A. Freeman
Agricultural and Biosystems Engineering Publications
An important component of the safe operation of agricultural equipment is the ability to read and understand universal symbols. The Internet educational module is designed to help participants recognize these symbols. The impact of using it was evaluated using a field trial study. Assessment consisted of pre- and post-tests. Youth who had access to it averaged an improvement 29 points higher on the post-test than that of the control group. Overall, the Internet learning environment increased participants' ability to recognize universal symbols faster and more accurately. The study serves as a model for supplementing Extension programming with Web-based educational material.
Rfid Techniques For Passive Electronics, 2011 California Polytechnic State University - San Luis Obispo
Rfid Techniques For Passive Electronics, Ryan Behr, David Cobos
No abstract provided.
Determining A Method For Rendering Low Cost Cdse(Zns) Core(Shell) Quantum Dots Aqueous Soluble Via Amphiphilic Polymer Wrapping, 2011 California Polytechnic State University - San Luis Obispo
Determining A Method For Rendering Low Cost Cdse(Zns) Core(Shell) Quantum Dots Aqueous Soluble Via Amphiphilic Polymer Wrapping, Patrick Mcbride
Herein is described the procedure of two amphiphilic polymer wrapping techniques that may be employed for obtaining aqueous soluble quantum dots (QDs) for use in biological fluorescent imaging applications. The advent of QDs has led to new nanoscale fluorescent materials that exhibit unparalleled quantum yields (QYs), high resistance to photobleaching, tunable emissions, and
absorption over a large optical range. However, the QD synthesis employed here at Cal Poly to obtain bright, photostable CdSe(ZnS) core(shell) QDs involves the use of organic solvents and surfactants, leading to hydrophobic QDs. Since all of biology relies on aqueous solubility, this hydrophobicity creates ...
Structure Of The Atp Synthase Catalytic Complex (F(1)) From Escherichia Coli In An Autoinhibited Conformation., 2011 Dept. of Biochemistry and Molecular Biology, Thomas Jefferson University
Structure Of The Atp Synthase Catalytic Complex (F(1)) From Escherichia Coli In An Autoinhibited Conformation., Gino Cingolani, Thomas M Duncan
Department of Biochemistry and Molecular Biology Faculty Papers
ATP synthase is a membrane-bound rotary motor enzyme that is critical for cellular energy metabolism in all kingdoms of life. Despite conservation of its basic structure and function, autoinhibition by one of its rotary stalk subunits occurs in bacteria and chloroplasts but not in mitochondria. The crystal structure of the ATP synthase catalytic complex (F(1)) from Escherichia coli described here reveals the structural basis for this inhibition. The C-terminal domain of subunit ɛ adopts a heretofore unknown, highly extended conformation that inserts deeply into the central cavity of the enzyme and engages both rotor and stator subunits in extensive ...
Smoking During Pregnancy: Its Effects On The Prevalence Of Low Birth Weight Infants, 2011 Wright State University - Main Campus
Smoking During Pregnancy: Its Effects On The Prevalence Of Low Birth Weight Infants, Lynda M. Colussi
Master of Public Health Program Student Publications
Objective: The purpose of this research was to determine what impact demographic characteristics and the smoking status of mothers had on the prevalence and risk for LBW births. Methods: Birth certificate data from Montgomery County, Ohio from 2006-2009 was analyzed. Among the information collected were the infant's birth weight, the mother's age, marital status, education level, race, payer status at time of delivery, WIC status, and smoking status. The impact demographic characteristics and smoking status had on the prevalence of LBW births was determined by a logistic regression model. The effect of when women smoked during pregnancy had ...
Informatics And Data Mining Tools And Strategies For The Human Connectome Project, 2011 Washington University School of Medicine in St. Louis
Informatics And Data Mining Tools And Strategies For The Human Connectome Project, Daniel S. Marcus, John Harwell, Timothy Olsen, Michael Hodge, Matthew F. Glasser, Fred Prior, Mark Jenkinson, Timothy Laumann, Sandra W. Curtiss, David C. Van Essen
Open Access Publications
No abstract provided.
The Believe In All Your Possibilities Campaign: Updating A Social Marketing Campaign On A Shoe String Budget, 2011 Georgia Southern University
The Believe In All Your Possibilities Campaign: Updating A Social Marketing Campaign On A Shoe String Budget, John S. Luque, Moya L. Alfonso
Community Health Faculty Presentations
The purpose of this presentation is to provide participants with an understanding of how to revamp or refresh a brand on a limited budget using a case study approach. The ‘Believe in All Your Possibilities’ community-based prevention marketing campaign, which was targeted at reducing alcohol and tobacco use among middle school youth, was the result of a long term school-community-university partnership in Southeast Florida. This alcohol campaign has been continuously implemented for eight years. Encouraging evaluation results combined with recently acquired alcohol prevention funding served as the impetus for conducting research to determine if ‘Believe’: a) was still relevant to ...
Ischemia Impairs Vasodilation In Skeletal Muscle Resistance Artery, 2011 California Polytechnic State University - San Luis Obispo
Ischemia Impairs Vasodilation In Skeletal Muscle Resistance Artery, Kyle Remington Struthers
Master's Theses and Project Reports
Functional vasodilation in arterioles is impaired with chronic ischemia. We sought to examine the impact of chronic ischemia and age on skeletal muscle resistance artery function. To examine the impact of chronic ischemia, the femoral artery was resected from young (2-3mo) and adult (6-7mo) mice and the profunda femoris artery diameter was measured at rest and following gracilis muscle contraction 14 days later using intravital microscopy. Functional vasodilation was significantly impaired in ischemic mice (14.4±4.6% vs. 137.8±14.3%, p<0.0001 n=8) and non-ischemic adult mice (103.0±9.4% vs. 137.8±14.3%, p=0.05 n=10). In order to analyze the cellular mechanisms of the impairment, a protocol was developed to apply pharmacological agents to the experimental preparation while maintaining tissue homeostasis. Endothelial and smooth muscle dependent vasodilation were impaired with ischemia, 39.6 ± 13.6% vs. 80.5 ± 11.4% and 43.0 ± 11.7% vs. 85.1 ± 10.5%, respectively. From this data, it can be supported that smooth muscle dysfunction is the reason for the observed impairment in arterial vasodilation.
The Experience Of Forgiving In The Marital Relationship, 2011 Seton Hall University
The Experience Of Forgiving In The Marital Relationship, Kathleen M. Leo
Seton Hall University Dissertations and Theses (ETDs)
Congenital Diaphragmatic Hernia Presenting In The Sixth Decade Mimicking Pneumonia, 2011 Aga Khan University
Congenital Diaphragmatic Hernia Presenting In The Sixth Decade Mimicking Pneumonia, Saulat H. Fatimi, Nida Sajjad, Marium Muzaffar, Hashim Muhammad Hanif
Section of Cardiothoracic Surgery
Congenital diaphragmatic hernia presentation in adults is extremely rare. Patients who present with late diaphragmatic hernias complain of a wide variety of symptoms and diagnosis can be difficult. We report a case of a 64 year old male who presented with a six month history of cough, shortness of breath and weight loss. The most common strategy to treat a Bochdalek hernia is via a thoracotomy or laparotomy or both. In our patient the repair was performed with a thoracotomy.
Hub City Steps: Methods And Early Findings From A Community-Based Participatory Research Trial To Reduce Blood Pressure Among African Americans, 2011 Virgnia Polytechnic Institute and State University
Hub City Steps: Methods And Early Findings From A Community-Based Participatory Research Trial To Reduce Blood Pressure Among African Americans, Jamie M. Zoellner, Carol L. Connell, Michael B. Madson, Bo Wang, Vickie Blakely Reed, Elaine F. Molaison, M. Kathleen Yadrick
Background: Community-based participatory research (CBPR) has been recognized as an important approach to develop and execute health interventions among marginalized populations, and a key strategy to translate research into practice to help reduce health disparities. Despite growing interest in the CBPR approach, CBPR initiatives rarely use experimental or other rigorous research designs to evaluate health outcomes. This behavioral study describes the conceptual frameworks, methods, and early findings related to the reach, adoption, implementation, and effectiveness on primary blood pressure outcomes.
Methods: The CBPR, social support, and motivational interviewing frameworks are applied to test treatment effects of a two-phased CBPR walking ...
Effect Of Topical Menthol On Ipsilateral And Contralateral Superficial Blood Flow Following A Bout Of Maximum Voluntary Muscle Contraction, Robert V. Topp, Lee J. Winchester, Jessica Schilero, Dean E. Jacks
College of Nursing Faculty Research and Publications
Purpose/Background: Various doses of topical menthol are commonly applied prior to, during, and after exercise to relieve pain although there is limited empirical evidence examining the physiological effects of this treatment. The purpose of this study was to examine the effects of two different doses of menthol (3.5% and 10%) on blood flow and arterial diameter before and after an acute bout of three isokinetic maximum voluntary muscular contraction (MVMC) of the quadriceps and hamstrings.
Methods: Blood flow and arterial diameter of the right and left popliteal arteries were measured with an ultrasound Doppler prior to and after ...
Stem Cells And Tissue Engineering In Dentistry — A Myth Or Reality, 2011 Aga Khan University
Stem Cells And Tissue Engineering In Dentistry — A Myth Or Reality, Farhan Raza Khan, Tashfeen Ahmad, Nurrudin Badruddin
Section of Dental-Oral Maxillofacial Surgery
No abstract provided.
Regular Post Dinner Walk; Can Be A Useful Lifestyle Modification For Gastroesophageal Reflux, 2011 Aga khan University
Regular Post Dinner Walk; Can Be A Useful Lifestyle Modification For Gastroesophageal Reflux, Shahid Karim, Wasim Jafri, Afsheen Faryal, Shahid Majid, Mohammad Salih, Fatima Jafri, Saeed Hamid, Hasnain Ali Shah, Zohaib Nawaz, Usman Tariq
Section of Gastroenterology
OBJECTIVES: To evaluate the correlation of gastroesophageal reflux disease (GERD) symptoms with routine post dinner physical activity and time interval before going to bed, in multiethnic South Asian population.
METHODS: Prospective, cross sectional analytical, multicenter study was conducted from February 2009 to March 2010. Patient's relative sitting in outpatient clinics with no comorbids, nonsmoker and non alcoholic were included. They were asked to fill a validated GERD questionnaire and were also inquired about routine post dinner physical activity (lying, sitting, walking) and dinner-bed time interval. Odds Ratios (OR) and their 95% Confidence Intervals (CI) were estimated using Logistic Regression ...