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Predictors Of Limb Fat Gain In Hiv Positive Patients Following A Change To Tenofovir-Emtricitabine Or Abacavir-Lamivudine, Allison Martin, Janaki Amin, Sean Emery, David Baker, Andrew Carr, David A. Cooper, Mark Bloch 2011 University of New South Wales

Predictors Of Limb Fat Gain In Hiv Positive Patients Following A Change To Tenofovir-Emtricitabine Or Abacavir-Lamivudine, Allison Martin, Janaki Amin, Sean Emery, David Baker, Andrew Carr, David A. Cooper, Mark Bloch

Faculty of Science, Medicine and Health - Papers

Background Antiretroviral treatment (cART) in HIV causes lipoatrophy. We examined predictors of anthropometric outcomes over 96 weeks in HIV-infected, lipoatrophic adults receiving stable cART randomised to tenofovir-emtricitabine (TDF-FTC) or abacavir-lamivudine (ABC-3TC) fixed dose combinations. Methodology/Principal Findings The STEAL study was a prospective trial of virologically suppressed participants randomised to either TDF-FTC (n = 178) or ABC-3TC (n = 179). Anthropometric assessment was conducted at baseline, weeks 48 and 96. The analysis population included those with baseline and week 96 data remaining on randomised therapy. Distribution of limb fat change was divided into four categories (≤0%, >0-10%, >10-20%, >20%). Baseline characteristics [demographics ...


How Generalisable Are Results Of Studies Conducted In Practicebased Research Networks? A Cross-Sectional Study Of General Practitioner Demographics In Two New South Wales Networks, Parker Magin, Melanie Marshall, Susan Goode, Georgina Cotter, C Dimity Pond, Nicholas Zwar 2011 University of Newcastle

How Generalisable Are Results Of Studies Conducted In Practicebased Research Networks? A Cross-Sectional Study Of General Practitioner Demographics In Two New South Wales Networks, Parker Magin, Melanie Marshall, Susan Goode, Georgina Cotter, C Dimity Pond, Nicholas Zwar

Faculty of Science, Medicine and Health - Papers

Objective: To compare the demographics of general practitioners in two practice-based research networks (PBRNs) and to explore the generalisability of research findings from these PBRNs. Design, setting and participants: Cross-sectional questionnaire-based study of two geographically-based PBRNs - Hunter New England Central Coast Network of Research General Practices (NRGP) and Primary Healthcare Research Network-General Practice (PHReNet-GP) - during August-September 2010. All 183 GP members of both PBRNs were invited to participate; of these, 140 (77%) participated. Main outcome measures: GPs' demographics, use of languages other than English in consultations, and previous participation in research. Practices' use of practice nurses. Socioeconomic status and rurality ...


Feasibility And Effectiveness Of Nurse-Delivered Smoking Cessationcounselling Combined With Nicotine Replacement In Australiangeneral Practicedar_2, Nicholas Zwar, Robyn Richmond, Gail Forlonge, Iqbal Hasan 2011 University of New South Wales

Feasibility And Effectiveness Of Nurse-Delivered Smoking Cessationcounselling Combined With Nicotine Replacement In Australiangeneral Practicedar_2, Nicholas Zwar, Robyn Richmond, Gail Forlonge, Iqbal Hasan

Faculty of Science, Medicine and Health - Papers

Introduction and Aims. Practice nurses (PN) are an alternative workforce for cessation support in primary care, but their role and effectiveness is underdeveloped and underresearched. This study evaluated a model of smoking cessation intervention in Australian general practice based on PNs. Smokers were identified by their general practitioner (GP) and referred to the PN for cessation support over four counselling visits and offered free nicotine patches. Design and Methods. Pre- and post-study using mixed quantitative and qualitative methods. Cessation outcomes were collected by patient self-report at 6months. Semistructured interviews were conducted with PNs and GPs to provide qualitative data on ...


Strategic Approaches To The Development Of Australia's Future Primary Care Workforce, Mark Fort Harris, Nicholas Arnold Zwar, Christine Walker, Sabina M. Knight 2011 University of New South Wales

Strategic Approaches To The Development Of Australia's Future Primary Care Workforce, Mark Fort Harris, Nicholas Arnold Zwar, Christine Walker, Sabina M. Knight

Faculty of Science, Medicine and Health - Papers

Shortages in, and maldistribution of, the primary health care workforce will continue to limit access to health care. The current health reform proposals and policies recognise workforce development as a priority, but only partially address the barriers to improvement. In particular, there will need to be more systematic development of interdisciplinary education within primary health care services, and funding to support this.


Annual Influenza Vaccination: Coverage And Attitudes Of Primary Care Staff In Australia, Kirsten Ward, Holly Seale, Nicholas Zwar, Julie Leask, C Raina Macintyre 2011 GP NSW

Annual Influenza Vaccination: Coverage And Attitudes Of Primary Care Staff In Australia, Kirsten Ward, Holly Seale, Nicholas Zwar, Julie Leask, C Raina Macintyre

Faculty of Science, Medicine and Health - Papers

Background Annual influenza vaccination is recommended for all Australian health care workers (HCWs) including those working in primary health care. There is limited published data on coverage, workplace provision, attitudes and personal barriers to influenza vaccination amongst primary health care staff. The aim of this study was to contribute to the limited literature base in this important area by investigating these issues in the primary health care setting in New South Wales (NSW), Australia. Methods A postal survey was sent to general practitioners (GPs) and practice nurses (PNs) from inner city, semi-urban and rural areas of NSW, Australia. There were ...


Investigation Of Diarrhoea In A Traveller Just Returned From India, Nicholas Arnold Zwar, Adrienne Torda 2011 University of New South Wales

Investigation Of Diarrhoea In A Traveller Just Returned From India, Nicholas Arnold Zwar, Adrienne Torda

Faculty of Science, Medicine and Health - Papers

The causes of diarrhoea in people returning from travelling can be infective and non-infective, and the duration of symptoms is an important factor in identifying the cause. The article outlines the appropriate investigations


Approaches For Enhancing Therapeutic Efficacy Of A Novel Il-10 Gene Family Member: Mda-7/Il-24, Belal Azab 2011 Virginia Commonwealth University

Approaches For Enhancing Therapeutic Efficacy Of A Novel Il-10 Gene Family Member: Mda-7/Il-24, Belal Azab

Theses and Dissertations

Melanoma differentiation associated gene-7 (mda-7) was discovered in the Fisher laboratory by subtraction hybridization of temporally spaced subtracted cDNA libraries prepared from terminally differentiated human melanoma cells treated with human fibroblast interferon (IFN-β) and the protein kinase C activator mezerein (MEZ), an approach called ‘differentiation induction subtraction hybridization’ (DISH). mda-7 is located in human chromosome 1q32–33 and based on sequence homology, chromosomal localization, and its functional properties, the mda-7 gene is now classified as a member of the IL-10 family of cytokines and named IL-24. The mda-7/IL-24 cDNA encodes a protein of 206-amino acids with a predicted size ...


New Perspectives On Melanoma: The Role Of Pax3, Sandra Medic 2011 Edith Cowan University

New Perspectives On Melanoma: The Role Of Pax3, Sandra Medic

Theses: Doctorates and Masters

Background: Cutaneous melanoma is an aggressive form of skin cancer, arising in cutaneous melanocytes. The transcription factor PAX3 is critical for the proper development of neural crest lineages including melanocytes. Melanocytic cells show continued PAX3 expression from melanoblast formation in the neural crest to their differentiation into melanocytes. While many studies clarify the importance of PAX3 in embryonic development of melanocytes, less well understood, and more perplexing, is the continued PAX3 expression in adult skin melanocytes. By contrast PAX3 is frequently found in melanomas and naevi, and its expression correlates with melanoma staging. In this study we explore the multiple ...


Creating Persuasive Messages To Promote Abstinence From Alcohol During Pregnancy, Kathryn France 2011 Edith Cowan University

Creating Persuasive Messages To Promote Abstinence From Alcohol During Pregnancy, Kathryn France

Theses: Doctorates and Masters

While the rates of Fetal Alcohol Spectrum Disorder within Australia are unknown, the rates of alcohol use during pregnancy and at-risk alcohol use by women of childbearing age highlight the need for universal prevention strategies addressing prenatal alcohol exposure. Though many awareness-raising campaigns for alcohol use during pregnancy have been conducted, predominantly in North America, they have rarely been developed using formative research nor have they been comprehensively evaluated (Saskatchewan Prevention Institute, 2009; Elliott et al., 2008). This lack of published information on the development and evaluation of campaigns makes it difficult to determine what communication elements are most credible ...


Lesion Of Cholinergic Neurons In Nucleus Basalis Enhances Response To General Anesthetics, Leung L. Stan 2011 University of Western Ontario

Lesion Of Cholinergic Neurons In Nucleus Basalis Enhances Response To General Anesthetics, Leung L. Stan

Physiology and Pharmacology Publications

Acetylcholine in the brain has been associated with consciousness and general anesthesia effects. We tested the hypothesis that the integrity of the nucleus basalis magnocellularis (NBM) affects the response to general anesthetics. Cholinergic neurons in NBM were selectively lesioned by bilateral infusion of 192IgG-saporin in adult, male Long–Evans rats, and control rats were infused with saline. Depletion of choline-acetyltransferase (ChAT)-immunoreactive cells in the NBM and decrease in optical density of acetylcholinesterase (AChE) staining in the frontal and visual cortices confirmed a significant decrease in NBM cholinergic neurons in lesioned as compared to control rats. AChE staining in the ...


Anticipatory Testosterone Response To Competition In Female Collegiate Endurance Athletes, Becca Adams 2011 University of Puget Sound

Anticipatory Testosterone Response To Competition In Female Collegiate Endurance Athletes, Becca Adams

Summer Research

High blood testosterone has been linked to the expression of aggressive personalities, but few studies have investigated the relationship between testosterone and competitiveness in anticipation of athletic competition. The purpose of this study was to examine the relationship between self-reported competitiveness and the anticipatory pre-competition circulating testosterone level. Twelve college-aged female athletes participated in a track relay-style race. Blood serum testosterone was tested 24 hours prior and 15 minutes prior to a competition using chemiluminescent immunoassay. Subjects completed the Revised Competitiveness Index (RCI) upon finishing the race. A dependent t-test was used to calculate differences between the two serum samples ...


The Acute Effect Of Pre-Exercise Static And Dynamic Stretching Of The Leg Flexors, Jocelyn Riordan 2011 University of Puget Sound

The Acute Effect Of Pre-Exercise Static And Dynamic Stretching Of The Leg Flexors, Jocelyn Riordan

Summer Research

The purpose of this study was to investigate the acute effects of pre-exercise static and dynamic stretching on peak torque of the knee extensors in female athletes and non-athletes. Thirty subjects (15 athletes and 15 non-athletes) completed three tests on an isokinetic dynamometer. After performing a randomly assigned pre-exercise stretching protocol (no stretching, static or dynamic) the subjects performed eight maximal, reciprocal knee extensions on an isokinetic dynamometer at three speeds (180, 120, 60˚/s) while measuring peak torque. No significant differences (p < .05) were found among the three stretching protocols for either the athletes or non-athletes. However, the results suggest that static stretching may cause a loss in overall peak torque in contrast to dynamic stretching in athletes.


Force Characteristics In Different Shoe Designs, Bryson Nakamura 2011 University of Puget Sound

Force Characteristics In Different Shoe Designs, Bryson Nakamura

Summer Research

Women’s shoes are known to be constructed from the same parameters as men’s shoes but on a smaller scale. However, foot and gait characteristics are different between genders The purpose of this study was to determine if mid-sole design has an effect on ground reaction force characteristics during running, cutting and jumping motions. Twenty-two apparently healthy female (73.8±8.4 kg; 1.74±0.06 m) and seven male (73.5±5.3 kg; 1.68±0.02 m) current or recently graduated NCAA Division III athletes voluntarily participated in this study. Subjects wore four shoes with ...


The Relationship Between Dynamic Balance And Isokinetic Ankle Strength In Female College Athletes, Nika Evans 2011 University of Puget Sound

The Relationship Between Dynamic Balance And Isokinetic Ankle Strength In Female College Athletes, Nika Evans

Summer Research

Conflicting results have been found between dynamic balance and isokinetic ankle strength. PURPOSE: To investigate the relationships between ankle strength and dynamic balance. METHOD: 15 healthy female Division III varsity athletes (INSERT DEMOGRAPHIC DATA) were tested on a Cybex NORM isokinetic dynamometer performing maximal ankle plantar and dorsiflexion. Dynamic balance was assessed using the SEBT. Isokinetic strength was assessed through 8 maximal contractions of plantar and dorsiflexion at 60, 120, and 180º/s with a 60 second rest period between each velocity set. Pearson’s correlations were used to assess the relationship between the dynamic balance score and peak torque ...


Effect Of Shoe Design And Gender On Valgus Angle, Mandy Warner 2011 University of Puget Sound

Effect Of Shoe Design And Gender On Valgus Angle, Mandy Warner

Summer Research

The purpose of this study was to determine the difference between genders in body position during jumping movements while wearing shoes with varying midsoles. Twenty-two apparently healthy female and seven males voluntarily participated in this study. Subjects were current or recently graduated NCAA division III athletes of weight bearing sports and familiar with plyometric jumping. Subjects performed plyometric jumps from three box heights (46 cm, 30.5 cm and 21.6 cm) while being filmed from both the front and side view. Each jump was completed wearing four different pairs of shoes. The subject was represented as digitized points designed ...


Yogic Diffusion The Effects Of Yogic Practice And Philosophy On Beliefs About Complementary And Alternative Medicine, Jacqueline Marie Siven 2011 University of Central Florida

Yogic Diffusion The Effects Of Yogic Practice And Philosophy On Beliefs About Complementary And Alternative Medicine, Jacqueline Marie Siven

Electronic Theses and Dissertations

This research is a qualitative study that aimed to anthropologically explore the effects of consistent long-term yogic practice on the acceptance and practice of complementary and alternative medicine (CAM) among yoga practitioners at a South Florida yoga center. I wished to determine, through in-depth interviews, whether or not yogic practice affects acceptance of CAM. The main objective was to interview individuals from a single yoga center that have practiced yoga at least once per week for at least one year concerning their beliefs about CAM, yoga, and health. This project will begin to fill the gap in social science, in ...


Creating Community-Academic Partnerships For Cancer Disparities Research And Health Promotion, John S. Luque, Cathy D. Meade, Janelle M. Menard, Dinorah Martinez Tyson, Clement K. Gwede 2011 Georgia Southern University

Creating Community-Academic Partnerships For Cancer Disparities Research And Health Promotion, John S. Luque, Cathy D. Meade, Janelle M. Menard, Dinorah Martinez Tyson, Clement K. Gwede

John S. Luque

To effectively attenuate cancer disparities in multiethnic, medically underserved populations, interventions must be developed collaboratively through solid community-academic partnerships and driven by community-based participatory research (CBPR). The Tampa Bay Community Cancer Network (TBCCN) has been created to identify and implement interventions to address local cancer disparities in partnership with community-based nonprofit organizations, faith-based groups, community health centers, local media, and adult literacy and education organizations. TBCCN activities and research efforts are geared toward addressing critical information and access issues related to cancer control and prevention in diverse communities in the Tampa Bay area. Such efforts include cross-cultural health promotion, screening ...


Arthroscopic Repair Of Meniscal Tears With Inside-Out Technique, Hasnain Raza, Kashif Abbas, Masood Umer 2011 Aga Khan University

Arthroscopic Repair Of Meniscal Tears With Inside-Out Technique, Hasnain Raza, Kashif Abbas, Masood Umer

Section of Orthopaedic Surgery

OBJECTIVE: To review the clinical results of arthroscopic meniscal repair and to identify factors that may affect the outcome.

METHODS: A total of 15 arthroscopic meniscal repairs with inside-out in 14 patients over a 7-year period were evaluated retrospectively. The mean age was 41.2 +/- 11.5 years with a range of 26-64 years. Eleven patients underwent repair for medial meniscal tear, two patients for lateral meniscus and one patient for both in the same knee. All patients were functionally evaluated by Lysholm functional knee scores over an average follow-up of 1 year and 5 months (range: 0.5-7 years ...


Factors Associated With Older Patients' Engagement In Exercise After Hospital Discharge, Anne-Marie Hill, Tammy Hoffmann, Steven McPhail, Christopher Beer, Keith D. Hill, Sandra G. Brauer, Terrence P. Haines 2011 University of Notre Dame Australia

Factors Associated With Older Patients' Engagement In Exercise After Hospital Discharge, Anne-Marie Hill, Tammy Hoffmann, Steven Mcphail, Christopher Beer, Keith D. Hill, Sandra G. Brauer, Terrence P. Haines

Physiotherapy Papers and Journal Articles

Objectives: To identify factors that are associated with older patients' engagement in exercise in the 6 months after hospital discharge.

Design: A prospective observational study using qualitative and quantitative evaluation.

Setting: Follow-up of hospital patients in their home setting after discharge from a metropolitan general hospital.

Participants: Participants (N=343) were older patients (mean age ± SD, 79.4±8.5y) discharged from medical, surgical, and rehabilitation wards and followed up for 6 months after discharge.

Interventions: Not applicable.

Main Outcome Measures: Self-perceived awareness and risk of falls measured at discharge with a survey that addressed elements of the Health Belief ...


Consultation Etiquette In General Practice: A Qualitative Study Of What Makes It Different For Lay Cancer Caregivers, Geoffry K. Mitchell, Moyez Jiwa, Afaf Girgis 2011 University of Notre Dame Australia

Consultation Etiquette In General Practice: A Qualitative Study Of What Makes It Different For Lay Cancer Caregivers, Geoffry K. Mitchell, Moyez Jiwa, Afaf Girgis

Medical Papers and Journal Articles

Background: It is commonplace for lay caregivers to overlook their own health concerns when supporting someone with advanced cancer. During this time, caregivers’ needs as patients are often marginalised by health professionals, including General Practitioners (GPs), who may miss the breadth of caregivers’ needs by focusing on the practicalities of caregiving. GPs traditionally rely on patients to raise their concerns, and then respond to these concerns, but caregivers as patients may be disinclined to cue their GP. The norms of engagement when caregivers consult their GP are less defined, and how they interact with their GP regarding their own health ...


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