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Down-Regulation Of The Transcription Factor Snail In The Placentas Of Patients With Preeclampsia And In A Rat Model Of Preeclampsia, Larissa Federova, Cara Gatto-Weis, Sleiman Smaili, Nauman Khurshid, Joseph I. Shapiro M.D., Deepak Malhorta, Terrence Horrigan 2012 Marshall University

Down-Regulation Of The Transcription Factor Snail In The Placentas Of Patients With Preeclampsia And In A Rat Model Of Preeclampsia, Larissa Federova, Cara Gatto-Weis, Sleiman Smaili, Nauman Khurshid, Joseph I. Shapiro M.D., Deepak Malhorta, Terrence Horrigan

Biochemistry and Microbiology

Background: Placental malfunction in preeclampsia is believed to be a consequence of aberrant differentiation of trophoblast lineages and changes in utero-placental oxygenation. The transcription factor Snail, a master regulator molecule of epithelial-mesenchymal transition in embryonic development and in cancer, is shown to be involved in trophoblast differentiation as well. Moreover, Snail can be controlled by oxidative stress and hypoxia. Therefore, we examined the expression of Snail and its downstream target, e-cadherin, in human normal term, preterm and preeclamptic placentas, and in pregnant rats that developed preeclampsia-like symptoms in the response to a 20- fold increase in sodium intake.

Methods: Western ...


Perceptual Enhancement Of Arteriovenous Malformation In Mri Angiography Displays, Abhari Kamyar, John S. H. Baxter, Roy Eagleson, Terry Peters, Sandrine De Ribaupierre 2012 Western University

Perceptual Enhancement Of Arteriovenous Malformation In Mri Angiography Displays, Abhari Kamyar, John S. H. Baxter, Roy Eagleson, Terry Peters, Sandrine De Ribaupierre

Anatomy and Cell Biology Publications

The importance of presenting medical images in an intuitive and usable manner during a procedure is essential. However, most medical visualization interfaces, particularly those designed for minimally-invasive surgery, suffer from a number of issues as a consequence of disregarding the human perceptual, cognitive, and motor system's limitations. This matter is even more prominent when human visual system is overlooked during the design cycle. One example is the visualization of the neuro-vascular structures in MR angiography (MRA) images. This study investigates perceptual performance in the usability of a display to visualize blood vessels in MRA volumes using a contour enhancement ...


A Preliminary Study Into The Immediate Effects Of Ankle Foot Orthoses Of Varying Design On The Walking Of People In The Early Stages Of Stroke Recovery And Healthy Individuals, Robert John Mehan 2012 Australian Catholic University

A Preliminary Study Into The Immediate Effects Of Ankle Foot Orthoses Of Varying Design On The Walking Of People In The Early Stages Of Stroke Recovery And Healthy Individuals, Robert John Mehan

Theses

Ankle foot orthoses (AFO’s) are prescribed to patients who have ankle impairments causing difficulty walking following stroke. The evidence regarding the benefit of prescribing AFO’s, particularly with regard to type of AFO and timing of intervention, is unclear. There are few studies that investigate the effect of AFO’s in the subacute phase following stroke and few studies that compare different types of AFO. There is little evidence regarding the effect of AFO’s on the gait of normal healthy individuals. This study aimed to compare the effects on walking in different AFO’s, of varying degrees of ...


Effects Of An 8-Week Meditation Program On Mood And Anxiety In Patients With Memory Loss., Aleezé Sattar Moss, Nancy Wintering, Hannah Roggenkamp, Dharma Singh Khalsa, Mark R Waldman, Daniel Monti, Andrew B Newberg 2012 Jefferson-Myrna Brind Center of Integrative Medicine

Effects Of An 8-Week Meditation Program On Mood And Anxiety In Patients With Memory Loss., Aleezé Sattar Moss, Nancy Wintering, Hannah Roggenkamp, Dharma Singh Khalsa, Mark R Waldman, Daniel Monti, Andrew B Newberg

Marcus Institute of Integrative Health Faculty Papers

Abstract Background: This study assesses changes in mood and anxiety in a cohort of subjects with memory loss who participated in an 8-week Kirtan Kriya meditation program. Perceived spirituality also was assessed. Previous reports from this cohort showed changes in cognitive function and cerebral blood flow (CBF). The purpose of this analysis was to assess outcome measures of mood and affect, and also spirituality, and to determine whether or not results correlated with changes in CBF.

Methods: Fifteen (15) subjects (mean age 62±7 years) with memory problems were enrolled in an 8-week meditation program. Before and after the 8-week ...


Neuroimaging During Trance State: A Contribution To The Study Of Dissociation., Julio Fernando Peres, Alexander Moreira-Almeida, Leonardo Caixeta, Frederico Leao, Andrew Newberg 2012 University of Pennsylvania; Universidade de Sao Paulo

Neuroimaging During Trance State: A Contribution To The Study Of Dissociation., Julio Fernando Peres, Alexander Moreira-Almeida, Leonardo Caixeta, Frederico Leao, Andrew Newberg

Marcus Institute of Integrative Health Faculty Papers

Despite increasing interest in pathological and non-pathological dissociation, few researchers have focused on the spiritual experiences involving dissociative states such as mediumship, in which an individual (the medium) claims to be in communication with, or under the control of, the mind of a deceased person. Our preliminary study investigated psychography - in which allegedly "the spirit writes through the medium's hand" - for potential associations with specific alterations in cerebral activity. We examined ten healthy psychographers - five less expert mediums and five with substantial experience, ranging from 15 to 47 years of automatic writing and 2 to 18 psychographies per month ...


The Effect On Colon Visualization During Colonoscopy Of The Addition Of Simethicone To Polyethylene Glycol-Electrolyte Solution: A Randomized Single-Blind Study., Rebecca Matro, Keegan Tupchong, Constantine Daskalakis, Victoria Gordon, Leo Katz, David Kastenberg 2012 Thomas Jefferson University Hospitals

The Effect On Colon Visualization During Colonoscopy Of The Addition Of Simethicone To Polyethylene Glycol-Electrolyte Solution: A Randomized Single-Blind Study., Rebecca Matro, Keegan Tupchong, Constantine Daskalakis, Victoria Gordon, Leo Katz, David Kastenberg

Division of Gastroenterology and Hepatology Faculty Papers

OBJECTIVES: Colonic bubbles associated with polyethylene glycol-electrolyte solution (PEG-ELS) are common and obscure mucosal visualization. This study aimed to determine whether adding simethicone decreases the incidence of bubbles.

METHODS: Prospective, single-blind, randomized comparison of split dose PEG-ELS vs. PEG-ELS+simethicone (PEG-S) for outpatient colonoscopy. Bubble severity for colonic segments was assessed on withdrawal as A=no/minimal bubbles, B=moderate bubbles/interfere with detecting 5 mm polyp, C=severe bubbles/interfere with detecting 10 mm polyp. Primary end point was Grade B or C bubbles in any colon segment. Secondary end points were cleansing quality, incidence and severity of side ...


Preventing Muscle Atrophy With Protein And Amino Acid Supplementation, J. Bunn 2012 Campbell University

Preventing Muscle Atrophy With Protein And Amino Acid Supplementation, J. Bunn

Physical Therapy

No abstract provided.


Internet Trials: Participant Experiences And Perspectives, Erin Mathieu, Alexandra Barratt, Stacey Carter, Gro Jamtvedt 2012 Australian Catholic University

Internet Trials: Participant Experiences And Perspectives, Erin Mathieu, Alexandra Barratt, Stacey Carter, Gro Jamtvedt

Faculty of Health Sciences Publications

Background: Use of the Internet to conduct randomised controlled trials is increasing, and provides potential to increase equity of access to medical research, increase the generalisability of trial results and decrease the costs involved in conducting large scale trials. Several studies have compared response rates, completeness of data, and reliability of surveys using the Internet and traditional methods, but very little is known about participants’ attitudes towards Internet-based randomised trials or their experience of participating in an Internet-based trial. Objective: To obtain insights into the experiences and perspectives of participants in an Internet-based randomised controlled trial, their attitudes to the ...


Prognostic Value Of Semi-Quantitative Bacteruria Counts In The Diagnosis Of Group B Streptococcus Urinary Tract Infection: A 4-Year Retrospective Study In Adult Patients, Chee K. Tan, Kimberly B. Ulett, Michael C. Steele, William H. Benjamin, Glen C. Ulett 2012 Australian Catholic University

Prognostic Value Of Semi-Quantitative Bacteruria Counts In The Diagnosis Of Group B Streptococcus Urinary Tract Infection: A 4-Year Retrospective Study In Adult Patients, Chee K. Tan, Kimberly B. Ulett, Michael C. Steele, William H. Benjamin, Glen C. Ulett

Faculty of Health Sciences Publications

Background: Semi-quantitative bacteruria counts (s-QBC) are important in the diagnosis of urinary tract infection (UTI) due to most uropathogens. The prognostic value of s-QBC for diagnosis of UTI due to group B streptococcus (GBS) is unknown. In this study, we assessed the value of s-QBC for differentiating acute GBS UTI from asymptomatic bacteruria (ABU), independent of other potential prognostic indicators. Methods: Medical record review and urinalysis (UA) values for 1593 patients who had urinary GBS isolated (103 to ≥105CFU/ml) during a four-year period were analyzed using binary logistic regression to determine the predictive values of s-QBC, age, and gender ...


Peri-Operative Nurses' Knowledge And Reported Practice Of Pressure Injury Risk Assessment And Prevention: A Before-After Intervention Study, Sally Sutherland-Fraser, Elizabeth McInnes, Elisabeth Maher, Sandy Middleton 2012 Australian Catholic University

Peri-Operative Nurses' Knowledge And Reported Practice Of Pressure Injury Risk Assessment And Prevention: A Before-After Intervention Study, Sally Sutherland-Fraser, Elizabeth Mcinnes, Elisabeth Maher, Sandy Middleton

Faculty of Health Sciences Publications

Background

Patients are at risk of developing pressure injuries in the peri-operative setting. Studies evaluating the impact of educational interventions on peri-operative nurses’ knowledge and reported practice are scarce. The purpose of this study was to evaluate the effect of a multifaceted intervention on peri-operative nurses’ (a) knowledge of pressure injury risks, risk assessment and prevention strategies for patients in the operating suite; and (b) reported practice relating to risk assessment practices and implementation of prevention strategies for patients in the operating suite.

Methods

A before-after research design was used. A convenience sample of all registered and enrolled nurses employed ...


Prevalence Of Obesity And The Relationship Between The Body Mass Index And Body Fat: Cross-Sectional, Population-Based Data, Julie A. Pasco, Geoffrey C. Nicholson, Sharon L. Brennan, Mark A. Kotowicz 2012 Australian Catholic University

Prevalence Of Obesity And The Relationship Between The Body Mass Index And Body Fat: Cross-Sectional, Population-Based Data, Julie A. Pasco, Geoffrey C. Nicholson, Sharon L. Brennan, Mark A. Kotowicz

Faculty of Health Sciences Publications

Background: Anthropometric measures such as the body mass index (BMI) and waist circumference are widely used as convenient indices of adiposity, yet there are limitations in their estimates of body fat. We aimed to determine the prevalence of obesity using criteria based on the BMI and waist circumference, and to examine the relationship between the BMI and body fat. Methodology/Principal Findings: This population-based, cross-sectional study was conducted as part of the Geelong Osteoporosis Study. A random sample of 1,467 men and 1,076 women aged 20–96 years was assessed 2001–2008. Overweight and obesity were identified according ...


Reaching Smokers Via Email Blasts - Cost Effective Blast To The Future, Alice Dalla-Palu MPA, CTTS-M, CAC, Jeanne Fignar AAS, Edward Frack BA 2012 Lehigh Valley Health Network

Reaching Smokers Via Email Blasts - Cost Effective Blast To The Future, Alice Dalla-Palu Mpa, Ctts-M, Cac, Jeanne Fignar Aas, Edward Frack Ba

Department of Emergency Medicine

No abstract provided.


Contegra Valved Conduit In The Paediatric Population: An Exciting Prospect For Right Ventricle To Pulmonary Artery Reconstruction; Experience And Outcomes At Aga Khan University, Maria Tariq Siddiqui, Asif Hasan, Shazia Mohsin, Mohammad Hamid, Muneer Amanullah 2012 Liaquat National Hospital

Contegra Valved Conduit In The Paediatric Population: An Exciting Prospect For Right Ventricle To Pulmonary Artery Reconstruction; Experience And Outcomes At Aga Khan University, Maria Tariq Siddiqui, Asif Hasan, Shazia Mohsin, Mohammad Hamid, Muneer Amanullah

Department of Anaesthesia

Objective: The focus of this study is to share the experience and outcomes of Contegra graft implantation in the paediatric and adult population in Pakistan. Methods: Between May 2007 and July 2011, 16 patients, underwent implantation of a Contegra valved conduit. All operations were performed through a median sternotomy with cardiopulmonary bypass. Indications included: Pulmonary atresia with ventricular septal defect (n=11), Tetralogy of Fallot with absent Pulmonary Valve (PV) syndrome (n=2), double outlet right ventricle, transposition of great arteries and pulmonary stenosis (n=1), isolated aortic valve disease (n=1) and a pseudo-aneurysm with infective endocarditis (n=1 ...


Formative Research On Perceptions Of Biobanking: What Community Members Think, John S. Luque, Gwendolyn P. Quinn, Francisco A. Montel-Ishino, Mariana Arevalo, Shalanda A. Bynum, Shalewa Noel-Thomas, Kristen J. Wells, Clement K. Gwede, Cathy D. Meade, Tampa Bay Community Cancer Network Partners 2012 Georgia Southern University

Formative Research On Perceptions Of Biobanking: What Community Members Think, John S. Luque, Gwendolyn P. Quinn, Francisco A. Montel-Ishino, Mariana Arevalo, Shalanda A. Bynum, Shalewa Noel-Thomas, Kristen J. Wells, Clement K. Gwede, Cathy D. Meade, Tampa Bay Community Cancer Network Partners

Community Health Faculty Publications

Preparing healthy community members with timely communications prior to engaging them in a request to donate biospecimens promises to improve the experience of biobanking participation. To this end, a qualitative study was conducted to assess community member knowledge, attitudes, beliefs, and informational needs about cancer-related biospecimen collection in a large metropolitan area in southwest Florida. The study utilized purposive sampling techniques to recruit a total of 95 participants to participate in 12 focus groups, segmented by race/ethnicity and language preference (mixed race, African American only, and Spanish speaking) and age (18–29, 30–54, and 55 and older). Focus ...


How Vats Has Changed The Management Of Spontaneous Pneumothorax In The 21st Century, Saulat H. Fatimi, Hashim Muhammad Hanif, Sana Mansoor, Marium Muzaffar 2012 Aga Khan University

How Vats Has Changed The Management Of Spontaneous Pneumothorax In The 21st Century, Saulat H. Fatimi, Hashim Muhammad Hanif, Sana Mansoor, Marium Muzaffar

Section of Cardiothoracic Surgery

Objective: To determine the outcome of patients having undergone Video Assisted Thoracoscopic Surgery (VATS) for spontaneous pneumothrox in terms of hospital stay, complications and recurrence.
Methods:
The netrospective study included the review of 39 cases who had presented with spontaneous pneumothorax at the Aga Khan University Hospital, Karachi, Pakistan, between January 2001 to November 2008 and had undergone video assisted thoracoscopic surgery (VATS).
Results:
The duration of hospital stay (had a range of 3 to 9 days), and the length of chest tube in place (a range of 2 to 8 days), 2 (5.1%) patients developed recurrence after VATS ...


Development Of The Stroke Modules For Kent County Hospital Stroke Unit, Barbara J. Bird 2012 Rhode Island College

Development Of The Stroke Modules For Kent County Hospital Stroke Unit, Barbara J. Bird

Master's Theses, Dissertations, Graduate Research and Major Papers Overview

Stroke is the number one cause of disability in the United States and costs over $68 billion annually. The majority of strokes are preventable but require education of the public on modifiable risk factors and prevention. Nurses play a major role in education related to prevention and care of stroke patients. The purpose of this project was to develop a self study educational program for nurses caring for stroke patients. A four module program was created. It was piloted by the sample population of nurses working on the stroke unit at Kent County Hospital. There was a thirteen point improvement ...


Quality Management Of Chemotherapy: Induced Nausea And Vomiting With Minimal Constipation, Mary Ellen Danzer 2012 Rhode Island College

Quality Management Of Chemotherapy: Induced Nausea And Vomiting With Minimal Constipation, Mary Ellen Danzer

Master's Theses, Dissertations, Graduate Research and Major Papers Overview

Although clients diagnosed with colorectal cancer (CRC) are receiving more advanced and successful chemotherapy treatments, the side effects of these treatments continue to cause anxiety, discomfort, pain, and a diminished quality of life. Treatments must be developed to avoid some of the most unpleasant symptoms a client experiences as a result of these treatments. The purpose of this study was to examine the incidence of constipation related to the treatment of chemotherapy-induced nausea and vomiting (CINV) and to identify treatments that are successful in managing constipation while maintaining effective control of CINV. Constipation can be a significant problem with a ...


Factors Relating To Hpv Behaviors Of Female College Students, Nicole Rachael Peritore 2012 University of Kentucky

Factors Relating To Hpv Behaviors Of Female College Students, Nicole Rachael Peritore

Theses and Dissertations--Kinesiology and Health Promotion

This study examined the knowledge, sources of information, reasons for and against Gardasil® uptake, and possible relationships between unhealthy behaviors and vaccination for undergraduate college females at a public university. Utilizing an online survey, 2400 random students were emailed as well as recruited through online classes. The final sample size was 516 females. The study determined how many participants had been vaccinated and their rationale for or against vaccination. The majority of study participants were knowledgeable about HPV and Gardasil®. The primary sources of information about HPV and Gardasil® were doctors and television; however parents and friends were also common ...


The Impact Of Maternal Smoking In Kentucky And Effect Of The Giving Infants And Families Tobacco-Free Starts Pilot Project On Smoking Cessation And Birth Outcomes, Joyce Madeline Robl 2012 University of Kentucky

The Impact Of Maternal Smoking In Kentucky And Effect Of The Giving Infants And Families Tobacco-Free Starts Pilot Project On Smoking Cessation And Birth Outcomes, Joyce Madeline Robl

Theses and Dissertations--Kinesiology and Health Promotion

Smoking during pregnancy remains a significant public health issue despite knowledge about the adverse maternal and fetal health effects. This research had six purposes: identifying effective smoking cessation strategies for low income pregnant women; identifying characteristics of Kentucky women who smoke during pregnancy; estimating the role of smoking on birth outcomes in Kentucky; exploring the impact of tobacco reduction on birth outcomes; identifying the characteristics of women participating in the Giving Infants and Families Tobacco-free Starts (GIFTS) pilot program; and evaluating the impact of GIFTS on smoking status and birth outcomes.

Seven randomized controlled trials targeting low income women with ...


The Impact Of Timing, Selection, And Dosage Of Preoperative Prophylactic Antibiotics On Preventable Surgical Site Infections, Cathy S. Insana 2012 Rhode Island College

The Impact Of Timing, Selection, And Dosage Of Preoperative Prophylactic Antibiotics On Preventable Surgical Site Infections, Cathy S. Insana

Master's Theses, Dissertations, Graduate Research and Major Papers Overview

Surgical site infections (SSIs) are a subset of a larger group of infections that are known as hospital acquired infections (HAis). SSIs are a huge financial burden, costing billions of dollars in excess hospital charges every year. There is a considerable amount of evidence-based practice recommendations that can help reduce the incidence of SSIs. Research has supported the efficacy of preoperative antibiotic prophylaxis when appropriately selected and timed according to published guidelines. In addition to these measures, re-dosing of antibiotics must occur for those procedures that last more than four hours in order to continue to maintain tissue perfusion throughout ...


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