Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

134255 Full-Text Articles 213771 Authors 33395202 Downloads 383 Institutions

All Articles in Medicine and Health Sciences

Faceted Search

134255 full-text articles. Page 4346 of 4520.

Acetylation Of Wrn Protein Regulates Its Stability By Inhibiting Ubiquitination, Kai Li, Rui Wang, Enerlyn Lozada, Wei Fan, David K. Orren, Jianyuan Luo 2010 University of Massachusetts Medical School Worcester

Acetylation Of Wrn Protein Regulates Its Stability By Inhibiting Ubiquitination, Kai Li, Rui Wang, Enerlyn Lozada, Wei Fan, David K. Orren, Jianyuan Luo

Toxicology and Cancer Biology Faculty Publications

BACKGROUND: WRN is a multi-functional protein involving DNA replication, recombination and repair. WRN acetylation has been demonstrated playing an important role in response to DNA damage. We previously found that WRN acetylation can regulate its enzymatic activities and nuclear distribution.

METHODOLOGY/PRINCIPAL FINDING: Here, we investigated the factors involved in WRN acetylation and found that CBP and p300 are the only major acetyltransferases for WRN acetylation. We further identified 6 lysine residues in WRN that are subject to acetylation. Interestingly, WRN acetylation can increase its protein stability. SIRT1-mediated deacetylation of WRN reverses this effect. CBP dramatically increases the half-life of ...


Acetylation Of Wrn Protein Regulates Its Stability By Inhibiting Ubiquitination, Kai Li, Rui Wang, Enerlyn M. Lozada, Wei Fan, David K. Orren, Jianyuan Luo 2010 University of Massachusetts Medical School

Acetylation Of Wrn Protein Regulates Its Stability By Inhibiting Ubiquitination, Kai Li, Rui Wang, Enerlyn M. Lozada, Wei Fan, David K. Orren, Jianyuan Luo

Open Access Articles

BACKGROUND: WRN is a multi-functional protein involving DNA replication, recombination and repair. WRN acetylation has been demonstrated playing an important role in response to DNA damage. We previously found that WRN acetylation can regulate its enzymatic activities and nuclear distribution.

METHODOLOGY/PRINCIPAL FINDING: Here, we investigated the factors involved in WRN acetylation and found that CBP and p300 are the only major acetyltransferases for WRN acetylation. We further identified 6 lysine residues in WRN that are subject to acetylation. Interestingly, WRN acetylation can increase its protein stability. SIRT1-mediated deacetylation of WRN reverses this effect. CBP dramatically increases the half-life of ...


Assessing The Quality Of Service Of Village Malaria Workers To Strengthen Community-Based Malaria Control In Cambodia, Junko Yasuoka, Krishna C. Poudel, Kalpana Poudel-Tandukar, Chea Nguon, Po Ly, Duong Socheat, Masamine Jimba 2010 University of Massachusetts - Amherst

Assessing The Quality Of Service Of Village Malaria Workers To Strengthen Community-Based Malaria Control In Cambodia, Junko Yasuoka, Krishna C. Poudel, Kalpana Poudel-Tandukar, Chea Nguon, Po Ly, Duong Socheat, Masamine Jimba

Krishna C. Poudel

Background
Malaria continues to be a major public health problem in remote forested areas in Cambodia. As a national strategy to strengthen community-based malaria control, the Cambodian government has been running the Village Malaria Worker (VMW) project since 2001. This study sought to examine the nature and quality of the VMWs' services.
Methods
Data collection was carried out in February and March 2008 through interviews with one of the two VMWs who takes the lead in malaria control activities in each of the 315 VMW villages (n = 251). The questionnaire addressed 1) the sociodemographic characteristics of VMWs, 2) service quality ...


Designing For An Aging Population, Allison Shives 2010 Stephen F Austin State University

Designing For An Aging Population, Allison Shives

Undergraduate Research Conference

Aging starts at birth and continues throughout life. As people age, they need to continue to live a happy life. A designer’s job is to design a facility that will encourage an independent lifestyle while providing the help and community involvement aging requires. The design solution should meet the aging population’s desire to age in place. An assisted living facility allows older adults to live independently while being surrounded by a support group and events that promote an active lifestyle which is conducive to physical and mental wellbeing.


Spontaneous Feline Mammary Intraepithelial Lesions As A Model For Human Estrogen Receptor- And Progesterone Receptor-Negative Breast Lesions, Giovanni P. Burrai, Sulma Mohammed, Margaret A. Miller, Vincenzo Marras, Salvatore Pirino, Maria F. Addis, Sergio Uzzau, Elisabetta Antuofermo 2010 Purdue University

Spontaneous Feline Mammary Intraepithelial Lesions As A Model For Human Estrogen Receptor- And Progesterone Receptor-Negative Breast Lesions, Giovanni P. Burrai, Sulma Mohammed, Margaret A. Miller, Vincenzo Marras, Salvatore Pirino, Maria F. Addis, Sergio Uzzau, Elisabetta Antuofermo

Department of Comparative Pathobiology Faculty Publications

Background: Breast cancer is the most frequently diagnosed cancer in women. Intraepithelial lesions (IELs), such as usual ductal hyperplasia (UH), atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS) are risk factors that predict a woman’s chance of developing invasive breast cancer. Therefore, a comparative study that establishes an animal model of pre-invasive lesions is needed for the development of preventative measures and effective treatment for both mammary IELs and tumors. The purpose of this study was to characterize the histologic and molecular features of feline mammary IELs and compare them with those in women. Methods: Formalin-fixed, paraffin-embedded ...


Fluorescence Spectroscopy Of The Retina For Diagnosis Of Transmissible Spongiform Encephalopathies, Ramkrishna Adhikary, Prasun Mukherjee, Govindarajan Krishnamoorthy, Robert A. Kunkle, Thomas A. Casey, Mark A. Rasmussen, Jacob W. Petrich 2010 Iowa State University

Fluorescence Spectroscopy Of The Retina For Diagnosis Of Transmissible Spongiform Encephalopathies, Ramkrishna Adhikary, Prasun Mukherjee, Govindarajan Krishnamoorthy, Robert A. Kunkle, Thomas A. Casey, Mark A. Rasmussen, Jacob W. Petrich

Chemistry Publications

The feasibility of exploiting fluorescence spectra of the eye for diagnosis of transmissible spongiform encephalopathies (TSEs) was examined. Retinas from scrapie-positive sheep were compared with scrapie-negative sheep using fluorescence spectroscopy, and distinct differences in the fluorescence intensity and spectroscopic signatures were observed. The characteristic fluorescent signatures are thought to be the result of an accumulation of lipofuscin in the retina. It appears that the eye, in particular the retina, is a useful tissue for noninvasive examination of some neurological pathologies such as scrapie. The development of procedures based on examinations of the eye that permit the detection of neurological disorders ...


Characterization Of The Staphylococcus Aureus Immunodominant Surface Antigen B, Isab, Nicole Lawrence 2010 Virginia Commonwealth University

Characterization Of The Staphylococcus Aureus Immunodominant Surface Antigen B, Isab, Nicole Lawrence

Theses and Dissertations

Staphylococcus aureus is a significant cause of morbidity and mortality world-wide. This opportunistic pathogen is capable of causing several severe diseases that are exacerbated by its diverse and widespread antibiotic resistance profile. Therefore it is necessary to identify novel therapeutic targets to effectively treat S. aureus disease. Lorenz et al first described the Immunodominant Surface Antigen B, IsaB, because it was 1 of 4 unique proteins immunogenic during septicemia and not colonization, suggesting that IsaB may be a virulence factor and a possible novel therapeutic target. Interestingly, IsaB has no homology to proteins of known function and appears to be ...


Increase In Isolation Of Extended Spectrum Beta Lactamase Producing Multidrug Resistant Non Typhoidal Salmonellae In Pakistan., Kauser Jabeen, Afia Zafar, Seema Irfan, Erum Khan, Vikram Mehraj, Rumina Hasan 2010 Aga Khan University

Increase In Isolation Of Extended Spectrum Beta Lactamase Producing Multidrug Resistant Non Typhoidal Salmonellae In Pakistan., Kauser Jabeen, Afia Zafar, Seema Irfan, Erum Khan, Vikram Mehraj, Rumina Hasan

Department of Pathology and Laboratory Medicine

Background:Increasing resistance to quinolones and ceftriaxone in non typhoidal Salmonellae is a global concern. Resistance to quinolone and 3rd generation cephalosporin amongst non typhoidal Salmonellae (NTS) from Pakistan has been reported in this study.

Methods:

Retrospective analysis of laboratory data was conducted (1990-2006). NTS were isolated and identified from clinical samples using standard microbiological techniques. Antimicrobial susceptibility testing was performed by Kirby Bauer. Extended spectrum beta lactamase production (ESBL) was detected using combined disc method. Ciprofloxacin sensitivity was detected by nalidixic acid screening method. Minimum inhibitory concentration (MIC) of ciprofloxacin was determined by agar dilution method. Statistical analysis was ...


Community-Based Nursing Education At The Campsite, M. Susan Jones, Donna Bussey, Carrie Morgan 2010 Western Kentucky University

Community-Based Nursing Education At The Campsite, M. Susan Jones, Donna Bussey, Carrie Morgan

M. Susan Jones

No abstract provided.


Impacts Of Medical Error On Members Of The Family. Podium/Regional, Linda Treiber 2010 Kennesaw State University

Impacts Of Medical Error On Members Of The Family. Podium/Regional, Linda Treiber

Linda A. Treiber

No abstract provided.


Correlates Of Sharing Injection Equipment Among Male Injecting Drug Users In Kathmandu, Nepal (International Journal Of Drug Policy), Krishna C. Poudel, Kalpana Poudel-Tandukar, Junko Yasuoka, Anand B. Joshi, Masamine Jimba 2010 University of Massachusetts - Amherst

Correlates Of Sharing Injection Equipment Among Male Injecting Drug Users In Kathmandu, Nepal (International Journal Of Drug Policy), Krishna C. Poudel, Kalpana Poudel-Tandukar, Junko Yasuoka, Anand B. Joshi, Masamine Jimba

Kalpana Poudel-Tandukar

Background: HIV prevalence is high and risky injection practices occur frequently among injecting drug users (IDUs) in Nepal. We explored the correlates of sharing injection equipment (having injected with a needle or syringe previously used by another) among male IDUs in Kathmandu, Nepal.
Methods: From August to September 2007, we anonymously interviewed 296 male IDUs in Kathmandu, Nepal, using a structured questionnaire. We performed bivariate and multivariable logistic regression analysis and identified variables associated with sharing injection equipment.
Results: Over half (n = 152) of the participants reported injecting drugs with a needle or syringe previously
used by another in the ...


Sp441-C-Smart Choices...How Your Baby Grows - The Last Trimester, The University of Tennessee Agricultural Extension Service 2010 University of Tennessee, Knoxville

Sp441-C-Smart Choices...How Your Baby Grows - The Last Trimester, The University Of Tennessee Agricultural Extension Service

Health, and Fitness

During the last three months, your baby grows very fast. It is important that you eat enough food so you will gain weight. Much of the weight you gain goes to the baby. Alcohol, drugs and tobacco can cause your baby to come too early and be too small. Sexually transmitted diseases can also hurt your baby.


Sp441-B-Smart Choices...How Your Baby Grows - The Second Trimester, The University of Tennessee Agricultural Extension Service 2010 University of Tennessee, Knoxville

Sp441-B-Smart Choices...How Your Baby Grows - The Second Trimester, The University Of Tennessee Agricultural Extension Service

Health, and Fitness

Your body goes through many changes in the 4th, 5th and 6th months of pregnancy. For example, you will make a lot of blood. Your uterus (womb) and breasts grow larger. You will store extra body fat.


Sp441-A-Smart Choices...How Your Baby Grows - The First Trimester, The University of Tennessee Agricultural Extension Service 2010 University of Tennessee, Knoxville

Sp441-A-Smart Choices...How Your Baby Grows - The First Trimester, The University Of Tennessee Agricultural Extension Service

Health, and Fitness

The first three months are a very important time for you and your baby. Most of your baby's organs are forming early in pregnancy. Alcohol, drugs and tobacco can cause birth defects and miscarriages.


A Pilot Study To Prevent Hearing Loss In Farmers, Donna M. Gates, M. Susan Jones 2010 University of Cincinnati - Main Campus

A Pilot Study To Prevent Hearing Loss In Farmers, Donna M. Gates, M. Susan Jones

M. Susan Jones

Objective: Determine the feasibility and outcome of a pilot program to increase farm workers' use of hearing protection when performing activities with high noise exposure. Design: The study was a quasi-experimental study. Sample: Eight intervention farmers and 17 comparison farmers participated in the study. Measures: Before and after the intervention, farmers complted a survey to identify their frequency of use of hearing protection and their beliefs about hearing loss and use of hearing protection. Intervention: The intervention consisted of noise assessments, educational sessions, mailed reminders with brochures, and placement of hearing protection on the farm. Results: The intervention was effective ...


Nonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations, Lu Wang, Andrea Rotnitzky, Xihong Lin 2010 University of Michigan

Nonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations, Lu Wang, Andrea Rotnitzky, Xihong Lin

Harvard University Biostatistics Working Paper Series

No abstract provided.


Microrna-184 Inhibits Neuroblastoma Cell Survival Through Targeting The Serine/Threonine Kinase Akt2., Niamh H. Foley, Isabella Bray, Amanda Tivnan, Kenneth Bryan, Derek M. Murphy, Patrick G. Buckley, Jacqueline Ryan, Anne O'Meara, Maureen O'Sullivan, Raymond L. Stallings 2010 Royal College of Surgeons in Ireland

Microrna-184 Inhibits Neuroblastoma Cell Survival Through Targeting The Serine/Threonine Kinase Akt2., Niamh H. Foley, Isabella Bray, Amanda Tivnan, Kenneth Bryan, Derek M. Murphy, Patrick G. Buckley, Jacqueline Ryan, Anne O'Meara, Maureen O'Sullivan, Raymond L. Stallings

Cancer Genetics Articles

BACKGROUND: Neuroblastoma is a paediatric cancer of the sympathetic nervous system. The single most important genetic indicator of poor clinical outcome is amplification of the MYCN transcription factor. One of many down-stream MYCN targets is miR-184, which is either directly or indirectly repressed by this transcription factor, possibly due to its pro-apoptotic effects when ectopically over-expressed in neuroblastoma cells. The purpose of this study was to elucidate the molecular mechanism by which miR-184 conveys pro-apoptotic effects.

RESULTS: We demonstrate that the knock-down of endogenous miR-184 has the opposite effect of ectopic up-regulation, leading to enhanced neuroblastoma cell numbers. As a ...


Associations Between Sport And Screen-Entertainment With Mental Health Problems In 5-Year-Old Children, Lucy J. Griffiths, Marsha Dowda, Carol Dezateux, Russell R. Pate 2010 University of South Carolina - Columbia

Associations Between Sport And Screen-Entertainment With Mental Health Problems In 5-Year-Old Children, Lucy J. Griffiths, Marsha Dowda, Carol Dezateux, Russell R. Pate

Faculty Publications

Background: Few studies have examined the benefits of regular physical activity, and risks of sedentary behavior, in young children. This study investigated associations between participation in sports and screen-entertainment (as components of physical activity and sedentary behavior), and emotional and behavioral problems in this population.

Methods: Cross-sectional analysis of data from 13470 children (50.9% boys) participating in the nationally representative UK Millennium Cohort Study. Time spent participating in sports clubs outside of school, and using screen-entertainment, was reported by the child's mother at child age 5 years, when mental health was also measured using the Strengths and Difficulties ...


The Effects Of Motivational Interviewing In Pregnancy On Knowledge And Retention Of Infant Oral Health Information, Andrew Zima 2010 Virginia Commonwealth University

The Effects Of Motivational Interviewing In Pregnancy On Knowledge And Retention Of Infant Oral Health Information, Andrew Zima

Theses and Dissertations

THE EFFECTS OF MOTIVATIONAL INTERVIEWING IN PREGNANCY ON KNOWLEDGE AND RETENTION OF INFANT ORAL HEALTH INFORMATION By Andrew D. Zima, Jr., B.S., M.S., D.D.S. A thesis submitted in partial fulfillment of the requirements for the degree of Masters of Science in Dentistry at Virginia Commonwealth University. Virginia Commonwealth University, 2010 Major Director: Tegwyn H. Brickhouse, D.D.S., Ph.D Associate Professor, Department of Pediatric Dentistry Purpose: The purpose was to examine the effect of motivational counseling in pregnancy with readiness and acceptance of infant oral health information. Methods: The study used a prospective cohort design ...


Genetic Variations Of Cyp2b6 Enzyme And The Response To Meperidine In Oral Sedation, Heath Whitfield 2010 Virginia Commonwealth University

Genetic Variations Of Cyp2b6 Enzyme And The Response To Meperidine In Oral Sedation, Heath Whitfield

Theses and Dissertations

Purpose: The purpose of this study was to determine the relationship of the CYP2B6 genotype to the clinical response to meperidine in pediatric dental patients. Methods: Forty-nine patients, ASA I/ II, 41–101 months old, received an oral sedative regimen containing meperidine for dental treatment. The North Carolina Behavior Rating Scale (NCBRS) and Overall Effectiveness of Sedation Scale (OESS) were used to assess their behavior and sedation outcome. Saliva DNA samples were genotyped by PCR-RFLP. Results: We found the following genotype distributions: homozygous wild-type 1*1 (n = 19, 39%), heterozygous 1*6 (n = 25, 51%), and homozygous variant 6*6 ...


Digital Commons powered by bepress