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Brain Mri Tissue Classification Based On Local Markov Random Fields, Ivo Dinov 2009 University of Michigan - Ann Arbor

Brain Mri Tissue Classification Based On Local Markov Random Fields, Ivo Dinov

Ivo D Dinov

A new method for tissue classification of brain magnetic resonance images (MRI) of the brain is proposed. The method is based on local image models where each models the image content in a subset of the image domain. With this local modeling approach, the assumption that tissue types have the same characteristics over the brain needs not to be evoked. This is important because tissue type characteristics, such as T1 and T2 relaxation times and proton density, vary across the individual brain and the proposed method offers improved protection against intensity non-uniformity artifacts that can hamper automatic tissue classification methods ...


Repairing A Mortgage Crisis: Holc Lending And Its Impact On Local Housing Markets, Charles Courtemanche, Ken Snowden 2009 University of North Carolina at Greensboro

Repairing A Mortgage Crisis: Holc Lending And Its Impact On Local Housing Markets, Charles Courtemanche, Ken Snowden

Charles Courtemanche

The Home Owners’ Loan Corporation purchased more than a million delinquent mortgages from private lenders between 1933 and 1936 and refinanced the loans for the borrowers. Its primary goal was to break the cycle of foreclosure, forced property sales and decreases in home values that was affecting local housing markets throughout the nation. We find that HOLC loans were targeted at local (county-level) housing markets that had experienced severe distress and that the intervention increased 1940 median home values and homeownership rates, but not new home building.


Role Of Mitogen-Activated Protein Kinase In Zn-Bc-Am Pdt-Induced Apoptosis In Nasopharyngeal Carcinoma Cells, HK Koon, PS Chan, ZG Wu, RN Wong, ML Lung, CK Chang, N.K. Mak 2009 Hong Kong Baptist University

Role Of Mitogen-Activated Protein Kinase In Zn-Bc-Am Pdt-Induced Apoptosis In Nasopharyngeal Carcinoma Cells, Hk Koon, Ps Chan, Zg Wu, Rn Wong, Ml Lung, Ck Chang, N.K. Mak

Professor MAK, Nai Ki

No abstract provided.


Mollicutes Species And Mycoplasma Bovis Prevalence And Association With Health Outcomes In Beef Feeder Calves At Arrival And Initial Treatment For Bovine Respiratory Disease., B. White, G. Hanzlicek, M. Sanderson, David Anderson, R. Larson 2009 Kansas State University

Mollicutes Species And Mycoplasma Bovis Prevalence And Association With Health Outcomes In Beef Feeder Calves At Arrival And Initial Treatment For Bovine Respiratory Disease., B. White, G. Hanzlicek, M. Sanderson, David Anderson, R. Larson

David Edgar Anderson, DVM, MS, DACVS

Mollicutes nasal swab culture status and potential associations with health outcomes were determined in beef feeder calves. Mollicutes culture was positive in 7.6% (22/291) of calves at arrival and in 26.2% (34/130) of calves at first disease treatment. Positive Mollicutes culture at first treatment was associated with increased odds for subsequent retreatment or death.


Some Design Issues In Phase 2b Prevention Trials For Testing Efficacy Of Products Or Concepts, Peter Gilbert 2009 Fred Hutchinson Cancer Research Center & University of Washington

Some Design Issues In Phase 2b Prevention Trials For Testing Efficacy Of Products Or Concepts, Peter Gilbert

Peter B. Gilbert

After one or more Phase 2 trials show that a candidate preventive vaccine induces immune responses that putatively protect against an infectious disease for which there is no licensed vaccine, the next step is to evaluate the efficacy of the candidate. The trial-designer faces the question of what is the optimal size of the initial efficacy trial? Part of the answer will entail deciding between a large Phase 3 licensure trial or an intermediate-sized Phase 2b screening trial, the latter of which may be designed to directly contribute to the evidence-base for licensing the candidate, or, to test a scientific ...


Bacterial Resistance To Antibiotics:How It Happens,Why It's Important,And What You Can Do About It., Richard Philp 2009 University of Western Ontario

Bacterial Resistance To Antibiotics:How It Happens,Why It's Important,And What You Can Do About It., Richard Philp

Richard B. Philp

Bacterial resistance to antibiotics has become a major clinical problem exacerbated by the widespread and sometimes inappropriate use of antibiotics. Reasons for its emergence, mechanisms of resistance, types of resistance and appropriate public behaviour to combat the problem are discussed in language accessable to the general public.


Science And Morals In The Affective Psychopathology Of Philippe Pinel, Louis Charland 2009 The University of Western Ontario

Science And Morals In The Affective Psychopathology Of Philippe Pinel, Louis Charland

Louis C. Charland

No abstract provided.


Code For Fitting Bdsacgh, Veera Baladandayuthapani 2009 UT MD Anderson Cancer Center

Code For Fitting Bdsacgh, Veera Baladandayuthapani

Veera Baladandayuthapani

No abstract provided.


Analyzing Histology Images With Photoshop Extended Cs3 And Cs4, Deborah Haines, Kim Newkirk 2009 University of Tennessee - Knoxville

Analyzing Histology Images With Photoshop Extended Cs3 And Cs4, Deborah Haines, Kim Newkirk

Kim M Newkirk

No abstract provided.


Comparison Of Maternal Milk Expression Methods With Ugandan Mothers Of Premature Or Sick Infants, Ida Slusher 2009 Eastern Kentucky University

Comparison Of Maternal Milk Expression Methods With Ugandan Mothers Of Premature Or Sick Infants, Ida Slusher

Ida Slusher

This study compares maternal milk volumes (MMVs) of Ugandan mothers whose infants were in a special care nursery and who used one of three maternal milk expression techniques: double electric breast pump, single non-electric manual breast pump, and hand breastmilk expression.


Epigenetic Silencing Of Cyp24 In The Tumor Microenvironment, Ivy Chung 2009 University of Malaya

Epigenetic Silencing Of Cyp24 In The Tumor Microenvironment, Ivy Chung

Ivy Chung

Calcitriol (1,25 dihydroxycholecalciferol) has significant anti-tumor activity in vitro and in vivo in a number of tumor model systems. We developed a system for isolation of fresh endothelial cells from tumors and Matrigel environments which demonstrate that CYP24, the catabolic enzyme involved in vitamin D signaling, is epigenetically silenced selectively in tumor-derived endothelial cells (TDEC). TDEC maintain phenotypic characteristics which are distinct from endothelial cells isolated from normal tissues and from Matrigel plugs (MDEC). In TDEC, calcitriol induces G(0)/G(1) arrest, modulates p27 and p21, and induces apoptotic cell death and decreases P-Erk and P-Akt. In contrast ...


Merleau-Ponty And James Agee: Guides To The Novice Phenomenologist, Sandra Thomas 2009 University of Tennessee-Knoxville

Merleau-Ponty And James Agee: Guides To The Novice Phenomenologist, Sandra Thomas

Sandra Thomas

No abstract provided.


Association Of Season And Pasture Grazing With Blood Hormone And Metabolite Concentrations In Horses With Presumed Pituitary Pars Intermedia Dysfunction, N Frank, Sarah Elliott, K Chameroy, Ferenc Toth 2009 University of Tennessee - Knoxville

Association Of Season And Pasture Grazing With Blood Hormone And Metabolite Concentrations In Horses With Presumed Pituitary Pars Intermedia Dysfunction, N Frank, Sarah Elliott, K Chameroy, Ferenc Toth

Ferenc Toth

Background: Pituitary pars intermedia dysfunction (PPID) is a risk factor for pasture-associated laminitis, which follows a seasonal pattern. Hypothesis: Hormonal responses to season differ between PPID and unaffected horses. Animals: Seventeen horses aged 8-30 years (14 horses ≥ 20 years of age). Methods: Longitudinal observational study. Blood was collected monthly from August 2007 until July 2008 after pasture grazing and again after overnight stall confinement. Blood hormone and metabolite concentrations were measured and pasture grass samples were analyzed to determine carbohydrate content. Analysis of variance analysis for repeated measures was performed. Results: Mean ACTH concentrations varied significantly over time (P < .001), with higher concentrations detected in August, September, and October compared with November-April. Pasture × time effects were detected for glucose and insulin concentrations, with peaks observed in September. Horses were retrospectively allocated to PPID (n = 8) and control (n = 9) groups on the basis of plasma ACTH concentrations. Changes in insulin concentrations over time differed in the PPID group when compared with the control group. Insulin concentrations were positively correlated with grass carbohydrate composition. Conclusions and Clinical Importance: PPID did not affect the timing or duration of the seasonal increase in ACTH concentrations, but higher values were detected in affected horses. Insulin concentrations differed between groups, but hyperinsulinemia was rarely detected. Glucose and insulin concentrations peaked in September when horses were grazing on pasture, which could be relevant to the seasonal pattern of laminitis.


Risk Of Cancer In Patients With Biopsy-Proven Giant Cell Arteritis., Catherine Hill, A Cole, M Rischmueller, T Dodd, M Coleman, G Tucker, PJ Roberts-Thomson 2009 Government of South Australia, SA Health

Risk Of Cancer In Patients With Biopsy-Proven Giant Cell Arteritis., Catherine Hill, A Cole, M Rischmueller, T Dodd, M Coleman, G Tucker, Pj Roberts-Thomson

Catherine Hill

Objective. Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study of the risk of cancer in patients with biopsy-proven GCA. Methods. Patients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies from the major pathology laboratories in South Australia (SA). All subjects with biopsy-proven GCA were linked to the SA Cancer Registry to identify cases of cancer until 31 December 2006. Standardized incidence ratios (SIRs) for cancer were determined using the age- and gender-specific rates for SA. Results. There were 226 cases of biopsy-proven GCA (163 females and 63 ...


Implementation Issues For Mobile-Wireless Infrastructure And Mobile Health Care Computing Devices For A Hospital Ward Setting, Liza Heslop, Stephen Weeding, Linda Dawson, Julie Fisher, Andrew Howard 2009 Monash University

Implementation Issues For Mobile-Wireless Infrastructure And Mobile Health Care Computing Devices For A Hospital Ward Setting, Liza Heslop, Stephen Weeding, Linda Dawson, Julie Fisher, Andrew Howard

Associate Professor Linda Dawson

mWard is a project whose purpose is to enhance existing clinical and administrative decision support and to consider mobile computers, connected via wireless network, for bringing clinical information to the point of care. The mWard project allowed a limited number of users to test and evaluate a selected range of mobile-wireless infrastructure and mobile health care computing devices at the neuroscience ward at Southern Health’s Monash Medical Centre, Victoria, Australia. Before the project commenced, the ward had two PC’s which were used as terminals by all ward-based staff and numerous multidisciplinary staff who visited the ward each day ...


The Ces-D In Chinese American Women: Construct Validity, Diagnostic Validity For Major Depression, And Cultural Response Bias., Z Li, M Hicks 2009 Selected Works

The Ces-D In Chinese American Women: Construct Validity, Diagnostic Validity For Major Depression, And Cultural Response Bias., Z Li, M Hicks

Madelyn Hsiao-Rei Hicks

Previous studies of the Center for Epidemiologic Studies Depression Scale (CES-D) in Chinese Americans describe internal reliability and factor structure. We report CES-D construct validity and diagnostic validity for major depression in a probability sample of 168 community-dwelling Chinese American women. Internal consistency was satisfactory (Cronbach's alpha=0.86). Good construct validity was indicated by significantly higher mean CES-D scores for respondents who reported lower social support, worse self-perceived general health, or stressful life events, including intimate partner violence. Cultural response bias was found, with positively-stated CES-D items (e.g. "I was happy") producing higher depression scores in immigrants ...


Targeted Maximum Likelihood Estimation Of The Parameter Of A Marginal Structural Model, Michael Rosenblum, Mark van der Laan 2009 Johns Hopkins University

Targeted Maximum Likelihood Estimation Of The Parameter Of A Marginal Structural Model, Michael Rosenblum, Mark Van Der Laan

Michael Rosenblum

Targeted maximum likelihood estimation is a versatile tool for estimating parameters in semiparametric and nonparametric models. We work through an example applying targeted maximum likelihood methodology to estimate the parameter of a marginal structural model. In the case we consider, we show how this can be easily done by clever use of standard statistical software. We point out differences between targeted maximum likelihood estimation and other approaches (including estimating function based methods). The application we consider is to estimate the effect of adherence to antiretroviral medications on virologic failure in HIV positive individuals.


Femoral Diaphysis Fractures In Cattle: 26 Cases (1994-2005)., S. Nichols, David Anderson, M. Miesner, K. Newman 2009 Kansas State University

Femoral Diaphysis Fractures In Cattle: 26 Cases (1994-2005)., S. Nichols, David Anderson, M. Miesner, K. Newman

David Edgar Anderson, DVM, MS, DACVS

OBJECTIVE: This retrospective study was conducted to evaluate the outcome for cattle with diaphyseal fractures of the femur, but not including capital physeal injuries. METHODS: Sources of information were medical records of cattle having a definitive diagnosis of diaphyseal femoral fractures and telephone survey of owners. RESULTS: Medical records for 26 cattle with femoral fracture were found; of the 20 aged less than 2 months, 15 were treated surgically, 4 conservatively (stall rest) and 1 was euthanased without treatment. The surgical treatment varied according to the configuration of the fracture and the surgeon's experience. Surgery for mid-diaphyseal fractures had ...


Enhancing Interprofessional Collaboration And Community-Based Participatory Research Through Technology, Kevin Willison, Tom Palos 2009 Lakehead University - Orillia Campus

Enhancing Interprofessional Collaboration And Community-Based Participatory Research Through Technology, Kevin Willison, Tom Palos

Kevin D Willison

Effective community development to maximize a given area’s potential requires strategies that enhance interprofessional collaboration (IPC) and community-based participatory research (CBPR). The role technology has to enable this has to date received little attention. Drawing from such diverse fields as Sociology and Public Health, this cross-disciplinary article provides an overview of what CBPR and IPC are and how it may be practically implemented via use of technology so as to improve knowledge mobilization and, in turn, effective decision making. CBPR, IPC, sociology and public health all share a common theme - community empowerment. To mobilize and maximize empowerment, knowledge transfer ...


Legal Briefing: Crisis Standards Of Care And Legal Protections During Disasters And Emergencies, Thaddeus Pope, Mitchell Palazzo 2009 Widener University - Delaware Campus

Legal Briefing: Crisis Standards Of Care And Legal Protections During Disasters And Emergencies, Thaddeus Pope, Mitchell Palazzo

Thaddeus Mason Pope

This article outlines current safe harbors in the law for healthcare practitioners who work in a disaster setting. It reviews available legal protection in crisis situations with respect to the Emergency Medical Treatment and Labor Act (EMTALA), criminal liability, and licensure.


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