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Differential Requirement For The Cd45 Splicing Regulator Hnrnpll For Accumulation Of Nkt And Conventional T Cells, Mehmet Yabas, Dale I. Godfrey, Christopher C. Goodnow, Gerard F. Hoyne 2011 University of Notre Dame Australia

Differential Requirement For The Cd45 Splicing Regulator Hnrnpll For Accumulation Of Nkt And Conventional T Cells, Mehmet Yabas, Dale I. Godfrey, Christopher C. Goodnow, Gerard F. Hoyne

Health Sciences Papers and Journal Articles

Natural killer T (NKT) cells represent an important regulatory T cell subset that develops in the thymus and contains immature (NK1.1lo) and mature (NK1.1hi) cell subsets. Here we show in mice that an inherited mutation in heterogeneous ribonucleoprotein L-like protein (hnRNPLLthunder), that shortens the survival of conventional T cells, has no discernible effect on NKT cell development, homeostasis or effector function. Thus, Hnrpll deficiency effectively increases the NKTT cell ratio in the periphery. However, Hnrpll mutation disrupts CD45RA, RB and RC exon silencing of the Ptprc mRNA in both NKT and conventional T cells, and ...


Angiogenic Biomarkers For Risk Stratification In Women With Suspected Preeclampsia, Andreea Balan, Heather Young, Linda Ojo, Jennifer Keller, Sharon Maynard 2011 George Washington University

Angiogenic Biomarkers For Risk Stratification In Women With Suspected Preeclampsia, Andreea Balan, Heather Young, Linda Ojo, Jennifer Keller, Sharon Maynard

Epidemiology and Biostatistics Faculty Posters and Presentations

This poster presents the results of a single-center prospective cohort study of 315 pregnant women who presented to George Washington University Hospital Labor and Delivery service with a clinical suspicion of preeclampsia between February 2007 and November 2011. Informed consent was obtained. Baseline demographic information and medical history was collected on each patient including maternal age, ethnicity, body mass index, tobacco and other substance use, gestational age, medical problems and obstetric history. Serum samples were obtained from each enrolled subject within 24 hours of admission, and sFlt1, PlGF and sEng ELISA assays were performed in duplicate by a blinded laboratory ...


Using Script Concordance Testing (Sct) As A New Modality Of Assessment For Graduate Entry Medical Students – A Pilot Study., Michael Wan, Rosa Canalese, Lawrence T. Lam, Gavin Frost, Paul Duggan 2011 University of Notre Dame Australia

Using Script Concordance Testing (Sct) As A New Modality Of Assessment For Graduate Entry Medical Students – A Pilot Study., Michael Wan, Rosa Canalese, Lawrence T. Lam, Gavin Frost, Paul Duggan

Medical Conference Papers

Background: SCT is a new modality of assessment in medical education. By presenting a clinical scenario, additional pieces of information are given and the students are asked to assess whether this information increases or decreases the probability of the diagnosis. This reflects the clinician’s everyday real-world script determination. It tests the clinical reasoning and problem solving ability and how they apply their learned knowledge in the context of uncertainty. Their decision is compared to a panel of clinicians. Studies have shown that the scores correlate with the level of training and predict future performance on clinical reasoning

Methods: The ...


Treating Chronic Nonspecific Low Back Pain With A Sensorimotor Retraining Approach: An Exploratory Multiple-Baseline Study Of 3 Participants, Benedict M. Wand, Neil E. O'Connell, Flavia Di Pietro, Max Bulsara 2011 University of Notre Dame Australia

Treating Chronic Nonspecific Low Back Pain With A Sensorimotor Retraining Approach: An Exploratory Multiple-Baseline Study Of 3 Participants, Benedict M. Wand, Neil E. O'Connell, Flavia Di Pietro, Max Bulsara

Physiotherapy Conference Papers

Chronic nonspecific low back pain (CNSLBP) is a common healthcare problem for which current interventions are only moderately successful [1]. There is growing evidence of extensive cortical reorganisation and perceptual disturbances which may contribute to the condition [2]. The aim of this study was to test whether a graded sensorimotor retraining program, aimed at influencing cortical representation, would reduce pain intensity, interference of pain on daily life and self reported disability.


Patient Satisfaction With Musculoskeletal Physiotherapy Care In Australia Is High, Vivian Yung, Martin Mackey, Benedict M. Wand, Roger Adams, Roger Nelson, Paul Beattie, Julia Hush 2011 University of Notre Dame Australia

Patient Satisfaction With Musculoskeletal Physiotherapy Care In Australia Is High, Vivian Yung, Martin Mackey, Benedict M. Wand, Roger Adams, Roger Nelson, Paul Beattie, Julia Hush

Physiotherapy Conference Papers

Patient satisfaction is an important outcome of care and is intrinsically valuable to clinicians. The level of patient satisfaction with musculoskeletal physiotherapy care in Australia is unknown. Increased understanding of patient satisfaction will benefit patients by facilitating clinicians to optimise clinical service delivery.


What Factors Determine Patient Satisfaction With Musculoskeletal Physiotherapy Care In Australia?, Julia Hush, Vivian Yung, Martin Mackey, Benedict M. Wand, Roger Adams, Roger Nelson, Paul Beattie 2011 University of Notre Dame Australia

What Factors Determine Patient Satisfaction With Musculoskeletal Physiotherapy Care In Australia?, Julia Hush, Vivian Yung, Martin Mackey, Benedict M. Wand, Roger Adams, Roger Nelson, Paul Beattie

Physiotherapy Conference Papers

Patient satisfaction is an important patient-focussed indicator of the quality of physiotherapy care. We have completed an evaluation of patient satisfaction with musculoskeletal physiotherapy in Australia using the 20-item MedRisk Instrument for Measuring Patient Satisfaction With Physical Therapy Care (MRPS). In this paper we report on factors that influence patient satisfaction in this cultural context.


Transcranial Direct Current Stimulation Of The Motor Cortex In The Treatment Of Chronic Non-Specific Low Back Pain. A Randomised, Double-Blind Exploratory Study, Neil E. O'Connell, John Cossar, Louise Marston, Benedict M. Wand, David Bunce, Lorraine H. De Souza, David W. Maskill, Andrew Sharp, G Lorimer Moseley 2011 University of Notre Dame Australia

Transcranial Direct Current Stimulation Of The Motor Cortex In The Treatment Of Chronic Non-Specific Low Back Pain. A Randomised, Double-Blind Exploratory Study, Neil E. O'Connell, John Cossar, Louise Marston, Benedict M. Wand, David Bunce, Lorraine H. De Souza, David W. Maskill, Andrew Sharp, G Lorimer Moseley

Physiotherapy Conference Papers

This exploratory study aimed to test the proof of principle that active anodal transcranial direct current stimulation (tDCS) applied to the motor cortex reduces pain significantly more than sham stimulation in a group of participants with chronic non-specific low back pain.


Tactile Thresholds Are Preserved Yet Complex Sensory Function Is Impaired Over The Lumbar Spine Of Chronic Non-Specific Low Back Pain Patients: A Preliminary Investigation, Benedict M. Wand, Flavia Di Pietro, Pamela George, Neil E. O'Connell 2011 University of Notre Dame Australia

Tactile Thresholds Are Preserved Yet Complex Sensory Function Is Impaired Over The Lumbar Spine Of Chronic Non-Specific Low Back Pain Patients: A Preliminary Investigation, Benedict M. Wand, Flavia Di Pietro, Pamela George, Neil E. O'Connell

Physiotherapy Conference Papers

Evidence indicates that chronic non-specific low back pain (CNSLBP) is associated with alteration in the brain’s cortical representation of the back, resulting in body perception disturbance and contributing to the condition [1,2]. This study investigated perception via ‘cortical’ sensory tests, in this case two-point discrimination and graphaesthesia—whose results partly depend on the integrity of cortical representation [2]. The hypothesis was dysfunction in these higher-order tasks, with simple tactile thresholds remaining unchanged. Furthermore a relationship between cortical sensation and severity of the condition was predicted.


Evaluation Of A Treatment-Based Classification Algorithm For Low Back Pain, Tasha R. Stanton, Julie Fritz, Mark J. Hancock, Jane Latimer, Chris G. Maher, Benedict M. Wand, Eric Parent 2011 The University of Notre Dame Australia

Evaluation Of A Treatment-Based Classification Algorithm For Low Back Pain, Tasha R. Stanton, Julie Fritz, Mark J. Hancock, Jane Latimer, Chris G. Maher, Benedict M. Wand, Eric Parent

Physiotherapy Conference Papers

Poster Presentation

Theme: How can we better translate evidence into clinical practice?

Background: Several studies have investigated criteria for classifying patients with low back pain into treatment-based subgroups. A comprehensive algorithm was recently created to translate these criteria into a clinical decision-making guide. This study investigated the translation of the individual subgroup criteria into a comprehensive algorithm by studying the prevalence of patients meeting each treatment subgroup, more than one treatment subgroup, and none of the treatment subgroups. The reliability of the classification decision was also investigated.


Non-Invasive Brain Stimulation Techniques For Chronic Pain. A Cochrane Systematic Review And Meta-Analysis, Neil E. O'Connell, Louise Marston, Benedict M. Wand, Sally Spencer, Lorraine H. De Souza 2011 University of Notre Dame Australia

Non-Invasive Brain Stimulation Techniques For Chronic Pain. A Cochrane Systematic Review And Meta-Analysis, Neil E. O'Connell, Louise Marston, Benedict M. Wand, Sally Spencer, Lorraine H. De Souza

Physiotherapy Conference Papers

Poster Presentation

Non-invasive brain stimulation techniques aim to induce an electrical stimulation of the brain in an attempt to reduce chronic pain by directly altering brain activity. They include repetitive transcranial magnetic stimulation (rTMS), cranial electrotherapy stimulation (CES) and transcranial direct current stimulation (tDCS). These approaches to pain treatment are relatively novel. It is important to assess the existing literature robustly to ascertain the current level of supporting evidence and to inform future research and potential clinical use.


Clinical Leadership: A Matter Of Trust?, Tracey Thornley 2011 University of Notre Dame Australia

Clinical Leadership: A Matter Of Trust?, Tracey Thornley

Nursing Conference Papers

One of the many challenges facing the nursing profession in 2011 is the visibility of clinical leadership. Clinical leadership is essential for positive patient outcomes and a productive work environment; given this, the need for strong and effective leadership has never been more urgent. The attributes of leadership and how they are used to inspire and lead others are often overlooked. A research study (Thornley 2007) exploring the concept of expert, found that many personal characteristics were used by nurses to facilitate their expertise and it was these characteristics that expert nurses used to lead and inspire others.


Fusion, 2011, George Washington University, William H. Beaumont Medical Research Honor Society 2011 Himmelfarb Health Sciences Library, The George Washington University

Fusion, 2011, George Washington University, William H. Beaumont Medical Research Honor Society

Fusion

No abstract provided.


Cuentos - 2011, George Washington University, Medical Faculty Associates 2011 Himmelfarb Health Sciences Library, The George Washington University

Cuentos - 2011, George Washington University, Medical Faculty Associates

Cuentos

Cuentos is an artistic and literary magazine created by medical residents, attendings, and faculty of the George Washington University Medical Faculty Associates Department of Internal Medicine.


When East Meets West: Understanding The Misconduct Of Teenage Girls In Hong Kong, Violet Cheung 2011 University of San Francisco

When East Meets West: Understanding The Misconduct Of Teenage Girls In Hong Kong, Violet Cheung

Psychology

Although acculturation towards western culture has been linked to higher levels of misconduct in previous research, little is understood about the mechanisms involved. The present study uses two mediators, early autonomy timetable and large family obligation discrepancy to explain how western values alter children’s behavior and family dynamics, that would push them towards misconduct. The sample included 138 girls (M = 13.8 years) from Hong Kong, a former British colony. Results showed that when indigenous youths adopted western values, their autonomy timetables were accelerated, which in turn manifested itself as misconduct. Meanwhile, the western acculturated youths also had a ...


An Exploration Of The Acute Stress Response To Psychological And Physical Stressors, Utilising Biomarkers Of The Cardiovascular, Hpa, Sam And Secretory Immune Systems, Ann Michelle Mulder 2011 Southern Cross University

An Exploration Of The Acute Stress Response To Psychological And Physical Stressors, Utilising Biomarkers Of The Cardiovascular, Hpa, Sam And Secretory Immune Systems, Ann Michelle Mulder

Theses

Current understanding of the biochemical changes associated with acute ‘stress’ is equivocal and unresolved. Whilst it has been hypothesised (Selye, 1976) that both psychological and physical stressors produce a non-specific stress response, it has also been suggested that psychological stress is common to a diversity of stressors, and that it is the psychological component that elicits the stress response (Mason, 1975b). To date, there appears no conclusive evidence to accept or refute either hypothesis. Therefore, the aim of this study was, by application of psychological and physical stressors to a single group of participants, and measurement of a variety of ...


The Appropriateness Of Using Laboratories And Student Participants In Gambling Research, Sally M. Gainsbury, Alex Blaszczynski 2011 Southern Cross University

The Appropriateness Of Using Laboratories And Student Participants In Gambling Research, Sally M. Gainsbury, Alex Blaszczynski

School of Tourism and Hospitality Management

Increased recognition of the risks associated with gambling has resulted in a greater focus on empirical research to increase the understanding of gambling and design appropriate response strategies. Laboratory studies are a popular mode of research due to their relative ease and lower costs compared to field research; however such studies may be limited in the extent to which results can be generalized to real gambling scenarios. The current research investigated the validity of a laboratory research study using 127 university students (male = 97, mean age = 20.4) investigating the impact of harm-minimisation measures by replicating the study in gambling ...


Building Effective Service Linkages In Primary Mental Health Care: A Narrative Review Part 2, Jeffrey D. Fuller, David Perkins, Sharon Parker, Louise Holdsworth, Brian Kelly, Russell Roberts, Lee Martinez, Lyn Fragar 2011 University of Sydney

Building Effective Service Linkages In Primary Mental Health Care: A Narrative Review Part 2, Jeffrey D. Fuller, David Perkins, Sharon Parker, Louise Holdsworth, Brian Kelly, Russell Roberts, Lee Martinez, Lyn Fragar

School of Tourism and Hospitality Management

Background: Primary care services have not generally been effective in meeting mental health care needs. Thereis evidence that collaboration between primary care and specialist mental health services can improve clinical andorganisational outcomes. It is not clear however what factors enable or hinder effective collaboration. The objectiveof this study was to examine the factors that enable effective collaboration between specialist mental healthservices and primary mental health care.

Methods: A narrative and thematic review of English language papers published between 1998 and 2009. Anexpert reference group helped formulate strategies for policy makers. Studies of descriptive and qualitative designfrom Australia, New Zealand, UK ...


Effectiveness Of Service Linkages In Primary Mental Health Care: A Narrative Review Part 1, Jeffrey D. Fuller, David Perkins, Sharon Parker, Louise Holdsworth, Brian Kelly, Russell Roberts, Lee Martinez, Lyn Fragar 2011 University of Sydney

Effectiveness Of Service Linkages In Primary Mental Health Care: A Narrative Review Part 1, Jeffrey D. Fuller, David Perkins, Sharon Parker, Louise Holdsworth, Brian Kelly, Russell Roberts, Lee Martinez, Lyn Fragar

School of Tourism and Hospitality Management

Background: With the move to community care and increased involvement of generalist health care providers in mental health, the need for health service partnerships has been emphasised in mental health policy. Within existing health system structures the active strategies that facilitate effective partnership linkages are not clear. The objective of this study was to examine the evidence from peer reviewed literature regarding the effectiveness of service linkages in primary mental health care. Methods: A narrative and thematic review of English language papers published between 1998 and 2009. Studies of analytic, descriptive and qualitative designs from Australia, New Zealand, UK, Europe ...


Himmelfarb Library Annual Report 2011, George Washington University, Himmelfarb Health Sciences Library 2011 Himmelfarb Health Sciences Library, The George Washington University

Himmelfarb Library Annual Report 2011, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Annual Report

No abstract provided.


Bilateral Knee Lipoma Arborescence Diagnosed By Ultrasound, Mahnaz Momeni, Nora Taylor, Mahsa Tehrani 2011 George Washington University

Bilateral Knee Lipoma Arborescence Diagnosed By Ultrasound, Mahnaz Momeni, Nora Taylor, Mahsa Tehrani

Rheumatology Faculty Publications

Ankylosing spondylitis is a chronic inflammatory condition that usually affects young men. Cardiac dysfunction and pulmonary disease are well-known and commonly reported extra-articular manifestation, associated with ankylosing spondylitis (AS). AS has also been reported to be specifically associated with aortitis, aortic valve diseases, conduction disturbances, cardiomyopathy and ischemic heart disease. The pulmonary manifestations of the disease include fibrosis of the upper lobes, interstitial lung disease, ventilatory impairment due to chest wall restriction, sleep apnea, and spontaneous pneumothorax. They are many reports detailing pathophysiology, hypothesized mechanisms leading to these derangements, and estimated prevalence of such findings in the AS populations. At ...


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