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L-Deprenyl, A Selective Mao-B Inhibitor, Raymond W. Lam, MD 2011 University of British Columbia

L-Deprenyl, A Selective Mao-B Inhibitor, Raymond W. Lam, Md

Jefferson Journal of Psychiatry

Monoamine oxidase inhibitors (MAOIs) are now recognized as effective medications in the treatment of major depression (1). However, their clinical use has been limited by the risk of severe hypertensive reactions to oral tyramine challenge. Prevention of this so-called "cheese effect " requires adherence to diet restrictions that can lead to problems with patient compliance to MAOIs.

L-deprenyl is a selective MAO-B inhibitor that is reportedly free of the "cheese effect" (2). This review will discuss the clinical and theoretical importance of this interesting drug.


The Usefulness Of Neutrality, Julia Jones Zawatsky, MD 2011 Sheppard and Enoch Pratt Hospital, Towson Maryland

The Usefulness Of Neutrality, Julia Jones Zawatsky, Md

Jefferson Journal of Psychiatry

Recently, the idea of therapeutic neutrality has been attacked. Many observers have suggested that the neutral therapist is inhuman and unempathic. Actually, being a neutral therapist means being especially human and empathic. The neutral therapist's empathic contact with the patient is the most extensive in that it includes not only contact with feelings and thoughts of which the patient is aware, but also contact with all those intolerable thoughts and feelings of which the patient prefers to be unaware. Such awareness in the therapist is possible only when the therapist remains, as Anna Freud (I) recommends, equidistant from the ...


Trauma And Its Ramifications In Vietnamese Victims Of Piracy, Stuart Kleinman, MD 2011 New York University Medical Center

Trauma And Its Ramifications In Vietnamese Victims Of Piracy, Stuart Kleinman, Md

Jefferson Journal of Psychiatry

Approximately 400,000 Vietnamese fled by boat from their homeland to the United States during the years 1975 to 1985. Many of these people were brutally attacked by pirates during their sojourn. This paper is a preliminary investigation of various ramifications of this trauma in seven Vietnamese "boat people."

We found significant psychopathology which is temporally related to the pirate attacks in two of those interviewed and a prominent absence of survivor guilt in all of those interviewed. Factors such as mastery of previous trauma, advanced knowledge of potential traumata, empowerment fantasies, religious beliefs, and altruistic actions may have helped ...


Mead Johnson Award-1987, 2011 Thomas Jefferson University

Mead Johnson Award-1987

Jefferson Journal of Psychiatry

The editorial board of The Jefferson Journal of Psychiatry-A Resident Publication is pleased to announce the winner of the first annual Mead Johnson Award for excellence in writing as submitted to the Journal. Paul V. Trad, M.D. has received the one thousand dollar award for his work, "Infant Depression: Nature Seeking Nurture " (JP 5( 1) 15-33, 1987 ). His ambitious synthesis exemplifies the creative potential with in residency and fellowship programs. We hope that this further acknowledgement of Dr. Trad 's work will help to inspire other trainees to undertake such an ...


Editor's Column, Gregory B. Sullivan, MD 2011 Thomas Jefferson University Hospital

Editor's Column, Gregory B. Sullivan, Md

Jefferson Journal of Psychiatry

As the Jefferson Journal of Psychiatry continues in its early growth phase, having accomplished a successful synthesis to become a national publication, we note its own apparent power of accommodation equal to the strain of fusing and adjusting internal and external changes.

Psychiatric residency in itself demands such accommodation. A group of finishing second year residents were taking stock of the fir st half of this process: They noted the difficulty in reconciling their initial conceptions and intentions with the subsequent realization of the limits to knowledge or intervention; they called this disillusionment. Others spoke of a converse strengthening ...


Resident Editorial Board, 2011 Thomas Jefferson University

Resident Editorial Board

Jefferson Journal of Psychiatry

List of Resident Editorial Board for Volume 5, Issue 2, 1987.


Reciprocal Effects Of Oxidative Stress On Heme Oxygenase Expression And Activity Contributes To Reno-Vascular Abnormalities In Ec-Sod Knockout Mice, Tomoko Kawakami, Nitin Puri, Komal Sodhi, Lars Bellner, Toru Takahashi, Kiyoshi Morita, Rita Rezzani, Tim D. Oury, Nader G. Abraham 2011 Marshall University

Reciprocal Effects Of Oxidative Stress On Heme Oxygenase Expression And Activity Contributes To Reno-Vascular Abnormalities In Ec-Sod Knockout Mice, Tomoko Kawakami, Nitin Puri, Komal Sodhi, Lars Bellner, Toru Takahashi, Kiyoshi Morita, Rita Rezzani, Tim D. Oury, Nader G. Abraham

Biochemistry and Microbiology

Heme oxygenase (HO) system is one of the key regulators of cellular redox homeostasis which responds to oxidative stress (ROS) via HO-1 induction. However, recent reports have suggested an inhibitory effect of ROS on HO activity. In light of these conflicting reports, this study was designed to evaluate effects of chronic oxidative stress on HO system and its role in contributing towards patho-physiological abnormalities observed in extracellular superoxide dismutase (EC-SOD, SOD3) KO animals. Experiments were performed in WT and EC-SOD(−/−) mice treated with and without HO inducer, cobalt protoporphyrin (CoPP). EC-SOD(−/−) mice exhibited oxidative stress, renal histopathological abnormalities, elevated blood ...


Severe Propylthiouracil-Induced Hepatotoxicity In Pregnancy Managed Successfully By Liver Transplantation: A Case Report, Evan Sequeira, Sikolia Wanyonyi, Raj Dodia 2011 Aga Khan University

Severe Propylthiouracil-Induced Hepatotoxicity In Pregnancy Managed Successfully By Liver Transplantation: A Case Report, Evan Sequeira, Sikolia Wanyonyi, Raj Dodia

Obstetrics and Gynaecology, East Africa

Introduction: Propylthiouracil-induced severe hepatotoxicity is a relatively rare occurrence, with very few cases reported in the literature. The management of this complication in pregnancy can be a challenge because of the effects of the various treatment options on the fetus.

Case presentation: We report a rare case of fulminant hepatic failure in a 36-year-old gravida 2 black woman of African descent that occurred at 17 weeks gestation following propylthiouracil treatment for Graves’ disease. Her liver failure was managed by liver transplantation and thyroidectomy. Her pregnancy was continued to term, though with not so favorable early childhood sequelae.

Conclusion: This case ...


The Effect Of Carbohydrate Amount, Quality And Type On Arterial Pulse Pressure In Cuban-Americans With And Without Type 2 Diabetes, Fatma G. Huffman, Joan A. Vaccaro, Noorus Saba Nusrath, Gustavo G. Zarini 2011 Department of Dietetics and Nutrition, Florida International University

The Effect Of Carbohydrate Amount, Quality And Type On Arterial Pulse Pressure In Cuban-Americans With And Without Type 2 Diabetes, Fatma G. Huffman, Joan A. Vaccaro, Noorus Saba Nusrath, Gustavo G. Zarini

Department of Dietetics and Nutrition

Background: Arterial pulse pressure, the difference between systolic and diastolic blood pressure, has been used as an indicator (surrogate measure) of arterial stiffness. High arterial pulse pressure (> 40) has been associated with increased cardiovascular disease and mortality. Several clinical trials have reported that the proportion of calories from carbohydrate has an effect on blood pressure. The primary objective of this study was to assess arterial pulse pressure and its association with carbohydrate quantity and quality (glycemic load) with diabetes status for a Cuban American population.

Methods: A single point analysis included 367 participants. There was complete data for 365 (190 ...


Stimulant Reduction Intervention Using Dosed Exercise (Stride) - Ctn 0037: Study Protocol For A Randomized Controlled Trial, Madhukar H. Trivedi, Tracy L. Greer, Bruce D. Grannemann, Timothy S. Church, Eugene Somoza, Steven N. Blair, Jose Szapocznik, Mark Stoutenberg, Chad Rethorst, Diane Warden, Kolette M. Ring, Robrina Walker, David W. Morris, Andrzej S. Kosinski, Tiffany Kyle, Bess H. Marcus, Becca Crowell, Neal Oden, Edward Nunes 2011 University of South Carolina - Columbia

Stimulant Reduction Intervention Using Dosed Exercise (Stride) - Ctn 0037: Study Protocol For A Randomized Controlled Trial, Madhukar H. Trivedi, Tracy L. Greer, Bruce D. Grannemann, Timothy S. Church, Eugene Somoza, Steven N. Blair, Jose Szapocznik, Mark Stoutenberg, Chad Rethorst, Diane Warden, Kolette M. Ring, Robrina Walker, David W. Morris, Andrzej S. Kosinski, Tiffany Kyle, Bess H. Marcus, Becca Crowell, Neal Oden, Edward Nunes

Faculty Publications

Background: There is a need for novel approaches to the treatment of stimulant abuse and dependence. Clinical data examining the use of exercise as a treatment for the abuse of nicotine, alcohol, and other substances suggest that exercise may be a beneficial treatment for stimulant abuse, with direct effects on decreased use and craving. In addition, exercise has the potential to improve other health domains that may be adversely affected by stimulant use or its treatment, such as sleep disturbance, cognitive function, mood, weight gain, quality of life, and anhedonia, since it has been shown to improve many of these ...


Library Impact Statement For Phc 515 Integrated Pharmacy Lab 5, Robin B. Devin 2011 University of Rhode Island

Library Impact Statement For Phc 515 Integrated Pharmacy Lab 5, Robin B. Devin

Library Impact Statements

Library Impact Statement submitted in response to new course proposal for PHC 516 Integrated Pharmacy Lab 5. New course was supported with no need for additional resources.


Library Impact Statement For Phc 515 Integrated Pharmacy Lab 4, Robin B. Devin 2011 University of Rhode Island

Library Impact Statement For Phc 515 Integrated Pharmacy Lab 4, Robin B. Devin

Library Impact Statements

Library Impact Statement in response to new course proposal for PHC 515 Integrated Pharmacy Lab 4. New course was supported with no need for additional resources.


Library Impact Statement For Phc 416 Integrated Pharmacy Lab 3, Robin B. Devin 2011 University of Rhode Island

Library Impact Statement For Phc 416 Integrated Pharmacy Lab 3, Robin B. Devin

Library Impact Statements

Library Impact Statement submitted in response to new course proposal for PHC 416 Integrated Pharmacy Lab 3


Library Impact Statement For Phc 415 Integrated Pharmacy Lab 2, Robin B. Devin 2011 URI

Library Impact Statement For Phc 415 Integrated Pharmacy Lab 2, Robin B. Devin

Library Impact Statements

Library Impact Statement submitted in response to new course proposal for PHC 415 Integrated Pharmacy Lab 2. New course was supported with no need for additional resources.


Community Patterns Of Stigma Towards Persons Living With Hiv: A Population-Based Latent Class Analysis From Rural Vietnam., Anastasia Pharris, Nguyen Phuong Hoa, Carol Tishelman, Gaetano Marrone, Nguyen Thi Kim Chuc, Ruairi Brugha, Anna Thorson 2011 Karolinska Institute

Community Patterns Of Stigma Towards Persons Living With Hiv: A Population-Based Latent Class Analysis From Rural Vietnam., Anastasia Pharris, Nguyen Phuong Hoa, Carol Tishelman, Gaetano Marrone, Nguyen Thi Kim Chuc, Ruairi Brugha, Anna Thorson

Epidemiology and Public Health Medicine Articles

ABSTRACT: BACKGROUND: The negative effects of stigma on persons living with HIV (PLHIV) have been documented in many settings and it is thought that stigma against PLHIV leads to more difficulties for those who need to access HIV testing, treatment and care, as well as to limited community uptake of HIV prevention and testing messages. In order to understand and prevent stigma towards PLHIV, it is important to be able to measure stigma within communities and to understand which factors are associated with higher stigma. METHODS: To analyze patterns of community stigma and determinants to stigma toward PLHIV, we performed ...


Relationships Between Self-Reported Smoking, Household Environmental Tobacco Smoke Exposure And Depressive Symptoms In A Pregnant Minority Population, Sylvia Tan, Lauren P. Courtney, Ayman El-Mohandes, Susan M. Blake, Marie G. Gantz, Jutta Thornberry, M. Nabil El-Khorazaty, David Perry, Michele Kiely 2011 RTI International

Relationships Between Self-Reported Smoking, Household Environmental Tobacco Smoke Exposure And Depressive Symptoms In A Pregnant Minority Population, Sylvia Tan, Lauren P. Courtney, Ayman El-Mohandes, Susan M. Blake, Marie G. Gantz, Jutta Thornberry, M. Nabil El-Khorazaty, David Perry, Michele Kiely

Publications and Research

This study sought to examine relationships between depressive symptoms and prenatal smoking and/or household environmental tobacco smoke exposure (HHETSE) among urban minority women. We analyzed private, audio computer-assisted self interview data from a clinic-based sample of 929 minority pregnant women in Washington, DC. Depressive symptoms were assessed via the Beck Depression Inventory Fast Screen. HH-ETSE, current smoking, and former smoking were assessed via self-report. Depression levels and demographic characteristics were compared: (1) among nonsmokers, for those reporting HH-ETSE versus no HH-ETSE; and (2) among smokers, for those reporting current smoking (in last 7 days) versus former smokers. Measures associated ...


Cranioplasty After Decompressive Craniectomy: An Institutional Audit And Analysis Of Factors Related To Complications., Zain A. Sobani, Muhammad Shahzad Shamim, Syed Nabeel Zafar, Mohsin Qadeer, Najiha Bilal, Syed Ghulam Murtaza, Syed Anther Enam, Muhammad Ehsan Bari 2011 Aga Khan University

Cranioplasty After Decompressive Craniectomy: An Institutional Audit And Analysis Of Factors Related To Complications., Zain A. Sobani, Muhammad Shahzad Shamim, Syed Nabeel Zafar, Mohsin Qadeer, Najiha Bilal, Syed Ghulam Murtaza, Syed Anther Enam, Muhammad Ehsan Bari

Section of Neurosurgery

Background:Although a relatively simple procedure, cranioplasties have been associated with high complication rates. Keeping this in perspective, we aimed to determine the factors associated with immediate and long-term complications of cranioplasties at our institution.

Methods:

A retrospective review of Patient records was carried out for Patients having undergone reconstructive cranioplasties at our institution during the last 10 years (2001-2010). All case notes, records, and investigations were reviewed and the data were recorded in a predesigned questionnaire. Complications were recorded along with existing comorbids and measures taken for their prevention and management. Univariate and multivariate logistic regression analysis was performed ...


Letters To The Editor, 2011 Thomas Jefferson University

Letters To The Editor

Jefferson Journal of Psychiatry

Letters to the Editor.


In Response: New Controversial Diagnoses: Self-Defeating And Sadistic Personality Disorders, Frederic Kass, MD 2011 Columbia University College of Physicians and Surgeons

In Response: New Controversial Diagnoses: Self-Defeating And Sadistic Personality Disorders, Frederic Kass, Md

Jefferson Journal of Psychiatry

Until several years ago the entire literature on Masochistic Personality was theoretical or anecdotal. Dr. Fuller's recent paper, "Masochistic Personality Disorder: A Diagnosis Under Consideration," is a timely contribution in that it is one of a growing number of empirical studies on this topic (1). His major finding, that Masochistic Personality describes a disorder which is not adequately described by the existing Axis II disorders, is consistent with data we recently reported (2). We have found, in addition, that the diagnosis is common, and that the criteria have good internal consistency, specificity, and sensitivity (3,4). At this point ...


Commentary, 2011 Thomas Jefferson University

Commentary

Jefferson Journal of Psychiatry

DR. KRAMER COMMENTS ON PSYCHOACTIVITY OF CALCIUM CHANNEL BLOCKERS, CASE REPORTS, AND RESEARCH.


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