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Functional Magnetic Resonance Imaging In Conscious Animals: A New Tool In Behavioural Neuroscience Research, Craig F. Ferris, Marcelo Febo, Feng Luo, Karl F. Schmidt, Mathew E. Brevard, Josie A. Harder, Praveen P. Kulkarni, Tara L. Messenger, Jean A. King 2010 University of Massachusetts Medical School

Functional Magnetic Resonance Imaging In Conscious Animals: A New Tool In Behavioural Neuroscience Research, Craig F. Ferris, Marcelo Febo, Feng Luo, Karl F. Schmidt, Mathew E. Brevard, Josie A. Harder, Praveen P. Kulkarni, Tara L. Messenger, Jean A. King

Jean A. King

Functional magnetic resonance imaging (fMRI) is a unique window to the brain, enabling scientists to follow changes in brain activity in response to hormones, ageing, environment, drugs of abuse and other stimuli. In this review, we present a general background to fMRI and the different imaging modalities that can be used in fMRI studies. Included are examples of the application of fMRI in behavioural neuroscience research, along with discussion of the advantages and disadvantages of this technology.


Today - November 3, 2010, Loma Linda University 2010 Loma Linda University

Today - November 3, 2010, Loma Linda University

TODAY

Inside this issue:

-- Annual convocation chapel celebrates spiritual roots of Loma Linda University
-- Free flu shots and health screenings offered at LLUMC Family Health Fair
-- LLU Medical Center ophthalmologist named among 'Best Doctors in America'
-- Japanese exchange program enriches GIS at Loma Linda University
-- Wholeness lecture series begins with lesson in personality
-- Marine officer shares his personal story of recovery from addition
-- Doctor of nursing practice program experiences rapid growth
-- Adults needed as subjects for an avocado research study
-- School of Religion hosts roundtable discussion on young Adventists
-- Pharmacy student network organized
-- Family ministries department leaders visit Loma Linda University ...


The Relative Influence Of Demographic, Individual, Social, And Environmental Factors On Physical Activity Among Boys And Girls, Carrie D. Patnode, Leslie A. Lytle, Darin J. Erickson, John R. Sirard, Daheia J. Barr-Anderson, Mary Story 2010 University of South Carolina - Columbia

The Relative Influence Of Demographic, Individual, Social, And Environmental Factors On Physical Activity Among Boys And Girls, Carrie D. Patnode, Leslie A. Lytle, Darin J. Erickson, John R. Sirard, Daheia J. Barr-Anderson, Mary Story

Faculty Publications

Background: This study aimed to evaluate the associations of selected demographic, individual, social, and environmental factors with moderate-to-vigorous physical activity (MVPA) in a sample of children and adolescents.

Methods: MVPA was assessed among youth (n = 294) 10-17-years-old using the ActiGraph accelerometer. Youth completed measures of demographic and individual variables related to physical activity (PA), perceived social support by parents and peers, and perceived neighborhood characteristics. Parents completed the long-form of the International Physical Activity Questionnaire. The Physical Activity and Media Inventory was used to measure the home environment and Geographical Information Systems software was used to measure the physical neighborhood ...


The Endogenous Soluble Vegf Receptor-2 Isoform Suppresses Lymph Node Metastasis In A Mouse Immunocompetent Mammary Cancer Model, Masa-Aki Shibata, Jayakrishna Ambati, Eiko Shibata, Romulo J. C. Albuquerque, Junji Morimoto, Yuko Ito, Yoshinori Otsuki 2010 Osaka Medical College, Japan

The Endogenous Soluble Vegf Receptor-2 Isoform Suppresses Lymph Node Metastasis In A Mouse Immunocompetent Mammary Cancer Model, Masa-Aki Shibata, Jayakrishna Ambati, Eiko Shibata, Romulo J. C. Albuquerque, Junji Morimoto, Yuko Ito, Yoshinori Otsuki

Ophthalmology and Visual Science Faculty Publications

BACKGROUND: Cancer metastasis contributes significantly to cancer mortality and is facilitated by lymphangiogenesis and angiogenesis. A new splicing variant, endogenous soluble vascular endothelial growth factor receptor-2 (esVEGFR-2) that we recently identified is an endogenous selective inhibitor of lymphangiogenesis. To evaluate the antimetastatic potential of esVEGFR-2, gene therapy with vector expressing esVEGFR-2 (pesVEGFR-2) or endostatin (pEndo) as a positive control was conducted on murine metastatic mammary cancer.

METHODS: Syngeneic inoculated metastatic mammary cancers received direct intratumoral injection of pesVEGFR-2, pEndo or pVec as control, once a week for six weeks. In vivo gene electrotransfer was performed on the tumors after each ...


Linnaeus Turns 300... Carl Linnaeus, Hans Wohlmuth 2010 Southern Cross University

Linnaeus Turns 300... Carl Linnaeus, Hans Wohlmuth

Dr Hans Wohlmuth

The article highlights the celebration of the 300th birthday of Carl Linnaeus, or Carl von Linne (as he is known in Scandinavi). Three centuries after his birth Linnaeus remains among the most famous and influential Swedes of all time, indeed his fame as a naturalist is eclipsed only by the great Charles Darwin (1809-1882).


Modulation Of Macrophage Immune Responses By Echinacea, Lesley Stevenson, Anita Matthias, Linda Banbury, Kerry Penman, Kerry Bone, David Leach, Reg Lehmann 2010 Southern Cross University

Modulation Of Macrophage Immune Responses By Echinacea, Lesley Stevenson, Anita Matthias, Linda Banbury, Kerry Penman, Kerry Bone, David Leach, Reg Lehmann

David N Leach

Echinacea preparations are widely used herbal medicines for the prevention and treatment of colds and minor infections. There is little evidence for the individual components in Echinacea that contribute to immune regulatory activity. Activity of an ethanolic Echinacea extract and several constituents, including cichoric acid, have been examined using three in vitro measures of macrophage immune function – NF-κB, TNF- α and nitric oxide (NO). In cultured macrophages, all components except the monoene alkylamide (AA1) decreased lipopolysaccharide (LPS) stimulated NF-κB levels. 0.2 μg/ml cichoric acid and 2.0μg/mL Echinacea Premium Liquid (EPL) and EPL alkylamide fraction (EPL AA ...


Dynamics Of Hiv Risk Behavior In Hiv-Infected Injection Drug Users, 2010 University of Connecticut

Dynamics Of Hiv Risk Behavior In Hiv-Infected Injection Drug Users

CHIP Documents

Forty-six individuals with a history of injection drug use participated in a questionnaire and an interview study assessing their HIV risk behaviors, and their HIV risk and prevention information, motivation, and behavioral skills related to injection drug use and sexual behavior. High levels of past and current risky injection drug use and sexual behavior were reported. HIV risk reduction information was generally high, and many participants reported proprevention attitudes and supportive perceived norms toward HIV risk reduction behaviors. However, many did not intend to engage in these preventive behaviors, and some reported deficits in prevention behavioral skills. Interview data revealed ...


Endogenous Sirnas And Noncoding Rna-Derived Small Rnas Are Expressed In Adult Mouse Hippocampus And Are Up-Regulated In Olfactory Discrimination Training., Neil Smalheiser, G Lugli, Jyothi Thimmapuram, E.H. Cook, J Larson 2010 University of Illinois at Chicago

Endogenous Sirnas And Noncoding Rna-Derived Small Rnas Are Expressed In Adult Mouse Hippocampus And Are Up-Regulated In Olfactory Discrimination Training., Neil Smalheiser, G Lugli, Jyothi Thimmapuram, E.H. Cook, J Larson

Cyber Center Publications

We previously proposed that endogenous siRNAs may regulate synaptic plasticity and long-term gene expression in the mammalian brain. Here, a hippocampal-dependent task was employed in which adult mice were trained to execute a nose-poke in a port containing one of two simultaneously present odors in order to obtain a reward. Mice demonstrating olfactory discrimination training were compared to pseudo-training and nose-poke control groups; size-selected hippocampal RNA was subjected to Illumina deep sequencing. Sequences that aligned uniquely and exactly to the genome without uncertain nucleotide assignments, within exons or introns of MGI annotated genes, were examined further. The data confirm that ...


The Decompensating Pediatric Inpatient Simulation Scenarios, Aisha Davis, Pavan P. Zaveri 2010 George Washington University

The Decompensating Pediatric Inpatient Simulation Scenarios, Aisha Davis, Pavan P. Zaveri

E-Learning Modules

Introduction: In July of 2009, Children’s National Medical Center (CNMC) Hospitalist and Emergency Department (ED) educators collaborated to create and implement unique simulation scenarios for trainees rotating on the pediatric hospitalist teams. The goal of this educational intervention is to teach and allow rehearsal of an approach to the unstable patient across three scenarios. Trainees use this high-fidelity, low-risksimulation to apply targeted clinical reasoning and their initial assessment and management strategies to core clinical problems. The three scenarios included in this resource cover altered mental status and seizure, respiratory distress and anaphylaxis, and refractory status asthmaticus, respectively.

Methods:This ...


Midgut Barrier Imparts Selective Resistance To Filarial Worm Infection In Culex Pipiens Pipiens, Michelle L. Michalski, Sarah M. Erickson, Bruce M. Christensen, Lyric C. Bartholomay 2010 University of Wisconsin–Oshkosh

Midgut Barrier Imparts Selective Resistance To Filarial Worm Infection In Culex Pipiens Pipiens, Michelle L. Michalski, Sarah M. Erickson, Bruce M. Christensen, Lyric C. Bartholomay

Entomology Publications

Mosquitoes in the Culex pipiens complex thrive in temperate and tropical regions worldwide, and serve as efficient vectors of Bancroftian lymphatic filariasis (LF) caused by Wuchereria bancrofti in Asia, Africa, the West Indies, South America, and Micronesia. However, members of this mosquito complex do not act as natural vectors for Brugian LF caused by Brugia malayi, or for the cat parasite B. pahangi, despite their presence in South Asia where these parasites are endemic. Previous work with the Iowa strain of Culex pipiens pipiens demonstrates that it is equally susceptible to W. bancrofti as is the natural Cx. p. pipiens ...


Do General, Community Hospitals Compete By Specializing In High Volume, High Revenue-Generating Service Lines?, Nancy J. Muller 2010 Virginia Commonwealth University

Do General, Community Hospitals Compete By Specializing In High Volume, High Revenue-Generating Service Lines?, Nancy J. Muller

Theses and Dissertations

To determine if general, community hospitals show evidence of specializing in the nation's six highest volume, highest revenue-generating service lines, 2003-2007 data of hospitals throughout Florida, Virginia, and Nevada were analyzed using backward deletion, stepwise regression. Service lines selected for study were cardiac surgery, cardiology, invasive cardiology, orthopedics, labor and delivery, and pulmonary services. Results do show evidence of specialization, but characteristics of hospitals vary by service line. Findings suggest that the general, community hospital, traditionally a full-service provider, may be undergoing transformation including specialization. The study demonstrates the usefulness of studying specialization at the service line level.


Sorption Of Pharmaceuticals On Model Sorbent Systems: Implications For Wastewater Reuse, Simone Charles 2010 Georgia Southern University

Sorption Of Pharmaceuticals On Model Sorbent Systems: Implications For Wastewater Reuse, Simone Charles

Simone M. Charles

One concern with the reuse of wastewater is the presence of pharmaceuticals and other similar compounds in wastewater. Different classes of pharmaceuticals have been reported in over 100 rivers and streams in the US and in drinking water. Development of a system that could effectively and efficiently remove pharmaceuticals and their metabolites from wastewaters would inform environmental risk assessment. Sorption processes play an important role in determining mobility, (bio) availability and, hence, persistence of contaminants in soil. Clay minerals and soil organic matter (SOM) are generally considered to be the two most active soil components in the sorption of aqueous ...


Critical Illness Myopathy, Tazeen S. Ali Dr, Salima Moez Meherali Dr, Yasmin Parpio Dr 2010 Aga Khan University

Critical Illness Myopathy, Tazeen S. Ali Dr, Salima Moez Meherali Dr, Yasmin Parpio Dr

Tazeen S Ali Dr

Critical illness myopathy (CIM) is a syndrome of widespread muscle weakness and neurological dysfunction which can develop in critically ill patients receiving intensive care. CIM are often distinguished largely on the basis of specialized electrophysiologic testing or muscle and nerve biopsy and its causes are unknown, though they are thought to be a possible neurological manifestation of systemic inflammatory response syndrome usually developing in patients after a brief period of stay in the Intensive Care Unit (ICU). This case report aims to analyze the Clinical feature, diagnosis and treatment of CIM of 60 years old male case with Chronic Obstructive ...


Step Counts Of Non-White Minority Children And Youth By Gender, Grade Level, Race/Ethnicity, And Mode Of School Transportation, Tyler G. Johnson, Timothy A. Brusseau, Paul W. Darst, Pamela H. Kulinna, Janel White-Taylor 2010 Boise State University

Step Counts Of Non-White Minority Children And Youth By Gender, Grade Level, Race/Ethnicity, And Mode Of School Transportation, Tyler G. Johnson, Timothy A. Brusseau, Paul W. Darst, Pamela H. Kulinna, Janel White-Taylor

Kinesiology Faculty Publications and Presentations

Background: The purposes of this study were to describe and analyze the steps/d of nonwhite minority children and youth by gender, grade level, race/ethnicity, and mode of school transportation. A secondary purpose was to compare the steps/d of minority children and youth to their Caucasian grade-level counterparts. Methods: Participants were 547 minority youth grades 5 to 8 from 4 urban schools. Participants wore sealed pedometers for 6 consecutive week/school days. Three hundred and ten participants responded to a questionnaire concerning their mode of transportation to and from school. Results: Statistical analyses indicated a main effect for ...


Wild-Type And Mutant Sod1 Share An Aberrant Conformation And A Common Pathogenic Pathway In Als., Daryl A Bosco, Gerardo Morfini, N Murat Karabacak, Yuyu Song, Francois Gros-Louis, Piera Pasinelli, Holly Goolsby, Benjamin A Fontaine, Nathan Lemay, Diane McKenna-Yasek, Matthew P Frosch, Jeffrey N Agar, Jean-Pierre Julien, Scott T Brady, Robert H Brown 2010 University of Massachusetts Medical Center

Wild-Type And Mutant Sod1 Share An Aberrant Conformation And A Common Pathogenic Pathway In Als., Daryl A Bosco, Gerardo Morfini, N Murat Karabacak, Yuyu Song, Francois Gros-Louis, Piera Pasinelli, Holly Goolsby, Benjamin A Fontaine, Nathan Lemay, Diane Mckenna-Yasek, Matthew P Frosch, Jeffrey N Agar, Jean-Pierre Julien, Scott T Brady, Robert H Brown

Faculty papers Farber Institute for Neurosciences

Many mutations confer one or more toxic function(s) on copper/zinc superoxide dismutase 1 (SOD1) that impair motor neuron viability and cause familial amyotrophic lateral sclerosis (FALS). Using a conformation-specific antibody that detects misfolded SOD1 (C4F6), we found that oxidized wild-type SOD1 and mutant SOD1 share a conformational epitope that is not present in normal wild-type SOD1. In a subset of human sporadic ALS (SALS) cases, motor neurons in the lumbosacral spinal cord were markedly C4F6 immunoreactive, indicating that an aberrant wild-type SOD1 species was present. Recombinant, oxidized wild-type SOD1 and wild-type SOD1 immunopurified from SALS tissues inhibited kinesin-based ...


Area Under The Curve Bioequivalence Of Mycophenolate Mofetil: Cellcept® Vs Generic, Ian C. Doyle PharmD, Ahmed Zikri PharmD, William M. Bennett MD, Leslie M. Shaw PhD, Michal J. Figurski PhD 2010 Pacific University School of Pharmacy

Area Under The Curve Bioequivalence Of Mycophenolate Mofetil: Cellcept® Vs Generic, Ian C. Doyle Pharmd, Ahmed Zikri Pharmd, William M. Bennett Md, Leslie M. Shaw Phd, Michal J. Figurski Phd

Faculty Scholarship (PHRM)

Therapeutic drug monitoring (TDM) of mycophenolate mofetil (MMF) has been investigated using multiple linear regression (MLR) and bayesian pharmacokinetics (BAY) independently. Some studies have shown that therapeutic drug monitoring (TDM) of MMF via measuring area under the curve (AUC) may decrease risk of rejection as well as toxicity. Between May 2008 and June 2009, the FDA granted approval to 7 different manufacturers of generic MMF. Secondary to the between-patient and within-patient variability of MMF pharmacokinetics, it is important to use validated MLR and BAY models. These models have thus far been designed using only CellCept®. In this study, MLR and ...


Mycophenolate Mofetil Therapeutic Drug Monitoring: Combined Multi-Linear Regression And Bayesian Limited Sampling Area Under The Curve Versus Standard Care, Ian C. Doyle PharmD, Ahmed Zikri PharmD, William M. Bennett MD, Leslie M. Shaw PhD, Michal J. Figurski PhD 2010 Pacific University School of Pharmacy

Mycophenolate Mofetil Therapeutic Drug Monitoring: Combined Multi-Linear Regression And Bayesian Limited Sampling Area Under The Curve Versus Standard Care, Ian C. Doyle Pharmd, Ahmed Zikri Pharmd, William M. Bennett Md, Leslie M. Shaw Phd, Michal J. Figurski Phd

Faculty Scholarship (PHRM)

Therapeutic drug monitoring (TDM) of mycophenolate mofetil (MMF) has been investigated using multiple linear regression (MLR) and bayesian pharmacokinetics (BAY) independently. We hypothesize that performing TDM using simultaneous MLR and BAY for guidance in MMF dose selection will decrease acute rejection and risk of toxicity. Twenty-nine renal transplant (RT) patients were prospectively enrolled into a study of CellCept® (MMF, Roche), having their mycophenolic acid (MPA) levels monitored and dose adjusted to achieve target area under the curve (AUC) level of 45 mg.hr/L (range 40 – 50 mg.hr/L). This cohort is compared to 28 control patients prescribed standard ...


Nfκb Activation And Stimulation Of Chemokine Production In Normal Human Macrophages By The Gadolinium-Based Magnetic Resonance Contrast Agent Omniscan: Possible Role In The Pathogenesis Of Nephrogenic Systemic Fibrosis., Francesco Del Galdo, Peter J Wermuth, Sankar Addya, Paolo Fortina, Sergio A Jimenez 2010 Thomas Jefferson University

Nfκb Activation And Stimulation Of Chemokine Production In Normal Human Macrophages By The Gadolinium-Based Magnetic Resonance Contrast Agent Omniscan: Possible Role In The Pathogenesis Of Nephrogenic Systemic Fibrosis., Francesco Del Galdo, Peter J Wermuth, Sankar Addya, Paolo Fortina, Sergio A Jimenez

Jefferson Institute of Molecular Medicine Papers and Presentations

OBJECTIVE: Nephrogenic systemic fibrosis (NSF) is a generalised fibrotic disorder occurring in certain individuals with renal insufficiency exposed to gadolinium-based contrast agents (GdBCA) for MRI. Histopathological examination of affected tissues shows increased numbers of activated macrophages. To elucidate the mechanisms responsible for macrophage activation, the effects of the GdBCA Omniscan on normal human macrophage global gene expression, chemokine production and nuclear factor κB (NFκB) activation was examined.

METHODS: Normal human monocyte-derived macrophages were incubated with Omniscan (50 mM) and their gene expression analysed by microarrays and real-time PCR. Macrophage chemokine production was assayed by multiplex ELISA. NFκB activation was assessed ...


Transforming Learning: Using A Multi-User Virtual Environment For Simulation, Michelle Honey, Kelley Connor 2010 University of Auckland

Transforming Learning: Using A Multi-User Virtual Environment For Simulation, Michelle Honey, Kelley Connor

Kelley Connor

Simulations are well known in education, including health professional education. Traditionally simulations have included role plays and demonstration rooms where skills can be practiced and more recently high-fidelity mannequins have lifted the level of simulation. The use of the Internet has allowed synchronous learning that permits sharing experiences and social interactivity. One specific option that has emerged which has the potential to transform health professional clinical education is the use of multi-user virtual environments for simulated learning. A pilot using Second Life, a web-based virtual environment, to teach haemorrhage management to undergraduate nurses is described. Findings include that with pre-simulation ...


Hemispheric Differences In Specificity Effects In Talker Identification, Julio Gonza´lez, Teresa Cervera-Crespo, Conor T. McLennan 2010 University Jaume I

Hemispheric Differences In Specificity Effects In Talker Identification, Julio Gonza´Lez, Teresa Cervera-Crespo, Conor T. Mclennan

Psychology Faculty Publications

In the visual domain, Marsolek and colleagues (1999, 2008) have found support for two dissociable and parallel neural subsystems underlying object and shape recognition: an abstract-category subsystem that operates more effectively in the left cerebral hemisphere (LH), and a specific-exemplar subsystem that operates more effectively in the right cerebral hemisphere (RH). Evidence of this asymmetry has been observed in priming specificity for linguistic (words, pseudoword forms) and nonlinguistic (objects) stimuli. In the auditory domain, the authors previously found hemispheric asymmetries in priming effects for linguistic (spoken words) and nonlinguistic (environmental sounds) stimuli. In the present study, the same asymmetrical pattern ...


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