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Inference Of Cancer-Specific Gene Regulatory Networks Using Soft Computing Rules., Xiaosheng Wang, Osamu Gotoh 2010 University of Nebraska Medical Center

Inference Of Cancer-Specific Gene Regulatory Networks Using Soft Computing Rules., Xiaosheng Wang, Osamu Gotoh

Journal Articles: Genetics, Cell Biology & Anatomy

Perturbations of gene regulatory networks are essentially responsible for oncogenesis. Therefore, inferring the gene regulatory networks is a key step to overcoming cancer. In this work, we propose a method for inferring directed gene regulatory networks based on soft computing rules, which can identify important cause-effect regulatory relations of gene expression. First, we identify important genes associated with a specific cancer (colon cancer) using a supervised learning approach. Next, we reconstruct the gene regulatory networks by inferring the regulatory relations among the identified genes, and their regulated relations by other genes within the genome. We obtain two meaningful findings. One ...


Today - March 31, 2010, Loma Linda University 2010 Loma Linda University

Today - March 31, 2010, Loma Linda University

TODAY

Inside this issue:

-- Lifestyle and chronic diseases discussed at Healthy People 2010
-- Walter's Children's Charity Classic raises $200,000 for pediatric ophthalmology
-- Strengthening Hospital Adventiste d'Haiti
-- Pediatric RN residents celebrate with Drs. Clark and Seuss
-- Public health student speaks at One Young World Summit
-- The renewal of spiritual emphasis at Loma Linda University in the 1970s
-- LLU summer internship and management residency programs continue to shape the Adventist health care, business, and communication leaders of tomorrow
-- LLU prepares county environmental health departments
-- Children's Assessment Center combats the effects of sexual child abuse
-- LLU School of Pharmacy ...


Examination Of The Mental Health And Family Dynamics In Caribbean Immigrants Using The National Survey Of American Life, Brian D. Carter 2010 Georgia State University

Examination Of The Mental Health And Family Dynamics In Caribbean Immigrants Using The National Survey Of American Life, Brian D. Carter

Public Health Theses

Previous studies have documented an association between mental illness rates and US-nativity, younger age at immigration, and recent immigration status among Caribbean immigrants to the US. This analysis examines these associations with the addition of important demographic controls and two indices of family support and conflict in Caribbean immigrants represented in the National Survey of American Life (n = 1623). The results indicate that previous correlates disappear when the index of family conflict is taken into account. Future efforts should focus on culturally appropriate identification and treatment methods addressing family dynamics in Caribbean immigrants. INDEX WORDS: immigrant mental health, family dynamics ...


Effects Of Perceived Fitness Level Of Exercise Partner On Intensity Of Exertion, Thomas G. Plante, Meghan Madden, Sonia Mann, Grace Lee 2010 Santa Clara University

Effects Of Perceived Fitness Level Of Exercise Partner On Intensity Of Exertion, Thomas G. Plante, Meghan Madden, Sonia Mann, Grace Lee

Psychology

Problem statement: Social comparison theory was used to examine if exercising with a research confederate posing as either high fit or low fit would increase the exertion in exercising. Approach: 91 college students were randomly assigned to one of three conditions: Biking alone, biking with a high fit confederate, or biking with a low fit confederate. All participants were instructed to complete 20 min of exercise at 60-70% of their maximum target heart rate. Results: Results indicated that participants in the high fit condition exercised harder than those in the low fit condition. However, no mood differences emerged between conditions ...


Improving Health Outcomes For Children In Maine Logic Model For Primary Care Practice Improvement, University of Southern Maine 2010 University of Southern Maine

Improving Health Outcomes For Children In Maine Logic Model For Primary Care Practice Improvement, University Of Southern Maine

Population Health and Health Policy

No abstract provided.


Trastuzumab Sensitizes Ovarian Cancer Cells To Egfr-Targeted Therapeutics, Jason A. Wilken, Kristy T. Webster, Nita J. Maihle 2010 Yale University

Trastuzumab Sensitizes Ovarian Cancer Cells To Egfr-Targeted Therapeutics, Jason A. Wilken, Kristy T. Webster, Nita J. Maihle

Open Access Articles

BACKGROUND: Early studies have demonstrated comparable levels of HER2/ErbB2 expression in both breast and ovarian cancer. Trastuzumab (Herceptin), a therapeutic monoclonal antibody directed against HER2, is FDA-approved for the treatment of both early and late stage breast cancer. However, clinical studies of trastuzumab in epithelial ovarian cancer (EOC) patients have not met the same level of success. Surprisingly, however, no reports have examined either the basis for primary trastuzumab resistance in ovarian cancer or potential ways of salvaging trastuzumab as a potential ovarian cancer therapeutic.

METHODS: An in vitro model of primary trastuzumab-resistant ovarian cancer was created by long-term ...


The Influences Of Matrix Metalloproteinase-1 Expression On Glioblastoma Pathology, Nicholas Pullen 2010 Virginia Commonwealth University

The Influences Of Matrix Metalloproteinase-1 Expression On Glioblastoma Pathology, Nicholas Pullen

Theses and Dissertations

Glioblastoma multiforme (GBM) is an aggressive central nervous system (CNS) cancer characterized by enhanced tumor cell motility, pernicious invasion into the normal brain, extensive tumor-induced angiogenesis, and adaptive resistance to current therapeutic paradigms. One of the difficulties associated with GBM is the ability of the tumor cells to infiltrate normal CNS tissue. Neurosurgeons can remove the primary tumor mass, but peripheral cells that are inaccessible will ultimately result in a secondary lesion that can lead to death. The matrix metalloproteinases (MMP) are well known for their abilities to facilitate processes of cellular motility and invasion through their clearance of extracellular ...


Oral Health Checkup: Progress In Tough Fiscal Times?, Cynthia Shirk 2010 Himmelfarb Health Sciences Library, The George Washington University

Oral Health Checkup: Progress In Tough Fiscal Times?, Cynthia Shirk

National Health Policy Forum

Almost ten years after the surgeon general’s report designating dental disease as the “silent epidemic,” the nation continues to struggle with adequate access to and utilization of dental services. This is particularly true for low-income individuals, who experience more than twice the amount of untreated dental disease as their higher-income peers. This issue brief reviews sources of dental coverage for low-income children and adults and the challenges these programs face. It highlights some examples of state Medicaid initiatives to improve access and utilization for children and the progress of these initiatives. Finally, it examines the potential effects of the ...


The State Health Insurance Assistance Program (Ship), Carol O'Shaughnessy 2010 George Washington University

The State Health Insurance Assistance Program (Ship), Carol O'Shaughnessy

National Health Policy Forum

The State Health Insurance Assistance Program (SHIP), created by section 4360 of the Omnibus Budget Reconciliation Act (OBRA) of 1990 and administered by the Centers for Medicare & Medicaid Services (CMS), supports grants to states and jurisdictions to provide information, counseling, and assistance to Medicare beneficiaries and their families on Medicare and other health insurance questions. This publication describes the program and presents its funding history.


Associations Of Race, Age, And Socioeconomic Status Among Women With Prediabetes: An Examination Of Nhanes Data 2005-2006 Regarding Prediabetes Risk, Rose T. Kattakayam 2010 Georgia State University

Associations Of Race, Age, And Socioeconomic Status Among Women With Prediabetes: An Examination Of Nhanes Data 2005-2006 Regarding Prediabetes Risk, Rose T. Kattakayam

Public Health Theses

Background: Prediabetes (PD) defined as having glucose values above normal but not high enough to be diagnosed as diabetes, is known to be a risk factor for type 2 diabetes and associated complications. Early prevention efforts can reverse the condition or delay the development of type 2 diabetes. This study examines the sociodemographic risk factors for PD in women. Methods: Using secondary data from National Health and Nutrition Examination Survey NHANES 2005-2006, chi-square analysis was done to find the prevalence of the disease among different categories of women with respect to age, ethnicity, and socioeconomic status. Univariate and multivariate analyses ...


A View Of The Imd Pathway From The Rhim, Kamna Aggarwal 2010 University of Massachusetts Medical School

A View Of The Imd Pathway From The Rhim, Kamna Aggarwal

GSBS Dissertations and Theses

Innate immunity is the first line of defense against invading pathogens. It functions to eliminate pathogens and also to control infections. The innate immune response is also important for the development of pathogen-specific adaptive immune responses. As a result, the study of innate immune signaling pathways is crucial for understanding the interactions between host and pathogen. Unlike mammals, insects lack a classical adaptive immune response and rely mostly on innate immune responses.

Innate immune mechanisms have been widely studied in the fruit fly, Drosophila melanogaster. The genetic and molecular tools available in the Drosophila system make it an excellent model ...


Predictors Of Retention In Physical Therapy: Client-, Disease-, And Treatment-Related Factors, Marc A. Silva 2010 Marquette University

Predictors Of Retention In Physical Therapy: Client-, Disease-, And Treatment-Related Factors, Marc A. Silva

Counselor Education and Counseling Psychology Research Exchange Conference

OBJECTIVES: The objectives of the study are to (1) document the incidence of veterans who prematurely terminate physical therapy before medically indicated, and (2) identify reliable predictors of treatment retention and attrition. The potential benefit of this study is the identification of reliable variables that predict who is at risk for terminating physical therapy prematurely, which may lead to targeted interventions designed to increase treatment retention. RESEARCH DESIGN: This study will be a retrospective design involving a review of medical records of veterans receiving referral to physical therapy. METHODOLOGY: Multinomial logistic regression (MLR) will be used to examine the effects ...


Client-Treatment Matching In Substance Use Disorder Treatment: A Delphi Study, Noah Elijah Adrians 2010 Marquette University

Client-Treatment Matching In Substance Use Disorder Treatment: A Delphi Study, Noah Elijah Adrians

Counselor Education and Counseling Psychology Research Exchange Conference

Client-treatment matching (CTM) practices have been identified as important in enhancing substance use disorder (SUD) treatment outcomes while also minimizing the investment of time and resources necessary to achieve such outcomes. Despite strong positive effects associated with CTM, many questions remain regarding how CTM is implemented in treatment settings. This dissertation examines expert perspectives on how CTM practices are implemented in real world treatment settings, how to improve upon current practices, barriers to improvement, strategies for overcoming barriers, and consequensces of existing treatment system flaws. In this study, qualitative and quantitative data will be collected and analyzed through an iterative ...


Latino Family Variables And Sexual Activity In Latino Adolescents, Brittany Nicole Barber 2010 Marquette University

Latino Family Variables And Sexual Activity In Latino Adolescents, Brittany Nicole Barber

Counselor Education and Counseling Psychology Research Exchange Conference

Researchers’ focused examination of Latino adolescents’ cultural values and sexual activity has yielded questions regarding the cultural- and gender-specific attitudes and practices of these youth (Deardorff, Tschann, & Flores, 2008). Cultural values include family-related variables such as different aspects of familism, parent-adolescent communication, and parental monitoring, which have been found to decrease adolescents’ engagement in other negative activities such as aggressive behavior, (Dishion & McMahon, 1998), substance use (Estrada, Rabow, & Watts, 1982), and delinquency (Clark & Shields, 1997). Research investigating these risk behaviors has often implicated Latino adolescents’ level of assimilation to White, mainstream society as a potential risk factor for higher engagement in negative behaviors. This dissertation study, therefore, will examine the relationship between five Latino family variables (i.e., attitudinal familism, behavioral familism, structural familism, parent-adolescent communication, and parental monitoring), assimilation to White society, and the sexual activity of Latino adolescents. A mixed-methods project has been designed to explore and test the relationships between these variables. Focus groups will be conducted with adolescents on the topics of family, gender, and sexual activity; data will be analyzed using Grounded Theory methodology (Strauss & Corbin, 1990). Latino youth will also complete surveys about these topics; the relationships among these variables will be explored statistically. For the purposes of the Research Exchange, a description of the current stage of the project at that time, a discussion of the anticipated results of the study, and an explanation of the contributions of this study to the Milwaukee and psychological communities will be included.


Language Outcome After Left Anterior Temporal Lobectomy In Patients With Discordant Functional Magnetic Resonance Imaging And Intracarotid Sodium Amobarbital Testing Results, Julie K. Janecek 2010 Marquette University

Language Outcome After Left Anterior Temporal Lobectomy In Patients With Discordant Functional Magnetic Resonance Imaging And Intracarotid Sodium Amobarbital Testing Results, Julie K. Janecek

Counselor Education and Counseling Psychology Research Exchange Conference

Language Outcome after Left Temporal Anterior Lobectomy in Patients with Discordant Functional Magnetic Resonance Imaging and Intracarotid Sodium Amobarbital Testing Results Rationale: Previous research has examined concordance rates between Wada and fMRI language lateralization indices (LIs) and has yielded variable results with limited post-surgical language outcome data. Therefore, additional evidence of the concurrent and predictive validity of fMRI LIs is needed. We will calculate Wada/fMRI LI concordance rates in the largest sample to date, investigate predictors of discordance and examine the ability of each procedure to predict language outcome in discordant cases. Methods: A consecutive series of 229 presurgical ...


Seeking Safety Group Proposal For Posttraumatic Stress Disorder And Co-Occurring Substance Use Disorder, Caryn P. Brakenridge 2010 Marquette University

Seeking Safety Group Proposal For Posttraumatic Stress Disorder And Co-Occurring Substance Use Disorder, Caryn P. Brakenridge

Counselor Education and Counseling Psychology Research Exchange Conference

Reports on rates of PTSD among women receiving treatment for substance use disorders (SUDs) ranges from 20% to as much as 59%. Research however has shown that fewer than half of women with SUDs will receive treatment that addresses their PTSD symptoms. Research over the past three decades has shown an increased interest in individuals diagnosed with posttraumatic stress disorder (PTSD) using group psychotherapy. However, group psychotherapy approaches for co-occurring PTSD and substance use disorders are not as well developed. This proposal suggests the creation of a psychotherapy group for women suffering from SUDs with co-occurring PTSD symptoms. The group ...


Nurses Of 2010: The Dichotomy Between Continuity Of Patient Care And Nursing Fatigue As Related To Shift Length, Christy Kurtz 2010 Southern Adventist Univeristy

Nurses Of 2010: The Dichotomy Between Continuity Of Patient Care And Nursing Fatigue As Related To Shift Length, Christy Kurtz

Senior Research Projects

Nursing shift lengths are widely debated, and the implications on both nurse and patient safety are quite large. This work seeks to present a current review of literature describing the current work schedules of nurses in comparison to the Institute of Medicine’s 2004 recommendations and both the positive and negative effects that these schedules have on nurses and their patients. Eleven studies from the past five years (2004-2009) are included, with particular emphasis on those studies that address the dispute between continuity of care and nursing fatigue. Results show that nurses are regularly working longer than is recommended, and ...


An Application Of Principal Component Analysis To The Clavicle And Clavicle Fixation Devices., Zubin J. Daruwalla, Patrick Courtis, Clare Fitzpatrick, David Fitzpatrick, Hannan Mullett 2010 Beaumont Hospital, Dublin

An Application Of Principal Component Analysis To The Clavicle And Clavicle Fixation Devices., Zubin J. Daruwalla, Patrick Courtis, Clare Fitzpatrick, David Fitzpatrick, Hannan Mullett

Trauma and Orthopaedic Surgery Articles

BACKGROUND: Principal component analysis (PCA) enables the building of statistical shape models of bones and joints. This has been used in conjunction with computer assisted surgery in the past. However, PCA of the clavicle has not been performed. Using PCA, we present a novel method that examines the major modes of size and three-dimensional shape variation in male and female clavicles and suggests a method of grouping the clavicle into size and shape categories.

MATERIALS AND METHODS: Twenty-one high-resolution computerized tomography scans of the clavicle were reconstructed and analyzed using a specifically developed statistical software package. After performing statistical shape ...


Multiple Oncogenic Viruses Identified In Ocular Surface Squamous Neoplasia In Hiv-1 Patients, Kenneth O. Simbiri, Masanao Murakami, Michael Feldman, Andrew P. Steenhoff, Oathokwa Nkomazana, Gregory P. Bisson, Erle S. Robertson 2010 University of Pennsylvania

Multiple Oncogenic Viruses Identified In Ocular Surface Squamous Neoplasia In Hiv-1 Patients, Kenneth O. Simbiri, Masanao Murakami, Michael Feldman, Andrew P. Steenhoff, Oathokwa Nkomazana, Gregory P. Bisson, Erle S. Robertson

Botswana-UPenn Scholarly Publications

Background

Ocular surface squamous neoplasia (OSSN) is a rare cancer that has increased in incidence with the HIV pandemic in Africa. The underlying cause of this cancer in HIV-infected patients from Botswana is not well defined.

Results

Tissues were obtained from 28 OSSN and 8 pterygia patients. The tissues analyzed from OSSN patients were 83% positive for EBV, 75% were HPV positive, 70% were KSHV positive, 75% were HSV-1/2 positive, and 61% were CMV positive by PCR. Tissues from pterygium patients were 88% positive for EBV, 75% were HPV positive, 50% were KSHV positive, and 60% were CMV positive ...


Safe Routes To School: Launching The Program At Oak Grove Elementary School, Susan Henderson 2010 Georiga State University

Safe Routes To School: Launching The Program At Oak Grove Elementary School, Susan Henderson

Public Health Theses

Safe Routes to School is a national program funded by the Department of Transportation. The goal of the program is to increase children’s active transport to and from school, primarily by walking, in response to the epidemic of childhood obesity. Implementation at the state and local level has had varying success. In my capstone presentation, I discuss the creation, implementation, and ongoing success of the program at Oak Grove Elementary, a local public school in Georgia. The program is comprised of the 5 Es: Education, Encouragement, Enforcement, Engineering, and Evaluation. Each of these five components will be focused on ...


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