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Daily Hypoxia Increases Basal Monocyte Hsp72 Expression In Healthy Human Subjects, Lee Taylor, Adrian Midgley, Bryna Crismas, Angela Hilman, Leigh Madden, Rebecca Vince, Lars McNaughton 2009 Bond University

Daily Hypoxia Increases Basal Monocyte Hsp72 Expression In Healthy Human Subjects, Lee Taylor, Adrian Midgley, Bryna Crismas, Angela Hilman, Leigh Madden, Rebecca Vince, Lars Mcnaughton

Lars McNaughton

Heat shock protein 72 (HSP72) performs vital roles within the body at rest and during periods of stress. In vitro, research demonstrates HSP72 induction in response to hypoxia. Recently, in vivo, an acute hypoxic exposure (75 min at 2,980 m) was sufficient to induce significant increases in monocyte expressed HSP72 (mHSP72) and a marker of oxidative stress in healthy human subjects. The purpose of the current study was to identify the impact of 10 consecutive days of hypoxic exposures (75 min at 2,980 m) on mHSP72 and erythropoietin (EPO) expression, markers of oxidative stress, and maximal oxygen consumption ...


Detecting Outlier Genes From High-Dimensional Data: A Fuzzy Approach, Debashis Ghosh 2009 Penn State University

Detecting Outlier Genes From High-Dimensional Data: A Fuzzy Approach, Debashis Ghosh

Debashis Ghosh

A recent #12;nding in cancer research has been the characterization of previously undis- covered chromosomal abnormalities in several types of solid tumors. This was found based on analyses of high-throughput data from gene expression microarrays and motivated the development of so-called `outlier' tests for di#11;erential expression. One statistical issue was the potential discreteness of the test statistics. Using ideas from fuzzy set theory, we develop fuzzy outlier detection algorithms that have links to ideas in multiple comparisons. Two- and K-sample extensions are considered. The methodology is illustrated by application to two microarray studies.


Giardiasis And Poor Vitamin A Status Among Aboriginal School Children In Rural Malaysia, Hesham Al-Mekhlafi 2009 University of Malaya

Giardiasis And Poor Vitamin A Status Among Aboriginal School Children In Rural Malaysia, Hesham Al-Mekhlafi

Hesham M Al-Mekhlafi

A cross-sectional studs' was carried out on 241 primary schoolchildren in Pahang. Malaysia to update their vitamin A status and to investigate the association of poor vitamin A status with their health and socioeconomic factors All children were screened for intestinal parasitic infections Blood samples were collected and vitamin A status was assessed. Socioeconomic data were collected by using pre-tested questionnaires. The results showed that 66 (27.4%) children had low serum retinol levels (< 0 70 mu mol/L) Giardiasis and severe ascariasis were significantly associated with low serum retinol levels (P = 0 004 and P = 0 018, respectively) Logistic regression confirmed the significant association of giardiasis with low serum retinol (odds ratio = 2 7.95% confidence interval = 1 3-5 5) In conclusion. vitamin A deficiency is still a public health problem in rural Malaysia. Vitamin A supplementation and treatment of intestinal parasitic infections should be distributed periodically to these children to improve their health and nutritional status


Effectiveness Of Virtual Reality Exercises In Stroke Rehabilitation (Evrest): Rationale, Design, And Protocol Of A Pilot Randomized Clinical Trial Assessing The Wii Gaming System., Gustavo Saposnik 2009 St Michael's Hospital, University of Toronto

Effectiveness Of Virtual Reality Exercises In Stroke Rehabilitation (Evrest): Rationale, Design, And Protocol Of A Pilot Randomized Clinical Trial Assessing The Wii Gaming System., Gustavo Saposnik

Gustavo Saposnik

No abstract provided.


Spline-Based Models For Predictiveness Curves, Debashis Ghosh, Michael Sabel 2009 Penn State University

Spline-Based Models For Predictiveness Curves, Debashis Ghosh, Michael Sabel

Debashis Ghosh

A biomarker is de#12;ned to be a biological characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. The use of biomarkers in cancer has been advocated for a variety of purposes, which include use as surrogate endpoints, early detection of disease, proxies for environmental exposure and risk prediction. We deal with the latter issue in this paper. Several authors have proposed use of the predictiveness curve for assessing the capacity of a biomarker for risk prediction. For most situations, it is reasonable to assume ...


Conducting A Needs Assessment For A Nurse-Managed Multidisciplinary Clinic, Sharon Strang, D. Glick, L. Hulton 2009 James Madison University

Conducting A Needs Assessment For A Nurse-Managed Multidisciplinary Clinic, Sharon Strang, D. Glick, L. Hulton

Sharon L. Strang

No abstract provided.


Measuring Parental Barriers To Childhood Immunizations: The Development And Validation Of The Searching For Hardships And Obstacles To Shots (Shots) Instrument, Victoria Niederhauser 2009 University of Tennessee, Knoxville

Measuring Parental Barriers To Childhood Immunizations: The Development And Validation Of The Searching For Hardships And Obstacles To Shots (Shots) Instrument, Victoria Niederhauser

Victoria Niederhauser

There is a plethora of literature on barriers to immunizations; however, these studies lack standardization of measurement. The aim of this study was to develop and establish an initial psychometric evaluation of an instrument to measure parental barriers to childhood immunizations. This was a cross-sectional study design. Data analysis included descriptive statistics, reliability estimates, item analysis, and factor analysis. Six hundred and fifty-five participants completed the survey. The Searching for Hardships and Obstacles to Shots instrument was developed with 60 items and reduced to 23 items thorough multiple statistical computations; the best factor model was a three-factor solution (Access to ...


Efficacy Of The Volleyball Game Actions Related To The Quality Of Opposition, Rui Marcelino, Isabel Mesquita, Jaime Sampaio 2009 Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport – University of Porto

Efficacy Of The Volleyball Game Actions Related To The Quality Of Opposition, Rui Marcelino, Isabel Mesquita, Jaime Sampaio

Rui Marcelino

No abstract provided.


Bovine Enucleation: A Retrospective Study Of 53 Cases (1998-2006)., K. Schulz, David Anderson 2009 Kansas State University

Bovine Enucleation: A Retrospective Study Of 53 Cases (1998-2006)., K. Schulz, David Anderson

David Edgar Anderson, DVM, MS, DACVS

Medical records of 53 cattle undergoing enucleation (1998-2006) were reviewed. Assessments of the outcomes were done via client surveys. Descriptive statistics were generated on the affected population, the underlying disease, the complications, and the length of retention within the herd. Hereford cattle comprised the majority of the cases (30/53; 57%). Most cattle (84.9%) were diagnosed with ocular squamous cell carcinoma (OSCC). Follow-up information was available for 22 cattle. Para-orbital infection was documented in 10 of 53 cattle (19%). Five cattle died of various causes 2 months to several years after enucleation. One cow was culled due to recurrence ...


Parelaphostrongylus Tenuis-Associated Meningoencephalitis In A Sika Deer (Cervus Nippon), Richard Gerhold Jr., M Keel, K Arnold, D Hotton, R Beckstead 2009 University of Tennessee, Knoxville

Parelaphostrongylus Tenuis-Associated Meningoencephalitis In A Sika Deer (Cervus Nippon), Richard Gerhold Jr., M Keel, K Arnold, D Hotton, R Beckstead

Richard W. Gerhold Jr., DVM, MS, PhD

An adult, female, free-ranging, sika deer (Cervus nippon yakushimae) from Wicomico County, Maryland, USA, was found circling and having no fear of humans. The animal was euthanized and submitted for a postmortem exam. There were no gross lesions and the deer was negative for rabies. Microscopic examination revealed lymphoplasmacytic, neutrophilic, and eosinophilic meningoencephalitis with intralesional adult nematodes, larvae, and eggs consistent with nematodes in the family Protostrongylidae. Parelaphostrongylus tenuis was identified by polymerase chain reaction and DNA sequencing. To our knowledge, this is the first report of P. tenuis-associated encephalitis in a sika deer.


Characterization Of Multiple Acquired Portosystemic Shunts Using Transplenic Portal Scintigraphy, Federica Morandi, Patricia Sura, Dorothy Sharp, Gregory Daniel 2009 University of Tennessee, Knoxville

Characterization Of Multiple Acquired Portosystemic Shunts Using Transplenic Portal Scintigraphy, Federica Morandi, Patricia Sura, Dorothy Sharp, Gregory Daniel

Federica Morandi

We describe the scintigraphic patterns observed in 14 patients with confirmed multiple portosystemic shunts imaged via transplenic portal scintigraphy. Parameters evaluated included presence of multiple anomalous vessels, presence of hepatofugal flow caudal to spleen, and/or to cranial margin of the kidneys, slow absorption resulting in longer spleen to heart transit time, and presence of biphasic or fragmented bolus. Twenty-eight additional patients, 14 with a confirmed single portocaval and 14 with a portoazygos shunt, were used for comparison. Nine of 14 (64.3%) patients with multiple shunts had multiple vessels, five (35.7%) had a biphasic bolus, 13 (92.9 ...


Inhibition Of Feline Herpesvirus 1 Replication In Vitro By Small Interfering Rnas, Rebecca Wilkes, Stephen Kania 2009 University of Tennessee - Knoxville

Inhibition Of Feline Herpesvirus 1 Replication In Vitro By Small Interfering Rnas, Rebecca Wilkes, Stephen Kania

Stephen A Kania

OBJECTIVE: To evaluate the ability of 5 small interfering RNAs (siRNAs) targeting mRNA of the feline herpesvirus-1 (FHV-1) DNA polymerase gene to reduce in vitro viral replication and gene expression of FHV-1, to evaluate combinations of these siRNAs with siRNAs that target the glycoprotein D gene of FHV-1, and to determine the combination or combinations of siRNAs that yield the greatest inhibition of in vitro viral replication. SAMPLE POPULATION: Cultured Crandell-Rees feline kidney (CRFK) cells. PROCEDURES: CRFK cells were transfected with siRNAs designed to target mRNA of the FHV-1 DNA polymerase gene. Effective treatment was determined by quantification of the ...


Cytokine Response Of Electrolytic Ablation In An Ex Vivo Perfused Liver Model., G Gravante, S Ong, M Metcalfe, R Sorge, J Overton, D Loyd, Guy Maddern, A Dennison 2009 Government of South Australia, SA Health

Cytokine Response Of Electrolytic Ablation In An Ex Vivo Perfused Liver Model., G Gravante, S Ong, M Metcalfe, R Sorge, J Overton, D Loyd, Guy Maddern, A Dennison

Guy Maddern

Background: The inflammatory response following hepatic ablation depends on different factors including the method used, the duration and intensity of the treatment and the presence or absence of ischemia. Debate continues about the use of different modalities and whether some aspects of the response may be advantageous by releasing immunological active substances. Little data have been published concerning the cytokine response elicited by hepatic electrolytic ablation (EA). Study of an ex vivo liver model could allow for the evaluation of this response without the influence of confounding systemic factors. Methods: Livers explanted from 11 pigs were perfused extracorporeally with normothermic ...


A Treatment Team Approach For Suicidal American Indian Youth In A Therapeutic Community, Kenneth Coll, B. Freeman, P. Thobro 2009 Boise State University

A Treatment Team Approach For Suicidal American Indian Youth In A Therapeutic Community, Kenneth Coll, B. Freeman, P. Thobro

Kenneth M. Coll

No abstract provided.


Tort Liability And The Irb, Thaddeus Pope 2009 Widener University - Delaware Campus

Tort Liability And The Irb, Thaddeus Pope

Thaddeus Mason Pope

No abstract provided.


Telemedicine In Orthopaedics, Trevor Russell, Tammy Hoffmann 2009 Bond University

Telemedicine In Orthopaedics, Trevor Russell, Tammy Hoffmann

Tammy Hoffmann

Extract:

This chapter will outline the state of the art of telemedicine practice and research in the four main orthopedic settings: outpatient orthopedics, trauma and emergency orthopedics, surgery, and rehabilitation. For each of these settings we present relevant research that has described and/or evaluated how telemedicine has been used, provided an overview of the range of telemedicine technologies that have been used, reported the main findings of these studies, and highlighted where further research is needed.


Testing Self-Efficacy As A Pathway That Supports Self Care Among Family Caregivers In A Psychoeducational Intervention, Marie Savundranayagam, M. Brintnall-Peterson 2009 Western University

Testing Self-Efficacy As A Pathway That Supports Self Care Among Family Caregivers In A Psychoeducational Intervention, Marie Savundranayagam, M. Brintnall-Peterson

Marie Y Savundranayagam

This study investigated the extent to which a psychoeducational intervention supports family-centered care by influencing health risk and self-care behaviors of caregivers of individuals with Alzheimer's disease (N = 325). Moreover, this study investigated the extent to which changes in self-efficacy explained changes in health risk and self-care behaviors. Data were analyzed using repeated measures and multivariate analysis of variance and multiple regression. Qualitative written accounts of the impact of the intervention augmented the quantitative findings. The study's findings revealed that family caregivers experienced reductions in health risk behaviors and improvements in exercise, stress management, and relaxation activities as ...


The Relation Of Aerobic Fitness To Neuroelectric Indices Of Cognitive And Motor Task Preparation, Jason Themanson, Keita Kamijo, Kevin O'leary, Matthew Pontifex, Charles Hillman 2009 Illinois Wesleyan University

The Relation Of Aerobic Fitness To Neuroelectric Indices Of Cognitive And Motor Task Preparation, Jason Themanson, Keita Kamijo, Kevin O'Leary, Matthew Pontifex, Charles Hillman

Jason R. Themanson, Ph.D

The relation of aerobic fitness to task preparation was examined in a sample of young adults separated into higher- and lower-fit groups according to their maximal oxygen consumption. Participants performed a modified Sternberg working memory task under speed and accuracy instructions while measures of task performance and contingent negative variation (CNV) were collected. Analyses revealed no significant fitness differences between groups on task performance measures. However, frontal CNVamplitude was significantly larger for lower-fit participants compared to higher-fit participants during the speed instructions, an effect not found for the accuracy instructions. These results suggest that lower-fit individuals may rely to a ...


(99m)Tc-Dtpa Diuretic Renal Scintigraphy In Dogs With Nephroureterolithiasis, Silke Hecht, Meg Lawson, India Lane, Dorothy Sharp, Gregory Daniel 2009 University of Tennessee - Knoxville

(99m)Tc-Dtpa Diuretic Renal Scintigraphy In Dogs With Nephroureterolithiasis, Silke Hecht, Meg Lawson, India Lane, Dorothy Sharp, Gregory Daniel

India F. Lane

This study evaluated the results of diuretic renal scintigraphy in dogs with urolithiasis. Eighty-three kidneys with nephroureterolithiasis +/- renal pelvis/ureteral dilation were included in the study. Sixty-three kidneys showed a non-obstructive pattern, with a steep drop or gradual downward slope of renal time-activity curve (TAG). Excretion half-time of radiopharmaceutical (T-1/2) was 3.99 (2.99 to 7.95) min. Three kidneys showed an obstructive pattern, with continuous rise of the TAG and median T-1/2 of -10.71 (-5.20 to -17.56) min. Fifteen kidneys had non-diagnostic studies characterized by flat TAG. Individual kidney glomerular filtration rate was ...


Go To Ruth's House: Ruth Lubic And Public Advocacy, Julie Fairman 2009 University of Pennsylvania

Go To Ruth's House: Ruth Lubic And Public Advocacy, Julie Fairman

Julie A Fairman

No abstract provided.


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