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Application Of Pharmacometric Methods To Improve Pediatric Drug Development, Mallika Lala 2011 Virginia Commonwealth University

Application Of Pharmacometric Methods To Improve Pediatric Drug Development, Mallika Lala

Theses and Dissertations

Pharmacometrics is a quantitative science that is rapidly changing the landscape of drug development, and particularly so for the pediatric population. The motivation behind the research underlying this dissertation is to contribute towards the improvement of pediatric drug development by the astute application of pharmacometric methods. Two distinct research areas have been focused upon: 1- improving pediatric pharmacokinetic (PK) trial design and 2- improving pediatric dosing of warfarin by using a genetics-based dosing regimen. The first project examined in detail the feasibility of and simulation-based methodology for implementing a recent regulatory PK quality standard. The focus was on designing pediatric ...


Health Conditions And Health-Policy Innovations In Brazil: The Way Forward, Cesar G. Victoria, Mauricio L. Barreto, Maria do Carmo, Carlos A. Monteiro, Maria Ines Schmidt, Jairnilson Paim, Francisco I. Bastos, Celia Almeida, Ligia Bahia, Claudia Travassos, Michael Reichenheim, Fernando C. Barros 2011 Western University

Health Conditions And Health-Policy Innovations In Brazil: The Way Forward, Cesar G. Victoria, Mauricio L. Barreto, Maria Do Carmo, Carlos A. Monteiro, Maria Ines Schmidt, Jairnilson Paim, Francisco I. Bastos, Celia Almeida, Ligia Bahia, Claudia Travassos, Michael Reichenheim, Fernando C. Barros

Aboriginal Policy Research Consortium International (APRCi)

No abstract provided.


The Role Of Mir-21 And Mir-31 In Cellular Responses Mediated By Tgf-Β: A Dissertation, Charisa L. Cottonham 2011 University of Massachusetts Medical School

The Role Of Mir-21 And Mir-31 In Cellular Responses Mediated By Tgf-Β: A Dissertation, Charisa L. Cottonham

GSBS Dissertations and Theses

The function of transforming growth factor β (TGF-β) in cancer is notoriously complex. Initially TGF-β limits tumorigenesis, but at later stages in tumor progression TGF-β promotes the malignant spread of tumor cells. Past studies to understand the pro-metastasis utility of TGF-β centered upon its ability to regulate protein-coding genes. Recently, a small class of non-coding RNAs known as microRNAs (miRNAs) emerged as novel posttranscriptional regulators of gene expression. The significance of miRNA function in cellular processes from embryonic development to the maintenance of homeostasis in adult tissues is becoming increasingly clear. Also apparent is the strong association between aberrant miRNA ...


Cardiovascular Risk Scores Do Not Account For The Effect Of Treatment: A Review, Su May Liew, Jenny Doust, Paul Glasziou 2011 University of Oxford

Cardiovascular Risk Scores Do Not Account For The Effect Of Treatment: A Review, Su May Liew, Jenny Doust, Paul Glasziou

Paul Glasziou

Objective - To compare the strengths and limitations of cardiovascular risk scores available for clinicians in assessing the global (absolute) risk of cardiovascular disease.Design - Review of cardiovascular risk scores.Data sources - Medline (1966 to May 2009) using a mixture of MeSH terms and free text for the keywords ‘cardiovascular’, ‘risk prediction’ and ‘cohort studies’.Eligibility - criteria for selecting studies A study was eligible if it fulfilled the following criteria: (1) it was a cohort study of adults in the general population with no prior history of cardiovascular disease and not restricted by a disease condition; (2) the primary objective was ...


Cardiovascular Risk Scores Do Not Account For The Effect Of Treatment: A Review, Su May Liew, Jenny Doust, Paul Glasziou 2011 University of Oxford

Cardiovascular Risk Scores Do Not Account For The Effect Of Treatment: A Review, Su May Liew, Jenny Doust, Paul Glasziou

Jenny Doust

Objective - To compare the strengths and limitations of cardiovascular risk scores available for clinicians in assessing the global (absolute) risk of cardiovascular disease.Design - Review of cardiovascular risk scores.Data sources - Medline (1966 to May 2009) using a mixture of MeSH terms and free text for the keywords ‘cardiovascular’, ‘risk prediction’ and ‘cohort studies’.Eligibility - criteria for selecting studies A study was eligible if it fulfilled the following criteria: (1) it was a cohort study of adults in the general population with no prior history of cardiovascular disease and not restricted by a disease condition; (2) the primary objective was ...


Predictors Of Elevated Depressive Symptoms In Pregnancy, Justine M. Kokoszka 2011 University of Connecticut - Storrs

Predictors Of Elevated Depressive Symptoms In Pregnancy, Justine M. Kokoszka

Honors Scholar Theses

The purpose of this quantitative study was to examine factors that may place women at risk for developing depressive symptoms during pregnancy. It was part of a larger, randomized, double-blinded, placebo-controlled trial investigating the impact of docosahexaenoic acid

(DHA) in pregnancy as it relates to postpartum depression. Participants were women with a confirmed pregnancy(N= 45) who were administered the CES-D at two different times, 20-22 weeks gestation and 30-32 weeks gestation. Factors from a self-report of personal history were included in an analysis with the CES-D scores. A significant positive correlation was found between the first CES-D scores and ...


Residents' Perceptions Of Social Interaction And Social Activity In An Affordable Assisted Living Facility, Elena Garcia 2011 University of Connecticut - Storrs

Residents' Perceptions Of Social Interaction And Social Activity In An Affordable Assisted Living Facility, Elena Garcia

Honors Scholar Theses

This study is a qualitative study looking at the social interactions and social activities in an assisted living facility, based on the residents’ perceptions. In this study I interviewed 20 residents of an affordable assisted living facility. The participants were male and female, 65 or older, and any ethnicity. Inclusion criteria include: (1) Residing in the assisted living facility at least 6 months and no more than 2 years; and (2) being mentally competent to give informed consent. I recruited the participants based on a list of who was eligible from the facilities administration and then asked the eligible participants ...


Language-Specific Tuning Of Audiovisual Integration In Early Development, Juliana Flynn 2011 University of Connecticut - Storrs

Language-Specific Tuning Of Audiovisual Integration In Early Development, Juliana Flynn

Honors Scholar Theses

According to the perceptual narrowing hypothesis, older infants look longer towards speech in a native language than towards a non-native language. We presented speech in English, Spanish, and mis-matched English and Spanish speech, and recorded looking-time towards the speech. Results suggest that the synchrony of speech plays a strong role in infants' attention to speech, whereas nativeness of language does not.


Moving United States Health Care Forward, Thomas R. O'Neill 2011 University of Connecticut - Storrs

Moving United States Health Care Forward, Thomas R. O'Neill

Honors Scholar Theses

Substantive Health Care reform poses one of the greatest current challenges to the American political system. The Patient Protection and Affordable Care Act of 2010 marks the most recent attempt at approaching this daunting task. Charged with expanding coverage while controlling costs, it pursues a sundry number of legislative solutions to achieve these seemingly incompatible goals. Despite the strides the Patient Protection and Affordable Care Act has made, lingering educational, pharmaceutical, and legal concerns stand to derail progress made on fixing the health care system. If these goals are to be successful, a number of additional measures are needed to ...


Individualized Healthcare And Health Disparities: An Examination Of Health Disparities Related To Short-Term Response To Food Insecurity In Low-Income, Urban Communities, Valen R. Diaz 2011 University of Connecticut - Storrs

Individualized Healthcare And Health Disparities: An Examination Of Health Disparities Related To Short-Term Response To Food Insecurity In Low-Income, Urban Communities, Valen R. Diaz

Honors Scholar Theses

The U.S. has seen a spike in chronic diseases along with worsening health outcomes. There are many factors at play to create these circumstances, especially regarding the social determinants of health, like socioeconomic status, access to food, and geographic location. Another concern is health disparities, particularly regarding obesity, and the fact that food access and neighborhood food environments contribute to these disparities. This paper gives a broad overview of American food culture and then focuses on the local food environment in urban, low-income communities, regarding both food deserts and food swamps. There is also a discussion about the response ...


The Lived Experience Of Mothers Bereaved By The Suicide Death Of A Child., Cynthia Walker Lynn 2011 East Tennessee State University

The Lived Experience Of Mothers Bereaved By The Suicide Death Of A Child., Cynthia Walker Lynn

Electronic Theses and Dissertations

Suicide has existed throughout recorded history. It is a phenomenon that has been both culturally and morally defined across time and civilizations. It is estimated that over 34,000 Americans deliberately take their own lives annually. Moreover, according to some experts, between 6 and 28 individuals are directly affected by each completed suicide. These individuals are referred to as suicide survivors. The consequences for suicide survivors are multidimensional in part because relationships to the deceased play a vital role in bereavement. Previous research studies in the areas of suicidology and bereavement have failed to explore the experience of mothers bereaved ...


Hiv/Aids In Haiti. An Analysis Of Demographics, Lifestyle, Std Awareness, Hiv Knowledge And Perception That Influence Hiv Infection Among Haitians., Yves Marie Dominique Georges 2011 Georgia State University

Hiv/Aids In Haiti. An Analysis Of Demographics, Lifestyle, Std Awareness, Hiv Knowledge And Perception That Influence Hiv Infection Among Haitians., Yves Marie Dominique Georges

Public Health Theses

Introduction

Haiti has the highest prevalence of HIV infection in Latina America and the Caribbean. The country faces the worst AIDS epidemic outside Africa and bears the greatest burden of HIV in the western hemisphere. Studies in the past recent years show that HIV/AIDS is most likely to be seen in developed countries. People with low education level and appropriate knowledge about STD’s are more susceptible to get HIV. Lifestyle behaviors represent significant factors in HIV transmission. Understandings these lifestyle factors are therefore critical in reversing the increasing prevalence of HIV/AIDS. The purpose of this investigation is ...


Diabetes Guidelines Implementation Toolkit, Gustavo Adolfo Arguello Lacayo 2011 Georgia State University

Diabetes Guidelines Implementation Toolkit, Gustavo Adolfo Arguello Lacayo

Public Health Theses

Diabetes Guidelines Implementation Toolkit is a capstone project aimed to help the Grady North Fulton Health Center to implement the American Diabetes Association (ADA) “Standards in Medical Care in Diabetes, 2011” guidelines. This toolkit can also be used to implement the diabetes guidelines in any other primary or community healthcare facility to improve diabetes care.

Diabetes can affect many parts of the body and can lead to serious complications such as blindness, kidney damage, and lower-limb amputations. Working together, people with diabetes, their support network, and their health care providers can reduce the occurrence of these and other diabetes complications ...


The Experiences Of Obese African American Women And Their Utilization Of Preventive Healthcare Services, Winsome Beverly Stephenson 2011 Georgia State University

The Experiences Of Obese African American Women And Their Utilization Of Preventive Healthcare Services, Winsome Beverly Stephenson

Nursing Dissertations (PhD)

Obesity is associated with higher death rates from breast and gynecological cancers. African American women(AAW) are more likely to be diagnosed with these cancers at later stages and have lower survival rates than Caucasian women. African American women are also disproportionately affected by obesity. Studies suggest that the healthcare experiences of obese women (primarily stigmatization), may contribute to their decisions to utilize healthcare services. However, these studies have largely comprised Caucasian women; there remains a paucity of studies addressing this issue in AAW. The purpose of this study was to explore the healthcare experiences of obese AAW and their ...


Perceived Susceptibility Of Cardiovascular Disease As A Moderator Of Relationships Between Perceived Severity And Cardiovascular Health Promoting Behaviors Among Female Registered Nurses, Deborah McClendon 2011 Georgia State University

Perceived Susceptibility Of Cardiovascular Disease As A Moderator Of Relationships Between Perceived Severity And Cardiovascular Health Promoting Behaviors Among Female Registered Nurses, Deborah Mcclendon

Nursing Dissertations (PhD)

Significance: Morbidity and mortality related to CVD among women in the U.S. and most developed countries surpasses that of all cancers combined (AHA, 2008). Yet, CVD in women remains understudied, yielding low awareness among women and healthcare providers. The purpose of this study was to examine whether the relationship between health beliefs related to perceived cardiovascular disease (CVD) severity and health promoting behaviors were different in women with high self perception of CVD susceptibility versus women with low self perception of CVD susceptibility.

Methods: This study used a descriptive, correlational design. A convenience sample (N = 220) included female registered ...


Robert Louis Stevenson's Dentist: Unsung Hero, Robert B. Stevenson 2011 The Ohio State University

Robert Louis Stevenson's Dentist: Unsung Hero, Robert B. Stevenson

Annual Conference Presentations, Papers, and Posters

A presentation given at the May 7th, 2011 meeting of the Ohio Academy of Medical History on Robert Louis Stevenson and treatment by his dentist.

Robert Louis Stevenson suffered from many illnesses but his condition improved dramatically in 1880 after dental care. This paper describes his treatment, including instruments and materials available.


Ohio Academy Of Medical History Annual Meeting Program, May 7, 2011, Ohio Academy of Medical History 2011 Wright State University

Ohio Academy Of Medical History Annual Meeting Program, May 7, 2011, Ohio Academy Of Medical History

Annual Conference Programs

This tri-fold program is from the annual meeting of the Ohio Academy of Medical History held on May 7, 2011 at the Glen Helen Nature Preserve in Yellow Springs, Ohio. The program details the events and presentations of the meeting.


Recalled Fruit And Vegetable Intake While Growing Up And Its Association With Adult Fruit And Vegetable Intake Among U.S. Adults - Analysis Of The Food Attitudes And Behaviors Survey, Mary D. Hill 2011 Centers for Disease Control and Prevention

Recalled Fruit And Vegetable Intake While Growing Up And Its Association With Adult Fruit And Vegetable Intake Among U.S. Adults - Analysis Of The Food Attitudes And Behaviors Survey, Mary D. Hill

Public Health Theses

ABSTRACT

MARY D. HILL

Recalled fruit and vegetable intake while growing up and its association with adult fruit and vegetable intake among U.S. adults – analysis of the food attitudes and behaviors survey

(Under the direction of DR. KYMBERLE STERLING)

High dietary intake of fruits and vegetables (FVs) is associated with a lower risk for chronic disease including certain cancers, optimal child growth, and weight management. More than 72 million U.S. adults are obese; therefore, fruit and vegetable intake is important in weight management. Using data from the Food Attitude and Behavior survey, this study will address the following ...


Comparison Of Post-Licensure Safety Surveillance Of 13-Valent Pneumococcal Conjugate Vaccine And 7-Valent Pneumococcal Conjugate Vaccine: Data From The Vaccine Advere Event Reporting System (Vaers), Jorge E. Arana 2011 Georgia State University

Comparison Of Post-Licensure Safety Surveillance Of 13-Valent Pneumococcal Conjugate Vaccine And 7-Valent Pneumococcal Conjugate Vaccine: Data From The Vaccine Advere Event Reporting System (Vaers), Jorge E. Arana

Public Health Theses

Comparison of Post-licensure safety surveillance of 13-Valent Pneumococcal Conjugate vaccine and 7-Valent Pneumococcal Conjugate vaccine: Data from the Vaccine Adverse Event Reporting System (VAERS).

Background: On February 24, 2010, Food and Drug Administration (FDA) licensed a 13-valent pneumococcal conjugate vaccine (Prevnar 13®, [PCV13]) for use among children aged 6 weeks--71 months. The Advisory Committee on Immunization Practices (ACIP) recommended PCV13 routine vaccination of all children aged 2--59 months, children aged 60--71 months with underlying medical conditions, with PCV13 replacing PCV7 for all doses.

Methods: We searched case reports to the Vaccine Adverse Event Reporting System (VAERS), a US passive surveillance ...


Evaluation On Health Impact Of Government Support For Ger (Traditional Dwelling) District's Electricity Night Rates In Ulaanbaatar City, Erdenekhuu Nansalmaa 2011 Georgia State University

Evaluation On Health Impact Of Government Support For Ger (Traditional Dwelling) District's Electricity Night Rates In Ulaanbaatar City, Erdenekhuu Nansalmaa

Public Health Theses

During the last 10 years, air pollution has become one of the major public health problems in Ulaanbaatar city of Mongolia, and concentrations of pollutants were measured 3 to 50 times higher than WHO recommendation. This devastating air pollution is produced mostly by thousands of families who migrated from countryside and live in gers (traditional dwellings) in the suburban area which is not connected to the central heating system, and nearly all of them burn coal to keep them warm. Due to air pollution, residents living in Ulaanbaatar city suffer health problems that equal to the smoking of 4-5 packs ...


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