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Amyloid Precursor Protein Cleavage-Dependent And -Independent Axonal Degeneration Programs Share A Common Nicotinamide Mononucleotide Adenylyltransferase 1-Sensitive Pathway, Bhupinder P.S. Vohra, Yo Sasaki, Bradley R. Miller, Jufang Chang, Aaron DiAntonio, Jeffrey Milbrandt 2010 Washington University School of Medicine in St. Louis

Amyloid Precursor Protein Cleavage-Dependent And -Independent Axonal Degeneration Programs Share A Common Nicotinamide Mononucleotide Adenylyltransferase 1-Sensitive Pathway, Bhupinder P.S. Vohra, Yo Sasaki, Bradley R. Miller, Jufang Chang, Aaron Diantonio, Jeffrey Milbrandt

Open Access Publications

No abstract provided.


Quantification Of Indirect Pathway Inhibition By The Adenosine A 2a Antagonist Syn115 In Parkinson Disease, Kevin J. Black, Jonathan M. Koller, Meghan C. Campbell, Debra A. Gusnard, Stephen I. Bandak 2010 Washington University School of Medicine in St. Louis

Quantification Of Indirect Pathway Inhibition By The Adenosine A 2a Antagonist Syn115 In Parkinson Disease, Kevin J. Black, Jonathan M. Koller, Meghan C. Campbell, Debra A. Gusnard, Stephen I. Bandak

Open Access Publications

No abstract provided.


The Epidemiology Of Hematogenous Vertebral Osteomyelitis: A Cohort Study In A Tertiary Care Hospital, Kavita P. Bhavan, Jonas Marschall, Margaret A. Olsen, Victoria J. Fraser, Neill M. Wright, David K. Warren 2010 Washington University School of Medicine in St. Louis

The Epidemiology Of Hematogenous Vertebral Osteomyelitis: A Cohort Study In A Tertiary Care Hospital, Kavita P. Bhavan, Jonas Marschall, Margaret A. Olsen, Victoria J. Fraser, Neill M. Wright, David K. Warren

Open Access Publications

No abstract provided.


No Dramatic Age-Related Loss Of Hair Cells And Spiral Ganglion Neurons In Bcl-2 Over-Expression Mice Or Bax Null Mice, Haiyan Shen, Jonathan I. Matsui, Debin Lei, Lirong Han, Kevin K. Ohlemiller, Jianxin Bao 2010 Nanjing University

No Dramatic Age-Related Loss Of Hair Cells And Spiral Ganglion Neurons In Bcl-2 Over-Expression Mice Or Bax Null Mice, Haiyan Shen, Jonathan I. Matsui, Debin Lei, Lirong Han, Kevin K. Ohlemiller, Jianxin Bao

Open Access Publications

No abstract provided.


The Novel Sigma-2 Receptor Ligand Sw43 Stabilizes Pancreas Cancer Progression In Combination With Gemcitabine, John R. Hornick, Jinbin Xu, Suwanna Vangveravong, Zhude Tu, Jonathan B. Mitchem, Dirk Spitzer, Peter Goedegebuure, Robert H. Mach, William G. Hawkins 2010 Washington University School of Medicine in St. Louis

The Novel Sigma-2 Receptor Ligand Sw43 Stabilizes Pancreas Cancer Progression In Combination With Gemcitabine, John R. Hornick, Jinbin Xu, Suwanna Vangveravong, Zhude Tu, Jonathan B. Mitchem, Dirk Spitzer, Peter Goedegebuure, Robert H. Mach, William G. Hawkins

Open Access Publications

No abstract provided.


Attention To Memory And The Environment: Functional Specialization And Dynamic Competition In Human Posterior Parietal Cortex, Carlo Sestieri, Gordon L. Shulman, Maurizio Corbetta 2010 Washington University School of Medicine in St. Louis

Attention To Memory And The Environment: Functional Specialization And Dynamic Competition In Human Posterior Parietal Cortex, Carlo Sestieri, Gordon L. Shulman, Maurizio Corbetta

Open Access Publications

No abstract provided.


Prospects And Pits On The Path Of Biomimetics: The Case Of Tooth Enamel, Vuk Uskoković 2010 Chapman University

Prospects And Pits On The Path Of Biomimetics: The Case Of Tooth Enamel, Vuk Uskoković

Pharmacy Faculty Articles and Research

This review presents a discourse on challenges in understanding and imitating the process of amelogenesis in vitro on the molecular scale. In light of the analysis of imitation of the growth of dental enamel, it also impends on the prospects and potential drawbacks of the biomimetic approach in general. As the formation of enamel proceeds with the protein matrix guiding the crystal growth, while at the same time conducting its own degradation and removal, it is argued that three aspects of amelogenesis need to be induced in parallel: a) crystal growth; b) protein assembly; c) proteolytic degradation. A particular emphasis ...


Major Challenges For The Modern Chemistry In Particular And Science In General, Vuk Uskoković 2010 Chapman University

Major Challenges For The Modern Chemistry In Particular And Science In General, Vuk Uskoković

Pharmacy Faculty Articles and Research

In the past few hundred years, science has exerted an enormous influence on the way the world appears to human observers. Despite phenomenal accomplishments of science, science nowadays faces numerous challenges that threaten its continued success. As scientific inventions become embedded within human societies, the challenges are further multiplied. In this critical review, some of the critical challenges for the field of modern chemistry are discussed, including: (a) interlinking theoretical knowledge and experimental approaches; (b) implementing the principles of sustainability at the roots of the chemical design; (c) defining science from a philosophical perspective that acknowledges both pragmatic and realistic ...


Practice Patterns For Antibiotic De-Escalation In Culture-Negative Healthcare-Associated Pneumonia, M. Schlueter, C. James, A. Dominguez, Laura V. Tsu, G. Seymann 2010 University of California - San Diego

Practice Patterns For Antibiotic De-Escalation In Culture-Negative Healthcare-Associated Pneumonia, M. Schlueter, C. James, A. Dominguez, Laura V. Tsu, G. Seymann

Pharmacy Faculty Articles and Research

Background Published guidelines for the treatment of healthcare-associated pneumonia (HCAP) recommend initial broad-spectrum antibiotics with appropriate de-escalation based on culture results. Guideline recommendations are based on data from intubated patients, in whom cultures are easily obtained. The approach to antibiotic de-escalation for culture-negative patients has not been addressed. Consequently, there are no published reports that describe the current standard of practice. Patients and methods All patients admitted to a university hospital with a diagnosis of HCAP, as defined by use of a pneumonia orderset, were identified retrospectively over a 2-year period. Antibiotics prescribed on admission, during hospital stay, and on ...


Impaired M3 And Enhanced M2 Muscarinic Receptor Contractile Function In A Streptozotocin Model Of Mouse Diabetic Urinary Bladder, K. J. Pak, Rennolds S. Ostrom, M. Matsui, F. J. Ehlert 2010 University of California, Irvine

Impaired M3 And Enhanced M2 Muscarinic Receptor Contractile Function In A Streptozotocin Model Of Mouse Diabetic Urinary Bladder, K. J. Pak, Rennolds S. Ostrom, M. Matsui, F. J. Ehlert

Pharmacy Faculty Articles and Research

We investigated the contractile roles of M2 and M3 muscarinic receptors in urinary bladder from streptozotocin-treated mice. Wild-type and M2 muscarinic receptor knockout (M2 KO) mice were given a single injection of vehicle or streptozotocin (125 mg kg−1) 2–24 weeks prior to bladder assays. The effect of forskolin on contractions elicited to the muscarinic agonist, oxotremorine-M, was measured in isolated urinary bladder (intact or denuded of urothelium). Denuded urinary bladder from vehicle-treated wild-type and M2 KO mice exhibited similar contractile responses to oxotremorine-M, when contraction was normalized relative to that elicited by KCl (50 mM). Eight to 9 ...


Intravenous Artesunate For Severe Malaria, Karl M. Hess, Jeffery A. Goad, Paul M. Arguin 2010 Western University of Health Sciences

Intravenous Artesunate For Severe Malaria, Karl M. Hess, Jeffery A. Goad, Paul M. Arguin

Pharmacy Faculty Articles and Research

OBJECTIVE: To review the pharmacodynamics and pharmacotherapeutic use of intravenous artesunate for the treatment of severe malaria.

DATA SOURCES: Literature was retrieved through PubMed (1999 March 2010), MEDLINE (1996 March 2010), and the Centers for Disease Control and Prevention (CDC), using the search terms artemisinin, artesunate, malaria, and severe malaria. In addition, reference citations from publications identified were reviewed.

STUDY SELECTION AND DATA EXTRACTION: All articles in English that were identified from the data sources were reviewed. Focus was placed on post-marketing trials examining the safety and efficacy of artesunate in comparison with other regimens.

DATA SYNTHESIS: The treatment of ...


Hypertension In Autosomal Dominant Polycystic Kidney Disease: A Clinical And Basic Science Perspective, Shobha Ratnam, Surya M. Nauli 2010 University of Toledo

Hypertension In Autosomal Dominant Polycystic Kidney Disease: A Clinical And Basic Science Perspective, Shobha Ratnam, Surya M. Nauli

Pharmacy Faculty Articles and Research

Cardiovascular complications are major causes of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). In particular, hypertension is insidious and remains a continuous problem that evolves during the course of the disease. Hypertension in ADPKD has been associated with abnormality in the renin-angiotensin-aldosterone system (RAAS). Early vascular changes have also been reported in young ADPKD patients. In addition, the cellular functions of mechanosensory cilia within vascular system have emerged recently. The basic and clinical perspectives of RAAS, vascular remodeling and sensory cilia are reviewed with regard to hypertension in ADPKD


Nanotechnology In Dental Sciences: Moving Towards A Finer Way Of Doing Dentistry, Vuk Uskoković, Luiz Eduardo Bertassoni 2010 Chapman University

Nanotechnology In Dental Sciences: Moving Towards A Finer Way Of Doing Dentistry, Vuk Uskoković, Luiz Eduardo Bertassoni

Pharmacy Faculty Articles and Research

Nanotechnologies are predicted to revolutionize: (a) the control over materials properties at ultrafine scales; and (b) the sensitivity of tools and devices applied in various scientific and technological fields. In this short review, we argue that dentistry will be no exception to this trend. Here, we present a dynamic view of dental tissues, an adoption of which may lead to finer, more effective and minimally invasive reparation approaches. By doing so, we aim at providing insights into some of the breakthroughs relevant to understanding the genesis of dental tissues at the nanostructural level or generating dental materials with nanoscale critical ...


The Effect Of A Tiered Body Armour System On Soldier Physical Mobility, Gregory Peoples, Aaron Silk, Sean Notley, Laura Holland, Brooke Collier, Daniel Lee 2010 University of Wollongong

The Effect Of A Tiered Body Armour System On Soldier Physical Mobility, Gregory Peoples, Aaron Silk, Sean Notley, Laura Holland, Brooke Collier, Daniel Lee

Faculty of Science, Medicine and Health - Papers

Current military operations involve complex omnipresent threats, resulting in the need for all soldiers, regardless of occupational speciality, to wear body armour during operational deployment. Body armour is typically comprised of both hard and soft armour and is designed to provide ballistic, fragmentation and stab protection. The weight load and bulk of body armour, which is influenced by the materials used and extent of hard and soft armour coverage of the body, has the potential to affect a soldiers physical mobility on the battlefield. Intuitively it would appear logical that as the external load a soldier carries increases there is ...


Building Capacity In Medical Education Research In Australia, Ian G. Wilson 2010 University of Western Sydney

Building Capacity In Medical Education Research In Australia, Ian G. Wilson

Faculty of Science, Medicine and Health - Papers

ANZAME (the Australian and New Zealand Association for Medical Education) shares two significant concerns about medical education in Australia that were raised in articles published recently in the Journal.


Learning The Ways Of Teaching: Medical Students As Co-Assessors And Peer Teachers, Susan Vella, Lisa Brown 2010 University of Wollongong

Learning The Ways Of Teaching: Medical Students As Co-Assessors And Peer Teachers, Susan Vella, Lisa Brown

Faculty of Science, Medicine and Health - Papers

No abstract provided.


A Comparative Study Of Assessment Grading And Nursing Students' Perceptions Of Quality In Sessional And Tenured Teachers, Yenna Salamonson, Elizabeth J. Halcomb, Sharon Andrew, Kathleen Peters, Debra Jackson 2010 University of Western Sydney

A Comparative Study Of Assessment Grading And Nursing Students' Perceptions Of Quality In Sessional And Tenured Teachers, Yenna Salamonson, Elizabeth J. Halcomb, Sharon Andrew, Kathleen Peters, Debra Jackson

Faculty of Science, Medicine and Health - Papers

Purpose: Although the global nursing faculty shortage has led to increasing reliance upon sessional staff, limited research has explored the impact of these sessional staff on the quality of teaching in higher education. We aim to examine differences in (a) student satisfaction with sessional and tenured staff and (b) assessment scores awarded by sessional and tenured staff in students' written assignments. Design: A comparative study method was used. Participants were recruited from students enrolled in the three nursing practice subjects across the 3 years of the baccalaureate program in an Australian university during the second semester of 2008. Methods: This ...


Casualisation Of The Teaching Workforce: Implications For Nursing Education, Elizabeth J. Halcomb, Sharon Andrew, Kath Peters, Yenna Salamonson, Debra Jackson 2010 University of Western Sydney

Casualisation Of The Teaching Workforce: Implications For Nursing Education, Elizabeth J. Halcomb, Sharon Andrew, Kath Peters, Yenna Salamonson, Debra Jackson

Faculty of Science, Medicine and Health - Papers

Internationally, nursing faculty shortages have been reported and there is a potential for them to worsen into the next decade as existing faculty age. To, in part, address this issue, across disciplines there is clearly an international trend towards the increasing casualisation of the higher education workforce. Despite the potential impact of this two-tiered workforce structure, there has been limited examination of the discipline specific issues related to the employment of a growing number of sessional nursing staff. This paper provides a critical review of the literature related to the employment of sessional teachers in higher education. The paper advances ...


Uptake Of Medicare Chronic Disease Items In Australia By General Practice Nurses And Aboriginal Health Workers, Elizabeth J. Halcomb, Patricia M. Davidson, Nicola Brown 2010 University of Western Sydney

Uptake Of Medicare Chronic Disease Items In Australia By General Practice Nurses And Aboriginal Health Workers, Elizabeth J. Halcomb, Patricia M. Davidson, Nicola Brown

Faculty of Science, Medicine and Health - Papers

The Australian health care system is currently in a state of reform and there is increasing pressure to provide care in community settings. Rising costs, demands and population ageing underscore the importance of adopting models of health care delivery to address changing epidemiological patterns. Population ageing and the increase of chronic conditions challenge models based on acute care. Changes to the Medicare benefits schedule have facilitated the development of a range of expanded nursing services in the general practice setting. In particular, item number 10997 was introduced to reimburse practice nurses and Aboriginal health workers (AHWs) for providing monitoring and ...


Sessional Teachers In A Bn Program: Bridging The Divide Or Widening The Gap?, Sharon Andrew, Elizabeth J. Halcomb, Debra Jackson, Kath Peters, Yenna Salamonson 2010 University of Western Sydney

Sessional Teachers In A Bn Program: Bridging The Divide Or Widening The Gap?, Sharon Andrew, Elizabeth J. Halcomb, Debra Jackson, Kath Peters, Yenna Salamonson

Faculty of Science, Medicine and Health - Papers

Casualisation of the academic workforce has resulted in an increase in the employment of sessional teachers in Bachelor of Nursing (BN) programs. Many of these teachers are drawn from specialty clinical areas and continue to work clinically while teaching part-time. The aim of this study was to explore the perceptions of sessional teachers about their perceived contribution to an undergraduate Bachelor of Nursing program in a single Australian university. Twelve sessional teachers participated in semi-structured interviews as part of a larger mixed method study exploring the issues related to sessional teaching in the Bachelor of Nursing program. Three themes emerged ...


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