Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

120015 Full-Text Articles 188878 Authors 24419255 Downloads 364 Institutions

All Articles in Medicine and Health Sciences

Faceted Search

120015 full-text articles. Page 4 of 3915.

Comparative Effectiveness Of Abatacept Versus Tocilizumab In Rheumatoid Arthritis Patients With Prior Tnfi Exposure In The Us Corrona Registry, Leslie R. Harrold, George W. Reed, Daniel H. Solomon, Jeffrey R. Curtis, Mei Liu, Jeffrey D. Greenberg, Joel M. Kremer 2017 University of Massachusetts Medical School

Comparative Effectiveness Of Abatacept Versus Tocilizumab In Rheumatoid Arthritis Patients With Prior Tnfi Exposure In The Us Corrona Registry, Leslie R. Harrold, George W. Reed, Daniel H. Solomon, Jeffrey R. Curtis, Mei Liu, Jeffrey D. Greenberg, Joel M. Kremer

Leslie R. Harrold

BACKGROUND: We compared the effectiveness of abatacept (ABA) vs tocilizumab (TCA) in tumor necrosis factor inhibitor (TNFi) experienced patients. METHODS: We identified rheumatoid arthritis (RA) patients from a large observational US cohort (1 January 2010-31 May 2014) who had discontinued at least one TNFi and initiated ABA or TCZ in moderate or high disease activity based on the Clinical Disease Activity Index (CDAI) and had no prior exposure to the comparator drug. Using propensity score matching (1:1) stratified by prior TNF use (1 TNFi vs ≥2 TNFis), effectiveness at 6 months after initiation was evaluated. Mean change in CDAI ...


Recombinant Aav Serotype And Capsid Mutant Comparison For Pulmonary Gene Transfer Of Alpha-1-Antitrypsin Using Invasive And Noninvasive Delivery, Rejean Liqun Wang, Thomas J. McLaughlin, Travis Cossette, Qiushi Tang, Kevin Foust, Martha Campbell-Thompson, Ashley Martino, Pedro Cruz, Scott Loiler, Christian Mueller, Terence R. Flotte 2017 University of Florida

Recombinant Aav Serotype And Capsid Mutant Comparison For Pulmonary Gene Transfer Of Alpha-1-Antitrypsin Using Invasive And Noninvasive Delivery, Rejean Liqun Wang, Thomas J. Mclaughlin, Travis Cossette, Qiushi Tang, Kevin Foust, Martha Campbell-Thompson, Ashley Martino, Pedro Cruz, Scott Loiler, Christian Mueller, Terence R. Flotte

Christian Mueller

Recombinant adeno-associated viral (rAAV) vectors have been widely used in pulmonary gene therapy research. In this study, we evaluated the transduction and expression efficiencies of several AAV serotypes and AAV2 capsid mutants with specific pulmonary targeting ligands in the mouse lung. The noninvasive intranasal delivery was compared with the traditional intratracheal lung delivery. The rAAV8 was the most efficient serotype at expressing alpha-1-antitrypsin (AAT) in the lung among all the tested serotypes and mutants. A dose of 1 x 1010 vg of rAAV8-CB-AAT transduced a high percentage of cells in the lung when delivered intratrachealy. The serum and the broncho-alveolar ...


Arteriovenous Fistula Patency In The 3 Years Following Vonapanitase And Placebo Treatment, Eric K. Peden, Timothy P. O'Connor, Barry J. Browne, Bradley S. Dixon, Andres Schanzer, Stephen C. Jensik, Albert D. Sam 2nd, Steven K. Burke 2017 Houston Methodist Hospital

Arteriovenous Fistula Patency In The 3 Years Following Vonapanitase And Placebo Treatment, Eric K. Peden, Timothy P. O'Connor, Barry J. Browne, Bradley S. Dixon, Andres Schanzer, Stephen C. Jensik, Albert D. Sam 2nd, Steven K. Burke

Andres Schanzer

OBJECTIVE: This study explored the long-term outcomes of arteriovenous fistulas treated with vonapanitase (recombinant human elastase) at the time of surgical creation.

METHODS: This was a randomized, double-blind, placebo-controlled trial of 151 patients undergoing radiocephalic or brachiocephalic arteriovenous fistula creation who were randomized equally to placebo, vonapanitase 10 mug, or vonapanitase 30 mug. The results after 1 year of follow-up were previously reported. The current analysis occurred when the last patient treated was observed for 3 years. For the current analysis, the primary end point was primary patency; the secondary end points included secondary patency, use of the fistula for ...


General Practitioners' Decision Making About Primary Prevention Of Cardiovascular Disease In Older Adults: A Qualitative Study, Jesse Jansen, Shannon McKinn, Carissa Bonner, Les Irwig, Jenny Doust, Paul Glasziou, Katy Bell, Vasi Naganathan, Kirsten McCaffery 2017 University of Sydney

General Practitioners' Decision Making About Primary Prevention Of Cardiovascular Disease In Older Adults: A Qualitative Study, Jesse Jansen, Shannon Mckinn, Carissa Bonner, Les Irwig, Jenny Doust, Paul Glasziou, Katy Bell, Vasi Naganathan, Kirsten Mccaffery

Jenny Doust

BACKGROUND:

Primary cardiovascular disease (CVD) prevention in older people is challenging as they are a diverse group with varying needs, frequent presence of comorbidities, and are more susceptible to treatment harms. Moreover the potential benefits and harms of preventive medication for older people are uncertain. We explored GPs' decision making about primary CVD prevention in patients aged 75 years and older.

METHOD:

25 GPs participated in semi-structured interviews in New South Wales, Australia. Transcribed audio-recordings were thematically coded and Framework Analysis was used.

RESULTS:

Analysis identified factors that are likely to contribute to variation in the management of CVD risk ...


Obesity Prevention Advocacy In Australia: An Analysis Of Policy Impact On Autonomy., Emily Haynes, Roger Hughes, Dianne P Reidlinger 2017 Bond University

Obesity Prevention Advocacy In Australia: An Analysis Of Policy Impact On Autonomy., Emily Haynes, Roger Hughes, Dianne P Reidlinger

Roger Hughes

OBJECTIVE: To explore obesity policy options recommended by stakeholders and identify their impact on individual autotomy. METHODS: Qualitative and quantitative methods were used. A content analysis of submissions to the Australian Government's Inquiry into Obesity was conducted. Each recommendation was categorised by its impact on autonomy, according to existing frameworks. Chi-square test for independence was used to explore the association between autonomy and stakeholder support defined as frequency of recommendation. RESULTS: The extent of support for a policy option was significantly associated with impact on autonomy (p CONCLUSIONS: Stakeholders advocated policy options that enhance individual autonomy to a greater ...


Is A Students’ Ability To Critically Self-Reflect, Related To Their Performance On Physiotherapy Clinical Placements?, Sarah Brooks, Nikki Milne, Rob Marc Orr, Rebecca Terry 2017 Bond University

Is A Students’ Ability To Critically Self-Reflect, Related To Their Performance On Physiotherapy Clinical Placements?, Sarah Brooks, Nikki Milne, Rob Marc Orr, Rebecca Terry

Rob Marc Orr

Background. The relationship between students’ reflective ability and performance on physiotherapy clinical placement is currently unclear.

Objectives. To investigate: i) if a relationship exists between students’ critical reflective ability and performance on physiotherapy clinical placement; and whether these relationships differ by ii) Critical reflective task (CRT) rank grade or, iii) by gender.

Design. An observational cohort study design.

Methods. Critical Reflection Task (CRT) marks and clinical placement (APP) scores from 196 (F=94; M=102) post-graduate, entry-level physiotherapy students were analyzed.

Results. A significant moderate predictive relationship was found between CRT marks and APP scores (r=.411, p2=.169, SEE ...


Is A Students’ Ability To Critically Self-Reflect, Related To Their Performance On Physiotherapy Clinical Placements?, Sarah Brooks, Nikki Milne, Rob Marc Orr, Rebecca Terry 2017 Bond University

Is A Students’ Ability To Critically Self-Reflect, Related To Their Performance On Physiotherapy Clinical Placements?, Sarah Brooks, Nikki Milne, Rob Marc Orr, Rebecca Terry

Dr Nikki Milne

Background. The relationship between students’ reflective ability and performance on physiotherapy clinical placement is currently unclear.

Objectives. To investigate: i) if a relationship exists between students’ critical reflective ability and performance on physiotherapy clinical placement; and whether these relationships differ by ii) Critical reflective task (CRT) rank grade or, iii) by gender.

Design. An observational cohort study design.

Methods. Critical Reflection Task (CRT) marks and clinical placement (APP) scores from 196 (F=94; M=102) post-graduate, entry-level physiotherapy students were analyzed.

Results. A significant moderate predictive relationship was found between CRT marks and APP scores (r=.411, p2=.169, SEE ...


Do Coursework Summative Assessments Predict Clinical Performance? A Systematic Review, Rebecca Terry, Wayne Hing, Robin Orr, Nikki Milne 2017 Bond University

Do Coursework Summative Assessments Predict Clinical Performance? A Systematic Review, Rebecca Terry, Wayne Hing, Robin Orr, Nikki Milne

Dr Nikki Milne

BACKGROUND:

Two goals of summative assessment in health profession education programs are to ensure the robustness of high stakes decisions such as progression and licensing, and predict future performance. This systematic and critical review aims to investigate the ability of specific modes of summative assessment to predict the clinical performance of health profession education students.

METHODS:

PubMed, CINAHL, SPORTDiscus, ERIC and EMBASE databases were searched using key terms with articles collected subjected to dedicated inclusion criteria. Rigorous exclusion criteria were applied to ensure a consistent interpretation of 'summative assessment' and 'clinical performance'. Data were extracted using a pre-determined format and ...


Effects Of Water-Based Exercise On Bone Health Of Middle-Aged And Older Adults: A Systematic Review And Meta-Analysis, Vini Simas, Wayne Hing, Rodney Pope, Mike Climstein 2017 Bond University

Effects Of Water-Based Exercise On Bone Health Of Middle-Aged And Older Adults: A Systematic Review And Meta-Analysis, Vini Simas, Wayne Hing, Rodney Pope, Mike Climstein

Rodney P Pope

BACKGROUND: Age-related bone loss is a major health concern. Only exercises associated with high-impact and mechanical loading have been linked to a positive effect on bone turnover; however, these types of exercises may not always be appropriate for middle-aged and older adults due to physical decline or chronic disorders such as osteoarthritis. Water-based exercise (WBE) has been shown to affect different components of physical fitness, has lower risks of traumatic fracture, and applies less stress to joints. However, the effects of WBE on bone health are unclear. OBJECTIVE: This study aimed to explore whether WBE is effective in preventing age-related ...


Effects Of Water-Based Exercise On Bone Health Of Middle-Aged And Older Adults: A Systematic Review And Meta-Analysis, Vini Simas, Wayne Hing, Rodney Pope, Mike Climstein 2017 Bond University

Effects Of Water-Based Exercise On Bone Health Of Middle-Aged And Older Adults: A Systematic Review And Meta-Analysis, Vini Simas, Wayne Hing, Rodney Pope, Mike Climstein

Wayne Hing

BACKGROUND:

Age-related bone loss is a major health concern. Only exercises associated with high-impact and mechanical loading have been linked to a positive effect on bone turnover; however, these types of exercises may not always be appropriate for middle-aged and older adults due to physical decline or chronic disorders such as osteoarthritis. Water-based exercise (WBE) has been shown to affect different components of physical fitness, has lower risks of traumatic fracture, and applies less stress to joints. However, the effects of WBE on bone health are unclear.

OBJECTIVE:

This study aimed to explore whether WBE is effective in preventing age-related ...


Do Coursework Summative Assessments Predict Clinical Performance? A Systematic Review, Rebecca Terry, Wayne Hing, Robin Orr, Nikki Milne 2017 Bond University

Do Coursework Summative Assessments Predict Clinical Performance? A Systematic Review, Rebecca Terry, Wayne Hing, Robin Orr, Nikki Milne

Wayne Hing

BACKGROUND:

Two goals of summative assessment in health profession education programs are to ensure the robustness of high stakes decisions such as progression and licensing, and predict future performance. This systematic and critical review aims to investigate the ability of specific modes of summative assessment to predict the clinical performance of health profession education students.

METHODS:

PubMed, CINAHL, SPORTDiscus, ERIC and EMBASE databases were searched using key terms with articles collected subjected to dedicated inclusion criteria. Rigorous exclusion criteria were applied to ensure a consistent interpretation of 'summative assessment' and 'clinical performance'. Data were extracted using a pre-determined format and ...


Investigation Of The Beliefs And Experiences Of Key Stakeholders In Massachusetts Related To Medical/Dental Integration Programs And Practices, Ann Cadoret, Lori Rainchuso, Robyn Olson, Christine Dominick 2017 MCPHS University

Investigation Of The Beliefs And Experiences Of Key Stakeholders In Massachusetts Related To Medical/Dental Integration Programs And Practices, Ann Cadoret, Lori Rainchuso, Robyn Olson, Christine Dominick

Health and Interprofessional Practice

INTRODUCTION Oral health care access for vulnerable populations is an important public health issue in America, and is becoming a priority for discussion among policy makers, health care educational institutions, providers, and a segment of the public at large. Improving overall health outcomes requires a collaborative effort and innovative approaches that address education, delivery, and financing of oral health care. The purpose of this study was to investigate Massachusetts’ key informants’ knowledge and experience regarding development and implementation of medical/dental integration practices, including recognized barriers and possible solutions for integration enhancement.

METHODS This phenomenological, qualitative study used a criterion-based ...


Using Quicksin Speech Material To Measure Acceptable Noise Level For Adults With Hearing Loss, Lauren E. Bentley, Hua Ou 2017 Illinois State University

Using Quicksin Speech Material To Measure Acceptable Noise Level For Adults With Hearing Loss, Lauren E. Bentley, Hua Ou

AuD Capstone Projects - Communication Sciences and Disorders

It is clinically useful to predict potential for hearing aid use success prior to the initial fitting of hearing aids. This information may be used to help with additional counseling for speech understanding in noisy listening environments and can also be used to describe the use of communication skills in combination with the dynamic functionality of hearing aids to guide patients that are hearing aid candidates towards success. The Quick Speech-In-Noise (QuickSIN) test and the Acceptable Noise Level (ANL) test have been recognized for their ability to predict hearing aid use success; however, the two measures use different stimuli and ...


Paranormal Activity: Para-Esophageal/Gastric Hemorrhage In A Patient With A Heartmate Ii Lvad, Anna Stone, Ashwin Ravichandran 2017 St. Vincent's Indianapolis/Heart Center of Indiana, Indianapolis, Indiana

Paranormal Activity: Para-Esophageal/Gastric Hemorrhage In A Patient With A Heartmate Ii Lvad, Anna Stone, Ashwin Ravichandran

The VAD Journal

In this report we present an unusual case of non-traumatic, spontaneous para-esophageal/para-gastric hemorrhage requiring multiple units of red blood cells in a female patient with a continuous flow left ventricular assist device. She presented with dysphagia and atypical chest pain 18 months post implantation, on the recommended anticoagulation regimen for HeartMate II support of ASA 81mg and international normalized ratio goal (INR) of 2-3 and was successfully managed with conservation support, volume resuscitation and multiple transfusions. Non-traumatic causes of acute bleeding, including acquired platelet dysfunction are considered.


A Qualitative Study Exploring High School Students' Understanding Of, And Attitudes Towards, Health Information And Claims, Leila Cusack, Laura N Desha, Chris B Del Mar, Tammy C Hoffmann 2017 Bond University

A Qualitative Study Exploring High School Students' Understanding Of, And Attitudes Towards, Health Information And Claims, Leila Cusack, Laura N Desha, Chris B Del Mar, Tammy C Hoffmann

Tammy Hoffmann

BACKGROUND:

Exposure to health claims, particularly in the media and social media, is pervasive, and the information conveyed is often inaccurate, incomplete or misleading. Some young people of high school ages are already making decisions about using readily available health interventions (such as sports drinks and beauty products).Although previous research has assessed adults' understanding of health claims, no research has examined this issue in young adults who are attending high school.

OBJECTIVE:

To explore high school students' understanding of, and attitudes towards, concepts relevant to assessing health information and claims.

DESIGN:

A qualitative study involving semi-structured interviews with 27 ...


A Qualitative Study Exploring High School Students' Understanding Of, And Attitudes Towards, Health Information And Claims, Leila Cusack, Laura N Desha, Chris B Del Mar, Tammy C Hoffmann 2017 Bond University

A Qualitative Study Exploring High School Students' Understanding Of, And Attitudes Towards, Health Information And Claims, Leila Cusack, Laura N Desha, Chris B Del Mar, Tammy C Hoffmann

Christopher Del Mar

BACKGROUND:

Exposure to health claims, particularly in the media and social media, is pervasive, and the information conveyed is often inaccurate, incomplete or misleading. Some young people of high school ages are already making decisions about using readily available health interventions (such as sports drinks and beauty products).Although previous research has assessed adults' understanding of health claims, no research has examined this issue in young adults who are attending high school.

OBJECTIVE:

To explore high school students' understanding of, and attitudes towards, concepts relevant to assessing health information and claims.

DESIGN:

A qualitative study involving semi-structured interviews with 27 ...


Determining The Gaps Between Cochrane Reviews And Trials Of Effectiveness Of Interventions For Acute Respiratory Infections: An Audit, Jasmin Alloo, Sanya Vallath, Chris Del Mar, Matt Carter, Sarah Thorning, Justin Clark 2017 Bond University

Determining The Gaps Between Cochrane Reviews And Trials Of Effectiveness Of Interventions For Acute Respiratory Infections: An Audit, Jasmin Alloo, Sanya Vallath, Chris Del Mar, Matt Carter, Sarah Thorning, Justin Clark

Christopher Del Mar

BACKGROUND:

Cochrane primarily aims to systematically review trials of effectiveness that are important to inform clinical decisions. Editorial groups support authors to achieve high-quality reviews and prioritise review proposals in their clinical domain that are submitted or elicited. Prioritising proposals requires two approaches, identifying (1) clinical practises for which the evidence of effectiveness is uncertain and (2) interventions in which there are trials of effectiveness (especially randomised controlled trials (RCTs)) not systematically reviewed. This study addresses this second approach for the Cochrane Acute Respiratory Infections Group (CARIG) in order to identify RCTs of acute respiratory infections that have not been ...


"Carer-Centred Care": Family Carer Experiences, Roles And Support Needs: Implications For Dietitians In Rehabilitation, Skye Marshall, Dianne Reidlinger, Adrienne Young, Elizabeth Isenring 2017 Bond University

"Carer-Centred Care": Family Carer Experiences, Roles And Support Needs: Implications For Dietitians In Rehabilitation, Skye Marshall, Dianne Reidlinger, Adrienne Young, Elizabeth Isenring

Liz Isenring

Title on the Conference Program:

"Family carer experiences, roles and support needs: Implications for dietitians in rehabilitation"


Do Making Habits Or Breaking Habits Influence Weight Loss And Weight Loss Maintenence? A Randomised Controlled Trial, Gina Cleo, Rae Thomas, Liz Isenring, Paul P. Glasziou 2017 Bond University

Do Making Habits Or Breaking Habits Influence Weight Loss And Weight Loss Maintenence? A Randomised Controlled Trial, Gina Cleo, Rae Thomas, Liz Isenring, Paul P. Glasziou

Liz Isenring

- After losing it, keeping weight off is difficult.

- Around 40% of weight loss is regained over the first year following treatment, and much of the rest over the next three years

- Habitual behaviour and automaticity have been suggested as the most plausible explanation for this overwhelming lack of long-term weight loss success

‘Most of the time what we do is what we do most of the time, sometimes we do something different’


Dietary Fibre Modification In The Recovery And Prevention Of Reoccurrence Of Acute, Uncomplicated Diverticulitis: A Systematic Review And Meta-Analysis, Camilla Dahl, Megan Crichton, Julie Jenkins, Romina Nucera, Sophie Mahoney, Skye Marshall 2017 Bond University

Dietary Fibre Modification In The Recovery And Prevention Of Reoccurrence Of Acute, Uncomplicated Diverticulitis: A Systematic Review And Meta-Analysis, Camilla Dahl, Megan Crichton, Julie Jenkins, Romina Nucera, Sophie Mahoney, Skye Marshall

Skye Marshall

Title on the Conference Program:

"The effect of dietary fibre modification and bowel rest on patient and health care outcomes in patients admitted to hospital with acute, uncomplicated diverticulitis: a systematic literature review and meta-analysis"


Digital Commons powered by bepress