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Posttraumatic Stress Disorder: Changing Soldiers Lives Forever, Scott Blanck 2012 Parkland College

Posttraumatic Stress Disorder: Changing Soldiers Lives Forever, Scott Blanck

A with Honors Projects

This is a research paper on post-traumatic stress disorder (PTSD) and its affects on soldiers.


Confounding Issues In Estimation Of Patient-Specific Pharmacokinetic Parameters And Dosage Individualization Of Aminoglycosides, Reza Mehvar 2012 Chapman University

Confounding Issues In Estimation Of Patient-Specific Pharmacokinetic Parameters And Dosage Individualization Of Aminoglycosides, Reza Mehvar

Pharmacy Faculty Articles and Research

Aminoglycoside antibiotics are usually administered by multiple short intravenous infusions at fixed intervals. Today, equations reported 35 years ago by Sawchuk and Zaske are still the cornerstone of methods used for determination of patient-specific pharmacokinetic parameters of aminoglycosides and individualization of drug dosage regimens in many clinical settings. Additionally, these methods are included in many clinical pharmacology curricula in pharmacy and other related fields. However, there are a few issues with regard to the application and/or modification of this method in clinical settings, which may result in some confusion among novice clinicians. For example, serum samples collected from different ...


Quantitative Analysis Of Some Important Metals And Metalloids In Tobacco Products By Inductively Coupled Plasma-Mass Spectrometry (Icp-Ms), Syed Ghulam Musharraf, Muhammad Shoaib, Amna Jabbar Siddiqui, Muhammad Najam-ul-Haq, Aftab Ahmed 2012 University of Karachi

Quantitative Analysis Of Some Important Metals And Metalloids In Tobacco Products By Inductively Coupled Plasma-Mass Spectrometry (Icp-Ms), Syed Ghulam Musharraf, Muhammad Shoaib, Amna Jabbar Siddiqui, Muhammad Najam-Ul-Haq, Aftab Ahmed

Pharmacy Faculty Articles and Research

Background: Large scale usage of tobacco causes a lot of health troubles in human. Various formulations of tobacco are extensively used by the people particularly in developing world. Besides several toxic tobacco constituents some metals and metalloids are also believed to pose health risks. This paper describes inductively coupled plasma-mass spectrometric (ICP-MS) quantification of some important metals and metalloids in various brands of smoked, sniffed, dipped and chewed tobacco products.

Results: A microwave-assisted digestion method was used for sample preparation. The method was validated by analyzing a certified reference material. Percentage relative standard deviation (% R.S.D.) between recovered and ...


A New, Simple, Green And One-Pot Four-Component Synthesis Of Bare And Poly(Α, Γ, L-Glutamic Acid) Capped Silver Nanoparticles, Magdalena Stevanović, Igor Savanović, Vuk Uskoković, Srečo D. Škapin, Ines Bračko, Uroš Jovanović, Dragan Uskoković 2012 Serbian Academy of Sciences and Arts

A New, Simple, Green And One-Pot Four-Component Synthesis Of Bare And Poly(Α, Γ, L-Glutamic Acid) Capped Silver Nanoparticles, Magdalena Stevanović, Igor Savanović, Vuk Uskoković, Srečo D. Škapin, Ines Bračko, Uroš Jovanović, Dragan Uskoković

Pharmacy Faculty Articles and Research

A simple and green chemical method has been developed to synthesize stable bare and capped silver nanoparticles based on the reduction of silver ions by glucose and capping by poly(α,γ,Lglutamic acid) (PGA). The use of ammonia during synthesis was avoided. PGA has had a dual role in the synthesis and was used as a capping agent to make the silver nanoparticle more biocompatible and to protect the nanoparticles from agglomerating in the liquid medium. The synthesized PGA-capped silver nanoparticles in the size range 5–45 nm were stable over long periods of time, without signs of precipitation ...


Pegylated Silicon Nanowire Coated Silica Microparticles For Drug Delivery Across Intestinal Epithelium, Vuk Uskoković, Phin-Peng Lee, Laura Walsh, Kathleen Fischer, Tejal Dasai 2012 Chapman University

Pegylated Silicon Nanowire Coated Silica Microparticles For Drug Delivery Across Intestinal Epithelium, Vuk Uskoković, Phin-Peng Lee, Laura Walsh, Kathleen Fischer, Tejal Dasai

Pharmacy Faculty Articles and Research

Composite particles made by growing nanoscopic silicon wires from the surface of monodispersed, microsized silica beads were tested in this study for their ability to affect the integrity and permeability of an epithelial cell layer. Polyethylene glycol (PEG) is known to sterically stabilize particles and prevent protein binding; as such, it is a routine way to impart in vivo longevity to drug carriers. The effect of the silica beads, both with and without silicon nanowires and PEG, on the disruption of the tight junctions in Caco-2 cells was evaluated by means of: (a) analysis of the localization of zonula occludens-1 ...


Cilostazol Prevents Endothelin-Induced Smooth Muscle Constriction And Proliferation, Yoshifumi Kawanabe, Maki Takahashi, Xingjian Jin, Shakila Abdul-Majeed, Andromeda M. Nauli, Youssef Sari, Surya M. Nauli 2012 University of Toledo

Cilostazol Prevents Endothelin-Induced Smooth Muscle Constriction And Proliferation, Yoshifumi Kawanabe, Maki Takahashi, Xingjian Jin, Shakila Abdul-Majeed, Andromeda M. Nauli, Youssef Sari, Surya M. Nauli

Pharmacy Faculty Articles and Research

Cilostazol is a phosphodiesterase inhibitor that has been shown to inhibit platelet activation. Endothelin is known to be the most potent endogenous growth promoting and vasoactive peptide. In patients and animal models with stroke, the level of circulating endothelin increases and complicates the recovery progress contributed by vascular constriction (an immediate pathology) and vascular proliferation (a long-term pathology). However, the effects of cilostazol on endothelin have not been explored. To demonstrate the dual-antagonizing effects of cilostazol on vasoconstriction and cell proliferation induced by endothelin, we used primary culture of mouse vascular smooth muscle cells in vitro, mouse femoral artery ex ...


N-Myristoylglutamic Acid Derivative Of 3′-Fluoro-3′- Deoxythymidine As An Organogel, Bhupender S. Chhikara, Rakesh Tiwari, Keykavous Parang 2012 University of Rhode Island

N-Myristoylglutamic Acid Derivative Of 3′-Fluoro-3′- Deoxythymidine As An Organogel, Bhupender S. Chhikara, Rakesh Tiwari, Keykavous Parang

Pharmacy Faculty Articles and Research

Designing microbicidal gels of anti-HIV drugs for local application to prevent HIV infection is a subject of major interest. 3′-Fluoro-3′-deoxythymidine (FLT), a nucleoside reverse transcriptase inhibitor (NRTI), was conjugated with a N-myristoylglutamate scaffold. The conjugate showed gelation at 1% (w/w) in different organic solvents, such as toluene, dichloromethane, and chloroform. The gels were opaque and stable at room temperature. The results indicate that myristoyl glutamate derivative of FLT can form an organogel. The gel could have potential application as a topical anti-HIV microbicidal agent.


Hepatic Immunosuppressive Effects Of Systemically- Administered Novel Dextran-Methylprednisolone Prodrugs With Peptide Linkers In Rats, Imam H. Shaik, Hitesh K. Agarwal, Keykavous Parang, Reza Mehvar 2012 Texas Tech University

Hepatic Immunosuppressive Effects Of Systemically- Administered Novel Dextran-Methylprednisolone Prodrugs With Peptide Linkers In Rats, Imam H. Shaik, Hitesh K. Agarwal, Keykavous Parang, Reza Mehvar

Pharmacy Faculty Articles and Research

The hepatic immunosuppressive activities of two novel dextran prodrugs of methylprednisolone (MP) containing one (DMP1) or five (DMP5) amino acids as linkers were studied in rats. At various times (02 weeks) after intravenous administration of single 5 mg/kg (MP equivalent) doses of each prodrug or MP succinate (MPS), livers were isolated and immunologically stimulated ex vivo with lipopolysaccharide. The concentrations of tumor necrosis factor (TNF)-a in the outlet perfusate were then quantitated to assess immune response. Additionally, the concentrations of DMP1, DMP5, and/or MP were measured in the liver. MPS, DMP5, or DMP1 injections caused a maximum ...


4-Aryl-4h-Naphthopyrans Derivatives: One-Pot Synthesis, Evaluation Of Src Kinase Inhibitory And Anti-Proliferative Activities, Ali Rafinejad, Asal Fallah-Tafti, Rakesh Tiwari, Amir Nasrolahi Shirazi, Dindyal Mandal, Abbas Shafiee, Keykavous Parang, Alireza Foroumadi, Tahmineh Akbarzadeh 2012 University of Tehran

4-Aryl-4h-Naphthopyrans Derivatives: One-Pot Synthesis, Evaluation Of Src Kinase Inhibitory And Anti-Proliferative Activities, Ali Rafinejad, Asal Fallah-Tafti, Rakesh Tiwari, Amir Nasrolahi Shirazi, Dindyal Mandal, Abbas Shafiee, Keykavous Parang, Alireza Foroumadi, Tahmineh Akbarzadeh

Pharmacy Faculty Articles and Research

Background: A series of 2-amino-4-aryl-4H-benzo[h or f]chromene-3-carbonitrile derivatives were synthesized and evaluated for inhibition of Src kinase and cell proliferation in breast carcinoma (BT-20) cell lines.

Methods: The one-pot, three-component reaction of a or beta-naphthol, malonitrile and an aromatic aldehyde in the presence of diammonium hydrogen phosphate was afforded the corresponding 2-amino-4-aryl-4H-benzo[h or f]chromene-3-carbonitrile derivatives, All target compounds were evaluated for inhibition of Src kinase and cell proliferation in breast carcinoma (BT-20) cell lines.

Results: Among all tested compounds, unsubstituted 4-phenyl analog 4a showed Src kinas inhibitory effect with IC50 value of 28.1 mu M ...


Bsa Nanoparticles For Sirna Delivery: Coating Effects On Nanoparticle Properties, Plasma Protein Adsorption, And In Vitro Sirna Delivery, Haran Yogasundaram, Markian Stephan Bahniuk, Harsh-Deep Singh, Hamidreza Montazeri Aliabadi, Hasan Uludag, Larry David Unsworth 2012 University of Alberta

Bsa Nanoparticles For Sirna Delivery: Coating Effects On Nanoparticle Properties, Plasma Protein Adsorption, And In Vitro Sirna Delivery, Haran Yogasundaram, Markian Stephan Bahniuk, Harsh-Deep Singh, Hamidreza Montazeri Aliabadi, Hasan Uludag, Larry David Unsworth

Pharmacy Faculty Articles and Research

Developing vehicles for the delivery of therapeutic molecules, like siRNA, is an area of active research. Nanoparticles composed of bovine serum albumin, stabilized via the adsorption of poly-L-lysine (PLL), have been shown to be potentially inert drug-delivery vehicles. With the primary goal of reducing nonspecific protein adsorption, the effect of using comb-type structures of poly(ethylene glycol) (1 kDa, PEG) units conjugated to PLL (4.2 and 24 kDa) on BSA-NP properties, apparent siRNA release rate, cell viability, and cell uptake were evaluated. PEGylated PLL coatings resulted in NPs with ζ-potentials close to neutral. Incubation with platelet-poor plasma showed the ...


Effective Non-Viral Delivery Of Sirna To Acute Myeloid Leukemia Cells With Lipid-Substituted Polyethylenimines, Breanne Landry 2012 University of Alberta

Effective Non-Viral Delivery Of Sirna To Acute Myeloid Leukemia Cells With Lipid-Substituted Polyethylenimines, Breanne Landry

Pharmacy Faculty Articles and Research

Use of small interfering RNA (siRNA) is a promising approach for AML treatment as the siRNA molecule can be designed to specifically target proteins that contribute to aberrant cell proliferation in this disease. However, a clinical-relevant means of delivering siRNA molecules must be developed, as the cellular delivery of siRNA is problematic. Here, we report amphiphilic carriers combining a cationic polymer (2 kDa polyethyleneimine, PEI2) with lipophilic moieties to facilitate intracellular delivery of siRNA to AML cell lines. Complete binding of siRNA by the designed carriers was achieved at a polymer:siRNA ratio of ~0.5 and led to siRNA ...


Complexities In The Diagnosis And Treatment Of Thyroid Cancer: Discussions, Observations, Research And Public Policy, Hannah V. Gordon 2012 Claremont McKenna College

Complexities In The Diagnosis And Treatment Of Thyroid Cancer: Discussions, Observations, Research And Public Policy, Hannah V. Gordon

CMC Senior Theses

The impact of the increasing incidence of thyroid cancer presents an interesting case study in public health policy and resource allocation. During the last three decades, thyroid cancer cases have increased by more than 400%. As an illness that affects the lives of hundreds of thousands each year, the human and economic costs will be magnified in the next decade. It is estimated that approximately 13-67% of people will have thyroid nodules during their life of which approximately 5% will be malignant. The standard treatment, a thyroidectomy frequently followed by radioactive 131 iodine treatment, accordingly would seem to be a ...


A Proposal To Test The Effects Of Factor Ecat1 On Pluripotency, From Reprogramming To Differentiation Of Human Somatic Cells, Vritti R. Goel 2012 Scripps College

A Proposal To Test The Effects Of Factor Ecat1 On Pluripotency, From Reprogramming To Differentiation Of Human Somatic Cells, Vritti R. Goel

CMC Senior Theses

The field of stem cell research has been growing more because of the interest in using stem cells to cure diseases and heal injuries. Human embryonic stem cells, because of the controversy surrounding them—and subsequently the difficulties in acquiring samples of the existing aging cell lines—can only be used in limited capacities. While the development of induced pluripotent stem cells in the last decade has allowed the field to progress closer to medical treatments, the low efficiency of reprogramming a somatic cell to a pluripotent state, and the vast molecular and genomic differences between human embryonic stem cells ...


Artl@ S And Basart: A Loose Coupling Strategy For Digital Humanities, Sorin Matei 2012 Purdue University

Artl@ S And Basart: A Loose Coupling Strategy For Digital Humanities, Sorin Matei

Cyber Center Publications

The core ARTL@S digital humanities
strategy is that of loosely coupling
resources, platforms, and use scenarios.
A number of sites will feed from
the same geodatabase (BasArt),
which will be enriched by users with
new content. Inspired by the Web 2.0
design principles, ARTL@S relies on
the BasArt API, which will enable an
ecosystem of sites to use primary
data to generate their own maps,
charts, and tables. A variety of economic
models will also be used to
support the site, from free to paybased.
User-generated content will be
monitored by data management and
curation techniques that ...


Authenticated Top-K Aggregation In Distributed And Authenticated Top-K Aggregation In Distributed And, Sunoh Choi, Hyo-Sang Lim, Elisa Bertino 2012 Purdue University

Authenticated Top-K Aggregation In Distributed And Authenticated Top-K Aggregation In Distributed And, Sunoh Choi, Hyo-Sang Lim, Elisa Bertino

Cyber Center Publications

Top-k queries have attracted interest in many different areas like network and system monitoring, information retrieval, sensor networks, and so on. Since today many applications issue top-k queries on distributed and outsourced databases,
authentication of top-k query results becomes more important. This paper addresses the problem of authenticated top-k aggregation queries (e.g. “find the k objects with the highest aggregate values”) in a distributed system. We propose a new algorithm, called Authenticated Three Phase Uniform Threshold (A-TPUT), which provides not only efficient top-k aggregation over distributed databases but also authentication on the top-k results. We also introduce several enhancements ...


Ohio Northern Serves Community Both Home And Abroad, Andrew M. Straw 2012 Cedarville University

Ohio Northern Serves Community Both Home And Abroad, Andrew M. Straw

Pharmacy Practice Faculty Publications

No abstract provided.


Effects Of A Reading Strategy With Digital Social Studies Texts For Eighth Grade Students, Melissa Doan Malani 2012 University of Central Florida

Effects Of A Reading Strategy With Digital Social Studies Texts For Eighth Grade Students, Melissa Doan Malani

Electronic Theses and Dissertations

Recent data indicate that only 34% of American eighth grade students are able to demonstrate grade-level proficiency with academic reading tasks (NCES, 2011). The staggering nature of statistics such as this is even more profound when considering that high level literacy skills combined with mastery of digital texts have become practical requirements for success in secondary education, post-secondary education, and virtually all vocational contexts. Despite this incongruent scenario, little research has been conducted to evaluate instructional methods and reading comprehension strategies with digital texts. To address this critical issue, the present study examined the effects of a metacognitive reading comprehension ...


Innovative Drug Delivery And Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide, Fang Zhao 2012 St. John Fisher College

Innovative Drug Delivery And Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide, Fang Zhao

Pharmacy Faculty Publications

Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This chapter reviews the design and mechanism of five successful products in the opioid and anti-psychotic categories. Embeda™ is an extended release capsule containing morphine pellets with a sequestered core of naltrexone; naltrexone acts as an aversive agent and is released only when the product is crushed. Remoxy® is an extended release oxycodone capsule with a highly viscous liquid fill ...


Socioeconomic Disparities In Physical Health Among Aboriginal And Torres Strait Islander Children In Western Australia, Carrington C.J. Sheperd, Jianghong Li, Stephen R. Zubrick 2012 Western University

Socioeconomic Disparities In Physical Health Among Aboriginal And Torres Strait Islander Children In Western Australia, Carrington C.J. Sheperd, Jianghong Li, Stephen R. Zubrick

Aboriginal Policy Research Consortium International (APRCi)

Objective. Few empirical studies have specifically examined the relationship between socio-economic status (SES) and health in Indigenous populations of Australia. We sought to provide insights into the nature of this relationship by examining socio-economic disparities in physical health outcomes among Aboriginal and Torres Strait Islander children in Western Australia.

Design. We used a diverse set of health and SES indicators from a representative survey conducted in 2000􏰣2002 on the health and development of 5289 Indigenous children aged 0􏰣17 years in Western Australia. Analysis was conducted using multivariate logistic regression within a multilevel framework. Results. After controlling for age ...


Social And Emotional Outcomes Of Australian Children From Indigenous And Culturally And Linguistically Diverse Backgrounds, Naomi Priest, Jennifer Baxter, Linda Hayes 2012 University of Melbourne

Social And Emotional Outcomes Of Australian Children From Indigenous And Culturally And Linguistically Diverse Backgrounds, Naomi Priest, Jennifer Baxter, Linda Hayes

Aboriginal Policy Research Consortium International (APRCi)

Objectives: 1) profile the living environments and 2) examine the social and emotional outcomes of Australian children from Indigenous and cultural and linguistically diverse (CALD) backgrounds at school entry. Method: Secondary analysis of cross- sectional data collected in Wave 1 of the Longitudinal Study of Australian Children (n=4,735). Child mental-health outcomes were measured using parent report of the Strengths and Difficulties Questionnaire (SDQ). Results: Significant differences in family and neighbourhood characteristics, including parental income, maternal education, maternal parenting quality and neighbourhood safety, were found in children of Indigenous and CALD backgrounds compared to the reference group of Australian-born ...


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