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Editorial Board, 2012 Thomas Jefferson University

Editorial Board

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Editorial Board for Winter 2012, Volume 3, Issue 3 for INTERPROFESSIONAL EDUCATION AND CARE NEWSLETTER.


Upcoming Faculty And Staff Development Programs, 2012 Thomas Jefferson University

Upcoming Faculty And Staff Development Programs

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Upcoming Faculty and Staff Development Programs including: Manuscript Writing Workshop, Interprofessional Education and Care Practicum, Faculty Recruitment for the Health Mentors Program, Register today for JCIPE’s 2012 Conference, Interprofessional Education Collaborative (IPEC) 2012 Institute, Ehpic 2012—Educating Health Professionals in Interprofessional Care, Collaborative Change Leadership: A Certificate Program for Healthcare & Health Education Leaders and All Together Better Health VI.


In The News, 2012 Thomas Jefferson University

In The News

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

In the news including: APTR/Healthy People 2020 and Collaborating Across Borders (CAB III).


Exploring And Evaluating Interprofessional Training: A Brief Overview, Barret Michalec, PhD 2012 University of Delaware

Exploring And Evaluating Interprofessional Training: A Brief Overview, Barret Michalec, Phd

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

This paper provides a general overview of an upcoming

evaluation plan with JCIPE that began this fall. This plan was

constructed primarily because although numerous training

institutions have constructed and implemented various courses

and programs designed to provide students with extensive

learning opportunities steeped in interprofessional education

(IPE)1-3, projects employing longitudinal and/or mixed-methods

approaches to understanding the multi-faceted barriers to and

facilitators of IPE within health professions training have been

quite limited. Similarly, few evaluation plans have attempted to

unearth if and how students are exposed to interprofessional

values outside of IPE-specific programs or how these team-based

values ...


Team Training Obstetrical Simulation Drills To Improve Perinatal Outcomes, Deborah A. Cruz, MSN, RNC, CRNP, Carol Carofiglio, PhD, MSN 2012 Thomas Jefferson University

Team Training Obstetrical Simulation Drills To Improve Perinatal Outcomes, Deborah A. Cruz, Msn, Rnc, Crnp, Carol Carofiglio, Phd, Msn

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Sixteen year-old, timid Noelle arrived on the labor floor with complaints of severe abdominal pain and headache, onset earlier today at school. During her intake, she confided to her nurse that she is probably about 7 months pregnant with no prenatal care. Only her boyfriend knew. Her parents were oblivious. Noelle was petrified to tell her mother of the pregnancy. Mom arrived on the labor floor about thirty minutes later and was shocked to discover her daughter’s condition. The physician explained the situation to Mom. Noelle was 30 weeks pregnant, hypertensive with seizures. Mom could barely comprehend her daughter ...


Interprofessional Education In A Department Of Urology, Maryann Sonzogni 2012 Thomas Jefferson University

Interprofessional Education In A Department Of Urology, Maryann Sonzogni

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Optimum health care delivery requires increasing reliance allied health care professionals who are members of highly functioning teams. However, few allied health care professionals are trained in the specific field of urology. Within our urology department, care of patients is fragmented into different segments with little to no crossover of staff. Patient care may benefit from specialty training and additional education sessions for those involved in patient care. Interprofessional Education (IPE) offers a potential way to improve collaboration and may enhance healthcare outcomes.


From The Editors, Christine A. Arenson, MD, Elizabeth Speakman, EdD, RN, CDE, ANEF 2012 Thomas Jefferson University

From The Editors, Christine A. Arenson, Md, Elizabeth Speakman, Edd, Rn, Cde, Anef

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Welcome to the latest edition of the JCIPE Interprofessional Education and Care Newsletter! Since our last edition, we have had some changes at JCIPE. First, founding Co-Director Dr. Molly Rose has begun a phased retirement and stepped down from her JCIPE position. Although parting is always bittersweet, we are thrilled that Molly is continuing to champion interprofessional education from her position in the Jefferson School of Nursing (JSN), and also still serving as chair of our Evaluation Workgroup. At the same time, transitions bring us the joy of new partners – and we are delighted to introduce Elizabeth Speakman, EdD, RN ...


Vulvar Pythiosis In Two Captive Camels (Camelus Dromedarius)., Ricardo Videla, Sarel van Amstel, Sarah O'neill, Linda Frank, Shelley Newman, Raquel Vilela, Leonel Mendoza 2012 University of Tennessee, Knoxville

Vulvar Pythiosis In Two Captive Camels (Camelus Dromedarius)., Ricardo Videla, Sarel Van Amstel, Sarah O'Neill, Linda Frank, Shelley Newman, Raquel Vilela, Leonel Mendoza

Sarel R Van Amstel BVSc, Dip Med Vet, M MED VET, DACVIM

Two camels (Camelus dromedarius), 3- and 4-years-old, respectively, from an eastern Tennessee wildlife farm presented with persistent weight loss and large vulvar masses. An initial biopsy of the vulvar mass of one of the camels performed by a local veterinarian showed eosinophilic dermatitis. An allergic or parasitic dermatitis was suspected. The two camels were treated with one dose of sodium iodide (66 mg/kg, in 1.0 L of normosolR, IV) and ivermectin 1% (200 ug/kg PO). Upon presentation at the Veterinary Teaching Hospital, University of Tennessee, additional biopsies of the masses again revealed eosinophilic dermatitis. Microscopic examination of ...


The Nuclear Matrix Protein Nmp-1 Is The Transcription Factor Yy1, Bo Guo, Paul Odgren, Andre Van Wijnen, Thomas Last, Jeffrey Nickerson, Sheldon Penman, Jane Lian, Janet Stein, Gary Stein 2012 University of Massachusetts Medical School

The Nuclear Matrix Protein Nmp-1 Is The Transcription Factor Yy1, Bo Guo, Paul Odgren, Andre Van Wijnen, Thomas Last, Jeffrey Nickerson, Sheldon Penman, Jane Lian, Janet Stein, Gary Stein

Paul R. Odgren PhD

NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for the site IV regulatory element of a histone H4 gene. This distal promoter domain is a nuclear matrix interaction site. In the present study, we show that NMP-1 is the multifunctional transcription factor YY1. Gel-shift and Western blot analyses demonstrate that NMP-1 is immunoreactive with YY1 antibody. Furthermore, purified YY1 protein specifically recognizes site IV and reconstitutes the NMP-1 complex. Western blot and gel-shift analyses indicate that YY1 is present within the nuclear matrix. In situ immunofluorescence studies show that a significant fraction of YY1 ...


Evidence That The Rat Osteopetrotic Mutation Toothless (Tl) Is Not In The Tnfsf11 (Trance, Rankl, Odf, Opgl) Gene, Paul R. Odgren, Nacksung Kim, Liesbeth van Wesenbeeck, Carole A. MacKay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim van-Hul, Yongwon Choi, Sandy C. Marks Jr. 2012 University of Massachusetts Medical School

Evidence That The Rat Osteopetrotic Mutation Toothless (Tl) Is Not In The Tnfsf11 (Trance, Rankl, Odf, Opgl) Gene, Paul R. Odgren, Nacksung Kim, Liesbeth Van Wesenbeeck, Carole A. Mackay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim Van-Hul, Yongwon Choi, Sandy C. Marks Jr.

Paul R. Odgren PhD

The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required for normal osteoclast differentiation. Although the genetic locus remains unknown, the phenotypic impact of the tl mutation on multiple systems has been well characterized. Some of its actions are similar to tumornecrosis factor superfamily member 11(TNFSF11; also called TRANCE, RANKL, ODF and OPGL) null mice. TNFSF11 is a recently described member of the tumor necrosis factor superfamily which, when expressed by activated T cells, enhances the survival of antigen-presenting dendritic cells, and when expressed by osteoblasts, promotes the differentiation and activation of osteoclasts. The ...


Product Of The Oncogene-Activating Gene Tpr Is A Phosphorylated Protein Of The Nuclear Pore Complex, Peter Bangs, Cynthia Sparks, Paul Odgren, Edward Fey 2012 University of Massachusetts Medical School

Product Of The Oncogene-Activating Gene Tpr Is A Phosphorylated Protein Of The Nuclear Pore Complex, Peter Bangs, Cynthia Sparks, Paul Odgren, Edward Fey

Paul R. Odgren PhD

We have identified a component of the human nuclear pore complex and have shown that it is the product of a gene involved in oncogenic activation. A monoclonal antibody raised against purified nuclear matrix proteins recognizes a single protein with an electrophoretic mobility of approximately 300 kDa and stains the nuclear envelope in a punctate pattern typical of nuclear pores. The antibody was used to screen lambda gt11 human cDNA libraries, and the resulting clones were sequenced and compared to sequences in the Genbank database. An exact match was found with the human tpr (for translocated promoter region) gene, a ...


Molecular Characterization Of Mitofilin (Hmp), A Mitochondria-Associated Protein With Predicted Coiled Coil And Intermembrane Space Targeting Domains, Paul Odgren, Gary Toukatly, Peter Bangs, Reid Gilmore, Edward Fey 2012 University of Massachusetts Medical School

Molecular Characterization Of Mitofilin (Hmp), A Mitochondria-Associated Protein With Predicted Coiled Coil And Intermembrane Space Targeting Domains, Paul Odgren, Gary Toukatly, Peter Bangs, Reid Gilmore, Edward Fey

Paul R. Odgren PhD

We have identified and characterized a human protein of the mitochondria which we call mitofilin. Using monoclonal and polyclonal antibodies, we have isolated cDNA clones and characterized mitofilin biochemically. It appears as a 90 and 91 kDa doublet in western blots and is translated from a single 2.7 kb mRNA. Antibodies raised against cellular and bacterially-expressed protein given identical cytoplasmic immunofluorescence and immunoblot results. Mitofilin co-localizes with mitochondria in immunofluorescence experiments and co-purifies with mitochondria. Double label studies show co-localization only with mitochondria and not with Golgi or endoplasmic reticulum. Co-localization with mitochondria is retained when actin or tubulin ...


Cell Cycle-Dependent Modifications In Activities Of Prb-Related Tumor Suppressors And Proliferation-Specific Cdp/Cut Homeodomain Factors In Murine Hematopoietic Progenitor Cells, Andre Van Wijnen, Cathleen Cooper, Paul Odgren, Farah Aziz, Antonio De Luca, A. Shakoori, Antonio Giordano, Peter Quesenberry, Jane Lian, Gary Stein, Janet Stein 2012 University of Massachusetts Medical School

Cell Cycle-Dependent Modifications In Activities Of Prb-Related Tumor Suppressors And Proliferation-Specific Cdp/Cut Homeodomain Factors In Murine Hematopoietic Progenitor Cells, Andre Van Wijnen, Cathleen Cooper, Paul Odgren, Farah Aziz, Antonio De Luca, A. Shakoori, Antonio Giordano, Peter Quesenberry, Jane Lian, Gary Stein, Janet Stein

Paul R. Odgren PhD

The histone H4 gene promoter provides a paradigm for defining transcriptional control operative at the G1/S phase transition point in the cell cycle. Transcription of the cell cycle-dependent histone H4 gene is upregulated at the onset of S phase, and the cell cycle control element that mediates this activation has been functionally mapped to a proximal promoter domain designated Site II. Activity of Site II is regulated by an E2F-independent mechanism involving binding of the oncoprotein IRF2 and the multisubunit protein HiNF-D, which contains the homeodomain CDP/cut, CDC2, cyclin A, and the tumor suppressor pRb. To address mechanisms ...


Connective Tissue Growth Factor (Ctgf/Ccn2) Is A Downstream Mediator For Tgf-Beta1-Induced Extracellular Matrix Production In Osteoblasts, John Arnott, E. Nuglozeh, Mario Rico, Israel Arango-Hisijara, Paul Odgren, Fayez Safadi, Steven Popoff 2012 University of Massachusetts Medical School

Connective Tissue Growth Factor (Ctgf/Ccn2) Is A Downstream Mediator For Tgf-Beta1-Induced Extracellular Matrix Production In Osteoblasts, John Arnott, E. Nuglozeh, Mario Rico, Israel Arango-Hisijara, Paul Odgren, Fayez Safadi, Steven Popoff

Paul R. Odgren PhD

Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as an anabolic growth factor to regulate osteoblast differentiation and function. Recent studies have identified CTGF as a downstream effector of transforming growth factor-beta1 (TGF-beta1) for certain functions in specific cell types. In this study, we examined the role of CTGF as a downstream mediator of TGF-beta1-induced ECM production and cell growth in osteoblasts. Using primary cultures, we demonstrated that TGF-beta1 is a potent inducer of CTGF expression in osteoblasts, and that this induction occurred at all stages of osteoblast differentiation from the proliferative through ...


Phylogenetic Occurrence Of Coiled Coil Proteins: Implications For Tissue Structure In Metazoa Via A Coiled Coil Tissue Matrix, Paul Odgren, Lawrence Harvie, Edward Fey 2012 University of Massachusetts Medical School

Phylogenetic Occurrence Of Coiled Coil Proteins: Implications For Tissue Structure In Metazoa Via A Coiled Coil Tissue Matrix, Paul Odgren, Lawrence Harvie, Edward Fey

Paul R. Odgren PhD

We examined GenBank sequence files with a heptad repeat analysis program to assess the phylogenetic occurrence of coiled coil proteins, how heptad repeat domains are organized within them, and what structural/functional categories they comprise. Of 102,007 proteins analyzed, 5.95% (6,074) contained coiled coil domains; 1.26% (1,289) contained "extended" (> 75 amino acid) domains. While the frequency of proteins containing coiled coils was surprisingly constant among all biota, extended coiled coil proteins were fourfold more frequent in the animal kingdom and may reflect early events in the divergence of plants and animals. Structure/function categories of ...


The Nuclear Matrix: Defining Structural And Functional Roles, Edward Fey, Peter Bangs, Cynthia Sparks, Paul Odgren 2012 University of Massachusetts Medical School

The Nuclear Matrix: Defining Structural And Functional Roles, Edward Fey, Peter Bangs, Cynthia Sparks, Paul Odgren

Paul R. Odgren PhD

No abstract provided.


Sp1 Trans-Activation Of Cell Cycle Regulated Promoters Is Selectively Repressed By Sp3, Mark Birnbaum, Andre Van Wijnen, Paul Odgren, Thomas Last, Guntram Suske, Gary Stein, Janet Stein 2012 University of Massachusetts Medical School

Sp1 Trans-Activation Of Cell Cycle Regulated Promoters Is Selectively Repressed By Sp3, Mark Birnbaum, Andre Van Wijnen, Paul Odgren, Thomas Last, Guntram Suske, Gary Stein, Janet Stein

Paul R. Odgren PhD

The transcription factor Sp1 plays a key role in the activation of many cellular and viral gene promoters, including those that are regulated during the cell cycle. However, recent evidence indicates that Sp1 belongs to a larger family of factors which bind G/C box elements in order to either activate or repress transcription. Sp3, a member of this family, functions to repress transcriptional activation in two viral promoters, most likely by competing with Sp1 for GC box/Sp binding sites. However, the physiological role of Sp3 in the repression of endogenous cellular promoters has not been experimentally addressed. In ...


Endochondral Bone Formation In Toothless (Osteopetrotic) Rats: Failures Of Chondrocyte Patterning And Type X Collagen Expression, Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Paul R. Odgren, Mark F. Seifert, Carole A. MacKay, April Mason-Savas, Steven N. Popoff 2012 University of Massachusetts Medical School

Endochondral Bone Formation In Toothless (Osteopetrotic) Rats: Failures Of Chondrocyte Patterning And Type X Collagen Expression, Sandy C. Marks Jr., Carin Lundmark, Cecilia Christersson, Tilmann Wurtz, Paul R. Odgren, Mark F. Seifert, Carole A. Mackay, April Mason-Savas, Steven N. Popoff

Paul R. Odgren PhD

The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental stages of chondrocytes, characterized by the expression of collagen types II and X, are arranged in arrays across the growth zone. Mutations in collagen II and X genes as well as the absence of their gene products lead to different, altered patterns of chondrocyte stages which remain aligned across the growth plate (GP). Here we analyze GP of rats bearing the mutation toothless (tl) which, apart from bone defects, develop a progressive, severe chondrodystrophy during postnatal weeks 3 to 6. Mutant GP exhibited disorganized, non-aligned ...


Molecular Characterization Of Mitofilin, A Novel, Mitochondrial, Coiled Coil Protein, And The Relationship Between Organism Complexity And Coiled Coil Protein-Mediated Structure: A Dissertation, Paul R. Odgren 2012 University of Massachusetts Medical School

Molecular Characterization Of Mitofilin, A Novel, Mitochondrial, Coiled Coil Protein, And The Relationship Between Organism Complexity And Coiled Coil Protein-Mediated Structure: A Dissertation, Paul R. Odgren

Paul R. Odgren PhD

In the course of experiments designed to identify and characterize structural proteins of the nuclear matrix, one antibody was generated which recognized an extraction-resistant cytoplasmic protein. This antibody was used as the starting point in the cloning and molecular characterization of a novel protein of the inter-membrane space of the mitochondrion which has been named mitofilin. Mitofilin is expressed in all human cell types, and murine homologues also exist. Mitofilin associates only with mitochondria and not with other membrane-bounded organelles such as Golgi or endoplasmic reticulum. This observation has been confirmed both by biochemical fractionation and multi-label fluorescence microscopy. Recombinant ...


Bmp-5 Expression Increases During Chondrocyte Differentiation In Vivo And In Vitro And Promotes Proliferation And Cartilage Matrix Synthesis In Primary Chondrocyte Cultures, Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole MacKay, Irwin Leav, Paul Odgren 2012 University of Massachusetts Medical School

Bmp-5 Expression Increases During Chondrocyte Differentiation In Vivo And In Vitro And Promotes Proliferation And Cartilage Matrix Synthesis In Primary Chondrocyte Cultures, Genevieve Mailhot, Meilheng Yang, April Mason-Savas, Carole Mackay, Irwin Leav, Paul Odgren

Paul R. Odgren PhD

Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through phenotypes of short-ear (se) mice, which have BMP-5 mutations, a role for BMP-5 in some specific aspects of skeletogenesis and cartilage growth is known. This report examines BMP-5 expression in the growth plate and in differentiating cultures of primary chondrocytes, and the effects of addition of BMP-5 or its inhibition by anti-BMP-5 antibody in chondrocyte cultures. By laser capture microdissection and immunohistochemistry, we found that BMP-5 is expressed in proliferating zone (PZ) chondrocytes and that the expression increases sharply with hypertrophic differentiation. A similar pattern ...


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