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Leveraging Bio-Inspired Molecules For Cancer Theranostics, Douglas S. MacPherson 2023 The Graduate Center, City University of New York

Leveraging Bio-Inspired Molecules For Cancer Theranostics, Douglas S. Macpherson

Dissertations, Theses, and Capstone Projects

A variety of molecules can be radiolabeled and delivered to a cancer site for the purposes of diagnostics and therapy. Among the most promising of tumor targeting molecules are peptides and antibodies. These bio-inspired molecules can be designed and synthesized to target and respond to cancer cells based on the properties of those cells. Matrix metalloproteinase (MMP) enzymes are over-expressed by some metastatic cancers, in which they are responsible for the degradation and remodeling of the extracellular matrix. In recent years, MMPs have emerged as promising targets for enzyme-responsive diagnostic probes because oligopeptides can be designed to be selectively hydrolyzed …


Second Generation Phenyloxadiazolyl Methyl Sulfones For Thiol-Specific Bioconjugations, Guillaume Dewaele-Le Roi 2023 The Graduate Center, City University of New York

Second Generation Phenyloxadiazolyl Methyl Sulfones For Thiol-Specific Bioconjugations, Guillaume Dewaele-Le Roi

Dissertations, Theses, and Capstone Projects

The role of antibody-based molecular agents for diagnosis and therapy of cancer has expanded significantly over the past decades. However, most of these constructs are synthesized using traditional bioconjugation methods based on the random ligations between the molecular cargo and lysine residues within the protein. These non-specific approaches can create poorly defined conjugates with suboptimal immunoreactivity and in vivo performance while Site-specific approaches to antibody bioconjugation based on ligations between maleimides and free cysteine residues have long stood as attractive alternatives. Yet the inherent instability of the thiol-maleimide linkage has fueled the search for new, more stable thiol-reactive prosthetic groups. …


Synthesis Of Fluoroorganics And Applications Of Novel Fluorinated Building Blocks, Wei Wei 2023 The Graduate Center, City University of New York

Synthesis Of Fluoroorganics And Applications Of Novel Fluorinated Building Blocks, Wei Wei

Dissertations, Theses, and Capstone Projects

Diastereoselectivity of fluorination of a carbanion alpha to a sulfone in enantiomerically pure N-Boc protected (R)- and (S)-2,2-dimethyl-4-((arylsulfonyl)methyl)oxazolidines has been studied. Fluorination proceeded with good to excellent diastereoselectivity, which was base-dependent and was highest with lithium diisopropylamide (LDA). Diastereoselectivity also depended on the aryl moiety of the aryl sulfone and was highest with benzothiazole-derived sulfones. Under basic conditions, epimerization at the C–F stereogenic center alpha to the sulfone has been achieved for the first time and proceeded with good to excellent diastereoselectivity, which was highest in the case of a benzothiazole sulfone and with a lithium base. …


Motor Cortical Excitability And Pre-Supplementary Motor Area Neurochemistry In Healthy Adults With Substantia Nigra Hyperechogenicity, Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna-Katharina von Thaler, Clarence Chiang, Kay L. Double 2023 Edith Cowan University

Motor Cortical Excitability And Pre-Supplementary Motor Area Neurochemistry In Healthy Adults With Substantia Nigra Hyperechogenicity, Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna-Katharina Von Thaler, Clarence Chiang, Kay L. Double

Research outputs 2022 to 2026

Substantia nigra (SN) hyperechogenicity, viewed with transcranial ultrasound, is a risk marker for Parkinson's disease. We hypothesized that SN hyperechogenicity in healthy adults aged 50 – 70 years is associated with reduced short-interval intracortical inhibition in primary motor cortex, and that the reduced intracortical inhibition is associated with neurochemical markers of activity in the pre-supplementary motor area (pre-SMA). Short-interval intracortical inhibition and intracortical facilitation in primary motor cortex was assessed with paired-pulse transcranial magnetic stimulation in 23 healthy adults with normal (n = 14; 61 ± 7 yrs) or abnormally enlarged (hyperechogenic; n = 9; 60 ± 6 yrs) area …


Using Exterior Housing Conditions To Predict Elevated Pediatric Blood Lead Levels., Neal J Wilson, Elizabeth Friedman, Kevin Kennedy, Panayiotis T. Manolakos, Lori Reierson, Amy Roberts, Steve Simon 2023 Children's Mercy Kansas City

Using Exterior Housing Conditions To Predict Elevated Pediatric Blood Lead Levels., Neal J Wilson, Elizabeth Friedman, Kevin Kennedy, Panayiotis T. Manolakos, Lori Reierson, Amy Roberts, Steve Simon

Manuscripts, Articles, Book Chapters and Other Papers

Housing-based lead paint dust is the most common source of lead exposure for US-born children. Although year of housing construction is a critical indicator of the lead hazard to US children, not all housing of the same age poses the same risk to children. Additional information about housing condition is required to differentiate the housing-based lead risk at the parcel level. This study aimed to identify and assess a method for gathering and using observations of exterior housing conditions to identify active housing-based lead hazards at the parcel level. We used a dataset of pediatric blood lead observations (sample years …


A Review Of Covid-19 Lockdown Across Different Countries During 2020: Characterization Of Risk Factors And Severity Of Covid-19 In Egyptian Patients, Hanya Mohamed 2023 The American University in Cairo AUC

A Review Of Covid-19 Lockdown Across Different Countries During 2020: Characterization Of Risk Factors And Severity Of Covid-19 In Egyptian Patients, Hanya Mohamed

Theses and Dissertations

On March 12, 2020, The World Health Organization (WHO) announced the new coronavirus 2019 as a global pandemic. In January 2022, the number of COVID-19 cases reached 300 million confirmed cases with a total death count of 5.5 million cases. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was identified in a seafood wholesale market in Wuhan, China. At the time of the outbreak, there was no effective treatment to protect from the novel coronavirus; the only way to control the pandemic was through reducing person-to-person contact and taking preventive measures based on the severity of the disease among the population. The …


3d Printed Coronary Arteries: A Useful Tool In Anatomical Education, Zachary Pang, Shreyas Chandragiri, Alexander Hajduczok, MD, Zachary Mace, Jesse Ottaway, Cannon Greco Hiranaka, Michael Wong, Tammy Yoshioka, Noah Haroian, MD, PharmD, Guiyun Zhang, MD, PhD 2023 Thomas Jefferson University

3d Printed Coronary Arteries: A Useful Tool In Anatomical Education, Zachary Pang, Shreyas Chandragiri, Alexander Hajduczok, Md, Zachary Mace, Jesse Ottaway, Cannon Greco Hiranaka, Michael Wong, Tammy Yoshioka, Noah Haroian, Md, Pharmd, Guiyun Zhang, Md, Phd

Department of Medical Education Posters

Introduction

Learning 3D anatomy from 2D figures can be challenging. The use of 3D printing in medical education has shown to improve knowledge and skill in surgical training(1). We investigated the efficacy of 3D printed coronary artery models in teaching coronary anatomy to medical students.


Indiana Law Fertility Fraud Expert Participates In Washington, Dc Roundtable, James Owsley Boyd 2023 Maurer School of Law - Indiana University

Indiana Law Fertility Fraud Expert Participates In Washington, Dc Roundtable, James Owsley Boyd

Keep Up With the Latest News from the Law School (blog)

Professor Jody Madeira, an internationally recognized expert in fertility fraud, bioethics, and law and medicine, participated this morning (January 26) in a bipartisan roundtable discussion with victims of fertility fraud. The event was facilitated by U.S. Representatives Stephanie Bice (R-OK), Mikie Sherrill (D-NJ), Julia Letlow (R-LA), and Chrissy Houlahan (D-PA) following the January 23 introduction of their Protecting Families From Fertility Fraud Act, which would—for the first time—make it a federal crime to knowingly misrepresent the source of DNA used in any procedure that involves assisted reproduction.


Disparities In Contraception In Women With Cardiovascular Diseases In The Cardiac-Obstetrical Clinic, Laura Fiorini, Maria De Abreu Pineda, Jason K. Baxter, Rebekah J. McCurdy, Andria Jones, Indranee Rajapreyar, Amanda Roman-Camargo 2023 Thomas Jefferson University

Disparities In Contraception In Women With Cardiovascular Diseases In The Cardiac-Obstetrical Clinic, Laura Fiorini, Maria De Abreu Pineda, Jason K. Baxter, Rebekah J. Mccurdy, Andria Jones, Indranee Rajapreyar, Amanda Roman-Camargo

Department of Obstetrics and Gynecology Posters

Objective

- National Survey of Family Growth 2017-19 survey reported a 65.3% contraceptive use:

  • 18% tubal, 5.6% vasectomy
  • 18% hormonal therapy
  • 8.4% intrauterine devices (IUD)
  • 8.4% condoms

- To evaluate postpartum contraception plans and use in pregnant women with cardiovascular disease (CVD) after visits to the combined cardio-obstetric clinic


Conflict With Administrators: Overscheduling Appointments, Alexis Malecki, Benjamin Sliwinski, Ehsan Noori, Logan Nguyen, Neil Patel, Rana Elhamzawy 2023 Wayne State University School of Medicine

Conflict With Administrators: Overscheduling Appointments, Alexis Malecki, Benjamin Sliwinski, Ehsan Noori, Logan Nguyen, Neil Patel, Rana Elhamzawy

Patient Education Projects

No abstract provided.


Conflict With Administrators: Resolving Conflict Via Communication, Alex Rodriguez, David Greiver, Johan Harris, Kathy Lu, Minisha Kanakarajan 2023 Wayne State University School of Medicine

Conflict With Administrators: Resolving Conflict Via Communication, Alex Rodriguez, David Greiver, Johan Harris, Kathy Lu, Minisha Kanakarajan

Patient Education Projects

No abstract provided.


Conflict With Administrators: Negative Feedback, Andrea Prenkocevic, Andrew Kohrman, Annie Tonnu, Jordan Reid, Koushik Tuppil, Stefanie Hilton 2023 Wayne State University School of Medicine

Conflict With Administrators: Negative Feedback, Andrea Prenkocevic, Andrew Kohrman, Annie Tonnu, Jordan Reid, Koushik Tuppil, Stefanie Hilton

Patient Education Projects

No abstract provided.


Conflict With Administrators: Unfair Workload, Anthony Grayson, Joel Drazin, Matthew Kim, Mikaela Grudzien, Rachel Feldstein, Sara Kazyak 2023 Wayne State University School of Medicine

Conflict With Administrators: Unfair Workload, Anthony Grayson, Joel Drazin, Matthew Kim, Mikaela Grudzien, Rachel Feldstein, Sara Kazyak

Patient Education Projects

No abstract provided.


Conflict With Administrators: Nursing Staff Miscommunication, Chase Morrison, Erin Bybee, Isaiah Hough, Madison Graifman, Mehrnoosh Ghafouri Abbasabadi, Saranya Madan 2023 Wayne State University School of Medicine

Conflict With Administrators: Nursing Staff Miscommunication, Chase Morrison, Erin Bybee, Isaiah Hough, Madison Graifman, Mehrnoosh Ghafouri Abbasabadi, Saranya Madan

Patient Education Projects

No abstract provided.


Conflict With Administrators: Scheduling Issues, Amir Kalantar, Ismail Aijazuddin, Nada Jaradat, Raisa Zahir, Rubab Imtiaz, Tristan Papcun 2023 Wayne State University School of Medicine

Conflict With Administrators: Scheduling Issues, Amir Kalantar, Ismail Aijazuddin, Nada Jaradat, Raisa Zahir, Rubab Imtiaz, Tristan Papcun

Patient Education Projects

No abstract provided.


Conflict With Administrators: Scheduling Too Many Patients, George Kidess, James Mo, John Knapp, Nili Modi, Rebecca Adams, Shahrin Khan 2023 Wayne State University School of Medicine

Conflict With Administrators: Scheduling Too Many Patients, George Kidess, James Mo, John Knapp, Nili Modi, Rebecca Adams, Shahrin Khan

Patient Education Projects

No abstract provided.


Conflict With Administrators: Documentation Policy, Bhavana Garapati, Jhonny Lopez, Mariam Abdelmesih, Matthew Hansen, Omar Abbas, Shreya Balusu 2023 Wayne State University School of Medicine

Conflict With Administrators: Documentation Policy, Bhavana Garapati, Jhonny Lopez, Mariam Abdelmesih, Matthew Hansen, Omar Abbas, Shreya Balusu

Patient Education Projects

No abstract provided.


Conflict With Administrators: Ambiguous Hospital Policies, Allen Zhang, Daniel Domin, Karis Tutuska, Sarah Bassett, Varsha Kumar 2023 Wayne State University School of Medicine

Conflict With Administrators: Ambiguous Hospital Policies, Allen Zhang, Daniel Domin, Karis Tutuska, Sarah Bassett, Varsha Kumar

Patient Education Projects

No abstract provided.


Conflict With Administrators: Being Punctual, Alexandra Yorks, Ariana Madson, Aryamaan Gaddam, Janae Martin, Karthik Sridasyam, Samih Hamadeh 2023 Wayne State University School of Medicine

Conflict With Administrators: Being Punctual, Alexandra Yorks, Ariana Madson, Aryamaan Gaddam, Janae Martin, Karthik Sridasyam, Samih Hamadeh

Patient Education Projects

No abstract provided.


Conflict With Administrators: Physician Conflict, Arjun Muralidharan, Cecilly Kelleher, Dawei Chen, Eleftherios Halkias, Rumyah Rafique, Saiteja Mogasala 2023 Wayne State University School of Medicine

Conflict With Administrators: Physician Conflict, Arjun Muralidharan, Cecilly Kelleher, Dawei Chen, Eleftherios Halkias, Rumyah Rafique, Saiteja Mogasala

Patient Education Projects

No abstract provided.


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