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Transcriptome Analysis Of Neisseria Gonorrhoeae During Natural Infection Reveals Differential Expression Of Antibiotic Resistance Determinants Between Men And Women, Kathleen Nudel, Ryan McClure, Matthew Moreau, Emma Briars, A. Jeanine Abrams, Brian Tjaden, Xiao-Hong Su, David Trees, Peter A. Rice, Paola Massari, Caroline A. Genco 2018 Tufts University

Transcriptome Analysis Of Neisseria Gonorrhoeae During Natural Infection Reveals Differential Expression Of Antibiotic Resistance Determinants Between Men And Women, Kathleen Nudel, Ryan Mcclure, Matthew Moreau, Emma Briars, A. Jeanine Abrams, Brian Tjaden, Xiao-Hong Su, David Trees, Peter A. Rice, Paola Massari, Caroline A. Genco

Open Access Articles

Neisseria gonorrhoeae is a bacterial pathogen responsible for the sexually transmitted infection gonorrhea. Emergence of antimicrobial resistance (AMR) of N. gonorrhoeae worldwide has resulted in limited therapeutic choices for this infection. Men who seek treatment often have symptomatic urethritis; in contrast, gonococcal cervicitis in women is usually minimally symptomatic, but may progress to pelvic inflammatory disease. Previously, we reported the first analysis of gonococcal transcriptome expression determined in secretions from women with cervical infection. Here, we defined gonococcal global transcriptional responses in urethral specimens from men with symptomatic urethritis and compared these with transcriptional responses in specimens obtained from women ...


Central Precocious Puberty In Boston Boys: A 10-Year Single Center Experience, Lisa Swartz Topor, Kimberly Bowerman, Jason T. Machan, Courtney L. Gilbert, Tairmae Kangarloo, Natalie D. Shaw 2018 Brown University

Central Precocious Puberty In Boston Boys: A 10-Year Single Center Experience, Lisa Swartz Topor, Kimberly Bowerman, Jason T. Machan, Courtney L. Gilbert, Tairmae Kangarloo, Natalie D. Shaw

Open Access Articles

OBJECTIVE: Recent studies in the US and abroad suggest that boys are undergoing puberty at a younger age. It is unknown if this secular trend extends to boys with central precocious puberty (CPP), who sit at the extreme end of the pubertal spectrum, and if neuroimaging should remain a standard diagnostic tool.

STUDY DESIGN: Retrospective chart review of all boys with CPP seen by Endocrinology at a US pediatric hospital from 2001-2010.

RESULTS: Fifty boys had pubertal onset at an average age of 7.31 years (95CI 6.83-7.89), though many did not present until nearly one year thereafter ...


Therapeutic Benefit Of Apremilast On Enthesitis And Dactylitis In Patients With Psoriatic Arthritis: A Pooled Analysis Of The Palace 1-3 Studies, Dafna D. Gladman, Arthur Kavanaugh, Juan J. Gomez-Reino, Jurgen Wollenhaupt, Maurizio Cutolo, Georg Schett, Eric Lespessailles, Benoit Guerette, Nikolay Delev, Lichen Teng, Christopher J. Edwards, Charles Birbara, Philip J. Mease 2018 Toronto Western Hospital

Therapeutic Benefit Of Apremilast On Enthesitis And Dactylitis In Patients With Psoriatic Arthritis: A Pooled Analysis Of The Palace 1-3 Studies, Dafna D. Gladman, Arthur Kavanaugh, Juan J. Gomez-Reino, Jurgen Wollenhaupt, Maurizio Cutolo, Georg Schett, Eric Lespessailles, Benoit Guerette, Nikolay Delev, Lichen Teng, Christopher J. Edwards, Charles Birbara, Philip J. Mease

Open Access Articles

Objective: The Psoriatic Arthritis Long-term Assessment of Clinical Efficacy (PALACE) clinical trial programme findings demonstrated that apremilast, an oral phosphodiesterase 4 inhibitor, is effective for treating psoriatic arthritis (PsA). Enthesitis and dactylitis are difficult-to-treat features of PsA leading to disability and affecting quality of life. PALACE 1, 2 and 3 data were pooled to assess the efficacy of apremilast on enthesitis and dactylitis outcomes in patients with these conditions at baseline.

Methods: Patients with enthesitis (n=945) or dactylitis (n=633) at baseline were analysed after receiving double-blind treatment with placebo, apremilast 30 mg two times per day or apremilast ...


Local Bdnf Delivery To The Injured Cervical Spinal Cord Using An Engineered Hydrogel Enhances Diaphragmatic Respiratory Function., Biswarup Ghosh, Zhicheng Wang, Jia Nong, Mark W. Urban, Zhiling Zhang, Victoria A. Trovillion, Megan C. Wright, Yinghui Zhong, Angelo C. Lepore 2018 Thomas Jefferson University

Local Bdnf Delivery To The Injured Cervical Spinal Cord Using An Engineered Hydrogel Enhances Diaphragmatic Respiratory Function., Biswarup Ghosh, Zhicheng Wang, Jia Nong, Mark W. Urban, Zhiling Zhang, Victoria A. Trovillion, Megan C. Wright, Yinghui Zhong, Angelo C. Lepore

Farber Institute for Neurosciences Faculty Papers

We developed an innovative biomaterial-based approach to repair the critical neural circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic factor (BDNF) to injured cervical spinal cord. BDNF can be used to restore respiratory function via a number of potential repair mechanisms; however, widespread BDNF biodistribution resulting from delivery methods such as systemic injection or lumbar puncture can lead to inefficient drug delivery and adverse side effects. As a viable alternative, we developed a novel hydrogel-based system loaded with polysaccharide-BDNF particles self-assembled by electrostatic interactions that can be safely implanted in the intrathecal space for achieving local BDNF delivery ...


High-Risk Advanced Maternal Age And High Parity Pregnancy: Tackling A Neglected Need Through Formative Research And Action., Khadidiatou Ndiaye, Erin Portillo, Dieneba Ouedraogo, Allison Mobley, Stella Babalola 2018 George Washington University

High-Risk Advanced Maternal Age And High Parity Pregnancy: Tackling A Neglected Need Through Formative Research And Action., Khadidiatou Ndiaye, Erin Portillo, Dieneba Ouedraogo, Allison Mobley, Stella Babalola

Global Health Faculty Publications

Pregnancy among women of advanced maternal age (those 35 years or older) or among women of high parity (those having had 5 or more births) is linked to maternal and infant mortality. Yet little is known about the drivers of these pregnancies as they are often neglected in existing family planning and reproductive health programs. To better understand the context in which advanced maternal age and high parity pregnancies occur and the acceptability of discussing associated pregnancy risks, the Health Communication Capacity Collaborative (HC3) conducted formative qualitative research between January and March 2015 on the perception and determinants of such ...


Nurses' Spiritual Care Practices: Assessment, Type, Frequency, And Correlates, Iris Mamier 2018 Selected Works

Nurses' Spiritual Care Practices: Assessment, Type, Frequency, And Correlates, Iris Mamier

Iris Mamier, PhD

This descriptive, correlational study described the type, frequency, and correlates of nurses' spiritual care practices (quantitative) and their experiences with the sacred at work (qualitative). A convenience sample of 554 (24%) of the Registered Nurses employed at a western United States faith-based tertiary care health system participated in this online survey. Nurses' spiritual care practices were assessed using the 17-item Nurses' Spiritual Care Practice Questionnaire (NSCQ). Factorial validity and reliability of the pilot NSCQ were established. Spiritual care practices most frequently endorsed were assessing patients' spiritual beliefs pertaining to health and listening to patients' stories of illness and their spiritual ...


Translational Research: Ethical Considerations, Yiqing Dong 2018 University of Puget Sound

Translational Research: Ethical Considerations, Yiqing Dong

Honors Program Theses

Translational research (TR) is a new categorization for the efforts of biomedical research and emphasizes efficiency in achieving population health improvements through the application of basic science knowledge in clinical practice. It will be argued that the current emphasis on speed and collaboration with industry established by national policies provides challenges to maintaining the integrity of scientific research. There is no agreed upon definition of TR and the current standard of judging the success of TR focuses on product production. I propose that the principles of beneficence and responsive justice should be used to inform the values of TR and ...


Design, Development, Manufacturing And Biomechanical Testing Of Stand-Alone Cage For Posterior Lumbar Interbody Fusion, Fahad Alhelal 2018 The University of Western Ontario

Design, Development, Manufacturing And Biomechanical Testing Of Stand-Alone Cage For Posterior Lumbar Interbody Fusion, Fahad Alhelal

Electronic Thesis and Dissertation Repository

Introduction: The most common method of spinal fusion includes pedicle screws instrumentation, either with or without interbody cage fusion. This thesis aimed to develop and test a novel stand-alone intervertebral device that eliminates the need for pedicle screws and rods.

Method: The stand-alone cage was designed in collaboration with spinal surgeons and engineers using computer assisting drawings, and manufactured in titanium by 3D printing. Biomechanical testing comparing the stand-alone cage with standard posterior lumbar interbody fusion (PLIF) in sawbones (n=6) and cadavers (n=8).

Result: Compared to PLIF, the stand-alone cage demonstrated no significant difference in range of flexion ...


Comparing Participants’ Satisfaction With Behavioral Therapies For Chronic Insomnia, Souraya Sidani, Dana R. Epstein, Mary Fox, Laura Collins 2018 Ryerson University

Comparing Participants’ Satisfaction With Behavioral Therapies For Chronic Insomnia, Souraya Sidani, Dana R. Epstein, Mary Fox, Laura Collins

Science of Nursing and Health Practices - Science infirmière et pratiques en santé

Introduction. Extensive evidence supports the effectiveness of behavioral therapies for chronic insomnia, but there is limited information on patients’ satisfaction with these, which is a key factor in therapy uptake, adherence and effectiveness. Objective. This study compared participants’ satisfaction with the process and outcome attributes of single- and multi-component behavioral therapies for chronic insomnia. Methods. Data were obtained from 496 persons with chronic insomnia who chose or were randomized to one of three single-component behavioral therapies—sleep education and hygiene (SEH), stimulus control therapy (SCT), or sleep restriction therapy (SRT)—or a multi-component therapy (MCT) combining all three. At time ...


Adaptation Of An Existing Measure To Assess Professionals’ Attitudes Regarding The Importance Of Involving Fathers In Interventions With Families, Christine Gervais, Sophie Meunier, Francine deMontigny, Diane Dubeau 2018 Université du Québec en Outaouais

Adaptation Of An Existing Measure To Assess Professionals’ Attitudes Regarding The Importance Of Involving Fathers In Interventions With Families, Christine Gervais, Sophie Meunier, Francine Demontigny, Diane Dubeau

Science of Nursing and Health Practices - Science infirmière et pratiques en santé

Introduction. Despite greater father participation in child care/rearing nowadays and the challenge of involving fathers in nursing interventions, no instrument exists to measure professional attitudes toward father involvement in family interventions. Objectives. The aim of this study was to adapt an existing measure that assesses nurse attitudes regarding the importance of including families in nursing care into a measure that assesses professionals’ attitudes towards the importance of involving fathers in interventions with families. Method. The Professionals’ Attitudes towards Father Involvement (PAFI) scale was adapted from the Families’ Importance in Nursing Care – Nurse Attitudes (FINC-NA) scale. A total of 297 ...


Empirical Validation Of The Genetic Psychosocial Risk Instrument – French Version (Gpri-F), Christine Maheu, Mary Jane Esplen, Xin Gao, Irakli Dzneladze, Hao Bai, François Eisinger, Claire Julian-Reynier 2018 McGill University

Empirical Validation Of The Genetic Psychosocial Risk Instrument – French Version (Gpri-F), Christine Maheu, Mary Jane Esplen, Xin Gao, Irakli Dzneladze, Hao Bai, François Eisinger, Claire Julian-Reynier

Science of Nursing and Health Practices - Science infirmière et pratiques en santé

Objective. This study sought to validate a French version of the Genetic Psychosocial Risk Instrument (GPRI), an instrument used to screen for psychosocial risk in individuals undergoing genetic testing for adult-onset hereditary disease (AOHD). Methods. The French translation of the GPRI (GPRI-F) was first validated linguistically with ten French individuals undergoing genetic testing for AOHD. Then, a psychometric evaluation of the GPRI-F was carried out with a separate cohort of 132 individuals. Convergent validity was assessed with the Impact of Event Scale (IES) and the Perceived Risk Scale (PR), while divergent validity was assessed with a quality of life measure ...


Beliefs Of Adolescents On Sugar-Sweetened Beverages Abstinence: A Reasoned Action Approach Elicitation Study, Dominique Beaulieu, Lydi-Anne Vézina-Im, Dominic Simard, Danielle Boucher 2018 Université du Québec à Rimouski

Beliefs Of Adolescents On Sugar-Sweetened Beverages Abstinence: A Reasoned Action Approach Elicitation Study, Dominique Beaulieu, Lydi-Anne Vézina-Im, Dominic Simard, Danielle Boucher

Science of Nursing and Health Practices - Science infirmière et pratiques en santé

Introduction. Sugar-sweetened beverage (SSB) consumption is associated with many health problems, such as obesity and cardiovascular diseases. Objectives. To identify adolescents’ beliefs concerning SSB abstinence. Methods. Based on the Reasoned Action Approach, thirty semi-structured interviews were conducted with adolescents (12-17 years). They were selected based on age, sex and setting in order to ensure a broad representation of adolescents from two French-speaking regions of the province of Quebec in Canada (Eastern Canada). Adolescents were invited to answer eight open-ended questions regarding SSB abstinence in the next month. A qualitative content analysis was performed independently by two experts to identify the ...


Nuclear Export Through Nuclear Envelope Remodeling In Saccharomyces Cerevisiae, Baojin Ding, Anne M. Mirza, James A. Ashley, Vivian Budnik, Mary Munson 2018 University of Massachusetts Medical School

Nuclear Export Through Nuclear Envelope Remodeling In Saccharomyces Cerevisiae, Baojin Ding, Anne M. Mirza, James A. Ashley, Vivian Budnik, Mary Munson

University of Massachusetts Medical School Faculty Publications

In eukaryotes, subsets of exported mRNAs are organized into large ribonucleoprotein (megaRNP) granules. How megaRNPs exit the nucleus is unclear, as their diameters are much larger than the nuclear pore complex (NPC) central channel. We previously identified a non-canonical nuclear export mechanism in Drosophila (Speese et al., Cell 2012) and mammals (Ding et al., in preparation), in which megaRNPs exit the nucleus by budding across nuclear envelope (NE) membranes. Here, we present evidence for a similar pathway in the nucleus of the budding yeast S. cerevisiae, which contain morphologically similar granules bearing mRNAs. Wild-type yeast displayed these granules at very ...


Omega: A Software Tool For The Management, Analysis, And Dissemination Of Intracellular Trafficking Data That Incorporates Motion Type Classification And Quality Control, Alessandro Rigano, Vanni Galli, Jasmine M. Clark, Lara E. Pereira, Loris Grossi, Jeremy Luban, Raffaello Giulietti, Tiziano Leidi, Eric Hunter, Mario Valle, Ivo F. Sbalzarini, Caterina Strambio-De-Castilla 2018 University of Massachusetts Medical School

Omega: A Software Tool For The Management, Analysis, And Dissemination Of Intracellular Trafficking Data That Incorporates Motion Type Classification And Quality Control, Alessandro Rigano, Vanni Galli, Jasmine M. Clark, Lara E. Pereira, Loris Grossi, Jeremy Luban, Raffaello Giulietti, Tiziano Leidi, Eric Hunter, Mario Valle, Ivo F. Sbalzarini, Caterina Strambio-De-Castilla

University of Massachusetts Medical School Faculty Publications

MOTIVATION: Particle tracking coupled with time-lapse microscopy is critical for understanding the dynamics of intracellular processes of clinical importance. Spurred on by advances in the spatiotemporal resolution of microscopy and automated computational methods, this field is increasingly amenable to multi-dimensional high-throughput data collection schemes (Snijder et al, 2012). Typically, complex particle tracking datasets generated by individual laboratories are produced with incompatible methodologies that preclude comparison to each other. There is therefore an unmet need for data management systems that facilitate data standardization, meta-analysis, and structured data dissemination. The integration of analysis, visualization, and quality control capabilities into such systems would ...


Hidradenocarcinoma: Five Years Of Local And Systemic Control Of A Rare Sweat Gland Neoplasm With Nodal Metastasis, Benazir Mir, Muhammad Atif Mansha, Nasir Ali, Ahmed Nadeem Abbasi, Syed Mustajab Ahmed, Bilal Mazhar Qureshi 2018 Aga Khan University

Hidradenocarcinoma: Five Years Of Local And Systemic Control Of A Rare Sweat Gland Neoplasm With Nodal Metastasis, Benazir Mir, Muhammad Atif Mansha, Nasir Ali, Ahmed Nadeem Abbasi, Syed Mustajab Ahmed, Bilal Mazhar Qureshi

Department of Radiation Oncology

Hidradenocarcinoma is a rare and locally aggressive tumor rendering a poor prognosis. Furthermore, very few cases present with nodal metastasis. Diagnosing such an entity, and then differentiating it from a benign counterpart, poses a great challenge to the clinicians. There are no established treatment guidelines for the management of this disease, particularly in patients with nodal involvement. We present a case of a young male who was diagnosed with hidradenocarcinoma of the scalp, along with a neck swelling. A thorough diagnostic evaluation was done with endoscopy, pathological, and radiological investigations. He was successfully treated with resection of the scalp lesion ...


Early Gestational Mesenchymal Stem Cell Secretome Attenuates Experimental Bronchopulmonary Dysplasia In Part Via Exosome-Associated Factor Tsg-6., Sushma Chaubey, Sam Thueson, Devasena Ponnalagu, Mohammad Afaque Alam, Ciprian P. Gheorghe, Zubair Aghai, Harpreet Singh, Vineet Bhandari 2018 Drexel University

Early Gestational Mesenchymal Stem Cell Secretome Attenuates Experimental Bronchopulmonary Dysplasia In Part Via Exosome-Associated Factor Tsg-6., Sushma Chaubey, Sam Thueson, Devasena Ponnalagu, Mohammad Afaque Alam, Ciprian P. Gheorghe, Zubair Aghai, Harpreet Singh, Vineet Bhandari

Department of Pediatrics Faculty Papers

BACKGROUND: Mesenchymal stem cells (MSCs) are promising tools for the treatment of human lung disease and other pathologies relevant to newborn medicine. Recent studies have established MSC exosomes (EXO), as one of the main therapeutic vectors of MSCs in mouse models of multifactorial chronic lung disease of preterm infants, bronchopulmonary dysplasia (BPD). However, the mechanisms underlying MSC-EXO therapeutic action are not completely understood. Using a neonatal mouse model of human BPD, we evaluated the therapeutic efficiency of early gestational age (GA) human umbilical cord (hUC)-derived MSC EXO fraction and its exosomal factor, tumor necrosis factor alpha-stimulated gene-6 (TSG-6).

METHODS ...


Despite High Levels Of Expression In Thymic Epithelial Cells, Mir-181a1 And Mir-181b1 Are Not Required For Thymic Development., Heather E Stefanski, Yan Xing, Patricia A Taylor, Stefano Maio, Jorge Henao-Meija, Adam Williams, Richard A Flavell, Georg A Hollander, Bruce R Blazar 2018 The Jackson Laboratory

Despite High Levels Of Expression In Thymic Epithelial Cells, Mir-181a1 And Mir-181b1 Are Not Required For Thymic Development., Heather E Stefanski, Yan Xing, Patricia A Taylor, Stefano Maio, Jorge Henao-Meija, Adam Williams, Richard A Flavell, Georg A Hollander, Bruce R Blazar

Faculty Research 2018

MicroRNAs (miRNAs) have been shown to be key modulators of post-transcriptional gene silencing in many cellular processes. In previous studies designed to understand the role of miRNAs in thymic development, we globally deleted miRNA exclusively in thymic epithelial cells (TECs), which are critical in thymic selection. This resulted in the loss of stromal cells that instruct T cell lineage commitment and affect thymocyte positive selection, required for mature T cell development. Since murine miR-181 is expressed in the thymus and miR-181 deficiency disrupts thymocyte development, we first quantified and thereby demonstrated that miR181a1 and miR181b1 are expressed in purified TECs ...


Data From: Tobacco Smoke Exposure Is An Independent Predictor Of Vitamin D Deficiency In Us Children, Benjamin U. Nwosu, Philip Kum-Nji 2018 University of Massachusetts Medical School

Data From: Tobacco Smoke Exposure Is An Independent Predictor Of Vitamin D Deficiency In Us Children, Benjamin U. Nwosu, Philip Kum-Nji

Pediatric Research Data

Manuscript abstract:

IMPORTANCE:

The role of tobacco-smoke exposure on serum vitamin D concentration in US pediatric population is not known. We hypothesized that tobacco smoke exposure would increase the prevalence of vitamin D deficiency in US children.

METHODS:

Representative national data were accessed from the National Health and Nutrition Examination Survey (NHANES) 2009-2010 databank on 2,263 subjects of ages 3 to 17 years. Subjects were categorized into two groups based on their age: children, if <10 >years; and youth if 10 to 17 years. Descriptive and multiple logistic regression analyses were conducted to determine the effect of serum cotinine-verified tobacco ...


Central Venous Access System, John Gurley 2018 University of Kentucky

Central Venous Access System, John Gurley

Internal Medicine Faculty Patents

A catheter system and method of use for re-establishing venous access near an occluded vessel.


Pathways To Friendship - Building Friendships One Person At A Time: An Innovative Two-Year Project To Expand And Improve The Inclusion Of People With Idd, Christine J. Clifford, Jim Ross 2018 University of Massachusetts Medical School

Pathways To Friendship - Building Friendships One Person At A Time: An Innovative Two-Year Project To Expand And Improve The Inclusion Of People With Idd, Christine J. Clifford, Jim Ross

Eunice Kennedy Shriver Center Publications

For people with Intellectual and Developmental Disability (IDD), making friends and participating in the community can be a challenge. Pathways to Friendship (Pathways), is a collaboration between The Arc of Massachusetts (The Arc) and the Massachusetts Department of Developmental Services (DDS) with an evaluation component provided by The Center for Developmental Disabilities Evaluation and Research (CDDER). Pathways includes training and consultation to disability service organizations on approaches to improve community inclusion and establish friendships between people with and without IDD.


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