Substance Abuse and Addiction Commons^™

Effects Of Restraint Stress And Allopregnanolone Inhibition On Amphetamine Locomotor Sensitivity, Kelly Abuali, Laurel M. Pritchard

McNair Poster Presentations

The chronic, recurring nature of addiction remains a worldwide problem. Even after apparently successful clinical treatment and long term abstinence, individuals may still relapse many months or years later. Although many individual differences exist among substance abusers, relapse tends to occur during periods of high stress (Sinha et al., 2006). Behavioral training and therapy can help cope during these high stress times, but pharmacological interventions have not been shown to be effective (Ross & Peselow, 2009). Although some therapeutic options decrease relapse rates, more effective treatments for relapse need further consideration.

The effect of stress on use of and relapse …

A Good Enough Reason: Addiction, Agency And Criminal Responsibility, Stephen J. Morse

All Faculty Scholarship

The article begins by contrasting medical and moral views of addiction and how such views influence responsibility and policy analysis. It suggests that since addiction always involves action and action can always be morally evaluated, we must independently decide whether addicts do not meet responsibility criteria rather than begging the question and deciding by the label of ‘disease’ or ‘moral weakness’. It then turns to the criteria for criminal responsibility and shows that the criteria for criminal responsibility, like the criteria for addiction, are all folk psychological. Therefore, any scientific information about addiction must be ‘translated’ into the law’s folk …

Does The Use Of Varenicline For Smoking-Cessation Therapy Create Or Increase Depression In Patients Without Existing Depressive Illness?, Brett R. Brown

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not the use of varenicline for smoking-cessation therapy creates or increases depression in patients without existing depressive illness.

STUDY DESIGN: Review of two randomized controlled trials published in 2011 and one observational cohort study published in 2009, all English language.
DATA SOURCES: Two randomized, double-blind, controlled clinical trials comparing varenicline to placebo in smoking cessation, and one observational cohort study comparing varenicline use within subjects. All articles were found using PubMed and EBSCO.

OUTCOMES MEASURED: Changes in depression was evaluated using the MontgomeryÅsberg Depression Rating Scale …

Does Nicotine Replacement Therapy Reduce The Withdrawal Symptom Of Craving, Or Urge To Smoke, In Dependent Adult Smokers During Smoking Cessation?, Theresa Dijoseph

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not nicotine replacement therapy reduces the withdrawal symptom of craving, or urge to smoke, in dependent adult smokers during smoking cessation.

STUDY DESIGN: Systematic review of three English language and peer-reviewed randomized-controlled trials published in 2009, 2010, and 2011.

DATA SOURCES: One single-blinded randomized-controlled crossover trial, one double-blinded, placebo controlled, randomized-controlled crossover trial, and one single-blinded, placebo controlled, randomized-controlled crossover trial

OUTCOMES MEASURED: Withdrawal symptoms of craving, irritability, difficulty concentrating, and restlessness were measured on a 100mm visual analog scale (VAS). Adverse effects (AEs) of mouth and …

Methylphenidate And Atomoxetine Treatment During Adolescence In The Spontaneously Hypertensive Rat: Mechanisms Underlying High Cocaine Abuse Liability In Attention Deficit/Hyperactivity Disorder, Sucharita S. Somkuwar

Theses and Dissertations--Pharmacy

Effects of pharmacotherapies for Attention Deficit/Hyperactivity Disorder (ADHD) on cocaine abuse liability in ADHD are not understood. Spontaneously Hypertensive Rats (SHR), an ADHD model, exhibited greater cocaine self-administration than control Wistar-Kyoto and Wistar rats. Methylphenidate, but not atomoxetine during adolescence enhanced cocaine self-administration in adult SHRs compared to controls. The mesocortical dopaminergic system, including medial prefrontal (mPFC) and orbitofrontal (OFC) cortices, is important for ADHD and cocaine addiction. Dopamine and norepinephrine transporter (DAT and NET) are molecular targets for methylphenidate, atomoxetine and cocaine action.

In the current studies, SHR, Wistar-Kyoto and Wistar were administered methylphenidate (1.5 mg/kg/day, p.o.), atomoxetine (0.3 …

Preweanling Exposure To Selective Catecholamine Transporter Inhibitors Differentially Effects Morphine-Induced Antinociception In Adulthood, Joseph Marco Valentine

Theses Digitization Project

The purpose of this project is to determine how early methylphenidate exposure alters opioid receptor functioning in adulthood. To this end, we will administer selective monoamine transporter inhibitors for dopamine and norepinephrine (GBR-12904 and atomoxetine) during preweanling period and assess opioid function in adult rats by testing morphine-induced antinociception using the hot-plate and tail-flick tasks. In order to assess the effects of methylphenidate use on brain functions during development, investigations have been conducted in rats using ages roughly analogous to early and late childhood.

Social Workers' Perceptions Of Psychotropic Medication Use On Children And Adolescents In Foster Care, Tina Latrice Johnson Hollman, Dominic Marcus Ruffin

Theses Digitization Project

The purpose of this study was to evaluate the attitudes of social workers' regarding psychotropic medication use on children in foster care. This study also addressed any prospective concerns that social workers may have had as they relate to psychotropic medications being administered to children in foster care.

The Influences On Job Search Behaviors Among Convicted Felons With Substance Abuse Disorders, Anthony Raymond Saldana

Theses Digitization Project

This study examined job search intensity among felony-convicted, substance-abusing individuals who have been court mandated to attend community based treatment. Drug courts provide counseling and other services to help convicted felons become productive members of society. Studies show that if released prisoners become employed, they are less likely to return to prison.

Adolescent Substance Abuse Treatment: Does Family Systems Therapy Improve Family Functioning And Decrease Drug Use?, Darin J. Wallis

Electronic Theses and Dissertations

Family systems therapy is a way of working with individuals, couples, families, or a group of people that emphasizes relationships and a person's/family's greater "system" as important factors in establishing change and health (Haley, 1976; Minuchin, 1974). Treating adolescent substance abuse with family systems therapy has been demonstrated in the literature as being an effective method of intervention (Coatsworth, Santisteban, McBride, & Szapocznik, 2001; Kumfer & Alvarado, 2003; Leichtling, Gabriel, Lewis & Vander Ley, 2006; Liddle, 2002; Liddle et al., 2001; Rowe & Liddle, 2003), as the various ecological and epidemiological factors associated with adolescent substance abuse can be addressed …

Predictive Effects Of Good Self-Control And Poor Regulation On Alcohol-Related Outcomes: Do Protective Behavioral Strategies Mediate?, Matthew R. Pearson, Benjamin A. Kite, James M. Henson

Psychology Faculty Publications

In the present study, we examined whether use of protective behavioral strategies mediated the relationship between self-control constructs and alcohol-related outcomes. According to the two-mode model of self-control, good self-control (planfulness; measured with Future Time Perspective, Problem Solving, and Self-Reinforcement) and poor regulation (impulsivity; measured with Present Time Perspective, Poor Delay of Gratification, Distractibility) are theorized to be relatively independent constructs rather than opposite ends of a single continuum. The analytic sample consisted of 278 college student drinkers (68% women) who responded to a battery of surveys at a single time point. Using a structural equation model based on the …

Adolescent And Adult Nicotine Exposure On The Acquisition Of Methamphetamine Self-Administration And The Reinstatement Of Extinguished Methamphetamine-Seeking In Male Rats, Joseph Allan Pipkin

Theses Digitization Project

This study sought to determine the individual and combined contribution of adolescent and adult nicotine exposure on METH self-administration and METH-seeking behavior in male rats. Nicotine is a commonly abused substance among adolescents and is believed to be a "gateway" to other drugs of abuse. In support of the gateway hypothesis, cigarette smoking during adolescence is related to increased methamphetamine (METH) use in adulthood.

Papanicoloau Smear Uptake Among Substance-Using Mothers In Western Australia, Sadie Geraghty, Sara J. Bayes, Renate Mclaurin, Angela O'Connor

Research outputs 2013

Background: Papanicoloau (Pap) smear screening has helped to reduce cervical cancer rates significantly through the detection of premalignant cells (Bray et al, 2005). Uptake among women who use alcohol and other drugs (AOD) is known to be low (Chau et al, 2002) so they are at increased risk of being under-represented in the adequately screened population. AOD-using women experience disproportionately increased morbidity and mortality from cervical dysplasia and cancer (Nogara et al, 2013). Pregnancy may provide the midwife an opportunity to offer this vital screening test. Objective: The audit investigated Pap smear uptake and results among AOD-using pregnant women. Setting: …

Unplanned Drinking And Alcohol-Related Problems: A Preliminary Test Of The Model Of Unplanned Drinking Behavior, Matthew R. Pearson, James M. Henson

Psychology Faculty Publications

Much research links impulsivity with alcohol use and problems. In 2 studies, unplanned (or impulsive) drinking is assessed directly to determine whether it has direct effects on alcohol use and alcohol-related problems. In Study 1, we examined whether unplanned drinking serves as a proximal mediator of the effects of impulsivity-like traits on alcohol-related outcomes. With a sample of 211 college student drinkers, we found that the Unplanned Drinking Scale was significantly related to alcohol use, and perhaps more important, had a direct effect on alcohol-related problems even after controlling for frequency and quantity of alcohol use. Furthermore, unplanned drinking partially …

Internet-Based Photoaging Within Australian Pharmacies To Promote Smoking Cessation: Randomized Controlled Trial, Oksana Burford, Moyez Jiwa, Owen B. Carter, Richard Parsons, Delia Hendrie

Research outputs 2013

Background: Tobacco smoking leads to death or disability and a drain on national resources. The literature suggests that cigarette smoking continues to be a major modifiable risk factor for a variety of diseases and that smokers aged 18-30 years are relatively resistant to antismoking messages due to their widely held belief that they will not be lifelong smokers. Objective: To conduct a randomized controlled trial (RCT) of a computer-generated photoaging intervention to promote smoking cessation among young adult smokers within a community pharmacy setting. Methods: A trial was designed with 80% power based on the effect size observed in a …

A Brief Motivational Intervention For Heavy Alcohol Use In Dental Practice Settings: Rationale And Development, James A. Neff, Scott T. Walters, Abby L. Braitman, Michelle L. Kelley, Michele L. Darby, Margaret F. Lemaster

Psychology Faculty Publications

Although brief alcohol interventions have proven effective in a variety of health care settings, the present article describes the development of the first brief intervention for heavy drinkers in dental practice. Elements of motivational interviewing and personalized normative feedback were incorporated in a 3- to 5-minute intervention delivered by dental hygienists. The intervention is guided by a one-page feedback report providing personalized normative feedback regarding the patient's current oral health practices, their drinking in comparison to others, and oral cancer risk associated with current smoking and drinking. Future publications will present data regarding intervention effectiveness from an ongoing randomized trial.

Prevalence Of Hiv, Hepatitis B And C, And Co-Infection In A Cohort Of Male Injection Drug Users In Delhi, Lopamudra Saraswati, Mary Philip Sebastian, Avina Sarna, Vartika Sharma, Ira Madan, Dean Lewis, Ibou Thior, Waimar Tun

HIV and AIDS

India has a large injection drug user (IDU) population estimated at 177,000 nationally with an HIV prevalence of 7.2 percent. Historically, the presence of IDU populations and associated HIV infection was concentrated in the northeastern states of the country. Recent evidence documents IDU populations in other parts of the country. Delhi has an estimated 17,000 IDUs and the second highest HIV prevalence in India at 18.3 percent. The probability of becoming infected with HIV after using an infected syringe ranges from 0.34 percent to 1.4 percent. By comparison, the risk for hepatitis C (HCV) ranges from 1.5 percent to 5 …

Nurse Practitioner Knowledge Of Urine Drug Testing, Jessica L. Estes

DNP Projects

This DNP Capstone seeks to the review the literature surrounding provider knowledge of urine drug testing, evaluate the use of psychiatric mental health nurse practitioners as treating professionals, and to investigate the knowledge of current nurse practitioners related to urine drug testing.

Personality And Substance Abuse, Juliana Gonzalez

Masters Theses

The Big Five have shown to be distinct personality traits that do not overlap and have universal applicability, so this study examined whether there are specific personality trait differences in users of Marijuana, Pain Medication, Sedative/Hypnotics, and Stimulants.

Study was placed in the 50 most visited Craigslist pages in the United States. Anonymous web users (N = 547) were recruited through Craigslist. High Neuroticism was associated with Marijuana and Stimulant use. Low Conscientiousness was associated with Marijuana and Stimulant use. High Extraversion was associated with Pain Medication use only. Implications, limitations, and suggestions for future research were discussed.

Predictors Of Smoking Behavior And Readiness To Quit In Addiction Treatment, Arturo Soto-Nevarez, Joseph Guydish

McNair Poster Presentations

Background: Prevalence of tobacco use is 3 times higher for those seeking substance abuse treatment than those in the general population. Clinical practice guidelines recommend addressing smoking cessation. This population has more difficulty quitting than the general population. Methods: This paper analyzes predictors of smoking behavior and readiness to quit in patients enrolled in addiction treatment programs. Data from six substance abuse treatment centers was collected. A total of 235 clients were surveyed on their smoking attitudes and behaviors. Results: Survey data from 139 current smokers was analyzed. In logistic regression analyses predicting readiness to quit smoking, and controlling for …

Alcohol Use And Trauma Exposure Among Male And Female Veterans Before, During, And After Military Service, Michelle L. Kelley, Jennifer Runnals, Matthew R. Pearson, Marinell Miller, John A. Fairbank, Va Mid-Atlantic Mirecc Women Veterans Workgroup

Psychology Faculty Publications

Background: The present study examined lifespan and combat-related trauma exposure as predictors of alcohol use among male and female veterans. Posttraumatic stress and depressive symptoms were examined as mediators of the effects of trauma exposure on alcohol use.

Methods: Data were examined from 1825 (1450 male, 375 female) veterans and active duty service members who took part in a multi-site research study conducted through the Department of Veterans Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center (VISN 6 MIRECC).

Results: For both men and women, depressive symptoms significantly mediated the effects of non-combat trauma exposure experienced before, during and …