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Multiple Unerupted And Supernumerary Teeth In A Patient With Cleidocranial Dysplasia, Galal Omami 2018 University of Kentucky

Multiple Unerupted And Supernumerary Teeth In A Patient With Cleidocranial Dysplasia, Galal Omami

Oral Health Practice Faculty Publications

Cleidocranial dysplasia is an extremely rare familial disorder characterized by partial or complete absence of clavicles, characteristic craniofacial deformities, and the presence of numerous supernumerary and unerupted teeth. Here, the author reviews the striking radiographic findings of cleidocranial dysplasia in a 16-year-old adolescent boy who presented with delayed teeth eruption.


Deep Gaze Velocity Analysis During Mammographic Reading For Biometric Identification Of Radiologists, Hong-Jun Yoon, Folami Alamudun, Kathy Hudson, Garnetta Morin-Ducote, Georgia Tourassi 2018 Biomedical Sciences, Engineering, and Computing Group Health Data Sciences Institute, Oak Ridge National Laboratory

Deep Gaze Velocity Analysis During Mammographic Reading For Biometric Identification Of Radiologists, Hong-Jun Yoon, Folami Alamudun, Kathy Hudson, Garnetta Morin-Ducote, Georgia Tourassi

Journal of Human Performance in Extreme Environments

Several studies have confirmed that the gaze velocity of the human eye can be utilized as a behavioral biometric or personalized biomarker. In this study, we leverage the local feature representation capacity of convolutional neural networks (CNNs) for eye gaze velocity analysis as the basis for biometric identification of radiologists performing breast cancer screening. Using gaze data collected from 10 radiologists reading 100 mammograms of various diagnoses, we compared the performance of a CNN-based classification algorithm with two deep learning classifiers, deep neural network and deep belief network, and a previously presented hidden Markov model classifier. The study showed that ...


Mammographic Breast Density And Breast Cancer Molecular Subtypes: The Kenyan-African Aspect, Asim Jamal, Maeve Mullooly, Shahin Sayed, Rose Ndumia, Innocent Abayo, James Orwa, Ronald Wasike, Zahir Moloo, Gretchen L. Gierach 2018 Aga Khan University

Mammographic Breast Density And Breast Cancer Molecular Subtypes: The Kenyan-African Aspect, Asim Jamal, Maeve Mullooly, Shahin Sayed, Rose Ndumia, Innocent Abayo, James Orwa, Ronald Wasike, Zahir Moloo, Gretchen L. Gierach

Internal Medicine, East Africa

Introduction: Data examiningmammographic breast density (MBD) among patients in Sub-Saharan Africa are sparse.We evaluated how MBD relates to breast cancer characteristics in Kenyan women undergoing diagnostic mammography.

Methods: This crosssectional study included women with pathologically confirmed breast cancers (𝑛 = 123). Pretreatment mammograms of the unaffectedbreast were assessed to estimate absolute dense area (cm2), nondense area (cm2), and percent density (PD). Relationships between density measurements and clinical characteristics were evaluated using analysis of covariance.

Results: Median PD and dense area were 24.9% and 85.3 cm2. Higher PD and dense area were observed in younger women (𝑃 < 0.01). Higher dense and nondense areas were observed in obese women (𝑃-trend < 0.01). Estrogen receptor (ER) positive patients (73%) had higher PD and dense area than ER-negative patients (𝑃 ≤ 0.02). Triple negative breast cancer (TNBC) patients (17%) had lower PD and dense area (𝑃 ≤ 0.01) compared with non-TNBCs. No associations were observed between MBD and tumor size and grade.

Conclusions: Our ...


Superoxide Dismutase Mimetic Gc4419 Enhances The Oxidation Of Pharmacological Ascorbate And Its Anticancer Effects In An H₂O₂-Dependent Manner, Collin D Heer, Andrew B Davis, David R Riffe, Kelly C Falls, Bryan G Allen, Garry R Buettner, Robert A Beadsley, Dennis P Riley, Dougles P Spitz 2018 University of Iowa

Superoxide Dismutase Mimetic Gc4419 Enhances The Oxidation Of Pharmacological Ascorbate And Its Anticancer Effects In An H₂O₂-Dependent Manner, Collin D Heer, Andrew B Davis, David R Riffe, Kelly C Falls, Bryan G Allen, Garry R Buettner, Robert A Beadsley, Dennis P Riley, Dougles P Spitz

Department of Radiation Oncology Publications

Lung cancer, together with head and neck cancer, accounts for more than one-fourth of cancer deaths worldwide. New, non-toxic therapeutic approaches are needed. High-dose IV vitamin C (aka, pharmacological ascorbate; P-AscH) represents a promising adjuvant to radiochemotherapy that exerts its anti-cancer effects via metal-catalyzed oxidation to form H2O2. Mn(III)-porphyrins possessing superoxide dismutase (SOD) mimetic activity have been shown to increase the rate of oxidation of AscH, enhancing the anti-tumor effects of AscH in several cancer types. The current study demonstrates that the Mn(II)-containing pentaazamacrocyclic selective SOD mimetic GC4419 may serve as an AscH ...


Pilot Study To Assess Visualization And Therapy Of Inflammatory Mechanisms After Vessel Reopening In A Mouse Stroke Model, Ebba Beller, Laura Reuter, Anne Kluge, Christine Preibisch, Ute Lindauer, Alexei A. Bogdanov Jr., Friederike Lammer, Claire Delbridge, Kaspar Matiasek, Benedikt J. Schwaiger, Tobias Boeckh-Behrens, Claus Zimmer, Alexandra S. Gersing 2018 Klinikum rechts der Isar der Technischen Universität München

Pilot Study To Assess Visualization And Therapy Of Inflammatory Mechanisms After Vessel Reopening In A Mouse Stroke Model, Ebba Beller, Laura Reuter, Anne Kluge, Christine Preibisch, Ute Lindauer, Alexei A. Bogdanov Jr., Friederike Lammer, Claire Delbridge, Kaspar Matiasek, Benedikt J. Schwaiger, Tobias Boeckh-Behrens, Claus Zimmer, Alexandra S. Gersing

Radiology Publications and Presentations

After reperfusion therapy in stroke patients secondary inflammatory processes may increase cerebral damage. In this pilot study, effects of anti-inflammatory therapy were assessed in a middle cerebral artery occlusion (MCAO) mouse model after reperfusion. 1 hour after MCAO, the artery was reopened and tacrolimus or NaCl were administered intra-arterially. Perfusion-weighted (PWI) and diffusion-weighted images (DWI) were obtained by MRI during MCAO. DWI, T2- and T1-weighted images with and without Bis-5HT-DTPA administration were obtained 24 hours after MCAO. Neutrophils, Myeloperoxidase-positive-(MPO+)-cells and microglia, including M1 and M2 phenotypes, were assessed immunohistochemically. Treatment with tacrolimus led to significantly smaller apparent diffusion ...


Similarity Of Chest X-Ray And Thermal Imaging Of Focal Pneumonia: A Randomised Proof Of Concept Study At A Large Urban Teaching Hospital, Linda T. Wang, Robert H. Cleveland, William Binder, Robert G. Zwerdling, Caterina Stamoulis, Thomas Ptak, Mindy Sherman, Kenan Haver, Pallavi Sagar, Patricia Hibberd 2018 Massachusetts General Hospital

Similarity Of Chest X-Ray And Thermal Imaging Of Focal Pneumonia: A Randomised Proof Of Concept Study At A Large Urban Teaching Hospital, Linda T. Wang, Robert H. Cleveland, William Binder, Robert G. Zwerdling, Caterina Stamoulis, Thomas Ptak, Mindy Sherman, Kenan Haver, Pallavi Sagar, Patricia Hibberd

Open Access Articles

OBJECTIVE: To assess the diagnostic accuracy of thermal imaging (TI) in the setting of focal consolidative pneumonia with chest X-ray (CXR) as the gold standard.

SETTING: A large, 973-bed teaching hospital in Boston, Massachusetts.

PARTICIPANTS: 47 patients enrolled, 15 in a training set, 32 in a test set. Age range 10 months to 82 years (median=50 years).

MATERIALS AND METHODS: Subjects received CXR with subsequent TI within 4 hours of each other. CXR and TI were assessed in blinded random order. Presence of focal opacity (pneumonia) on CXR, the outcome parameter, was recorded. For TI, presence of area(s ...


Non-Ionic Iodinated Contrast-Induced Sialadenitis With Parotid Gland Sparing In Patient Of Hepatocellular Carcinoma, Muhammad Azeemuddin, Mustafa Belal Hafeez Chaudhry, Jehanzeb Shahid, Sarosh Zafar Belal 2018 Aga Khan University

Non-Ionic Iodinated Contrast-Induced Sialadenitis With Parotid Gland Sparing In Patient Of Hepatocellular Carcinoma, Muhammad Azeemuddin, Mustafa Belal Hafeez Chaudhry, Jehanzeb Shahid, Sarosh Zafar Belal

Department of Radiology

61-years-old male patient presented with complain of neck swelling and soreness following contrast-enhanced (CE) CT examination with resolution of symptoms in 36-48 hours. He is diagnosed with hepatitis C virus and hepatocellular carcinoma (HCC); already treated with radiofrequency ablation for HCC. He had already undergone two CECT examinations before he was referred to our institution for disease staging/treatment. He also underwent three triphasic CT scan examinations at our institution during the course of treatment for treatment response and staging. Patient remained undiagnosed up to his fourth CT scan due to inability to relate symptoms with contrast administration. The patient ...


Advances In Dual-Energy Computed Tomography Imaging Of Radiological Properties, Dong Han 2018 Virginia Commonwealth University

Advances In Dual-Energy Computed Tomography Imaging Of Radiological Properties, Dong Han

Theses and Dissertations

Dual-energy computed tomography (DECT) has shown great potential in the reduction of uncertainties of proton ranges and low energy photon cross section estimation used in radiation therapy planning. The work presented herein investigated three contributions for advancing DECT applications. 1) A linear and separable two-parameter DECT, the basis vector model (BVM) was used to estimate proton stopping power. Compared to other nonlinear two-parameter models in the literature, the BVM model shows a comparable accuracy achieved for typical human tissues. This model outperforms other nonlinear models in estimations of linear attenuation coefficients. This is the first study to clearly illustrate the ...


Pituitary Stalk Interruption Syndrome Presenting In A Euthyroid Adult With Short Stature, Atif Nawaz, Muhammad Azeemuddin, Jehanzeb Shahid 2018 Aga Khan University

Pituitary Stalk Interruption Syndrome Presenting In A Euthyroid Adult With Short Stature, Atif Nawaz, Muhammad Azeemuddin, Jehanzeb Shahid

Department of Radiology

Pituitary stalk interruption syndrome (PSIS) is a distinct and rare clinical entity responsible for congenital hypopituitarism resulting in deficiency of pituitary hormones with deficiency of the growth hormone (100%) and gonadotropins (97.2%) being its most common presentation at the time of hospital encounter (Wang et al., 2015). Isolated sparing of thyroid-stimulating hormone (TSH) with deficiency of the remaining anterior pituitary hormones may be present in PSIS, as is true in our case. Therefore, it should be kept in mind at the time of examination in suspected cases of PSIS.


Estimating The Respiratory Lung Motion Model Using Tensor Decomposition On Displacement Vector Field, Kingston Kang 2018 VCU

Estimating The Respiratory Lung Motion Model Using Tensor Decomposition On Displacement Vector Field, Kingston Kang

Theses and Dissertations

Modern big data often emerge as tensors. Standard statistical methods are inadequate to deal with datasets of large volume, high dimensionality, and complex structure. Therefore, it is important to develop algorithms such as low-rank tensor decomposition for data compression, dimensionality reduction, and approximation.

With the advancement in technology, high-dimensional images are becoming ubiquitous in the medical field. In lung radiation therapy, the respiratory motion of the lung introduces variabilities during treatment as the tumor inside the lung is moving, which brings challenges to the precise delivery of radiation to the tumor. Several approaches to quantifying this uncertainty propose using a ...


A Rare Case Of Presacral Epidermoid Cyst In An Adult Male: Emphasis On Diffusion Weighted Magnetic Resonance Sequences In Preoperative Imaging., Muhammad I. Alvi, Fatima Mubarak, Kumail Khandwala, Muhammad Nanish Barakzai, Aisha Memon 2018 Aga Khan University

A Rare Case Of Presacral Epidermoid Cyst In An Adult Male: Emphasis On Diffusion Weighted Magnetic Resonance Sequences In Preoperative Imaging., Muhammad I. Alvi, Fatima Mubarak, Kumail Khandwala, Muhammad Nanish Barakzai, Aisha Memon

Department of Radiology

Epidermoid cyst of the presacral space is a rare congenital lesion of ectodermal origin. Presacral epidermoid cysts have been previously reported in women, however are extremely rare in males. We report a case of presacral epidermoid cyst in a 55-year-old male who presented to our emergency department with acute urinary retention and history of chronic constipation. A non-contrast computed tomography scan was performed with suspicion of urolithiasis, which revealed a well circumscribed low attenuation presacral mass. Magnetic resonance imaging (MRI) of the pelvis was subsequently performed to further characterize the lesion. The mass was returning hypointense T1 and hyperintense T2 ...


Virtual Reality For The Characterization Of Blood Vessel To Airway Geometric Relationships, Mostafa Abdelraouf 2018 University of Iowa

Virtual Reality For The Characterization Of Blood Vessel To Airway Geometric Relationships, Mostafa Abdelraouf

Theses and Dissertations

An increase in the cross-sectional area (CSA) of the pulmonary arteries has been implicated in the progression of emphysema in COPD patients. Standardization of vessel size requires matching segments of the airway with their corresponding blood vessels. Automated matching is still error-prone, and manual matching by sifting through 2D slices is tedious and time-consuming. We propose a virtual reality (VR) system for the visualization of the airway and the vascular tree as a means of streamlining the verification of appropriate airway/vascular segment pairs selected for quantitation of arterial CSAs. In this work, we outline the technical specifications and design ...


Endoscopic Proximal Adductor Lengthening For Chronic Adductor-Related Groin Pain, S. Bharam, P. V. Bhagat, M. C. Spira, D. A. Klein 2018 Zucker School of Medicine at Hofstra/Northwell

Endoscopic Proximal Adductor Lengthening For Chronic Adductor-Related Groin Pain, S. Bharam, P. V. Bhagat, M. C. Spira, D. A. Klein

Journal Articles

© 2018 Arthroscopy Association of North America Proximal adductor injuries are relatively common groin injuries in athletes. Various tenotomy techniques have been described including open, partial, and percutaneous approaches. Current techniques help most athletes return to sport; however, many develop adductor weakness. Moreover, the procedures lack full visualization of the tendon and do not allow for return to athletes’ preinjury level of play. We describe an endoscopic z-lengthening of the proximal adductor tendon with the potential to minimize complications associated with open procedures such as incisional pain and neurovascular injury while affording a more complete tenotomy than current percutaneous techniques. This ...


Acute Pulmonary Embolism: Endovascular Therapy, S. P. Reis, K. Zhao, N. Ahmad, R. S. Widemon, C. W. Root, S. M. Toomay, J. M. Horowitz, A. K. Sista 2018 Zucker School of Medicine at Hofstra/Northwell

Acute Pulmonary Embolism: Endovascular Therapy, S. P. Reis, K. Zhao, N. Ahmad, R. S. Widemon, C. W. Root, S. M. Toomay, J. M. Horowitz, A. K. Sista

Journal Articles

© Cardiovascular Diagnosis and Therapy. All rights reserved. Pulmonary embolism (PE) is a leading cause of morbidity and mortality worldwide. PE is a complex disease with a highly variable presentation and the available treatment options for PE are expanding rapidly. Anticoagulation (AC), systemic lysis, surgery, and catheter-directed thrombolysis (CDT) play important roles in treating patients with PE. Thus, a multidisciplinary approach to diagnosis, risk stratification, and therapy is required to determine which treatment option is best for a given patient with this complex disease.


Cost-Effectiveness Of Magnetic Resonance Imaging In Cervical Clearance Of Obtunded Blunt Trauma After A Normal Computed Tomographic Finding, X. Wu, A. Malhotra, B. Geng, V. B. Kalra, K. Abbed, H. P. Forman, P. Sanelli 2018 Zucker School of Medicine at Hofstra/Northwell

Cost-Effectiveness Of Magnetic Resonance Imaging In Cervical Clearance Of Obtunded Blunt Trauma After A Normal Computed Tomographic Finding, X. Wu, A. Malhotra, B. Geng, V. B. Kalra, K. Abbed, H. P. Forman, P. Sanelli

Journal Articles

© 2018 American Medical Association. All rights reserved. IMPORTANCE Magnetic resonance imaging (MRI) continues to be performed for cervical clearance of obtunded blunt trauma, despite poor evidence regarding its utility after a normal computed tomographic (CT) finding. OBJECTIVE To evaluate the utility and cost-effectiveness of MRI vs no follow-up after a normal cervical CT finding in patients with obtunded blunt trauma. DESIGN, SETTING AND PARTICIPANTS This cost-effectiveness analysis evaluated an average patient aged 40 years with blunt trauma from an institutional practice. The analysis used a Markov decision model over a lifetime horizon from a societal perspective with variables from systematic ...


Management Of Tiny Unruptured Intracranial Aneurysms: A Comparative Effectiveness Analysis, A. Malhotra, X. Wu, H. P. Forman, C. C. Matouk, D. Gandhi, P. Sanelli 2018 Zucker School of Medicine at Hofstra/Northwell

Management Of Tiny Unruptured Intracranial Aneurysms: A Comparative Effectiveness Analysis, A. Malhotra, X. Wu, H. P. Forman, C. C. Matouk, D. Gandhi, P. Sanelli

Journal Articles

© 2017 American Medical Association. All rights reserved. Importance: Unruptured intracranial aneurysms (UIAs) are relatively common in the general population and are being increasingly diagnosed; a significant proportion are tiny (≤3 mm) aneurysms. There is significant heterogeneity in practice and lack of clear guidelines on the management of incidental, tiny UIAs. It is important to quantify the implications of different management strategies in terms of health benefits to patients. Objective: To evaluate the effectiveness of routine treatment (aneurysm coiling) vs 3 strategies for imaging surveillance compared with no preventive treatment or routine follow-up of tiny UIAs. Design, Setting, and Participants: A ...


Nuclear Medicine Imaging In Fever Of Unknown Origin: The New Paradigm, C. J. Palestro, C. Love 2018 Zucker School of Medicine at Hofstra/Northwell

Nuclear Medicine Imaging In Fever Of Unknown Origin: The New Paradigm, C. J. Palestro, C. Love

Journal Articles

No abstract provided.


Hybrid 3d/2d Convolutional Neural Network For Hemorrhage Evaluation On Head Ct, P. D. Chang, E. Kuoy, J. Grinband, B. D. Weinberg, M. Thompson, R. Homo, J. Chen, H. Abcede, C. G. Filippi, D. Chow, +5 additional authors 2018 Zucker School of Medicine at Hofstra/Northwell

Hybrid 3d/2d Convolutional Neural Network For Hemorrhage Evaluation On Head Ct, P. D. Chang, E. Kuoy, J. Grinband, B. D. Weinberg, M. Thompson, R. Homo, J. Chen, H. Abcede, C. G. Filippi, D. Chow, +5 Additional Authors

Journal Articles

No abstract provided.


Assessment Of The Albumin-Bilirubin (Albi) Grade As A Prognostic Indicator For Hepatocellular Carcinoma Patients Treated With Radioembolization., B. Gui, A. A. Weiner, J. Nosher, S. E. Lu, G. M. Foltz, O. Hasan, S. K. Kim, V. Gendel, N. B. Mani, S. K. Jabbour, +6 additional authors 2018 Zucker School of Medicine at Hofstra/Northwell

Assessment Of The Albumin-Bilirubin (Albi) Grade As A Prognostic Indicator For Hepatocellular Carcinoma Patients Treated With Radioembolization., B. Gui, A. A. Weiner, J. Nosher, S. E. Lu, G. M. Foltz, O. Hasan, S. K. Kim, V. Gendel, N. B. Mani, S. K. Jabbour, +6 Additional Authors

Journal Articles

OBJECTIVE: As the utility of Child-Pugh (C-P) class is limited by the subjectivity of ascites and encephalopathy, we evaluated a previously established objective method, the albumin-bilirubin (ALBI) grade, as a prognosticator for yttrium-90 radioembolization (RE) treatment for patients with hepatocellular carcinoma (HCC).

MATERIALS AND METHODS: A total of 117 patients who received RE for HCC from 2 academic centers were reviewed and stratified by ALBI grade, C-P class, and Barcelona Clinic Liver Cancer stage. The overall survival (OS) according to these 3 criteria was evaluated by Kaplan-Meier survival analysis. The utilities of C-P class and ALBI grade as prognostic indicators ...


Neuroimaging Of Meckel’S Cave In Normal And Disease Conditions, A. Malhotra, L. Tu, V. B. Kalra, X. Wu, A. Mian, R. Mangla, E. Michaelides, P. Sanelli, D. Gandhi 2018 Zucker School of Medicine at Hofstra/Northwell

Neuroimaging Of Meckel’S Cave In Normal And Disease Conditions, A. Malhotra, L. Tu, V. B. Kalra, X. Wu, A. Mian, R. Mangla, E. Michaelides, P. Sanelli, D. Gandhi

Journal Articles

© 2018, The Author(s). Abstract: Meckel’s cave is a dural recess in the posteromedial portion of the middle cranial fossa that acts as a conduit for the trigeminal nerve between the prepontine cistern and the cavernous sinus, and houses the Gasserian ganglion and proximal rootlets of the trigeminal nerve. It serves as a major pathway in perineural spread of pathologies such as head and neck neoplasms, automatically upstaging tumours, and is a key structure to assess in cases of trigeminal neuralgia. The purpose of this pictorial review is threefold: (1) to review the normal anatomy of Meckel’s cave ...


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