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Hyperammonemic Encephalopathy With Triphasic Waves: A Case, Brian Birdsong MD, Brielle Marks MD, Rishim Jayswal MD, Adeel Rahman 2020 HCA Healthcare

Hyperammonemic Encephalopathy With Triphasic Waves: A Case, Brian Birdsong Md, Brielle Marks Md, Rishim Jayswal Md, Adeel Rahman

Psychiatry

No abstract provided.


Famille+: A Multifamily Group Program For Families With Parental Depression, Genevieve Piche, Aude Villatte, Rima Habib, Kelly Vetri, William Beardslee 2020 Universite du Quebec en Outaouais

Famille+: A Multifamily Group Program For Families With Parental Depression, Genevieve Piche, Aude Villatte, Rima Habib, Kelly Vetri, William Beardslee

Journal of Parent and Family Mental Health

Children living with a parent with a depressive disorder are at higher risk for low adaptive functioning, in terms of social, academic, emotional, and mental health problems (Reupert, Maybery & Kowalenko, 2012).This brief describes FAMILLE+, a multifamily group program for parents with major depressive disorder and their 7 to 11 years old children. Its purpose is to prevent the development of mental health problems in children and to promote family resilience and was specifically adapted to fit the children's developmental (cognitive, attentional and socio-emotional) abilities.


A Phantom Of The Past: Withdrawal From Meprobamate Presenting With Focal Seizures., Thomas M. Zink, John E. Erickson 2020 Tufts University School of Medicine; Maine Medical Center

A Phantom Of The Past: Withdrawal From Meprobamate Presenting With Focal Seizures., Thomas M. Zink, John E. Erickson

Journal of Maine Medical Center

Introduction: Meprobamate (Miltown, Equinil) is a sedative-hypnotic medication that first gained popularity as an anxiolytic and later as a muscle relaxant. It is a major metabolite of the more commonly used muscle relaxant carisoprodol (Soma). In vitro and electroencephalogram studies demonstrated that meprobamate modulates gama-aminobutyric acid (GABA) receptors, similar to barbiturates. Withdrawal from meprobamate manifests in symptoms ranging from mild anxiety to severe autonomic instability and death. Meprobamate is rarely prescribed, but is still given to a small subset of elderly patients.

Clinical findings: In this case of meprobamate withdrawal, the patient initially displayed altered mental status and recurrent seizures ...


Comparing Sensitivity To Change Using The 6-Item Versus The 17-Item Hamilton Depression Rating Scale In The Guided Randomized Controlled Trial, Boadie W. Dunlop, Sagar V. Parikh, Anthony J. Rothschild, Michael E. Thase, Charles DeBattista, Charles R. Conway, Brent P. Forester, Francis M. Mondimore, Richard C. Shelton, Matthew Macaluso, Jennifer Logan, Paul Traxler, James Li, Holly Johnson, John F. Greden 2019 Emory University

Comparing Sensitivity To Change Using The 6-Item Versus The 17-Item Hamilton Depression Rating Scale In The Guided Randomized Controlled Trial, Boadie W. Dunlop, Sagar V. Parikh, Anthony J. Rothschild, Michael E. Thase, Charles Debattista, Charles R. Conway, Brent P. Forester, Francis M. Mondimore, Richard C. Shelton, Matthew Macaluso, Jennifer Logan, Paul Traxler, James Li, Holly Johnson, John F. Greden

Open Access Articles

BACKGROUND: Previous research suggests that the 17-item Hamilton Depression Rating Scale (HAM-D17) is less sensitive in detecting differences between active treatment and placebo for major depressive disorder (MDD) than is the HAM-D6 scale, which focuses on six core depression symptoms. Whether HAM-D6 shows greater sensitivity when comparing two active MDD treatment arms is unknown.

METHODS: This post hoc analysis used data from the intent-to-treat (ITT) cohort (N = 1541) of the Genomics Used to Improve DEpression Decisions (GUIDED) trial, a rater- and patient-blinded randomized controlled trial. GUIDED compared combinatorial pharmacogenomics-guided care with treatment as usual (TAU) in patients with MDD. Percent ...


Improving Access To Mental Health Care With Nurse Practitioners, Jessica Whelan 2019 University of Missouri-St. Louis

Improving Access To Mental Health Care With Nurse Practitioners, Jessica Whelan

Dissertations

Problem: Over 40% of those with mental illness are untreated since the supply of psychiatrists does not meet the demand. The psychiatric mental health nurse practitioner (PMHNP) may be an adjunct in providing those services. The purpose of this quality assurance study was to evaluate outcomes of care between a PMHNP and a psychiatrist (medical doctor [MD]).

Methods: An observational, descriptive design with a retrospective medical record review of adult patients over a six-month period in a suburban, Midwestern, privately owned psychiatric practice.

Results: A total of 787 individual patients encountered at least one visit (N=787) although 3,679 ...


Acute Diagnosis Of Wilson’S Disease In A Teenage Patient, Sarah Irvin, Ryan McCarthy 2019 West Virginia University School of Medicine

Acute Diagnosis Of Wilson’S Disease In A Teenage Patient, Sarah Irvin, Ryan Mccarthy

Marshall Journal of Medicine

Wilson’s Disease, a rare autosomal recessive genetic disease, is caused by a mutation in the ATP7B enzyme gene. Without this enzyme, copper builds up in the brain, liver, and cornea causing a multitude of symptoms. It is important to consider Wilson’s disease because the prognosis is dependent on timely diagnosis. This is an interesting case of a 19-year-old male who presented with suicidal thoughts and rapid weight loss. After many months and an extensive work-up, Wilson’s Disease was diagnosed. Due to his rapid decline, he was transferred to a larger university healthcare center where he is currently ...


Chromatin Profiling Of Cortical Neurons Identifies Individual Epigenetic Signatures In Schizophrenia, Fedor E. Gusev, Denis A. Reshetov, Amanda C. Mitchell, Tatiana V. Andreeva, Aslihan Dincer, Anastasia P. Grigorenko, Gennady Fedonin, Tobias Halene, Maria Aliseychik, Elena Filippova, Zhiping Weng, Schahram Akbarian, Evgeny I. Rogaev 2019 Russian Academy of Sciences

Chromatin Profiling Of Cortical Neurons Identifies Individual Epigenetic Signatures In Schizophrenia, Fedor E. Gusev, Denis A. Reshetov, Amanda C. Mitchell, Tatiana V. Andreeva, Aslihan Dincer, Anastasia P. Grigorenko, Gennady Fedonin, Tobias Halene, Maria Aliseychik, Elena Filippova, Zhiping Weng, Schahram Akbarian, Evgeny I. Rogaev

Open Access Articles

Both heritability and environment contribute to risk for schizophrenia. However, the molecular mechanisms of interactions between genetic and non-genetic factors remain unclear. Epigenetic regulation of neuronal genome may be a presumable mechanism in pathogenesis of schizophrenia. Here, we performed analysis of open chromatin landscape of gene promoters in prefrontal cortical (PFC) neurons from schizophrenic patients. We cataloged cell-type-based epigenetic signals of transcriptional start sites (TSS) marked by histone H3-K4 trimethylation (H3K4me3) across the genome in PFC from multiple schizophrenia subjects and age-matched control individuals. One of the top-ranked chromatin alterations was found in the major histocompatibility (MHC) locus on chromosome ...


Lars-Like Symptoms In The General Population May Suggest The Significance Of Postoperative Functional Problems And Emotional Implications Of Rectal Surgery, Tudor-Cristian Frunza, Sorinel Lunca, Iustina Baciu, Iulia Axinia, Cezar V. Mocanu, Andreea Crudu, Narcis Bujor, Lucia F. Livenschi, Claudiu A. Nicolaiev, Andreea Hulubencu, Anca Diaconu, Emilia Valasciu, Ioana Jalobceastai, Malina Tibirna, Mihail G. Dimofte 2019 Valparaiso University

Lars-Like Symptoms In The General Population May Suggest The Significance Of Postoperative Functional Problems And Emotional Implications Of Rectal Surgery, Tudor-Cristian Frunza, Sorinel Lunca, Iustina Baciu, Iulia Axinia, Cezar V. Mocanu, Andreea Crudu, Narcis Bujor, Lucia F. Livenschi, Claudiu A. Nicolaiev, Andreea Hulubencu, Anca Diaconu, Emilia Valasciu, Ioana Jalobceastai, Malina Tibirna, Mihail G. Dimofte

Journal of Mind and Medical Sciences

Background & Aim. Sphincter-saving rectal surgery is prone to cause changes in bowel function associated with Low Anterior Resection Syndrome (LARS). Our aim was to assess LARS-like symptoms within a population of 50-80-year old in order to understand the functional disturbances and emotional impact of LARS. Materials and methods: We used a questionnaire to evaluate LARS with the following categories of symptoms: flatulence control, anal incontinence, frequency, clustering and urgency of the stools, and the psycho-emotional impact created by the presence of these symptoms. We calculated the severity of LARS on 343 responders. Results. The average age of the responders (57 ...


Review Of The Effects Of Anesthetic Agents Used As Premedication For Patients Undergoing Electroconvulsive Therapy With Diagnoses Of Bipolar Disorder Or Major Depression On Convulsion, Recovery Period, And Hemodynamic Parameters, Volkan Ozen, Mehmet Emin Orhan 2019 Valparaiso University

Review Of The Effects Of Anesthetic Agents Used As Premedication For Patients Undergoing Electroconvulsive Therapy With Diagnoses Of Bipolar Disorder Or Major Depression On Convulsion, Recovery Period, And Hemodynamic Parameters, Volkan Ozen, Mehmet Emin Orhan

Journal of Mind and Medical Sciences

Objective: The aim of this study was to examine the effects of anesthetic agents used as premedication in patients undergoing electroconvulsive therapy (ECT) for diagnoses of bipolar disorder or major depression in terms of convulsion, recovery period, and hemodynamic parameters. Materials and Method: This retrospective study was carried out by screening the anesthesia forms of patients in a psychiatry clinic in Turkey. Results: Researchers reviewed 104 patient files, of which 39 fit the inclusion criteria. 26 patients were given premedication; 13 patients were not given premedication. The study found a significant difference between the group to which dexmedetomidine was given ...


Experimental Pharmacological Research Regarding The Antidepressant Effect Of Associating Doxepin And Selegiline In Normal Mice, Cornel Chiriță, Emil Ștefănescu, Cristina E. Zbârcea, Horațiu Mireșan, Simona Negreș, Diana C. Nuță, Carmen Limban, Rucsandra E. Dănciulescu Miulescu, Cristina D. Marineci 2019 Valparaiso University

Experimental Pharmacological Research Regarding The Antidepressant Effect Of Associating Doxepin And Selegiline In Normal Mice, Cornel Chiriță, Emil Ștefănescu, Cristina E. Zbârcea, Horațiu Mireșan, Simona Negreș, Diana C. Nuță, Carmen Limban, Rucsandra E. Dănciulescu Miulescu, Cristina D. Marineci

Journal of Mind and Medical Sciences

The severity and complexity of depression can vary widely among individuals, thus making single drug therapy ineffective in some cases. Taking this fact into account and using a mouse model, we set on investigating the possibility of obtaining a synergism of action between a classical tricyclic antidepressant that inhibits noradrenalin and serotonin reuptake (doxepin), and a modern antidepressant that inhibits type-B monoamine oxidase (selegiline). We measured the antidepressant effect using the forced swimming test and the tail suspension test. We determined motor activity using the Activity Cage test. Our results have shown that the antidepressant effect intensifies significantly in the ...


The Effects Of Stimulants On Eating Patterns In Children And Adolescents With Attention Deficit Hyperactivity Disorder, Serkan Turan, Aynur Pekcanlar Akay 2019 Valparaiso University

The Effects Of Stimulants On Eating Patterns In Children And Adolescents With Attention Deficit Hyperactivity Disorder, Serkan Turan, Aynur Pekcanlar Akay

Journal of Mind and Medical Sciences

Objectives. This study aims to evaluate the effects of methylphenidate (MPH) on eating patterns and body mass index (BMI) in children with attention deficit/hyperactivity disorder (ADHD). The secondary aim of this study is the comparison between weight and eating behavior of children with ADHD undergoing an MPH treatment, and of children without ADHD. Methods. One hundred fourty three children and adolescents who diagnosed with ADHD were enrolled, and the effects of MPH on the eating patterns and BMI were evaluated. All participants completed a number of tests to analyze eating patterns and clinical psychopathological profiles. Results. Children and adolescents ...


The Burden Of Clostridium Difficile Infection In Patients With Liver Cirrhosis, Despina Moraru, Andrada Dumitru, Sergiu I. Micu, Marilena Musat, Gabriel Preda, Popoiag R. Emanuela 2019 Valparaiso University

The Burden Of Clostridium Difficile Infection In Patients With Liver Cirrhosis, Despina Moraru, Andrada Dumitru, Sergiu I. Micu, Marilena Musat, Gabriel Preda, Popoiag R. Emanuela

Journal of Mind and Medical Sciences

Clostridium Difficile Infection (CDI) has registered a dramatically increasing incidence in the general population over the past decades. Nowadays, Clostridium Difficile is the leading cause of hospital-acquired diarrhea in Europe and North America. Liver cirrhosis is the final stage of any chronic liver disease (CLD). The most common causes are chronic hepatitis C or B and viral co-infections, alcohol misuse, and nonalcoholic fatty liver disease (NAFLD). CLD and cirrhosis are listed among the ten leading causes of death in the US. Cirrhosis due to any etiology disrupts the homeostatic role of the liver in the body. Cirrhosis-associated immune dysfunction (CAID ...


Alcoholic Liver Cirrhosis, More Than A Simple Hepatic Disease – A Brief Review Of The Risk Factors Associated With Alcohol Abuse, Sergiu I. Micu, Madalina E. Manea, Roxana Popoiag, Dragana Nikolic, Dumitru Andrada, Angelo M. Patti, Marilena Musat, Cristian Balalau, Anca Rogoveanu, Manfredi Rizzo, Anca Pantea Stoian 2019 Valparaiso University

Alcoholic Liver Cirrhosis, More Than A Simple Hepatic Disease – A Brief Review Of The Risk Factors Associated With Alcohol Abuse, Sergiu I. Micu, Madalina E. Manea, Roxana Popoiag, Dragana Nikolic, Dumitru Andrada, Angelo M. Patti, Marilena Musat, Cristian Balalau, Anca Rogoveanu, Manfredi Rizzo, Anca Pantea Stoian

Journal of Mind and Medical Sciences

Liver cirrhosis is a significant public health problem, being an important cause of mortality and morbidity, responsible for approximately 1.8% of the total number of deaths in Europe. Chronic alcohol consumption is the most common cause of liver cirrhosis in developed countries. Europe has the highest level of alcohol consumption among all the global World Health Organisation (WHO) regions. In this paper, we briefly review major factors leading to excessive alcohol consumption in order to draw attention to the fact that alcoholic liver cirrhosis is more than a simple liver disease, and if those risk/causal factors can be ...


Insights Into The Pathogenesis Of Nicotine Addiction. Could A Salivary Biosensor Be Useful In Nicotine Replacement Therapy (Nrt)?, Anida-Maria Băbțan, Nausica B. Petrescu, Anca Ionel, Bianca A. Boșca, Willi A. Uriciuc, Claudia N. Feurdean, Codruța I. Mirică, Roxana Bordea, Viorel Miclăuș, Flavia Ruxanda, Adina D. Todea, Teodora G. Alexescu, Radu S. Câmpian, Aranka Ilea 2019 Valparaiso University

Insights Into The Pathogenesis Of Nicotine Addiction. Could A Salivary Biosensor Be Useful In Nicotine Replacement Therapy (Nrt)?, Anida-Maria Băbțan, Nausica B. Petrescu, Anca Ionel, Bianca A. Boșca, Willi A. Uriciuc, Claudia N. Feurdean, Codruța I. Mirică, Roxana Bordea, Viorel Miclăuș, Flavia Ruxanda, Adina D. Todea, Teodora G. Alexescu, Radu S. Câmpian, Aranka Ilea

Journal of Mind and Medical Sciences

Nicotine has gained the attention of the medical community due to its insidious addictive mechanisms which lead to chronic consumption. The multitude of compounds derived from tobacco smoke have local and systemic negative impacts, resulting in a large number of smoking-related pathologies. The present review offers insights into nicotine addiction physiopathology, as well as social and medical implications, with emphasis on its correlation with Advanced Glycation End Products (AGEs). Therapeutic strategies and new approaches to nicotine assessment and cessation treatment are discussed, noting that such strategies could take into account the possibility of slow and gradual nicotine release from a ...


Reduced Brain Activity In The Right Putamen As An Early Predictor For Treatment Response In Drug-Naive, First-Episode Schizophrenia, Renrong Wu, Yangpan Ou, Feng Liu, Jindong Chen, Huabing Li, Jingping Zhao, Wenbin Guo, Xiaoduo Fan 2019 The Second Xiangya Hospital of Central South University

Reduced Brain Activity In The Right Putamen As An Early Predictor For Treatment Response In Drug-Naive, First-Episode Schizophrenia, Renrong Wu, Yangpan Ou, Feng Liu, Jindong Chen, Huabing Li, Jingping Zhao, Wenbin Guo, Xiaoduo Fan

Open Access Articles

Antipsychotic medications can have a significant effect on brain function after only several days of treatment. It is unclear whether such an acute effect can serve as an early predictor for treatment response in schizophrenia. Thirty-two patients with drug-naive, first-episode schizophrenia and 32 healthy controls underwent resting-state functional magnetic resonance imaging. Patients were treated with olanzapine and were scanned at baseline and 1 week of treatment. Healthy controls were scanned once at baseline. Symptom severity was assessed within the patient group using the Positive and Negative Syndrome Scale (PANSS) at three time points (baseline, 1 week of treatment, and 8 ...


Cultural Competency In Latinoamerican Countries: From A Hispanic Resident Perspective, Ivania T. Irby MD 2019 HCA Healthcare

Cultural Competency In Latinoamerican Countries: From A Hispanic Resident Perspective, Ivania T. Irby Md

Psychiatry

No abstract provided.


Somatic Symptom And Related Disorders: A Case Of Illness Anxiety Disorder In A Young Relatively Treatment Naive African American Male, Linda Zhang MD, Richard P. Leggett, Harrison Ross Galicki, William B. DeHart 2019 HCA Healthcare

Somatic Symptom And Related Disorders: A Case Of Illness Anxiety Disorder In A Young Relatively Treatment Naive African American Male, Linda Zhang Md, Richard P. Leggett, Harrison Ross Galicki, William B. Dehart

Psychiatry

Somatic symptom and related disorders (including illness anxiety disorder and somatic symptom disorder) is a diagnostic category in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) replacing somatoform and related disorders in the DSM-4 Text Revision. This classification eliminated the requirement that somatic symptoms must be nonorganic in nature, in an effort to reliably detect more cases of significant health anxiety than previously with DSM-4 criteria. Illness anxiety disorder is a primary anxiety disorder characterized by persistent preoccupation or excessive concern about having or developing an undiagnosed disease despite medical evaluation and reassurance. It is considered a ...


Psychosocial, Psychiatric And Work-Related Risk Factors Associated With Suicide In Ireland: Optimised Methodological Approach Of A Case-Control Psychological Autopsy Study, E. Arensman, Celine Larkin 2019 University College Cork

Psychosocial, Psychiatric And Work-Related Risk Factors Associated With Suicide In Ireland: Optimised Methodological Approach Of A Case-Control Psychological Autopsy Study, E. Arensman, Celine Larkin

Open Access Articles

BACKGROUND: Suicide has profound effects on families and communities, but is a statistically rare event. Psychological autopsies using a case-control design allow researchers to examine risk factors for suicide, using a variety of sources to detail the psychological and social characteristics of decedents and to compare them to controls. The Suicide Support and Information System Case Control study (SSIS-ACE) aimed to compare psychosocial, psychiatric and work-related risk factors across three groups of subjects: suicide decedents, patients presenting to hospital with a high-risk self-harm episode, and general practice controls.

METHODS: The study design includes two inter-related studies; one main case-control study ...


Treating Substance Use Disorders: Enhancing Attendance At The Weekly Inpatient Medication Assisted Treatment Group, Devon Gillis, Jayne Weisberg, Dena Whitesell, Amy McAuliffe, Amy Sparks, Suneela Nayak, Ruth Hanselman, Stephen Tyzik 2019 Maine Medical Center

Treating Substance Use Disorders: Enhancing Attendance At The Weekly Inpatient Medication Assisted Treatment Group, Devon Gillis, Jayne Weisberg, Dena Whitesell, Amy Mcauliffe, Amy Sparks, Suneela Nayak, Ruth Hanselman, Stephen Tyzik

Operational Excellence

At a large academic tertiary medical center, an Integrated Medication Assisted Treatment (IMAT) program has been established for those medically stable inpatients with an addiction diagnosis. Over a four month period, this program had experienced a decline in attendance and a quality improvement project was initiated is to better understand the barriers to attendance and institute a process that would reverse the decline.

A goal was established to improve attendance by medically stable patients that have consented to participate to a minimum of 50%.

A root cause analysis outlined numerous causes for low attendance and several countermeasures were established to ...


Trial Of Sage-217 In Patients With Major Depressive Disorder, Handan Gunduz-Bruce, Christopher Silber, Inder Kaul, Anthony J. Rothschild, Robert Riesenberg, Abdul J. Sankoh, Haihong Li, Robert Lasser, Charles F. Zorumski, David R. Rubinow, Steven M. Paul, Jeffrey Jonas, James J. Doherty, Stephen J. Kanes 2019 Sage Therapeutics

Trial Of Sage-217 In Patients With Major Depressive Disorder, Handan Gunduz-Bruce, Christopher Silber, Inder Kaul, Anthony J. Rothschild, Robert Riesenberg, Abdul J. Sankoh, Haihong Li, Robert Lasser, Charles F. Zorumski, David R. Rubinow, Steven M. Paul, Jeffrey Jonas, James J. Doherty, Stephen J. Kanes

Psychiatry Publications

BACKGROUND: Altered neurotransmission of gamma-aminobutyric acid (GABA) has been implicated in the pathogenesis of depression. Whether SAGE-217, an oral, positive allosteric modulator of GABA type A receptors, is effective and safe for the treatment of major depressive disorder is unknown.

METHODS: In this double-blind, phase 2 trial, we enrolled patients with major depression and randomly assigned them in a 1:1 ratio to receive 30 mg of SAGE-217 or placebo once daily. The primary end point was the change from baseline to day 15 in the score on the 17-item Hamilton Depression Rating Scale (HAM-D; scores range from 0 to ...


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