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1,352 full-text articles. Page 46 of 62.

Blood Conservation In Total Hip Arthroplasty: Interim Analysis Of The Tranexamic Acid Comparison In Hip Replacement (Teach-R) Trial, Richard P. Nadeau 2014 The University of Western Ontario

Blood Conservation In Total Hip Arthroplasty: Interim Analysis Of The Tranexamic Acid Comparison In Hip Replacement (Teach-R) Trial, Richard P. Nadeau

Electronic Thesis and Dissertation Repository

Intravenous tranexamic acid (TEA) is used in total hip arthroplasty (THA) to reduce blood loss. Concern of increased thromboembolic risk has prompted the search for treatment alternatives. The Tranexamic Acid Comparison in Hip Replacement (TeACH-R) trial is a prospective randomized controlled trial comparing the efficacy of intravenous and topical TEA in reducing perioperative blood loss. For interim data analysis, 52 of the planned 144 participants had completed the initial phase of the TeACH-R trial. No significant differences were identified between the intravenous and topical TEA treatment arms for delta-hemoglobin (ΔHgb; 34.81±13.78 vs. 35.65±15.54 mg ...


The Effect Of Tooth Presence On Identification Of Tooth Socket Lamina Dura Surface: A Cbct Study, Morse Stonecypher 2014 Loma Linda University

The Effect Of Tooth Presence On Identification Of Tooth Socket Lamina Dura Surface: A Cbct Study, Morse Stonecypher

Loma Linda University Electronic Theses, Dissertations & Projects

Aim: The accuracy in identifying anatomical landmarks on CBCT images can be affected by the presence of surrounding anatomical structures with similar radiodensity. The purpose of this study was to evaluate the effect of the presence of tooth structure on the accuracy in identifying the lamina dura surface, facial bone surface, facial and lingual bone margins, socket apex, as well as in facial bone thickness measurement. Materials & Methods: Three fresh cadaver heads were scanned using a NewTom 5G CBCT at 0.100 mm voxel size at three time-points: before extraction (T1), after extraction and reinsertion (T2), and after tooth removal ...


Functional Assessment And Potential Therapeutic Role Of Carbon Monoxide Releasing Molecule-­‐3 In A Rodent Model Of Compartment Syndrome, Al Walid Hamam 2014 The University of Western Ontario

Functional Assessment And Potential Therapeutic Role Of Carbon Monoxide Releasing Molecule-­‐3 In A Rodent Model Of Compartment Syndrome, Al Walid Hamam

Electronic Thesis and Dissertation Repository

Compartment syndrome (CS) is a life and limb threatening condition resulting in long term morbidity. Gold standard treatment of CS is surgical fasciotomy. Long-term morbidity is common post fasciotomy. We tested a gait analysis system (CatWalk™) to see if we could detect functional effects of CS in our rodent model. We also investigated the effects of carbon monoxide releasing molecule-3 (CORM-3) on the function of gait in rodents post CS.

The CatWalkTM system was able to detect abnormalities in a rodent’s gait post CS. CORM-3 was also found to alleviate the functional deficits following CS. Multiple dose but not ...


A Survey Of Expert Opinion Regarding Rotator Cuff Repair., Daniel C Acevedo, E Scott Paxton, Gerald R Williams, Joseph A Abboud 2014 Rothman Institute, Thomas Jefferson University

A Survey Of Expert Opinion Regarding Rotator Cuff Repair., Daniel C Acevedo, E Scott Paxton, Gerald R Williams, Joseph A Abboud

Rothman Institute Faculty Papers

Many patients with rotator cuff tears have questions for their surgeons regarding the surgical procedure, perioperative management, restrictions, therapy, and ability to work after a rotator cuff repair. The purpose of our study was to determine common clinical practices among experts regarding rotator cuff repair and to assist them in counseling patients. We surveyed 372 members of the American Shoulder and Elbow Surgeons (ASES) and the Association of Clinical Elbow and Shoulder Surgeons (ACESS); 111 members (29.8%) completed all or part of the survey, and 92.8% of the respondents answered every question. A consensus response (>50% agreement) was ...


Rapid Prototyping Amphiphilic Polymer/Hydroxyapatite Composite Scaffolds With Hydration-Induced Self-Fixation Behavior, Artem B. Kutikov, Anvesh Gurijala, Jie Song 2014 University of Massachusetts Medical School

Rapid Prototyping Amphiphilic Polymer/Hydroxyapatite Composite Scaffolds With Hydration-Induced Self-Fixation Behavior, Artem B. Kutikov, Anvesh Gurijala, Jie Song

GSBS Student Publications

Two major factors hampering the broad use of rapid prototyped biomaterials for tissue engineering applications are the requirement for custom-designed or expensive research-grade three-dimensional (3-D) printers and the limited selection of suitable thermoplastic biomaterials exhibiting physical characteristics desired for facile surgical handling and biological properties encouraging tissue integration. Properly designed thermoplastic biodegradable amphiphilic polymers can exhibit hydration-dependent hydrophilicity changes and stiffening behavior, which may be exploited to facilitate the surgical delivery/self-fixation of the scaffold within a physiological tissue environment. Compared to conventional hydrophobic polyesters, they also present significant advantages in blending with hydrophilic osteoconductive minerals with improved interfacial adhesion ...


Definition Of Periprosthetic Joint Infection, Javad Parvizi, MD, FRCS, Thorsten Gehrke, MD 2014 Rothman Institute, Thomas Jefferson University

Definition Of Periprosthetic Joint Infection, Javad Parvizi, Md, Frcs, Thorsten Gehrke, Md

Rothman Institute Faculty Papers

Diagnosis of periprosthetic joint infection (PJI) remains challenging as no “gold standard” for diagnosis exists [3]. The challenge is then what test(s) or criterion (ia) can be used to define PJI. In an effort to standardize the definition of PJI, Musculoskeletal Infection Society (MSIS) convened a workgroup in 2011 to issue diagnostic criteria for PJI [1]. The MSIS definition of PJI consists of two major criteria, when the presence of either criterion would indicate PJI, and six minor criteria, when the presence of four or more would indicate PJI.


The Repair, Reconstruction And Replacement Of The Coronoid Process, Bashar Alolabi 2014 The University of Western Ontario

The Repair, Reconstruction And Replacement Of The Coronoid Process, Bashar Alolabi

Electronic Thesis and Dissertation Repository

The coronoid process is the most important articular stabilizer of the elbow. While most large coronoid fractures are treated surgically with open reduction and internal fixation, there is limited data on the most effective fixation method. The strengths of five different coronoid fixation methods were assessed using a materials testing machine. Plate fixation proved to be stronger than screw fixation; two screws, regardless of the orientation, were stronger than one; and suture fixation was unreliable. In the setting of an unfixable coronoid fracture, reconstruction of the coronoid using the tip of the olecranon has been described. However, this technique has ...


What's New In Spine Surgery., Keith H Bridwell, Paul A Anderson, Scott D Boden, Han Jo Kim, Alexander Vaccaro, MD, PhD, Jeffrey C Wang 2014 Department of Orthopaedic Surgery, Washington University School of Medicine, Campus Box 8233, 660 South Euclid Avenue, St. Louis, MO 63110, United States

What's New In Spine Surgery., Keith H Bridwell, Paul A Anderson, Scott D Boden, Han Jo Kim, Alexander Vaccaro, Md, Phd, Jeffrey C Wang

Rothman Institute Faculty Papers

No abstract provided.


Aquacel Surgical Dressing Reduces The Rate Of Acute Pji Following Total Joint Arthroplasty: A Case-Control Study., Jenny Cai, Joseph A Karam, Javad Parvizi, Eric B Smith, Peter F. Sharkey 2014 The Rothman Institute at Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Aquacel Surgical Dressing Reduces The Rate Of Acute Pji Following Total Joint Arthroplasty: A Case-Control Study., Jenny Cai, Joseph A Karam, Javad Parvizi, Eric B Smith, Peter F. Sharkey

Rothman Institute Faculty Papers

An effort to prevent PJI has led to the development of antimicrobial dressings that support wound healing. We sought to determine whether Aquacel Surgical dressing independently reduces the rate of acute PJI following TJA. A single institution retrospective chart review of 903 consecutive cases who received the Aquacel Surgical dressing and 875 consecutive cases who received standard gauze dressing was conducted to determine the incidence of acute PJI (within 3months). The incidence of acute PJI is 0.44% in the Aquacel dressing group compared to 1.7% in the standard gauze dressing group (P=0.005). Multivariate analysis revealed that ...


The Role Of Rotator Interval Closure In Bankart Lesion Repair, Lauren L. Rainsford 2014 The University of Western Ontario

The Role Of Rotator Interval Closure In Bankart Lesion Repair, Lauren L. Rainsford

Electronic Thesis and Dissertation Repository

Twenty-nine patients who had sustained an anterior shoulder dislocation were randomly assigned to receive Bankart lesion repair, or Bankart lesion repair with rotator interval closure. External rotation range of motion with 90° of abduction external rotation range of motion with no abduction, and forward flexion range of motion were measured preoperatively, and at three and six months postoperatively. Quality of life, function, and pain were measured preoperatively, and at three, six, 12 and 24 weeks postoperatively. We found no significant differences between groups for any outcome but the confidence intervals were wide and definitive conclusions could not be made. This ...


The Relative Efficacy Of Antifibrinolytics In Adolescent Idiopathic Scoliosis: A Prospective Randomized Trial., Kushagra Verma, MD, Thomas Errico, Chris Diefenbach, Christian Hoelscher, Austin Peters, Joseph Dryer, Tessa Huncke, Kirstin Boenigk, Baron S Lonner 2014 Department of Orthopaedics, Jefferson Medical College, Thomas Jefferson University

The Relative Efficacy Of Antifibrinolytics In Adolescent Idiopathic Scoliosis: A Prospective Randomized Trial., Kushagra Verma, Md, Thomas Errico, Chris Diefenbach, Christian Hoelscher, Austin Peters, Joseph Dryer, Tessa Huncke, Kirstin Boenigk, Baron S Lonner

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Antifibrinolytics can reduce intraoperative blood loss. The primary aim of this study was to determine the efficacy of intraoperative tranexamic acid, epsilon-aminocaproic acid, and placebo at reducing perioperative blood loss and the transfusion rate in patients with adolescent idiopathic scoliosis undergoing posterior spinal arthrodesis.

METHODS: This is a prospective, randomized, double-blind comparison of tranexamic acid, epsilon-aminocaproic acid, and placebo used intraoperatively in patients with adolescent idiopathic scoliosis. One hundred and twenty-five patients with adolescent idiopathic scoliosis were randomly assigned to the tranexamic acid, epsilon-aminocaproic acid, or control groups. Parameters recorded included estimated blood loss, hematocrit, blood product usage, drain ...


Assessing Sedentary Behavior And Physical Activity With Wearable Sensors, Patty Freedson 2014 University of Massachusetts Amherst

Assessing Sedentary Behavior And Physical Activity With Wearable Sensors, Patty Freedson

UMass Center for Clinical and Translational Science Research Retreat

As part of the mini-symposium entitled "Physical Activity, Sedentary Behavior and Function in Individuals with Knee and Hip Osteoarthritis: Clinical Observations and Opportunities for Future Research," Dr. Freedson highlights her group's research on using wearable monitors to objectively quantify changes in physical activity and sedentary behavior in individuals with moderate to severe knee and/or hip osteoarthritis.


A Prospective Randomized Comparison Of Patient Specific Instruments With Standard Tka Instrumentation, Christina Kane, Anthony Porter, Patricia D. Franklin, David C. Ayers 2014 University of Massachusetts Medical School

A Prospective Randomized Comparison Of Patient Specific Instruments With Standard Tka Instrumentation, Christina Kane, Anthony Porter, Patricia D. Franklin, David C. Ayers

UMass Center for Clinical and Translational Science Research Retreat

Introduction: Patient specific instruments (PSI), an alternative to standard total knee arthroplasty (TKA) technology, have shown mixed results regarding effectiveness in previous studies. This study evaluated the accuracy of the predicted PSI plan, compared incremental cost savings with PSI, and compared outcomes of PSI and standard TKA patients.

Patients and Methods: This randomized, prospective feasibility study included 19 primary TKA patients receiving a cruciate-retaining cemented prosthesis from a single surgeon (DCA). 9 patients randomized to PSI received a pre-operative knee MRI for PSI fabrication using proprietary software.10 standard TKAs were completed. Operative data collected included operating times, implant details ...


Radiostereometric Analysis Of Tantalum Vs. Titanium Acetabular Shells In Young Thr Patients, Christina Kane, Anthony Porter, Benjamin Snyder, Marie Walcott, Michelle E. Aubin, Jacob M. Drew, Meridith Greene, Henrik Malchau, Charles R. Bragdon, David Ayers 2014 University of Massachusetts Medical School

Radiostereometric Analysis Of Tantalum Vs. Titanium Acetabular Shells In Young Thr Patients, Christina Kane, Anthony Porter, Benjamin Snyder, Marie Walcott, Michelle E. Aubin, Jacob M. Drew, Meridith Greene, Henrik Malchau, Charles R. Bragdon, David Ayers

UMass Center for Clinical and Translational Science Research Retreat

Introduction: In the active total hip replacement (THR) population, maintaining acetabular component stability and limiting polyethylene wear are crucial components to preventing premature implant failure. Titanium with Co/Cr/Mo fiber metal coating is among the most common materials used in cementless THR. Trabecular metal, composed of porous tantalum, has a metallic strut design resembling trabecular bone, designed to improve tissue infiltration and limit migration. This study assesses the stability and clinical outcomes of tantalum versus titanium acetabular shells using radiostereometric analysis (RSA) technology.

Methods: In this IRB approved, prospective, randomized, blinded study, 46 patients received a primary THR by ...


The Validity Of Patient-Reported Short-Term Complications Following Total Hip And Knee Arthroplasty, Leslie R. Harrold, Scott Pascal, David C. Ayers, Courtland Lewis, Regis O'Keefe, Patricia D. Franklin 2014 University of Massachusetts Medical School

The Validity Of Patient-Reported Short-Term Complications Following Total Hip And Knee Arthroplasty, Leslie R. Harrold, Scott Pascal, David C. Ayers, Courtland Lewis, Regis O'Keefe, Patricia D. Franklin

UMass Center for Clinical and Translational Science Research Retreat

Introduction: Given the lack of national data on outcomes of on patients who undergo total joint arthroplasty (TJA) and the limitations of hospital databases to capture information on patients who seek post-TJA care elsewhere, there is growing interest in using patient self-report to identify possible complications following surgery. We examined the concordance between patients self-report of potential short-term complications with review of available medical records as well as the location of the reported post-operative care.

Material & Methods: Patients undergoing primary hip or knee arthroplasty from 7/1/11 through 12/3/12 participating in a tertiary care center were identified ...


Do Younger Tkr And Thr Patients Have Similar Disability At Time Of Surgery As Older Adults? Lessons From Force-Tjr, Leslie R. Harrold, Wenjun Li, Courland Lewis, Jeroan J. Allison, David C. Ayers, Patricia D. Franklin 2014 University of Massachusetts Medical School

Do Younger Tkr And Thr Patients Have Similar Disability At Time Of Surgery As Older Adults? Lessons From Force-Tjr, Leslie R. Harrold, Wenjun Li, Courland Lewis, Jeroan J. Allison, David C. Ayers, Patricia D. Franklin

UMass Center for Clinical and Translational Science Research Retreat

Introduction: The number of US patients under 65 year old who are undergoing total knee replacement (TKR) and total hip replacement (THR) has been rising, raising concerns that younger patients may receive surgery prematurely. Therefore, we examined demographics and clinical factors and compared the severity of operative knee pain and functional status in younger versus older TKR patients from a US national sample. Materials & methods: The FORCE-TJR registry gathers data from patients, surgeons and hospitals on sociodemographic factors (age, sex, race), BMI, comorbid conditions using the modified Charlson comorbidity scores, burden of musculoskeletal disease using the Knee/Hip injury and Osteoarthritis Outcome Score (KOOS/HOOS) in both knees and hips, emotional health based on the Short Form 36 (SF-36) Mental Component Score (MCS) and physical function based on the Physical Component Score (SF-36 PCS). Results: We analysed data from 2035 younger (<65) and 3084 older (≥65) TKR patients and 1780 younger and 1831 older THR patients. Younger TKR and THR patients were more likely nonwhite (TKR: 13.1% vs. 6.6%; THR: 51.7% vs. 48.3%),), with greater body mass index (mean BMI TKR: 33.1 vs. 30.5; THR: 29.9 vs. 28.4), smokers, had fewer number of comorbid conditions. Younger TKR patients reported ...


Radiostereometric Analysis Of Femoral Head Penetration In Cross-Linked Polyethylene In Thr Patients, Christina Kane, Anthony Porter, Benjamin Snyder, Marie Walcott, Michelle E. Aubin, Jacob M. Drew, Meridith Greene, Henrik Malchau, Charles R. Bragdon, David Ayers 2014 University of Massachusetts Medical School

Radiostereometric Analysis Of Femoral Head Penetration In Cross-Linked Polyethylene In Thr Patients, Christina Kane, Anthony Porter, Benjamin Snyder, Marie Walcott, Michelle E. Aubin, Jacob M. Drew, Meridith Greene, Henrik Malchau, Charles R. Bragdon, David Ayers

UMass Center for Clinical and Translational Science Research Retreat

Background: In the young total hip replacement (THR) population limiting polyethylene liner wear is crucial to preventing premature implant failure. Highly cross-linked ultra-high molecular weight polyethylene (HXLPE) liners were designed to improve wear resistance of polyethylene liners. Radiostereometric analysis (RSA) provides highly precise measurements of liner wear. This study utilized RSA to characterize wear of conventional versus HXLPE liners up to five years following THR.

Methods: This IRB-approved, prospective, randomized, blinded study, involved 46 patients with a mean age of 58 and BMI of 30. Each patient was double randomized to receive a conventional or HXLPE liner with an uncemented ...


Stability Of A Tapered Femoral Stem In Total Hip Arthroplasty Using Radiostereometric Analysis, Christina Kane, Audrey Nebergall, Meridith Greene, Anthony Porter, Benjamin Snyder, Marie Walcott, Michelle E. Aubin, Jacob M. Drew, Peyton L. Hays, Mark S. Eskander, Henrik Malchau, Charles R. Bragdon, David Ayers 2014 University of Massachusetts Medical School

Stability Of A Tapered Femoral Stem In Total Hip Arthroplasty Using Radiostereometric Analysis, Christina Kane, Audrey Nebergall, Meridith Greene, Anthony Porter, Benjamin Snyder, Marie Walcott, Michelle E. Aubin, Jacob M. Drew, Peyton L. Hays, Mark S. Eskander, Henrik Malchau, Charles R. Bragdon, David Ayers

UMass Center for Clinical and Translational Science Research Retreat

Introduction: Early femoral implant stability is essential to long-term success in total hip replacement (THR). Radiostereometric analysis (RSA) provides highly precise measurements of stem micromotion relative to the femur that are otherwise not detectable by routine radiographs. This study characterized micromotion of a tapered, cementless femoral stem using RSA up to 5 years following THR.

Methods: This IRB-approved, prospective, randomized, blinded study, involved 46 patients with a mean age of 58 and BMI of 30. All patients received a cementless, porous-coated titanium double tapered stem (M/L Taper, Zimmer) manufactured with 3 tantalum RSA beads and underwent primary THR by ...


Low Self-Reported Physical Function Status Was An Excellent Predictor Of Adverse Postoperative Course In Older Veterans Having Knee And Hip Surgery, Alok Kapoor, Priscilla Chew, Joel Reisman, Dan Berlowitz 2014 University of Massachusetts Medical School

Low Self-Reported Physical Function Status Was An Excellent Predictor Of Adverse Postoperative Course In Older Veterans Having Knee And Hip Surgery, Alok Kapoor, Priscilla Chew, Joel Reisman, Dan Berlowitz

UMass Center for Clinical and Translational Science Research Retreat

Objectives: To measure the association between functional status and an adverse postoperative course.

Design: Retrospective cohort study.

Setting: Veterans Affairs Medical Center.

Participants: Older adults who underwent total hip and knee replacement (THR and TKR) at a VA facility from 2002-2009. To be included, subjects must have completed the Veteran Rand-12 (VR-12) within six months of surgery. VR-12 is a general purpose 12 item health quality survey nearly identical to the SF-12 for which the summary score of physical health called physical component score (PCS) is normed to a value of 50 for US adults with standard deviation of 10 ...


High Performance Amphiphilic Polymer/Hydroxyapatite Composite Tissue Scaffolds, Artem B. Kutikov, Jie Song 2014 University of Massachusetts Medical School

High Performance Amphiphilic Polymer/Hydroxyapatite Composite Tissue Scaffolds, Artem B. Kutikov, Jie Song

UMass Center for Clinical and Translational Science Research Retreat

There is a critical clinical need for alternatives to autograft and allograft bone for over 500,000 bone grafting operations performed each year in the United States. Current synthetic bone grafts suffer from poor handling characteristics, brittle mechanical properties, and inconsistent bioactivity. By blending a biodegradable amphiphilic polymer with hydroxyapatite (HA), the main mineral component in bone, we developed an improved synthetic bone graft. The polymer/HA composites were fabricated in both 2-D and 3-D forms by electrospinning and 3-D printing. These materials exhibited unique handling characteristics such as high tensile elasticity (>200% failure strain) and self-stiffening properties upon hydration ...


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