Mavs Is A Double-Edged Sword, 2023 Thomas Jefferson University
Mavs Is A Double-Edged Sword, Christina Huang, Jack L. Arbiser
Student Papers, Posters & Projects
No abstract provided.
The Safety And Efficacy Of Spironolactone Versus Oral Antibiotics For Moderate-Severe Acne In Post-Adolescent Females, 2023 Thomas Jefferson University
The Safety And Efficacy Of Spironolactone Versus Oral Antibiotics For Moderate-Severe Acne In Post-Adolescent Females, Bhav Patel
Master of Science in Physician Assistant Studies Capstone Presentations (Center City)
Introduction
- Acne is a common skin condition when the pores are clogged by particles like dead skin or oil, affecting approximately 50 million individuals in the U.S.1
- Over a third of females experience moderate-severe forms that persist into adulthood and that number seems to be on the rise3
- Persistent moderate-severe acne often requires systemic medications and oral antibiotics are the most frequently prescribed therapy2
- Dermatologists prescribe more antibiotics per provider than any other specialty, and often for longer durations than recommended2
- The inappropriate use of oral antibiotics is contributing to bacterial resistance and disruption of the …
Intralesional Injection Of Mumps, Measles, And Rubella Vaccine, Bleomycin, And Vitamin D3 In Warts Treatment, 2023 Dermatology and Andrology Department, Faculty of Medicine, Benha University, Egypt
Intralesional Injection Of Mumps, Measles, And Rubella Vaccine, Bleomycin, And Vitamin D3 In Warts Treatment, Osama Hussein Alkady, Karem Taha Khalil, Samah Ezza Ibrahim, Raghda Tohamy Farag, Shymaa Mostafa Rezk
Menoufia Medical Journal
Objectives: To compare the therapeutic efficacy of intralesional mumps, measles, and rubella (MMR) vaccination, vitamin D3 (VitD3), and bleomycin injection in patients with warts. Background With good outcomes, common warts have been treated with immunotherapy using intralesional antigens or vaccinations. It might result in resolution without any outward signs of deterioration or scarring and boost the host's defenses against the agent that caused the problem. Methods This study involved 84 wart patients in Benha University Hospitals, Egypt. All study participants gave their consent after being informed. MMR, bleomycin, and VitD3 were injected intralesionally to treat warts, whereas normal saline was …
The Impact Of Intralesional 5-Fluorouracil In The Treatment Of Keloid Scars, 2023 Thomas Jefferson University
The Impact Of Intralesional 5-Fluorouracil In The Treatment Of Keloid Scars, Madeline Derham
Master of Science in Physician Assistant Studies Capstone Presentations (Center City)
Background
- The American Academy of Dermatology (AAD) defines a keloid scar as a type of raised scar extending past the initial area of injury1
- Approximately 10% of the general population affected - significant risk factors include +family history, darker skin tones, mechanism of injury (burn, surgical)3
- Symptom presentation: pain, pruritus, burning, increased sensitivity3
- Varying existing treatment methods with high resistance and recurrence rates leading to no agreed upon standard approach5
- Most widely adopted method currently : intralesional (ILS) steroid injection5
Leser-Trélat Sign As A Marker For Underlying Pancreatic Cancer, 2023 Einstein Healthcare Network
Leser-Trélat Sign As A Marker For Underlying Pancreatic Cancer, Kalpit Modi, Richard Chen, Layla Abubshait
Einstein Health Papers
Case Presentation: Early diagnosis and rapid treatment of cancer is essential for good clinical outcomes for patients. In this case, an 85-year-old man presented with failure to thrive and was noted to have rapid-onset, multiple seborrheic keratoses (Leser-Trélat sign) on his chest and back. He was ultimately diagnosed with pancreatic cancer using computed tomography.
Discussion: Leser-Trélat sign is a rare cutaneous marker for underlying malignancy. Identification of this sign can help guide diagnostic imaging and lab work to identify an occult internal malignancy, resulting in more rapid diagnosis, earlier treatment, and potentially better clinical outcomes.
Application Of Teaching Regarding Injury Appearance In Darker Pigmented Skin Patients: A Quality Improvement Project, 2023 Sacred Heart University
Application Of Teaching Regarding Injury Appearance In Darker Pigmented Skin Patients: A Quality Improvement Project, Tiffany Akiba
DNP Projects
Significance and Background: The skin is the largest organ of our body, and skin injury prevention begins with accurately inspecting skin. Current practices stress on looking for any signs of redness which often signify that the skin is possibly injured or compromised. However, darker skin tones do not appear red when injured. Assessing for redness is a practice that is suited better for lighter skin tones.
Purpose: Provide education to providers on current skin assessment practices of darker skin tones.
Methods: The IHI Model of Improvement was used for this project, and the Plan-Do-Study-Act cycle was used to test for …
Understanding The Factors Associated With Us Dermatology Resident Trainees’ Diagnostic Confidence And Skill For Skin Of Color Pathology, 2023 LSU Health Sciences Center - New Orleans
Understanding The Factors Associated With Us Dermatology Resident Trainees’ Diagnostic Confidence And Skill For Skin Of Color Pathology, Alissa Jeanfreau, Kaylin Beiter, Deborah Hilton
School of Medicine Faculty Publications
Background: Inequities in dermatologic health outcomes translate to worsened clinical outcomes for minority groups. For example, despite a lower incidence of skin cancer overall, African Americans are diagnosed at later stages with greater degrees of lymph node involvement. This has been shown to lead to disproportionate mortality when compared to lighter skinned individuals. Medical education materials contain a significantly lower percentage of skin of color (SOC) images than of lighter skin and research has indicated lower diagnostic accuracy of dermatologic conditions in darker skin by U.S. medical students. The objective of this study was to explore U.S. resident dermatologists’ ability …
Phenotype And Genotype Heterogeneity Of Pla2g6-Associated Neurodegeneration In A Cohort Of Pediatric And Adult Patients, 2023 Thomas Jefferson University
Phenotype And Genotype Heterogeneity Of Pla2g6-Associated Neurodegeneration In A Cohort Of Pediatric And Adult Patients, Ali Zare Dehnavi, Maryam Bemanalizadeh, Seyyed Mohammad Kahani, Mahmoud Reza Ashrafi, Mohammad Rohani, Mehran Beiraghi Toosi, Morteza Heidari, Sareh Hosseinpour, Behnam Amini, Shaghayegh Zokaei, Zahra Rezaei, Hajar Aryan, Man Amanat, Hassan Vahidnezhad, Pouria Mohammadi, Masoud Garshasbi, Ali Reza Tavasoli
Department of Dermatology and Cutaneous Biology Faculty Papers
BACKGROUND: Phospholipase-associated neurodegeneration (PLAN) caused by mutations in the PLA2G6 gene is a rare neurodegenerative disorder that presents with four sub-groups. Infantile neuroaxonal dystrophy (INAD) and PLA2G6-related dystonia-parkinsonism are the main two subtypes. In this cohort, we reviewed clinical, imaging, and genetic features of 25 adult and pediatric patients harboring variants in the PLA2G6.
METHODS: An extensive review of the patients' data was carried out. Infantile Neuroaxonal Dystrophy Rating Scale (INAD-RS) was used for evaluating the severity and progression of INAD patients. Whole-exome sequencing was used to determine the disease's underlying etiology followed by co-segregation analysis using Sanger sequencing. In …
Resolved Peristomal Erosive Papulonodular Dermatitis Mimicking Nevoid Hyperkeratosis Of The Nipple And Areola, 2023 University of North Texas Health Science Center
Resolved Peristomal Erosive Papulonodular Dermatitis Mimicking Nevoid Hyperkeratosis Of The Nipple And Areola, Christa M. Tomc, Daniel A. Nguyen, Joseph S. Susa, Stephen E. Weis
HCA Healthcare Journal of Medicine
Introduction
Nevoid hyperkeratosis of the nipple and areola (NHKNA) is a rare cutaneous entity with a distinct clinical and histological presentation. The type II form of this condition can result from various dermatoses, such as irritant contact dermatitis. Erosive papulonodular dermatitis is a chronic irritant dermatitis that often occurs in areas of occlusion and maceration, such as peristomal skin. Pseudoverrucous papules and nodules are a variant of erosive papulonodular dermatitis and have a non-specific histologic pattern of reactive hyperplasia.
Case Presentation
We present a case of a patient with resolved peristomal erosive papulonodular dermatitis who presented status-post ileostomy reversal with …
An Overview Of Risk Factors For Androgenetic Alopecia Among Women At Pasar Ambacang, Kuranji, Padang, 2023 Faculty of Medicine Andalas University
An Overview Of Risk Factors For Androgenetic Alopecia Among Women At Pasar Ambacang, Kuranji, Padang, Lidya Aprilia Sugma, Satya Wydya Yenny, Roslaili Rasyid
Journal of General - Procedural Dermatology & Venereology Indonesia
Background: Androgenetic alopecia (AGA) is a patterned hair loss due to chronic and progressive miniaturization of hair follicles. Hair represents femininity and self-confidence in women. Therefore, AGA may affect the quality of life and psychology in women. This study aims to describe the risk factors for AGA in women living in Pasar Ambacang Sub-district, Kuranji District, Padang City.
Method: This was a descriptive, cross-sectional study that included 40 women with AGA. Interviews with subjects were conducted. This study was approved by the Health Research Ethics Committee at Universitas Andalas (252/UN.16.2/KEPK-FK/2021)
Results: AGA was mostly found on patients …
Challenges In Diagnosing Staphylococcal Scalded Skin Syndrome In Children With Kwashiorkor: A Case Report, 2023 Dermatovenereology Department, Faculty of Medicine, Universitas Indonesia/ Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Challenges In Diagnosing Staphylococcal Scalded Skin Syndrome In Children With Kwashiorkor: A Case Report, Christie Hamdali, Sondang Sirait, Adria Rusvita, Bawono Bhakti
Journal of General - Procedural Dermatology & Venereology Indonesia
Staphylococcal scalded skin syndrome (SSSS) is a type of exfoliating skin disease with high incidence in children. This condition can cause serious morbidity and even mortality with certain comorbid diseases such as malnutrition. Malnutrition could mask the diagnosis of SSSS because of its similarity to numerous differential diagnoses. Accuracy of clinical diagnosis is then essential to determine the proper initial management. This case report presents a 6-month-old male baby with staphylococcal scalded skin syndrome and kwashiorkor. The patient presented with complaints of multiple erythematous plaques and widespread vesicular lesions that subsequently ruptured, resulting in erosions. Physical examination revealed edema, coarse …
The Effectivity Of Ultrasound-Guided Platelet-Rich Plasma Perineural Injection In Improving Leprosy Sensory Peripheral Neuropathy, 2023 Department of Dermatology and Venereology, Dr. Saiful Anwar Regional General Hospital/ Faculty of Medicine, Universitas Brawijaya, Jl. Mayjen Haryono 169, Malang, East Java, 65145, Indonesia
The Effectivity Of Ultrasound-Guided Platelet-Rich Plasma Perineural Injection In Improving Leprosy Sensory Peripheral Neuropathy, Herwinda Brahmanti, Arif Widiatmoko, Dhelya Widasmara, Diane Tantia Sari, Shahdevi Nandar Kurniawan, Widodo Mardi Santoso, Ristiawan Muji Laksono, Abdul Gofur
Journal of General - Procedural Dermatology & Venereology Indonesia
Background: Sensory nerve damage is the earliest leprosy sign which can lead to disability. Previous studies showed that autologous platelet-rich plasma (PRP) perineural blind injection can stimulate leprosy sensory nerve regeneration. Our study provided a safer and more accurate PRP agent delivery method through ultrasound-guided injection and was the first to compare PRP versus standard neuropathy treatment, the neurotropic vitamin. This study aimed to determine the effectiveness of combination therapy of ultrasound-guided PRP perineural injection and oral vitamin B complex compared to single oral vitamin B complex in sensory peripheral neuropathy of posterior tibial nerve in leprosy patients.
Therapy Selection For Tinea Corporis And Cruris With Commorbidity: 3 Case Series, 2023 Departement of Dermatology and Venereology; Faculty of Medicine, Public Health and Nursing; Gadjah Mada University / Dr. Sardjito Hospital; Yogyakarta, Indonesia
Therapy Selection For Tinea Corporis And Cruris With Commorbidity: 3 Case Series, Yefta Yefta, Dwi Retno Adi Winarni, Agnes Sri Siswati
Journal of General - Procedural Dermatology & Venereology Indonesia
Background: Dermatophytosis is a superficial (skin, hair and nails) fungal infection caused by dermatophyte group fungi (Trichophyton, Epidermophyton and Microsporum). Immunocompromised conditions cause fungal infections to become more widespread and require consideration of therapy.
Case Illustration: This case series represented three cases of tinea corporis and tinea cruris in patients with comorbidities. The first case was tinea corporis and tinea cruris in a patient with congestive heart failure with oral terbinafine therapy. The second case was tinea corporis and tinea cruris in a patient with bilateral fourth degree hydronephrosis with oral griseofulvin therapy. The third case was tinea …
Lucio Phenomenon In Pregnancy: A Histopathology Review, 2023 Departement of Dermatology and Venereology, Faculty of Medicine, University of Sebelas Maret, Dr. Moewardi General Hospital, Surakarta, Indonesia
Lucio Phenomenon In Pregnancy: A Histopathology Review, Siti Efrida Fiqnasyani, Triasari Oktavriana,, Ervina Rosmarwati, Dita Eka Novriana, Ambar Mudigdo
Journal of General - Procedural Dermatology & Venereology Indonesia
Background: Lucio phenomenon (LP) is a reaction occurring in lepromatous, non-nodular, diffuse leprosypatients who have not received multidrug therapy (MDT). The diagnosis of LP are based on clinical features and supported by histopathological examination. This report was conducted to establish a diagnosis of LP byhistopathological examination, considering that cases of LP in pregnancy are quite rare so that clinicians can be more precise.
Case: A 35-year-old pregnant woman complained of extensive ulcers on her hand and legs. Madarosis, saddle nose, and earlobes were found A slit skin smear examination showed a bacterial index of +4 and a morphological …
Scientometric Evaluation Of The Global Research In Acne Disease, 2023 Department of Development of Scientific and Innovation Activities, Russian New University, Moscow, Russia
Scientometric Evaluation Of The Global Research In Acne Disease, Aida Khakimova, Oleg Zolotarev, Engin Senel
Journal of General - Procedural Dermatology & Venereology Indonesia
Background: Although acne is one of the most common diseases, medical literature lacks a scientometric analysis relevant to this disorder. In the present study we aimed to perform a scientometric evaluation of literature related to acne.
Methods: Publications were identified by searching for the term «acne» in PubMed. Papers from different countries were then identified by using the Advanced Search Builder. The indicators for evaluating of the absolute and relative increase in number of articles were proposed.
Results: Dynamic publication of activity is compared according to our proposed indicator - The Average Relative Growth Rate. After 1945 …
The Effect Of Topical Oatmeal (Avena Sativa) On Hydration-Related Skin Disorders: A Systematic Review, 2023 Faculty of Medicine and Health Sciences Atma Jaya Indonesia Catholic University, Jakarta, Indonesia
The Effect Of Topical Oatmeal (Avena Sativa) On Hydration-Related Skin Disorders: A Systematic Review, Karenina Novani Sugondo, Melyawati Hermawan
Journal of General - Procedural Dermatology & Venereology Indonesia
Background: In recent years, interest in developing cosmetics and beauty products based on natural ingredients has increased. The addition of herbal extracts to products could improve the effectiveness of therapy. One of the natural ingredients that can be found is oatmeal. Oatmeal has been used for a long time and has been approved by the U.S. Food and Drug Administration as a skin protective agent since 2003. This study aims to systematically review the literature to determine the effect of topical oatmeal (Avena sativa) on hydration-related skin disorders.
Methods: A total of 9,538 studies were found in the database sources …
Zosteriform Cutaneous Metastases From A Carcinoma Mammae, 2023 Dermatology & Venereology Department, Faculty of Medicine, Nursing and Public Health Gadjah Mada University, Jl. Farmako, Sekip Utara, Yogyakarta, Indonesia
Zosteriform Cutaneous Metastases From A Carcinoma Mammae, Kharisma Yuliasis Widiasri, Ayu Wikan Sayekti, Novian Febiyanto, Elliana Wahyuanggradewi, Jeffrey Giantoro, Satiti Retno Pudjiati, Hanggoro Tri Rinonce, Agnes Sri Siswati
Journal of General - Procedural Dermatology & Venereology Indonesia
Background: Cutaneous metastases were reported in 18.6-26.5% of breast cancer patients. Zosteriform cutaneous metastasis is an unusual and rare morphological variant. Clinicians, especially dermatovenereologists, should consider dermatomal cutaneous metastases in oncology patients aside from herpes zoster, which is common in this population.
Case Illustration: A 62-year-old woman presented with clustered papules and vesicles with an erythematous base, sometimes painful, on the right side of the chest in T5-T7 dermatomal distribution of 1-month duration. She had undergone a radical mastectomy for breast carcinoma and had been receiving chemoradiotherapy, which was completed in March 2018. A diagnosis of zosteriform cutaneous …
Recalcitrant Cutaneous Mastocytosis Treated With Genetically Informed Targeted Therapy: A Case Report, 2023 Thomas Jefferson University
Recalcitrant Cutaneous Mastocytosis Treated With Genetically Informed Targeted Therapy: A Case Report, Laura Gleason, Volkan Tekmen, Alexa Cohen, Safiyyah Bhatti, Burcu Beksac, Jisun Cha, Pierluigi Porcu, Neda Nikbakht
Department of Dermatology and Cutaneous Biology Faculty Papers
Introduction:
Mastocytosis, a clonal proliferation of mast cells commonly involving the skin and bone marrow, has a varied clinical presentation ranging from cutaneous lesions to systemic disease. Cutaneous mastocytosis is managed symptomatically, but systemic mastocytosis is treated with targeted therapy against the mutated receptor tyrosine kinase c-KIT, the pathogenic driver of mastocytosis. However, there are no guidelines for the treatment of cutaneous mastocytosis refractory to symptomatic management.
We herein report a method to select genetically informed therapy for symptomatic and recalcitrant cutaneous mastocytosis.
Case presentation:
We performed a mutational analysis of dermal mast cells after enrichment by laser capture in …
Kinetics Of Wound Development And Healing Suggests A Skin-Stabilizing Effect Of Allogeneic Abcb5+ Mesenchymal Stromal Cell Treatment In Recessive Dystrophic Epidermolysis Bullosa, 2023 Edith Cowan University
Kinetics Of Wound Development And Healing Suggests A Skin-Stabilizing Effect Of Allogeneic Abcb5+ Mesenchymal Stromal Cell Treatment In Recessive Dystrophic Epidermolysis Bullosa, Elke Niebergall-Roth, Kathrin Dieter, Cristina Daniele, Silvia Fluhr, Maria Khokhrina, Ines Silva, Christoph Ganss, Markus H. Frank, Mark A. Kluth
Research outputs 2022 to 2026
Recessive dystrophic epidermolysis (RDEB) is a rare, inherited, and currently incurable skin blistering disorder characterized by cyclically recurring wounds coexisting with chronic non-healing wounds. In a recent clinical trial, three intravenous infusions of skin-derived ABCB5+ mesenchymal stromal cells (MSCs) to 14 patients with RDEB improved the healing of wounds that were present at baseline. Since in RDEB even minor mechanical forces perpetually provoke the development of new or recurrent wounds, a post-hoc analysis of patient photographs was performed to specifically assess the effects of ABCB5+ MSCs on new or recurrent wounds by evaluating 174 wounds that occurred after baseline. During …
Clinical Presentation And Management Of Chromoblastomycosis: A Case Report And Review, 2023 LSU Health Sciences Center - New Orleans
Clinical Presentation And Management Of Chromoblastomycosis: A Case Report And Review, Lacey Falgout, Deborah Hilton
School of Medicine Faculty Publications
No abstract provided.