Optimizing Clinical And Cost Outcomes For Patients On Enteral Nutrition Support For Treatment Of Exocrine Pancreatic Insufficiency: Proceedings From An Expert Advisory Board Meeting, 2019 Drexel University; Hospital of the University of Pennsylvania
Optimizing Clinical And Cost Outcomes For Patients On Enteral Nutrition Support For Treatment Of Exocrine Pancreatic Insufficiency: Proceedings From An Expert Advisory Board Meeting, Joseph I. Boullata, Janice L. Clarke, Archie Stone, Alexis Skoufalos, David B. Nash
College of Population Health Faculty Papers
No abstract provided.
Limbic-Predominant Age-Related Tdp-43 Encephalopathy (Late): Consensus Working Group Report, 2019 University of Kentucky
Limbic-Predominant Age-Related Tdp-43 Encephalopathy (Late): Consensus Working Group Report, Peter T. Nelson, Dennis W. Dickson, John Q. Trojanowski, Clifford R. Jack, Patricia A. Boyle, Konstantinos Arfanakis, Rosa Rademakers, Irina Alafuzoff, Johannes Attems, Carol Brayne, Ian T. S. Coyle-Gilchrist, Helena C. Chui, David W. Fardo, Margaret E. Flanagan, Glenda Halliday, Suvi R. K. Hokkanen, Sally Hunter, Gregory A. Jicha, Yuriko Katsumata, Claudia H. Kawas, C. Dirk Keene, Gabor G. Kovacs, Walter A. Kukull, Allan I. Levey, Nazanin Makkinejad, Thomas J. Montine, Shigeo Murayama, Melissa E. Murray, Sukriti Nag, Robert A. Rissman, William W. Seeley, Reisa A. Sperling, Charles L. White Iii, Lei Yu, Julie A. Schneider
Sanders-Brown Center on Aging Faculty Publications
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a stereotypical TDP-43 proteinopathy in older adults, with or without coexisting hippocampal sclerosis pathology. LATE-NC is a common TDP-43 proteinopathy, associated with an amnestic dementia syndrome that mimicked Alzheimer’s-type dementia in retrospective autopsy studies. LATE is distinguished from frontotemporal lobar degeneration with TDP-43 pathology based on its epidemiology (LATE generally affects older subjects), and relatively restricted neuroanatomical distribution of TDP-43 proteinopathy. In community-based autopsy cohorts, ∼25% of brains had sufficient burden of LATE-NC to be associated with discernible cognitive impairment ...
The Generation Of Novel Metal-Folate- Phenanthroline Complexes And Phenanthroline-Folate Conjugates With Potential As Chemotherapeutic Agents, 2019 Technological University Dublin
The Generation Of Novel Metal-Folate- Phenanthroline Complexes And Phenanthroline-Folate Conjugates With Potential As Chemotherapeutic Agents, Aisling Crowley [Thesis]
The folate receptor (FR) was identified in 1986 and has been established as a ‘molecular Trojan Horse’ target for the uptake of folate-conjugated organic molecules into cells. The FR is overexpressed in many malignancies, including those of the ovary, uterus, breast, cervix, and prostate, yet it is reportedly under-expressed in normal healthy cells. This difference in expression and the high affinity/specificity of folate towards the folate receptor presents a promising drug delivery system. The aim of this research was to utilise folic acid as a targeting moiety and generate simple metal folate and novel folate-phenanthroline complexes with cytotoxic properties ...
Selenomethionine Protects Mutant Tau N27a Cell From Oxidative Stress And Decreases Phosphorylation Of Tau, 2019 Augustana College, Rock Island Illinois
Selenomethionine Protects Mutant Tau N27a Cell From Oxidative Stress And Decreases Phosphorylation Of Tau, Madelin Locicero
Celebration of Learning
Alzheimer’s Disease (AD) is neurodegenerative disease characterized by loss of cells and aggregated tau in the hippocampus. Hyperphosphorylated tau causes the misfolding of tau proteins (aggregated tau), which are responsible for proper neuronal activity. Selenium-methionine has been known to decrease the amount of phosphorylated tau within mutant and wild type 3xTg- AD mice. However, selenium can be toxic to cell depending on the type of cells and the concentration of selenium. The purpose of this study is to determine the effect selenium-methionine has on decreasing hyperphosphorylation of tau, protecting cells from oxidative stress, and decreasing the amount of aggregated ...
A Multimodal Approach To Investigate Brain Reorganization After Spinal Cord Injury Using Functional Magnetic Resonance Imaging And Functional Near-Infrared Spectroscopy, 2019 New Jersey Institute of Technology
A Multimodal Approach To Investigate Brain Reorganization After Spinal Cord Injury Using Functional Magnetic Resonance Imaging And Functional Near-Infrared Spectroscopy, Keerthana Deepti Karunakaran
Traumatic Spinal Cord Injury (SCI) results in structural and functional neurological changes at both the brain and the level of the spinal cord. Anatomical studies indicate decreased grey matter volume in sensorimotor and non-sensorimotor regions of the cortex following SCI; whereas, neurophysiological findings mostly report altered functional activity in the sensorimotor nodes of the cortex, subcortex, and cerebellum. Therefore, it is currently unknown whether tissue atrophy observed in non-motor related areas has any concomitant functional consequences. Furthermore, the neural underpinnings of adaptive neuroplasticity after SCI is not well-defined in the current literature. Hence, this dissertation is a pioneer study investigating ...
High-Performance Learning Systems Using Low-Precision Nanoscale Devices, 2019 New Jersey Institute of Technology
High-Performance Learning Systems Using Low-Precision Nanoscale Devices, Nandakumar Sasidharan Rajalekshmi
Brain-inspired computation promises a paradigm shift in information processing, both in terms of its parallel processing architecture and the ability to learn to tackle problems deemed unsolvable by traditional algorithmic approaches. The computational capability of the human brain is believed to stem from an interconnected network of 100 billion compute nodes (neurons) that interact with each other through approximately 1015 adjustable memory junctions (synapses). The conductance of synapses is modifiable allowing the network to learn and perform various cognitive functions. Artificial neural networks inspired by this architecture have demonstrated even super-human performance in many complex tasks.
Computational systems based ...
Technical Freediving: An Emerging Breath-Hold Diving Technique, 2019 University of Florida
Technical Freediving: An Emerging Breath-Hold Diving Technique, Derek Covington, Robert H. Lee, Steven Toffel, Alberto Bursian, Kirk Krack, Chris Giordano
Journal of Human Performance in Extreme Environments
Technical freediving can be defined as freediving augmented by the use of oxygen-enriched gases or oxygen before, during, or after a freedive. As a result of these techniques, breath-hold divers can visit and enjoy underwater wrecks, reefs, and other diving locations previously located at depths unreachable to apnea divers. By pre-breathing oxygen-enriched gases in conjunction with hyperventilation—which decreases the partial pressure of carbon dioxide (PCO2)—the technical freediver now has additional oxygen to facilitate aerobic respiration during the dive. In addition, pre-breathing oxygen decreases tissue nitrogen tensions, which limits inert gas loading and decreases the risk of decompression sickness ...
Control Of Antiviral Innate Immune Response By Protein Geranylgeranylation, 2019 Duke University
Control Of Antiviral Innate Immune Response By Protein Geranylgeranylation, Shigao Yang, Zhaozhao Jiang, Katherine A. Fitzgerald, Donghai Wang
Open Access Articles
The mitochondrial antiviral signaling protein (MAVS) orchestrates host antiviral innate immune response to RNA virus infection. However, how MAVS signaling is controlled to eradicate virus while preventing self-destructive inflammation remains obscure. Here, we show that protein geranylgeranylation, a posttranslational lipid modification of proteins, limits MAVS-mediated immune signaling by targeting Rho family small guanosine triphosphatase Rac1 into the mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) at the mitochondria-ER junction. Protein geranylgeranylation and subsequent palmitoylation promote Rac1 translocation into MAMs upon viral infection. MAM-localized Rac1 limits MAVS' interaction with E3 ligase Trim31 and hence inhibits MAVS ubiquitination, aggregation, and activation. Rac1 also facilitates ...
Adipocyte Acly Facilitates Dietary Carbohydrate Handling To Maintain Metabolic Homeostasis In Females, 2019 University of Pennsylvania
Adipocyte Acly Facilitates Dietary Carbohydrate Handling To Maintain Metabolic Homeostasis In Females, Sully Fernandez, John M. Viola, Annmarie Torres, Martina Wallace, Sophie Trefely, Steven Zhao, Hayley C. Affronti, Jivani M. Gengatharan, David A. Guertin, Nathaniel W. Snyder, Christian M. Metallo, Kathryn E. Wellen
Open Access Articles
Sugars and refined carbohydrates are major components of the modern diet. ATP-citrate lyase (ACLY) is upregulated in adipocytes in response to carbohydrate consumption and generates acetyl-coenzyme A (CoA) for both lipid synthesis and acetylation reactions. Here, we investigate the role of ACLY in the metabolic and transcriptional responses to carbohydrates in adipocytes and unexpectedly uncover a sexually dimorphic function in maintaining systemic metabolic homeostasis. When fed a high-sucrose diet, Acly(FAT-/-) females exhibit a lipodystrophy-like phenotype, with minimal fat accumulation, insulin resistance, and hepatic lipid accumulation, whereas Acly(FAT-/-) males have only mild metabolic phenotypes. We find that ACLY is ...
Scintillation Event Localization In Novel Hemi-Ellipsoid Detector For Spect, 2019 Louisiana State University and Agricultural and Mechanical College
Scintillation Event Localization In Novel Hemi-Ellipsoid Detector For Spect, Hanif R. Soysal
LSU Master's Theses
A high sensitivity Cardiac SPECT system using hemi-ellipsoid crystals with pinhole collimation was previously proposed by Dey et al. To investigate detector resolution for this design, the scintillation light spread on a monolithic hemi-ellipsoidal CsI crystal was simulated using Geant4 Monte Carlo. The expected distribution of scintillation light on the outer surface of the crystal from photoelectric absorption events was obtained from the simulations for selected points inside the crystal. Two sets of simulations were performed. For the first set, a look-up table (LUT) of 12 points was created and each point mapped to its expected light distribution—four points ...
Novel Amphiphilic Cyclobutene And Cyclobutane Cis-C18 Fatty Acid Derivatives Inhibit Mycobacterium Avium Subsp. Paratuberculosis Growth, 2019 University of Nebraska - Lincoln
Novel Amphiphilic Cyclobutene And Cyclobutane Cis-C18 Fatty Acid Derivatives Inhibit Mycobacterium Avium Subsp. Paratuberculosis Growth, Denise K. Zinniel, Wantanee Sittiwong, Darrell D. Marshall, Govardhan Rathnaiah, Isin Sakallioglu, Robert Powers, Patrick H. Dussault, Raul G. Barletta
Papers in Veterinary and Biomedical Science
Mycobacterium avium subspecies paratuberculosis (Map) is the etiologic agent of Johne’s disease in ruminants and has been associated with Crohn’s disease in humans. An ective control of Map by either vaccines or chemoprophylaxis is a paramount need for veterinary and possibly human medicine. Given the importance of fatty acids in the biosynthesis of mycolic acids and the mycobacterial cell wall, we tested novel amphiphilic C10 and C18 cyclobutene and cyclobutane fatty acid derivatives for Map inhibition. Microdilution minimal inhibitory concentrations (MIC) with 5 or 7 week endpoints were measured in Middlebrook 7H9 base broth media. We compared the ...
Sub-Region Based Radiomics Analysis For Survival Prediction In Oesophageal Tumours Treated By Definitive Concurrent Chemoradiotherapy, Congying Xie, Pengfei Yang, Xuebang Zhang, Lei Xu, Xiaoju Wang, Xiadong Li, Luhan Zhang, Ruifei Xie, Ling Yang, Zhao Jing, Hongfang Zhang, Lingyu Ding, Yu Kuang, Tianye Niu, Shixiu Wu
Health Physics & Diagnostic Sciences Faculty Publications
Background: Evaluating clinical outcome prior to concurrent chemoradiotherapy remains challenging for oesophageal squamous cell carcinoma (OSCC) as traditional prognostic markers are assessed at the completion of treatment. Herein, we investigated the potential of using sub-region radiomics as a novel tumour biomarker in predicting overall survival of OSCC patients treated by concurrent chemoradiotherapy. Methods: Independent patient cohorts from two hospitals were included for training (n = 87) and validation (n = 46). Radiomics features were extracted from sub-regions clustered from patients' tumour regions using K-means method. The LASSO regression for ‘Cox’ method was used for feature selection. The survival prediction model was constructed ...
Early Pre-Radiographic Structural Pathology Precedes The Onset Of Accelerated Knee Osteoarthritis, 2019 University of Massachusetts Medical School
Early Pre-Radiographic Structural Pathology Precedes The Onset Of Accelerated Knee Osteoarthritis, Matthew S. Harkey, Julie E. Davis, Bing Lu, Lori Lyn Price, Robert J. Ward, James W. Mackay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Timothy E. Mcalindon, Jeffrey B. Driban
Open Access Articles
BACKGROUND: Accelerated knee osteoarthritis (AKOA) is characterized by more pain, impaired physical function, and greater likelihood to receive a joint replacement compared to individuals who develop the typical gradual onset of disease. Prognostic tools are needed to determine which structural pathologies precede the development of AKOA compared to individuals without AKOA. Therefore, the purpose of this manuscript was to determine which pre-radiographic structural features precede the development of AKOA.
METHODS: The sample comprised participants in the Osteoarthritis Initiative (OAI) who had at least one radiographically normal knee at baseline (Kellgren-Lawrence [KL] grade < 1). Participants were classified into 2 groups based on radiographic progression from baseline to 48 months: AKOA (KL grade change from < 1 to > 3) and No AKOA. The index visit was ...
Dysfunction In Serotonergic And Noradrenergic Systems And Somatic Symptoms In Psychiatric Disorders, 2019 The Second Xiangya Hospital of Central South University
Dysfunction In Serotonergic And Noradrenergic Systems And Somatic Symptoms In Psychiatric Disorders, Yi Liu, Jingping Zhao, Xiaoduo Fan, Wenbin Guo
Open Access Articles
Somatic symptoms include a range of physical experiences, such as pain, muscle tension, body shaking, difficulty in breathing, heart palpitation, blushing, fatigue, and sweating. Somatic symptoms are common in major depressive disorder (MDD), anxiety disorders, and some other psychiatric disorders. However, the etiology of somatic symptoms remains unclear. Somatic symptoms could be a response to emotional distress in patients with those psychiatric conditions. Increasing evidence supports the role of aberrant serotoninergic and noradrenergic neurotransmission in somatic symptoms. The physiological alterations underlying diminished serotonin (5-HT) and norepinephrine (NE) signaling may contribute to impaired signal transduction, reduced 5-HT, or NE release from ...
The Study Of Neurological Response In Art Therapy And Trauma: A Literature Review, 2019 Lesley University
The Study Of Neurological Response In Art Therapy And Trauma: A Literature Review, Kristin Weber
Expressive Therapies Capstone Theses
This review will focus on neurological research and art therapy practice to consider benefits of the integration of science and the creative therapies. These topics will be addressed through a trauma informed theoretical lens, focusing on Post-Traumatic Stress Disorder and Traumatic Brain Injury diagnoses in the US military veteran population. Arts-based, qualitative, and quantitative research were correlated within this review to discover links between neurology and art therapy’s unique impact on trauma, and the outcome of combining these practices. The conclusions found that, with limited research connecting these two fields, there is a possibility for enhanced trauma treatment through ...
Assessment Of Motor Function, Motor Learning, & Olivary Climbing Fiber Distribution Within Developmental Hyperserotonemia Rat Model For Autism Spectrum Disorder, Elizabeth Diane Holland
MSU Graduate Theses
While Autism Spectrum Disorder (ASD) is defined by deficits in social communication, compromised motor function and motor learning have been increasingly reported. Motor deficits could compound social impairment through delayed language acquisition, reduced opportunity for social interaction, and affected nonverbal communication. One area of interest in the investigation of motor dysfunction is the cerebellum, where altered cerebellar structure and connectivity have been reported in those diagnosed with ASD. Morphological and functional changes in cerebellar circuitry could disrupt motor skill development and may be associated with developmental alterations of the serotonergic system. Elevated blood serotonin in perinatal development, developmental hyperserotonemia (DHS ...
Towards Human Retinal Cones Spatial Distribution Modeling, 2019 Università Degli Studi di Milano
Towards Human Retinal Cones Spatial Distribution Modeling, Matteo Paolo Lanaro, Hélène Perrier, David Coeurjolly, Victor Ostromoukhov, Alessandro Rizzi
No abstract provided.
A Pbpk Model Of Low-Concentration Vitamin D Supplementation In The Absence Of Sunlight, 2019 Southern New Hampshire University
A Pbpk Model Of Low-Concentration Vitamin D Supplementation In The Absence Of Sunlight, Megan Sawyer
Biology and Medicine Through Mathematics Conference
No abstract provided.
Decomposition Of Pig Carcasses At Varying Room Temperature, 2019 San Jose State University
Decomposition Of Pig Carcasses At Varying Room Temperature, Jacqueline Abad Santos
Themis: Research Journal of Justice Studies and Forensic Science
The goal of this study is to assess the qualitative scoring of decomposition scales with statistical analysis while also determining which indoor environment will decompose the fastest. When comparing the three indoor environments, water decomposition appears to be the fastest, but the method of analysis for this study determines that using decomposition scales to analyze such environments may produce statistically insignificant results. For this study, piglets were put in a dry steel tub, a water filled steel tub, and a suitcase. These were recorded using photographs for 25 days and then scored using decomposition scales. The total score was divided ...
Real-Time Interactive Simulation Of Human Atrial Electrical Activity On Realistic 3d Atrial Structures Using Webgl, 2019 Georgia Institute of Technology
Real-Time Interactive Simulation Of Human Atrial Electrical Activity On Realistic 3d Atrial Structures Using Webgl, Abouzar Kaboudian, Yanyan Ji, Elizabeth Cherry, Flavio H. Fenton
Biology and Medicine Through Mathematics Conference
No abstract provided.