He Utility Of Synovial Fluid Levels Of Adamts9 And Adamts4 In Predicting Treatment Responses To Intraarticular Steroid Injections In Patients With Knee Osteoarthritis, Kenan Özler
Turkish Journal of Medical Sciences
Background/aim: This study aims to identify the role of synovial fluid levels of a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) and a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) for the prediction of intraarticular steroid injection success in knee osteoarthritis (OA).Material and methods: A total of eighty-four advanced stage knee OA patients (42 with stage 3 OA and 42 with stage 4 OA) were enrolled in the study. Baseline and posttreatment outcomes were determined using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Pretreatment synovial fluid ADAMTS9 and ADAMTS4 levels were measured by enzyme linked immunosorbent assay …
Colchicine Intolerance In Fmf Patients And Primary Obstacles For Optimal Dosing, 2020 TÜBİTAK
Colchicine Intolerance In Fmf Patients And Primary Obstacles For Optimal Dosing, Hasan Satiş, Berkan Armağan, Erdal Bodakçi̇, Nuh Ataş, Alper Sari, Nazi̇fe Şule Yaşar Bi̇lge, Di̇lek Yapar, Reyhan Bi̇li̇ci̇ Salman, Gözde Kübra Yardimci, Hakan Babaoğlu, Levent Kiliç, Berna Göker, Şemi̇nur Haznedaroğlu, Ti̇muçi̇n Kaşi̇foğlu, Umut Kalyoncu
Turkish Journal of Medical Sciences
Background/aim: Colchicine is the mainstay of treatment in FMF. However, in daily practice it is not easy to maintain effective colchicine doses in a substantial number of patients due to its side effects. In this study, we aimed to investigate prevalence and risk factors for colchicine side effects that limit optimal drug dosing and cause permanent discontinuation. Materials and methods: All patients were recruited from "FMF in Central Anatolia" (FiCA) cohort, 915 adults with a minimum follow-up time of 6 months during which they had obeyed all treatment instructions. Demographic and anthropometric data, FMF disease characteristics, disease severity, complications, and …
Presence Of Paroxysmal Nocturnal Hemoglobinuria In Patients With Idiopathic Portal Vein Thrombosis: A Single-Center Study, 2020 TÜBİTAK
Presence Of Paroxysmal Nocturnal Hemoglobinuria In Patients With Idiopathic Portal Vein Thrombosis: A Single-Center Study, Cengi̇z Demi̇r, Senar Ebi̇nç, Ömer Eki̇nci̇
Turkish Journal of Medical Sciences
Background/aim: Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare clonal hematopoietic stem cell disease characterized by chronic hemolytic anemia and thrombosis. We report data from a study of the occurrence of PNH among patients with idiopathic portal vein thrombosis (PVT). Materials and methods: Patients who were followed up with the diagnosis of idiopathic PVT were enrolled into this study. Those with laboratory and/or imaging evidence of any local or systemic factor that could lead to PVT were excluded. PNH clone was examined in all patients using established FLAER methodology.Results: A total of 112 patients (42 males and 70 females), none …
Correlation Of Language Lateralization With Resting State Hippocampal Connectivity In Temporal Lobe Epilepsy Patients, 2020 TÜBİTAK
Correlation Of Language Lateralization With Resting State Hippocampal Connectivity In Temporal Lobe Epilepsy Patients, Ali̇ Murat Koç, Ali̇ Yusuf Öner, Hali̇l Özer, Meli̇ke Güryildirim, Emi̇n Turgut Tali, Fati̇h Öncü, Murat Uçar, Erhan Bi̇li̇r, İrem Çapraz, Gökhan Kurt
Turkish Journal of Medical Sciences
Background/aim: The main purpose of this study is to evaluate the resting state hippocampal connectivity with language areas and to correlate them with laterality index calculations on single subject basis, hence to present hippocampal lateralization for language with rs-fMRI.Materials and methods: Task based and rs-fMRI data were gathered from a total of 45 subjects in 3T scanner. BrainVoyager QX, SPM, and CONN softwares were used for data analysis. LI score of each subject was calculated and converted into normalized LI score (nLI). Intrahemispheric rs-connectivity analysis was performed between hippocampus and Broca's regions on both sides. Correlation between these variables was …
Posttraumatic Growth And Death Anxiety In Caregivers Of Cancer Patients: Phoenix Study, 2020 TÜBİTAK
Posttraumatic Growth And Death Anxiety In Caregivers Of Cancer Patients: Phoenix Study, Ali̇ Alkan, Eli̇f Berna Köksoy, Ebru Karci, Asli Alkan, Eduardo Bruera, Fi̇li̇z Çay Şenler
Turkish Journal of Medical Sciences
Background/aim: Posttraumatic growth (PTG) is defined as positive psychological changes following a challenging or traumatic life event. The purpose of this study is to define the predictors of PTG and death anxiety (DAN) in caregivers of cancer patients and evaluate the impact of DAN on PTG.Materials and methods: The caregivers of cancer patients were evaluated using structured questionnaires, including a validated PTG scale and Templer death anxiety scale.Results: In 3 different cancer centers, 426 participants were evaluated. In multivariate analysis of factors associated with PTG, a high DAN score was the only parameter associated with high PTG scores [OR: 1.6, …
Determination Of Related Factors About Diagnostic And Treatment Delays In Patients With Smear-Positive Pulmonary Tuberculosis In Turkey, Mustafa Hami̇dullah Türkkani, Tarkan Özdemi̇r, Çi̇ğdem Özdi̇lekcan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to analyze delays in diagnosis and treatment by defining the related demographic and clinical factors, to reveal obstacles, and to develop essential attempts to help reduce treatment delays.Materials and methods: We created a questionnaire on the subject of delays in diagnosis and treatment in tuberculosis (TB) control to be administered to the patients. The forms were distributed to dispensaries across the country by the General Directorate of Public Health via an official letter. Results: The study included 853 new patients with smear-positive pulmonary TB. The mean patient delay was 18.06 ± 22.27 days, the mean diagnosis …
Treatment Of Idiopathic Granulomatous Mastitis And Factors Related With Disease Recurrence, 2020 TÜBİTAK
Treatment Of Idiopathic Granulomatous Mastitis And Factors Related With Disease Recurrence, Emre Tekgöz, Seda Çolak, Muhammet Çinar, Sedat Yilmaz
Turkish Journal of Medical Sciences
Background/aim: Idiopathic granulomatous mastitis is a rare, benign inflammatory disease of breast. There is no general agreement on the appropriate treatment choice.The aim of the study was to investigate the immunosuppressive administer for idiopathic granulomatous mastitis and risk factors related with disease recurrence.Materials and methods: The data of 53 patients with idiopathic granulomatous mastitis were evaluated for this cross-sectional retrospective study. Demographic features and clinical characteristics and course of the patients were obtained from file records. Results: The mean age of the patients was 37.2 ± 6.6 years. Fifty-one of 53 patients received immunosuppressive treatment with or without surgery. Forty-seven …
Coenzyme Q10, Zinc And Mda Levels In Verruca Vulgaris, 2020 TÜBİTAK
Coenzyme Q10, Zinc And Mda Levels In Verruca Vulgaris, Selma Korkmaz, Fevzi̇ye Burcu Şi̇ri̇n, İjlal Erturan, Hali̇l İbrahi̇m Büyükbayram, Mehmet Yildirim
Turkish Journal of Medical Sciences
Background/aim: Verruca vulgaris is a benign disease characterized with papillomas on the skin and mucosa. The aim of this study was to investigate the serum levels of coenzyme Q10, MDA, and zinc as well as the lipid profile of verruca vulgaris patients and examine the relationship between these parameters and clinical manifestations of the disease.Materials and methods: The study included 49 verruca vulgaris patients (mean age: 32.01 ± 14.20 years; 22 males, 27 females) and 40 healthy volunteers (mean age: 31.63 ± 8.98 years; 21 males and 19 females). Coenzyme Q10 levels were assessed by using an enzyme-linked immunosorbent assay. …
Histopathological And Mechanical Effects Of Ankaferd Blood Stopper® On Wound Healing In Rats: An Experimental Model, 2020 TÜBİTAK
Histopathological And Mechanical Effects Of Ankaferd Blood Stopper® On Wound Healing In Rats: An Experimental Model, Sertaç Hancioğlu, Berat Di̇lek Demi̇rel, Ünal Biçakci, Seda Gün, Mehmet Ender Aritürk, Nurşen Aritürk
Turkish Journal of Medical Sciences
Background/aim: To evaluate the histopathological and mechanical effects of Ankaferd Blood Stopper (ABS) application on wound healing.Materials and methods: A total of 24 Wistar albino rats were randomly divided into three equal groups. In each group, a 3 cm-long midline vertical skin incision was performed in the back of the rats. In Group 1, the incision was sutured primarily. In Group 2, incision was left to secondary healing. In Group 3, ABS was applied to the incision. On the 10th day, burst pressure width was measured, and rats were sacrificed. The tissue samples were examined histopathologically. Statistical analysis was conducted …
Antiinfective And Wound-Healing Pleiotropic Actions Of Ankaferd Hemostat, 2020 TÜBİTAK
Antiinfective And Wound-Healing Pleiotropic Actions Of Ankaferd Hemostat, İbrahi̇m Celaletti̇n Haznedaroğlu, Mustafa Çelebi̇er
Turkish Journal of Medical Sciences
To the Editor,We read with great interest the article entitled "An evaluation of the effects of caffeic acid phenethyl ester and Ankaferd blood stopper on secondary wound healing of oral mucosal tissue", published recently in the Journal[1]. The authors indicated that Ankaferd Hemostat (Ankaferd Blood Stopper, ABS) and caffeic acid phenethyl ester had positive effects on the oral wound healing process. Since ABS has already been used in dental surgery for years, it is known as not irritable to the oral mucosa [2]. ABS antibacterial, antiinfective, and cellular features are also established [3]. More importantly, ABS is clinically effective in …
Characteristics Of The Initial Patients Hospitalized For Covid-19: A Single-Center Report, 2020 TÜBİTAK
Characteristics Of The Initial Patients Hospitalized For Covid-19: A Single-Center Report, Alpay Medetali̇beyoğlu, Naci̇ Şenkal, Gazi̇ Çapar, Murat Köse, Tufan Tükek
Turkish Journal of Medical Sciences
No abstract provided.
Radiological Approaches To Covid-19 Pneumonia, 2020 TÜBİTAK
Radiological Approaches To Covid-19 Pneumonia, Furkan Ufuk, Recep Savaş, Tuncay Hazirolan
Turkish Journal of Medical Sciences
No abstract provided.
Response To Letter To The Editor: Radiological Approaches To Covid-19 Pneumonia, 2020 TÜBİTAK
Response To Letter To The Editor: Radiological Approaches To Covid-19 Pneumonia, Müşerref Şule Akçay
Turkish Journal of Medical Sciences
No abstract provided.
A Study Of Drynariafortunei In Modulation Of Bmp-2 Signalling By Bone Tissue Engineering, 2020 TÜBİTAK
A Study Of Drynariafortunei In Modulation Of Bmp-2 Signalling By Bone Tissue Engineering, Guo-Chung Dong, Tzn-Yuan Ma, Chi-Han Li, Chih-Ying Chi, Chao-Ming Su, Chih-Ling Huang, Yan-Hsiung Wang, Tzer-Ming Lee
Turkish Journal of Medical Sciences
Background/aim: Drynaria fortunei (Gusuibu; GSB) is a popular traditional Chinese medicine used for bone repair. An increasing number of studies have reported that GSB induces osteogenic differentiation in bone marrow mesenchymal stem cells (BMSCs). These results provide insight into the application of GSB for bone tissue engineering techniques used to repair large bone defects. However, few studies have described the molecular mechanisms of GSB.Materials and methods: In the present study, the effects of GSB and naringin, a marker compound, on the binding of BMP-2 to BMPR and BMP-2-derived signal transduction were investigated using surface plasmon resonance (SPR) and coculturing with …
Surface Enhanced Raman Spectroscopy As A Novel Tool For Rapid Quantification Of Heroin And Metabolites In Saliva, 2020 TÜBİTAK
Surface Enhanced Raman Spectroscopy As A Novel Tool For Rapid Quantification Of Heroin And Metabolites In Saliva, Ramazan Akçan, Mahmut Şeri̇f Yildirim, Hasan İlhan, Burcu Güven, Uğur Tamer, Necdet Sağlam
Turkish Journal of Medical Sciences
Background: Heroin can be detected and quantified by certain analytical methods, however, forensic professionals and criminal laboratories study for cheaper and faster detection tools. Surface-enhanced Raman spectroscopy (SERS) rises as a possible alternative tool with its widening application spectra. There are few studies regarding Raman and SERS spectra of heroin and its metabolites, which are unfortunately controversial. In this study, we compared five different surfaces in order to find out more efficient Raman-active substrate for opiate detection and rapid quantification of heroin and its metabolites in saliva.Materials and methods: Morphine standard material was used to identify proper surface for SERS …
Posthepatectomy Liver Failure, 2020 TÜBİTAK
Posthepatectomy Liver Failure, İlhan Ocak, Serdar Topaloğlu, Koray Acarli
Turkish Journal of Medical Sciences
Liver surgery is one of the most complex surgical interventions with high risk and potential for complications. Posthepatectomy liver failure (PHLF) is a serious complication of liver surgery that occurs in about 10% of patients undergoing major liver surgery. It is the main source of morbidity and mortality. Appropriate surgical techniques and intensive care management are important in preventing PHLF. Early start of the liver support systems is very important for the PHLF patient to recover, survive, or be ready for a liver transplant. Nonbiological and biological liver support systems should be used in PHLF to prepare for treatment or …
Diagnostic Approach In Parenchymal Lung Diseases: Transbronchial Lung Biopsy Or Cryobiopsy?, 2020 TÜBİTAK
Diagnostic Approach In Parenchymal Lung Diseases: Transbronchial Lung Biopsy Or Cryobiopsy?, Ali̇ Kadri̇ Çirak, Nuran Katgi, Onur Fevzi̇ Erer, Pinar Çi̇men, Fatma Fevzi̇ye Tuksavul, Burçi̇n Hakoğlu
Turkish Journal of Medical Sciences
Background/aim: Diagnosis of interstitial lung diseases requires a multidisciplinary approach, and a gold standard for histological diagnosis is open lung biopsy. Transbronchial lung biopsy (TBLB) and in recent years an alternative method, cryobiopsy (TBLC), are used for the diagnosis of parenchymal lung lesions. The aim of this study is to compare the efficacy of concomitant conventional TBLB and TBLC. Materials and methods: A total of 82 patients who underwent TBLC for diagnosis of diffuse parenchymal lung diseases at Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital between 2015 and 2018 were screened retrospectively and included in the …
Is 48 H A Critical Cut-Off Point For Mortality In Geriatric Hip Fractures?, 2020 TÜBİTAK
Is 48 H A Critical Cut-Off Point For Mortality In Geriatric Hip Fractures?, Ahmet Emre Paksoy, Keri̇m Öner, Ferdi̇ Polat, Serhat Durusoy
Turkish Journal of Medical Sciences
Background/aim: In this study, our objective was to evaluate the mortality in geriatric hip fracture patients who were operated within 48 h after admission or after the 48th h. Materials and methods: A total of 194 patients who had undergone surgery for hip fracture between 2016 and 2018 were retrospectively evaluated. Patient information was obtained from the hospital?s database using the ICD codes 81.52, 82.00?82.09, and 82.10. Radiological examination reports were collected from the patient files. Information on mortality was obtained from the Death Notification System of the Turkish Ministry of Health. First-year mortality rates of patients operated within 48 …
Does The Volume Overload Exaggerate The Severity Of Mitral Regurgitation In Patients With Decompensated Heart Failure?, 2020 TÜBİTAK
Does The Volume Overload Exaggerate The Severity Of Mitral Regurgitation In Patients With Decompensated Heart Failure?, Göktuğ Savaş, Ömer Şahi̇n, Mustafa Yaşan, Uğur Karabiyik, Ni̇hat Kalay, Ali̇ Doğan, Ferhan Elmali, Abdurrahman Oğuzhan
Turkish Journal of Medical Sciences
Background/aim: Diagnosing and managing functional mitral regurgitation (MR) is often challenging and requires an integrated approach including a comprehensive echocardiographic examination. However, the effects of volume overload on the echocardiographic assessment of MR severity are uncertain. The purpose of this study was to weigh the effects of volume overload in the echocardiographic assessment of MR severity among patients with heart failure (HF). Materials and methods: Twenty-nine patients with decompensated HF, who had moderate or severe MR, were included in the present study. The volume status and the N-terminal pro-B-type natriuretic peptide (proBNP) levels were recorded and the echocardiographic parameters were …
Do Different Surgical Techniques In Tibia Pilon Fractures Change The Results Of The Midterm?, 2020 TÜBİTAK
Do Different Surgical Techniques In Tibia Pilon Fractures Change The Results Of The Midterm?, Vedat Bi̇çi̇ci̇, İzzet Bi̇ngöl
Turkish Journal of Medical Sciences
Background/aim: Pilon fracture is difficult to treat fractures due to many complications that can develop after surgery. To achieve the best results, different surgical approaches are used.In our study, we aimed to compare the functional results and complication rates of our treatments in patients treated with 3 different surgical tecniques. Materials and methods: 89 pilon fractures of 87 patients treated for pilon fracture were evaluated. Patients were examined in 3 different groups (one step, two step surgery and Ilizarov). Functional results, postoperative complications and ankle AOFAS scores were evaluated. Results: The mean AOFAS score of the all patients was 77.67. …