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Consumption Of High Ω-3 Fatty Acid Diet Suppressed Prostate Tumorigenesis In C3(1) Tag Mice, Juliana A. Akinsete, Gabriela Ion, Theodore R. Witte, W. Elaine Hardman 2012 Marshall University

Consumption Of High Ω-3 Fatty Acid Diet Suppressed Prostate Tumorigenesis In C3(1) Tag Mice, Juliana A. Akinsete, Gabriela Ion, Theodore R. Witte, W. Elaine Hardman

Elaine Hardman Ph.D.

Prostate cancer incidence and mortality are high in the Western world and high ω-6/ω-3 PUFA in the Western diet may be a contributing factor. We investigated whether changing from a diet that approximates ω-6 fat content of the Western diet to a high ω-3 fat diet at adulthood might reduce prostate cancer risk. Female SV 129 mice that had consumed a high ω-6 diet containing corn oil for 2 weeks were bred with homozygous C3(1)Tag transgenic male mice. All male offspring were weaned to the corn oil diet (CO) until postpuberty when half of the male offspring ...


Associations Between Toenail Arsenic Concentration And Dietary Factors In A New Hampshire Ppopulation, Joann F. Gruber, Margaret R. Karagas, Diane Gilbert-Diamond, Pamela J. Bagley, M Scot Zens, Vicki Sayarath, Tracy Punshon, J Steven Morris, Kathryn L. Cottingham 2012 Dartmouth College

Associations Between Toenail Arsenic Concentration And Dietary Factors In A New Hampshire Ppopulation, Joann F. Gruber, Margaret R. Karagas, Diane Gilbert-Diamond, Pamela J. Bagley, M Scot Zens, Vicki Sayarath, Tracy Punshon, J Steven Morris, Kathryn L. Cottingham

Open Dartmouth: Faculty Open Access Scholarship

Background: Dietary factors such as folate, vitamin B12, protein, and methionine are important for the excretion of arsenic via one-carbon metabolism in undernourished populations exposed to high levels of arsenic via drinking water. However, the effects of dietary factors on toenail arsenic concentrations in well-nourished populations exposed to relatively low levels of water arsenic are unknown.

Methods: As part of a population-based case-control study of skin and bladder cancer from the USA, we evaluated relationships between consumption of dietary factors and arsenic concentrations in toenail clippings. Consumption of each dietary factor was determined from a validated food frequency questionnaire. We ...


Induction Of Colon Cancer Cell Death By Cranberry Proanthocyanidins Via Mapk Pathway, Anne M. Liberty, Tracie P. Ferreira, Catherine C. Neto 2012 University of Massachusetts - Dartmouth

Induction Of Colon Cancer Cell Death By Cranberry Proanthocyanidins Via Mapk Pathway, Anne M. Liberty, Tracie P. Ferreira, Catherine C. Neto

UMass Center for Clinical and Translational Science Research Retreat

The potential ability of dietary cranberry to inhibit colon carcinogenesis is under investigation. Compounds isolated from locally grown cranberry fruit (Vaccinium macrocarpon) have been shown in vitro to decrease proliferation of colon cancer cells, in part by induction of apoptosis. These compounds include oligomeric polyphenols known as proanthocyanidins (PACs) containing two or more epicatechin units with different types of linkages. To further elucidate the mechanism by which PACs induce cell death, we transcriptionally profiled cells treated with PACs. HCT116 and HT29 colon cancer cells were exposed to a cranberry proanthocyanidin (PACs) fraction isolated from Early Black variety cranberry fruit, at ...


Clinical Utility Of Folate-Containing Oral Contraceptives., Zohra S Lassi, Zulfiqar Ahmed Bhutta 2012 Aga Khan University

Clinical Utility Of Folate-Containing Oral Contraceptives., Zohra S Lassi, Zulfiqar Ahmed Bhutta

Woman and Child Health

Folate is a generic term for a water-soluble B-complex vitamin which plays an important role in protein synthesis and metabolism and other processes related to cell multiplication and tissue growth. Pregnant and lactating women are at increased risk of folic acid deficiency because generally their dietary folate is insufficient to meet their physiological requirements and the metabolic demands of the growing fetus. The evidence pertaining to the reduction of the risk of neural tube defects (NTDs) due to folate is so compelling that supplementation with 400 mug of folic acid to all women trying to conceive until 12 weeks of ...


Consumption Of High Ω-3 Fatty Acid Diet Suppressed Prostate Tumorigenesis In C3(1) Tag Mice, Juliana A. Akinsete, Gabriela Ion, Theodore R. Witte, W. Elaine Hardman 2012 Marshall University

Consumption Of High Ω-3 Fatty Acid Diet Suppressed Prostate Tumorigenesis In C3(1) Tag Mice, Juliana A. Akinsete, Gabriela Ion, Theodore R. Witte, W. Elaine Hardman

Biochemistry and Microbiology

Prostate cancer incidence and mortality are high in the Western world and high ω-6/ω-3 PUFA in the Western diet may be a contributing factor. We investigated whether changing from a diet that approximates ω-6 fat content of the Western diet to a high ω-3 fat diet at adulthood might reduce prostate cancer risk. Female SV 129 mice that had consumed a high ω-6 diet containing corn oil for 2 weeks were bred with homozygous C3(1)Tag transgenic male mice. All male offspring were weaned to the corn oil diet (CO) until postpuberty when half of the male offspring ...


Sterol Lipid Metabolism In Down Syndrome Revisited: Down Syndrome Is Associated With A Selective Reduction In Serum Brassicasterol Levels, Gavin Tansley, Daniel T. Holmes, Dieter Lütjohann, Elizabeth Head, Cheryl L. Wellington 2012 University of British Columbia, Canada

Sterol Lipid Metabolism In Down Syndrome Revisited: Down Syndrome Is Associated With A Selective Reduction In Serum Brassicasterol Levels, Gavin Tansley, Daniel T. Holmes, Dieter Lütjohann, Elizabeth Head, Cheryl L. Wellington

Pharmacology and Nutritional Sciences Faculty Publications

Over the past 15 years, insights into sterol metabolism have improved our understanding of the relationship between lipids and common conditions such as atherosclerosis and Alzheimer's Disease (AD). A better understanding of sterol lipid metabolism in individuals with Down Syndrome (DS) may help elucidate how this population's unique metabolic characteristics influence their risks for atherosclerosis and AD. To revisit the question of whether sterol lipid parameters may be altered in DS subjects, we performed a pilot study to assess traditional serum sterol lipids and lipoproteins, as well as markers of sterol biosynthesis, metabolites, and plant sterols in 20 ...


Aging And Down Syndrome, Elizabeth Head, Wayne Silverman, David Patterson, Ira T. Lott 2012 University of Kentucky

Aging And Down Syndrome, Elizabeth Head, Wayne Silverman, David Patterson, Ira T. Lott

Pharmacology and Nutritional Sciences Faculty Publications

No abstract provided.


Nutrition Research From Cells To Communities, Patricia Beffa-Negrini, Elena Carbone, Nancy Cohen, Lorraine S. Cordeiro, Young-Cheul Kim, Jerusha Peterman, Alayne Ronnenberg, Richard J. Wood 2011 University of Massachusetts - Amherst

Nutrition Research From Cells To Communities, Patricia Beffa-Negrini, Elena Carbone, Nancy Cohen, Lorraine S. Cordeiro, Young-Cheul Kim, Jerusha Peterman, Alayne Ronnenberg, Richard J. Wood

Community Engagement and Research Symposia

Abstract:

The mission of the Department of Nutrition, UMass Amherst, is to provide excellence and innovation in teaching, research, and outreach by applying a scientific foundation that addresses the nutritional needs of individuals and diverse populations. We conduct laboratory and applied community-based research that spans a wide range of issues. Housed within the Department of Nutrition, the UMass Extension Nutrition Education Program (NEP) collaborates with more than 100 agencies and provides nutrition education in over 46 communities in Massachusetts. This poster presents 1) the range of work undertaken by faculty, students, and NEP; and 2) highlight faculty research areas as ...


Características Demográficas E Ocupacionais Do Estudante-Trabalhador De Enfermagem E O Risco De Acidentes De Trabalho / Demographical And Occupational Characteristics Of The Student-Worker Of Nursing And The Risk Of Accidents At Work, Everton Fernando Alves 2011 Universidade Estadual de Maringá

Características Demográficas E Ocupacionais Do Estudante-Trabalhador De Enfermagem E O Risco De Acidentes De Trabalho / Demographical And Occupational Characteristics Of The Student-Worker Of Nursing And The Risk Of Accidents At Work, Everton Fernando Alves

Everton Fernando Alves

Os estudantes-trabalhadores da enfermagem estão expostos a inúmeros acidentes de trabalho devido à dupla jornada, trabalho e estudo, que afeta o estilo de vida e o estado biopsicoemocional. Objetivou-se neste estudo realizar uma discussão de caráter introdutório sobre a análise de algumas características demográficas e ocupacionais de estudantes-trabalhadores de enfermagem e suas relações com o riscode acidentes de trabalho. Realizou-se um estudo exploratório, descritivo e com abordagem quantitativa de dados. Fizeram parte da amostra 88 estudantes-trabalhadores do curso de enfermagem regularmente matriculados do1º ao 4º ano. Observou-se que a maioria dos entrevistados eram mulheres (65,9%), com idades acima de ...


Sr-A Ligand And M-Csf Dynamically Regulate Sr-A Expression And Function In Primary Macrophages Via P38 Mapk Activation, Dejan Nikolic, Lindsay Calderon, Liqin Du, Steven R. Post 2011 University of Arkansas

Sr-A Ligand And M-Csf Dynamically Regulate Sr-A Expression And Function In Primary Macrophages Via P38 Mapk Activation, Dejan Nikolic, Lindsay Calderon, Liqin Du, Steven R. Post

Pharmacology and Nutritional Sciences Faculty Publications

BACKGROUND: Inflammation is characterized by dynamic changes in the expression of cytokines, such as M-CSF, and modifications of lipids and proteins that result in the formation of ligands for Class A Scavenger Receptors (SR-A). These changes are associated with altered SR-A expression in macrophages; however, the intracellular signal pathways involved and the extent to which SR-A ligands regulate SR-A expression are not well defined. To address these questions, SR-A expression and function were examined in resident mouse peritoneal macrophages incubated with M-CSF or the selective SR-A ligand acetylated-LDL (AcLDL).

RESULTS: M-CSF increased SR-A expression and function, and required the specific ...


Acute Arginine Supplementation Fails To Improve Muscle Endurance Or Affect Blood Pressure Responses To Resistance Training, Beau K. Greer, Brett T. Jones 2011 Sacred Heart University

Acute Arginine Supplementation Fails To Improve Muscle Endurance Or Affect Blood Pressure Responses To Resistance Training, Beau K. Greer, Brett T. Jones

All PTHMS Faculty Publications

Dietary supplement companies claim that arginine supplements acutely enhance skeletal muscular endurance. The purpose of this study was to determine whether acute arginine a-ketoglutarate supplementation (AAKG) will affect local muscle endurance of the arm and shoulder girdle or the blood pressure (BP) response to anaerobic exercise. Twelve trained college-aged men (22.6 +/- 3.8 years) performed 2 trials of exercise separated by at least 1 week. At 4 hours before, and 30 minutes before exercise, a serving of an AAKG supplement (3,700 mg arginine alpha-ketoglutarate per serving) or placebo was administered. Resting BP was assessed pre-exercise after 16 minutes ...


The Effects Of Curcumin On Body Composition Of Patients With Advanced Pancreatic Cancer, Henrique A. Parsons MD 2011 The University of Texas Graduate School of Biomedical Sciences at Houston

The Effects Of Curcumin On Body Composition Of Patients With Advanced Pancreatic Cancer, Henrique A. Parsons Md

UT GSBS Dissertations and Theses (Open Access)

Cachexia is very common among patients with advanced pancreatic cancer and is a marker of poor prognosis. Weight loss in cachexia is due to both adipose and muscle compartments, and sarcopenia (severe muscle depletion) is associated with worse outcomes. Curcumin has shown a myriad of biological effects, including anti-cancer and anti-inflammatory. The ability of curcumin to attenuate cachexia and muscle loss has been tested in animal models, with conflicting results so far. The hypothesis of this study was that patients with advanced pancreatic cancer treated with curcumin for two months have less fat and muscle loss as compared to matched ...


The Role Of The Nr4a Orphan Nuclear Receptor Nor1 In Vascular Cells And Atherosclerosis, Yue Zhao 2011 University of Kentucky

The Role Of The Nr4a Orphan Nuclear Receptor Nor1 In Vascular Cells And Atherosclerosis, Yue Zhao

University of Kentucky Doctoral Dissertations

The neuron-derived orphan receptor 1 (NOR1) belongs to the NR4A nuclear receptor subfamily. As an immediate early response gene, NOR1 is rapidly induced by a broad spectrum of physiological and pathological signals. Functional studies demonstrate NOR1 as a constitutively active ligand-independent nuclear receptor whose transcriptional activity is dependent on both expression level and posttranslational modifications. To date, an increasing number of studies have demonstrated a pivotal role of NOR1 in the transcriptional control of metabolism and the development of cardiovascular diseases.

In this dissertation, we demonstrate NOR1 expression in endothelial cells and sub-endothelial cells of human atherosclerotic lesions. In response ...


Vitamin D Levels And Risk Of Dyslipidemia Among Us Children With Diabetes And Obesity, Elsina E. Hagan 2011 University of Massachusetts Amherst

Vitamin D Levels And Risk Of Dyslipidemia Among Us Children With Diabetes And Obesity, Elsina E. Hagan

Masters Theses 1911 - February 2014

Dyslipidemia is increasing among U.S. children, and the prevalence is highest among children with diabetes and obesity. Recently, vitamin D deficiency has been suggested as a possible dietary risk factor for dyslipidemia. Despite the high prevalence of vitamin D deficiency amongst children, virtually no studies have evaluated the association between vitamin D and dyslipidemia among children. We evaluated the vitamin D and dyslipidemia relationship among 240 children and adolescents aged 2 through 21 years who were outpatients of a pediatric endocrinology unit at a large tertiary care facility in Western Massachusetts from April 2008 to April 2010. Eligible children ...


Urban Community Gardening The Impact On Fruit And Vegetable Intake, Christina Purcell 2011 Technological University Dublin

Urban Community Gardening The Impact On Fruit And Vegetable Intake, Christina Purcell

Students Learning with Communities: All of these projects were undertaken in collaboration with community partners and supervised by academic staff members

Urban community gardens are local projects managed for and by members of the local community. They may be run in partnership with local authorities or as part of community development or regeneration schemes (Hale et al., 2011). The gardens exist primarily in urban areas and are often established in response to a local community's lack of open green space (Viljoen et al., 2005). The scale and format of the gardens may vary. Depending on the available land and support, urban community gardening projects can be relatively small and in Dublin they range from small disused residential gardens (Cabra Park ...


Comparison Of Human Optimized Bacterial Luciferase, Firefly Luciferase, And Green Florescent Protein For Continuous Imaging Of Cell Cultures And Mouse Models., D Close, RE Hahn, S Patterson, Seung Baek, S Ripp, G Sayler 2010 The University of Tennessee

Comparison Of Human Optimized Bacterial Luciferase, Firefly Luciferase, And Green Florescent Protein For Continuous Imaging Of Cell Cultures And Mouse Models., D Close, Re Hahn, S Patterson, Seung Baek, S Ripp, G Sayler

Seung J Baek

No abstract provided.


Resveratrol-Induced Apoptosis Is Mediated By Early Growth Response-1, Krüppel-Like Factor 4, And Activating Transcription Factor 3, N Whitlock, J Bahn, S Lee, T Eling, Seung Baek 2010 The University of Tennessee

Resveratrol-Induced Apoptosis Is Mediated By Early Growth Response-1, Krüppel-Like Factor 4, And Activating Transcription Factor 3, N Whitlock, J Bahn, S Lee, T Eling, Seung Baek

Seung J Baek

Resveratrol, a dietary phytoalexin readily available in the diet, is reported to possess antitumorigenic properties in several cancers, including colorectal. However, the underlying mechanism(s) involved is not completely understood. In the present study, we investigated the effect of resveratrol treatment on gene modulation in human colorectal cancer cells and identified activating transcription factor 3 (ATF3) as the most highly induced gene after treatment. We confirmed that resveratrol upregulates ATF3 expression, both at the mRNA and protein level, and showed resveratrol involvement in ATF3 transcriptional regulation. Analysis of the ATF3 promoter revealed the importance of early growth response-1 (Egr-1; located ...


Antidiabetic Properties Involved In Insulin Sensitivity Of Abutilon Indicum Sweet Are Mediated By Enhancement Of Adipocyte Differentiation And Activation Of Glut1 Promoter, c 88. Krisanapun, Seong-Ho Lee, P Peungvicha, R Temsiririrkkul, Seung Baek 2010 The University of Tennessee

Antidiabetic Properties Involved In Insulin Sensitivity Of Abutilon Indicum Sweet Are Mediated By Enhancement Of Adipocyte Differentiation And Activation Of Glut1 Promoter, C 88. Krisanapun, Seong-Ho Lee, P Peungvicha, R Temsiririrkkul, Seung Baek

Seung J Baek

No abstract provided.


Molecular Characterisation Of Canine Nonsteroidal Anti-Inflammatory Drug-Activated Gene (Nag-1), K Yamaguchi, Nichelle Whitlock, Jason Liggett, Alfred Legendre, Michael Fry, Seung Baek 2010 University of Tennessee - Knoxville

Molecular Characterisation Of Canine Nonsteroidal Anti-Inflammatory Drug-Activated Gene (Nag-1), K Yamaguchi, Nichelle Whitlock, Jason Liggett, Alfred Legendre, Michael Fry, Seung Baek

Alfred M Legendre DVM, MS, DACVIM

Nonsteroidal anti-inflammatory drug (NSAID)-activated gene (NAG-1), a divergent member of the transforming growth factor beta superfamily, was previously identified as a gene induced by several anti-tumorigenic compounds, including NSAIDs and peroxisome proliferator-activated receptor gamma (PPARgamma) ligands in humans. In this study, canine NAG-1 was characterised from a canine genomic database. Gene induction by some NSAIDs and PPARgamma ligands was demonstrated in canine osteosarcoma cell lines. Phylogenetic analysis indicates that canine NAG-1 is more homologous with the corresponding mouse and rat genes than with human NAG-1. Expression of canine NAG-1 was increased by treatment with piroxicam and SC-560 (NSAIDs) and ...


Molecular Targets Of Apigenin In Colorectal Cancer Cells: Involvement Of P21, Nag-1 And P53., Yi Zhong, C Krisanapun, Seong-Ho Lee, T Nualsanit, C Sams, P Peungvicha, Seung Baek 2010 The University of Tennessee

Molecular Targets Of Apigenin In Colorectal Cancer Cells: Involvement Of P21, Nag-1 And P53., Yi Zhong, C Krisanapun, Seong-Ho Lee, T Nualsanit, C Sams, P Peungvicha, Seung Baek

Seung J Baek

Persuasive epidemiological and experimental evidence suggests that dietary flavonoids have anti-cancer activity. Since conventional therapeutic and surgical approaches have not been able to fully control the incidence and outcome of most cancer types, including colorectal neoplasia, there is an urgent need to develop alternative approaches for the management of cancer. We sought to develop the best flavonoids for the inhibition of cell growth, and apigenin (flavone) proved the most promising compound in colorectal cancer cell growth arrest. Subsequently, we found that pro-apoptotic proteins (NAG-1 and p53) and cell cycle inhibitor (p21) were induced in the presence of apigenin, and kinase ...


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