Effect Of Empagliflozin On Insulin Sensitivity In The Lean And Obese Zucker Rat: A Model Of Metabolic Syndrome, Veda Gayatri Sushma Penta
Theses, Dissertations and Capstones
Metabolic syndrome is one of the fastest growing health problems in the world. The medical costs associated with treating this disorder are staggering. Allowed to proceed untreated, metabolic syndrome can lead to a markedly decreased quality of life and a variety of medical conditions including heart and kidney failure. Whether the sodium glucose co-transporter-2 (SGLT-2) inhibitor Empagliflozin can be used to prevent the development of metabolic syndrome is not well understood. This proposal is specifically designed to address this gap in our knowledge. The expected outcomes of this work will identify the time course and degree of interrelatedness between changes ...
Erythropoiesis: Insights Into Pathophysiology And Treatments In 2017, 2018 Northwell Health
Erythropoiesis: Insights Into Pathophysiology And Treatments In 2017, A. Zivot, J. M. Lipton, A. Narla, L. Blanc
No abstract provided.
Neuro-Immune Interactions In Inflammation And Host Defense: Implications For Transplantation, 2018 Zucker School of Medicine at Hofstra/Northwell
Neuro-Immune Interactions In Inflammation And Host Defense: Implications For Transplantation, S. S. Chavan, P. Ma, I. M. Chiu
© 2017 The American Society of Transplantation and the American Society of Transplant Surgeons Sensory and autonomic neurons of the peripheral nervous system (PNS) play a critical role in regulating the immune system during tissue inflammation and host defense. Recent studies have identified the molecular mechanisms underlying the bidirectional communication between the nervous system and the immune system. Here, we highlight the studies that demonstrate the importance of the neuro-immune interactions in health and disease. Nociceptor sensory neurons detect immune mediators to produce pain, and release neuropeptides that act on the immune system to regulate inflammation. In parallel, neural reflex circuits ...
Smoking Is The Most Significant Modifiable Lung Cancer Risk Factor In Systemic Lupus Erythematosus, 2018 Zucker School of Medicine at Hofstra/Northwell
Smoking Is The Most Significant Modifiable Lung Cancer Risk Factor In Systemic Lupus Erythematosus, S. Bernatsky, R. Ramsey-Goldman, M. Petri, M. B. Urowitz, D. D. Gladman, P. R. Fortin, E. H. Yelin, E. Ginzler, C. Aranow, A. E. Clarke, +9 Additional Authors
Copyright © 2018 The Journal of Rheumatology. All rights reserved. Objective. To assess lung cancer risk in systemic lupus erythematosus (SLE), relative to demographics, drug exposures, smoking, and disease activity. Methods.We analyzed data from 14 SLE cohorts. We calculated adjusted HR estimates for lung cancer in SLE, relative to demographics, smoking, time-dependent medication exposures, and cumulative disease activity [mean adjusted SLE Disease Activity Index (SLEDAI) scores]. This project was approved by the ethics boards of all participating institutions, including the Institutional Review Board of the McGill University Health Centre. The ethics approval number for the Cancer Risk study is GEN-06-031 ...
Editorial: Neuro-Immune Interactions In Inflammation And Autoimmunity, 2018 Zucker School of Medicine at Hofstra/Northwell
Editorial: Neuro-Immune Interactions In Inflammation And Autoimmunity, N. Terrando, V. A. Pavlov
No abstract provided.
Reproducible Network And Regional Topographies Of Abnormal Glucose Metabolism Associated With Progressive Supranuclear Palsy: Multivariate And Univariate Analyses In American And Chinese Patient Cohorts, 2018 Northwell Health
Reproducible Network And Regional Topographies Of Abnormal Glucose Metabolism Associated With Progressive Supranuclear Palsy: Multivariate And Univariate Analyses In American And Chinese Patient Cohorts, J. Ge, J. Wu, S. Peng, P. Wu, J. Wang, H. Zhang, Y. Guan, D. Eidelberg, C. Zuo, Y. Ma
No abstract provided.
Persistent Stress-Induced Neuroplastic Changes In The Locus Coeruleus/Norepinephrine System, 2018 Rowan University
Persistent Stress-Induced Neuroplastic Changes In The Locus Coeruleus/Norepinephrine System, Olga Borodovitsyna, Neal Joshi, Daniel Chandler
School of Osteopathic Medicine Faculty Scholarship
Neural plasticity plays a critical role in mediating short- and long-term brain responses to environmental stimuli. A major effector of plasticity throughout many regions of the brain is stress. Activation of the locus coeruleus (LC) is a critical step in mediating the neuroendocrine and behavioral limbs of the stress response. During stressor exposure, activation of the hypothalamic-pituitary-adrenal axis promotes release of corticotropin-releasing factor in LC, where its signaling promotes a number of physiological and cellular changes. While the acute effects of stress on LC physiology have been described, its long-term effects are less clear. This review will describe how stress ...
B Cell-Intrinsic Role For Irf5 In Tlr9/Bcr-Induced Human B Cell Activation, Proliferation, And Plasmablast Differentiation, S. De, B. Zhang, T. Shih, S. Singh, A. Winkler, R. Donnelly, B. J. Barnes
© 2018 De, Zhang, Shih, Singh, Winkler, Donnelly and Barnes. Upon recognition of antigen, B cells undergo rapid proliferation followed by differentiation to specialized antibody secreting cells (ASCs). During this transition, B cells are reliant upon a multilayer transcription factor network to achieve a dramatic remodeling of the B cell transcriptional landscape. Increased levels of ASCs are often seen in autoimmune diseases and it is believed that altered expression of regulatory transcription factors play a role in this imbalance. The transcription factor interferon regulatory factor 5 (IRF5) is one such candidate as polymorphisms in IRF5 associate with risk of numerous autoimmune ...
Exploring The Biological Functional Mechanism Of The Hmgb1/Tlr4/Md-2 Complex By Surface Plasmon Resonance., M. He, M. E. Bianchi, T. R. Coleman, K. J. Tracey, Y. Al-Abed
High Mobility Group Box 1 (HMGB1) was first identified as a nonhistone chromatin-binding protein that functions as a pro-inflammatory cytokine and a Damage-Associated Molecular Pattern molecule when released from necrotic cells or activated leukocytes. HMGB1 consists of two structurally similar HMG boxes that comprise the pro-inflammatory (B-box) and the anti-inflammatory (A-box) domains. Paradoxically, the A-box also contains the epitope for the well-characterized anti-HMGB1 monoclonal antibody "2G7", which also potently inhibits HMGB1-mediated inflammation in a wide variety of in vivo models. The molecular mechanisms through which the A-box domain inhibits the inflammatory activity of HMGB1 and 2G7 exerts anti-inflammatory activity after ...
Altered Leukocyte Gene Expression After Traumatic Spinal Cord Injury: Clinical Implications, 2018 Zucker School of Medicine at Hofstra/Northwell
Altered Leukocyte Gene Expression After Traumatic Spinal Cord Injury: Clinical Implications, P. E. Herman, O. Bloom
No abstract provided.
Economic Evaluation Of Lupus Nephritis In The Systemic Lupus International Collaborating Clinics Inception Cohort Using A Multistate Model Approach., 2018 Hofstra Northwell School of Medicine
Economic Evaluation Of Lupus Nephritis In The Systemic Lupus International Collaborating Clinics Inception Cohort Using A Multistate Model Approach., M. R.W. Barber, J. G. Hanly, L. Su, M. B. Urowitz, Y. St Pierre, J. Romero-Diaz, C. Gordon, C. Aranow, M. Mackay, A. E. Clarke, +30 Additional Authors
OBJECTIVE: Little is known about the long-term costs of lupus nephritis (LN). The costs were compared between patients with and without LN using multistate modeling.
METHODS: Patients from 32 centers in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics inception cohort within 15 months of diagnosis and provided annual data on renal function, hospitalizations, medications, dialysis, and selected procedures. LN was diagnosed by renal biopsy or the American College of Rheumatology classification criteria. Renal function was assessed annually using the estimated glomerular filtration rate (GFR) or estimated proteinuria. A multistate model was used to predict 10-year cumulative ...
Anticancer And Differentiation Properties Of The Nitric Oxide Derivative Of Lopinavir In Human Glioblastoma Cells, 2018 Zucker School of Medicine at Hofstra/Northwell
Anticancer And Differentiation Properties Of The Nitric Oxide Derivative Of Lopinavir In Human Glioblastoma Cells, M. S. Basile, E. Mazzon, T. Krajnovic, D. Draca, E. Cavalli, Y. Al-Abed, P. Bramanti, F. Nicoletti, S. Mijatovic, D. Maksimovic-Ivanic
© 2018 by the authors. Glioblastoma (GBM) is the most frequent and deadly form of primary malignant brain tumor among adults. A promising emerging approach for GBM treatment may be offered from HIV protease inhibitors (HIV-PIs). In fact, in addition to their primary pharmacological activity in the treatment of HIV infection, they possess important anti-neoplastic effects. According to previous studies, the addition of a nitric oxide (NO) donating group to parental compounds can reduce their toxicity and enhance the anticancer action of various compounds, including HIV-PIs. In this study we compared the effects of the HIV-PI Lopinavir (Lopi) and of its ...
Comparison Of Therapeutic Triiodothyronine Versus Metoprolol In The Treatment Of Myocardial Infarction In Rats, 2018 Zucker School of Medicine at Hofstra/Northwell
Comparison Of Therapeutic Triiodothyronine Versus Metoprolol In The Treatment Of Myocardial Infarction In Rats, K. Zhang, Y. D. Tang, Y. Zhang, K. Ojamaa, Y. Li, A. S. Saini, M. A. Carrillo-Sepulveda, V. Rajagopalan, A. M. Gerdes
© 2018 Mary Ann Liebert, Inc. Background: Beta blockers are standard therapy for myocardial infarction (MI). Preclinical studies have shown efficacy and safety of thyroid hormone (TH) treatment of cardiovascular disorders. Since THs interact with the sympathoadrenergic system, this study aimed to compare triiodothyronine (T3) and metoprolol (Met) in the treatment of rats with MI on pathophysiology and TH-adrenergic signaling. Methods: Female Sprague-Dawley rats aged 12 weeks underwent left anterior descending coronary artery ligation (MI) or sham surgeries. T3 (5 μg/kg/day) or Met (100 mg/kg/day) was given in drinking water immediately after surgery for eight weeks. At ...
Analysis Of Menstrual Effluent: Diagnostic Potential For Endometriosis, 2018 Zucker School of Medicine at Hofstra/Northwell
Analysis Of Menstrual Effluent: Diagnostic Potential For Endometriosis, L. A. Warren, A. Shih, S. M. Renteira, T. Seckin, B. Blau, K. Simpfendorfer, C. N. Metz, P. K. Gregersen
No abstract provided.
Highly Conserved Molecular Pathways, Including Wnt Signaling, Promote Functional Recovery From Spinal Cord Injury In Lampreys, P. E. Herman, A. Papatheodorou, S. A. Bryant, C. K. Waterbury, J. R. Herdy, A. A. Arcese, J. D. Buxbaum, J. J. Smith, J. R. Morgan, O. Bloom
No abstract provided.
Hydroxychloroquine Prescription Trends And Predictors For Excess Dosing Per Recent Ophthalmology Guidelines, 2018 Zucker School of Medicine at Hofstra/Northwell
Hydroxychloroquine Prescription Trends And Predictors For Excess Dosing Per Recent Ophthalmology Guidelines, A. M. Jorge, R. B. Melles, Y. Zhang, N. Lu, S. K. Rai, L. H. Young, K. H. Costenbader, R. Ramsey-Goldman, C. Aranow Md, H. Choi, +6 Additional Authors
© 2018 The Author(s). Background: Hydroxychloroquine (HCQ) retinopathy may be more common than previously recognized; recent ophthalmology guidelines have revised recommendations from ideal body weight (IBW)-based dosing to actual body weight (ABW)-based dosing. However, contemporary HCQ prescribing trends in the UK remain unknown. Methods: We examined a UK general population database to investigate HCQ dosing between 2007 and 2016. We studied trends of excess HCQ dosing per ophthalmology guidelines (defined by exceeding 6.5 mg/kg of IBW and 5.0 mg/kg of ABW) and determined their independent predictors using multivariable logistic regression analyses. Results: Among 20 ...
Lineage-Specific Functionality Of An Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack Of B Cell Intrinsic Effects, 2018 Zucker School of Medicine at Hofstra/Northwell
Lineage-Specific Functionality Of An Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack Of B Cell Intrinsic Effects, J. Calise, S. M. Renteria, P. K. Gregersen, B. Diamond
No abstract provided.
Serologic Features Of Cohorts With Variable Genetic Risk For Systemic Lupus Erythematosus., 2018 Northwell Health
Serologic Features Of Cohorts With Variable Genetic Risk For Systemic Lupus Erythematosus., J. Bhattacharya, K. Pappas, B. Toz, C. Aranow, M. Mackay, P. K. Gregersen, O. Doumbo, A. K. Traore, M. L. Lesser, B. Diamond, +9 Additional Authors
Systemic lupus erythematosus (SLE) is an autoimmune disease with genetic, hormonal, and environmental influences. In Western Europe and North America, individuals of West African descent have a 3-4 fold greater incidence of SLE than Caucasians. Paradoxically, West Africans in sub-Saharan Africa appear to have a low incidence of SLE, and some studies suggest a milder disease with less nephritis. In this study, we analyzed sera from African American female SLE patients and four other cohorts, one with SLE and others with varying degrees of risk for SLE in order to identify serologic factors that might correlate with risk of or ...
Corrected And Republished From: The Cop9 Signalosome Interacts With And Regulates Interferon Regulatory Factor 5 Protein Stability., 2018 Zucker School of Medicine at Hofstra/Northwell
Corrected And Republished From: The Cop9 Signalosome Interacts With And Regulates Interferon Regulatory Factor 5 Protein Stability., J. Korczeniewska, B. J. Barnes
© 2018 American Society for Microbiology. The transcription factor interferon regulatory factor 5 (IRF5) exerts crucial functions in the regulation of host immunity against extracellular pathogens, DNA damage-induced apoptosis, death receptor signaling, and macrophage polarization. Tight regulation of IRF5 is thus warranted for an efficient response to extracellular stressors and for limiting autoimmune and inflammatory responses. Here we report that the COP9 signalosome (CSN), a general modulator of diverse cellular and developmental processes, associates constitutively with IRF5 and promotes its protein stability. The constitutive CSN/IRF5 interaction was identified using proteomics and confirmed by endogenous immunoprecipitations. The CSN/IRF5 interaction occurred ...
Fasudil In Combination With Bone Marrow Stromal Cells (Bmscs) Attenuates Alzheimer’S Disease-Related Changes Through The Regulation Of The Peripheral Immune System, 2018 Shanxi Datong University & Institute of Genetics and Development Biology
Fasudil In Combination With Bone Marrow Stromal Cells (Bmscs) Attenuates Alzheimer’S Disease-Related Changes Through The Regulation Of The Peripheral Immune System, Jiezhong Yu, Yuqing Yan, Qingfang Gu, Gajendra Kumar, Hongqiang Yu, Yijin Zhao, Chunyun Liu, Ye Gao, Zhi Chai, Jasleen Chumber, Bao-Guo Xiao, Guang-Xian Zhang, Han-Ting Zhang, Yuqiang Jiang, Cun-Gen Ma
Faculty & Staff Scholarship
Alzheimer’s disease (AD) is a chronic progressive neurodegenerative disease. Its mechanism is still not clear. Majority of research focused on the central nervous system (CNS) changes, while few studies emphasize on peripheral immune system modulation. Our study aimed to investigate the regulation of the peripheral immune system and its relationship to the severity of the disease after treatment in an AD model of APPswe/PSEN1dE9 transgenic (APP/PS1 Tg) mice. APP/PS1 Tg mice (8 months old) were treated with the ROCK-II inhibitor 1-(5-isoquinolinesulfonyl)- homo-piperazine (Fasudil) (intraperitoneal (i.p.) injections, 25 mg/kg/day), bone marrow stromal cells ...