Open Access. Powered by Scholars. Published by Universities.®

Medical Biochemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

1,093 Full-Text Articles 3,185 Authors 107,250 Downloads 78 Institutions

All Articles in Medical Biochemistry

Faceted Search

1,093 full-text articles. Page 39 of 39.

Synthesis And Evaluation Of Conformationally Constrained Peptide Analogues As The Src Sh3 Domain Binding Ligands, Rakesh Tiwari, Alex Brown, Seetha Narramaneni, Gongqin Sun, Keykavous Parang 2010 Chapman University

Synthesis And Evaluation Of Conformationally Constrained Peptide Analogues As The Src Sh3 Domain Binding Ligands, Rakesh Tiwari, Alex Brown, Seetha Narramaneni, Gongqin Sun, Keykavous Parang

Pharmacy Faculty Articles and Research

Src kinase activity is regulated by the interaction of SH3 domain with protein sequences that are rich in proline residues. Identification of more potent SH3 domain binding ligands that can regulate Src kinase activity is a subject of major interest. Conformationally constrained peptides have been previously used for improving the binding potency of the Src SH2 domain binding peptide ligands and peptide substrates of the substrate-binding site of Src. A series of peptide analogues of Ac-VSLARRPLPPLP (1, Ac-VSL-12, Kd = 0.34 M) were synthesized by introducing conformational constraints to improve the binding affinity towards the Src SH3 domain. Peptides synthesized ...


Recent Advances On Skin-Resident Stem/Progenitor Cell Functions In Skin Regeneration, Aging And Cancers And Novel Anti-Aging And Cancer Therapies., Murielle Mimeault, Surinder K. Batra 2010 University of Nebraska Medical Center

Recent Advances On Skin-Resident Stem/Progenitor Cell Functions In Skin Regeneration, Aging And Cancers And Novel Anti-Aging And Cancer Therapies., Murielle Mimeault, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

Recent advances in skin-resident adult stem/progenitor cell research have revealed that these immature and regenerative cells with a high longevity provide critical functions in maintaining skin homeostasis and repair after severe injuries along the lifespan of individuals. The establishment of the functional properties of distinct adult stem/progenitor cells found in skin epidermis and hair follicles and extrinsic signals from their niches, which are deregulated during their aging and malignant transformation, has significantly improved our understanding on the etiopathogenesis of diverse human skin disorders and cancers. Particularly, enhanced ultraviolet radiation exposure, inflammation and oxidative stress and telomere attrition during ...


Pathogenomics Of Culex Quinquefasciatus And Meta-Analysis Of Infection Responses To Diverse Pathogens, Lyric Bartholomay, Robert M. Waterhouse, George F. Mayhew, Corey L. Campbell, Kristin Michel, Zhen Zou, Jose L. Ramirez, Suchismita Das, Kanwal Alvarez, Peter Arensburger, Bart Bryant, Sinead B. Chapman, Yuemei Dong, Erickson Sara M., S.H.P. Parakrama Karunaratne, Vladimir Kokoza, Chinnappa D. Kodira, Patricia Pignatelli, Sang Woon Shin, Dana L. Vanlandingham, Peter W. Atkinson, Bruce Birren, Geoge K. Christophides, Rollie J. Clem, Janet Hemingway, Stephen Higgs, Karine Megy, Hilary Ranson, Evgeny M. Zdobnov, Alexander S. Raikhel, Bruce M. Christensen, George Dimopoulos, Marc A.T. Muskavitch 2010 Iowa State University

Pathogenomics Of Culex Quinquefasciatus And Meta-Analysis Of Infection Responses To Diverse Pathogens, Lyric Bartholomay, Robert M. Waterhouse, George F. Mayhew, Corey L. Campbell, Kristin Michel, Zhen Zou, Jose L. Ramirez, Suchismita Das, Kanwal Alvarez, Peter Arensburger, Bart Bryant, Sinead B. Chapman, Yuemei Dong, Erickson Sara M., S.H.P. Parakrama Karunaratne, Vladimir Kokoza, Chinnappa D. Kodira, Patricia Pignatelli, Sang Woon Shin, Dana L. Vanlandingham, Peter W. Atkinson, Bruce Birren, Geoge K. Christophides, Rollie J. Clem, Janet Hemingway, Stephen Higgs, Karine Megy, Hilary Ranson, Evgeny M. Zdobnov, Alexander S. Raikhel, Bruce M. Christensen, George Dimopoulos, Marc A.T. Muskavitch

Entomology Publications

The mosquito Culex quinquefasciatus poses a significant threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for ...


Prospects And Pits On The Path Of Biomimetics: The Case Of Tooth Enamel, Vuk Uskoković 2010 Chapman University

Prospects And Pits On The Path Of Biomimetics: The Case Of Tooth Enamel, Vuk Uskoković

Pharmacy Faculty Articles and Research

This review presents a discourse on challenges in understanding and imitating the process of amelogenesis in vitro on the molecular scale. In light of the analysis of imitation of the growth of dental enamel, it also impends on the prospects and potential drawbacks of the biomimetic approach in general. As the formation of enamel proceeds with the protein matrix guiding the crystal growth, while at the same time conducting its own degradation and removal, it is argued that three aspects of amelogenesis need to be induced in parallel: a) crystal growth; b) protein assembly; c) proteolytic degradation. A particular emphasis ...


5¢-O-B,G-Methylenetriphosphate Derivatives Of Nucleoside, Yousef Ahmadibeni, Chandravanu Dash, S. F. J. Le Grice, Keykavous Parang 2010 University of Rhode Island

5¢-O-B,G-Methylenetriphosphate Derivatives Of Nucleoside, Yousef Ahmadibeni, Chandravanu Dash, S. F. J. Le Grice, Keykavous Parang

Pharmacy Faculty Articles and Research

The solid-phase synthesis of 5¢-O-b,g-methylenetriphosphates of nucleosides 1–5 is described, where a 4-acetoxy-3-arylbenzyloxy group was used as a linker.


Chronic Inflammatory Responses To Microgel-Based Implant Coatings, Amanda W. Bridges, Rachel E. Whitmire, Neetu Singh, Kellie L. Templeman, Julia E. Babensee, L. Andrew Lyon, Andrés J. García 2010 Georgia Institute of Technology

Chronic Inflammatory Responses To Microgel-Based Implant Coatings, Amanda W. Bridges, Rachel E. Whitmire, Neetu Singh, Kellie L. Templeman, Julia E. Babensee, L. Andrew Lyon, Andrés J. García

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Inflammatory responses to implanted biomedical devices elicit a foreign body fibrotic reaction that limits device integration and performance in various biomedical applications. We examined chronic inflammatory responses to microgel conformal coatings consisting of thin films of poly(N-isopropylacrylamide) hydrogel microparticles cross-linked with poly(ethylene glycol) diacrylate deposited on poly(ethylene terephthalate) (PET). Unmodified and microgel-coated PET disks were implanted subcutaneously in rats for 4 weeks and explants were analyzed by histology and immunohistochemistry. Microgel coatings reduced chronic inflammation and resulted in a more mature/organized fibrous capsule. Microgel-coated samples exhibited 22% thinner fibrous capsules that contained 40% fewer cells compared ...


Fk228 And Oncogenic H-Ras Synergistically Induce Mek1/2 And Nox-1 To Generate Reactive Oxygen Species For Differential Cell Death, SHAMBHUNATH CHOUDHARY, Kusum Rathore, Hwa-Chain Robert Wang 2009 University of Tennessee - Knoxville

Fk228 And Oncogenic H-Ras Synergistically Induce Mek1/2 And Nox-1 To Generate Reactive Oxygen Species For Differential Cell Death, Shambhunath Choudhary, Kusum Rathore, Hwa-Chain Robert Wang

Shambhunath Choudhary DVM, PhD

To investigate the mechanism behind the pro-apoptotic ability of oncogenic H-Ras to enhance FK228-induced apoptosis, we primarily used the 10T1/2-TR-H-Ras cell line, in which ectopic expression of oncogenic H-Ras(V12) is controlled by the addition of tetracycline into cultures, and secondarily used oncogenic H-Ras-expressing MCF10A cells in our studies. Our results showed the pro-apoptotic roles of Mek1/2 activation, nicotinamide adenine dinucleotide phosphate-oxidase 1 (Nox-1) elevation, and reactive oxygen species (ROS) production in FK228-induced selective cell death of oncogenic H-Ras-expressing cells versus counterpart cells. We found that although Nox-1 elevation and ROS production played essential roles in oncogenic H-Ras-induced ...


Digital Commons powered by bepress