Advocacy Pays Off: Huntington’S Disease Stem-Cell Research Advances In California, 2012 University of San Diego
Advocacy Pays Off: Huntington’S Disease Stem-Cell Research Advances In California, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Let’S Turn Grief For ‘Hd Angels’ Into New Impetus For The Huntington's Cure, 2012 University of San Diego
Let’S Turn Grief For ‘Hd Angels’ Into New Impetus For The Huntington's Cure, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Ginkgo Extract Egb761 Confers Neuroprotection By Reduction Of Glutamate Release In Ischemic Brain, 2012 Texas Tech University Health Science Center
Ginkgo Extract Egb761 Confers Neuroprotection By Reduction Of Glutamate Release In Ischemic Brain, Alexander Mdzinarishvili, Rachita K. Sumbria, Dorothee Lang, Jochen Klein
Pharmacy Faculty Articles and Research
Purpose - Ginkgo extract EGb761 has shown anti-edema and anti-ischemic effects in various experimental models. In the present study, we demonstrate neuroprotective effects of EGb761 in experimental stroke while monitoring brain metabolism by microdialysis. Methods - We have used oxygen-glucose deprivation in brain slices in vitro and middle cerebral artery occlusion (MCAO) in vivo to induce ischemia in mouse brain. We used microdialysis in mouse striatum to monitor extracellular concentrations of glucose and glutamate. Results - In vitro, EGb761 reduced ischemia-induced cell swelling in hippocampal slices by 60%. In vivo, administration of EGb761 (300 mg/kg) reduced cell degeneration and edema …
Seven Years Of Striving For A Realistic And Unapologetic View Of Huntington's Disease, 2012 University of San Diego
Seven Years Of Striving For A Realistic And Unapologetic View Of Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Striving For Brave New Brains, 2012 University of San Diego
Striving For Brave New Brains, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Notch Regulation Of Adam12 Expression In Glioblastoma Multiforme, 2012 University of Massachusetts Amherst
Notch Regulation Of Adam12 Expression In Glioblastoma Multiforme, Ala'a S. Alsyaideh
Masters Theses 1911 - February 2014
Glioblastoma is the most common malignant brain tumor, accounting for 17% of all primary brain tumors in the United States. Despite the available surgical, radiation, and chemical therapeutic options, the invasive and infiltrative nature of the tumor render current treatment options minimally effective. Recent reports have identified multiple regulators of glioblastoma progression and invasiveness. It has been demonstrated that ADAM12, A Disintegrin And Metalloproteinase encoded by ADAM12 gene, is over-expressed in glioblastoma and directly correlated with tumor proliferation. Additionally, dysregulation of the Notch signaling pathway has been implicated in the pathogenesis of many gliomas. Lastly, an evolving role of microRNAs, …
Normal Pressure Hydrocephalus: How Can It Be Told Apart From Neurodegenerative Diseases Of The Elderly?, 2012 Touro College
Normal Pressure Hydrocephalus: How Can It Be Told Apart From Neurodegenerative Diseases Of The Elderly?, Raphael C. Zohn
The Science Journal of the Lander College of Arts and Sciences
Normal pressure hydrocephalus (NPH) affects more of the older population than people recognize. The underestimation of this neurological condition is due in most part to the overlap of its symptoms to other forms of dementia as well as many other geriatric conditions. The objective of this paper was to research and contrast various methods of differentiation in the diagnosis of normal pressure hydrocephalus as well as find pretreatment indicators of successful surgery. Methods included reviewing of articles and studies done to evaluate which symptoms are most commonly presented in normal pressure hydrocephalus and their subtle differences from the symptoms of …
Treatment Options For Parkinson’S Disease, 2012 Touro College
Treatment Options For Parkinson’S Disease, Sara Russ
The Science Journal of the Lander College of Arts and Sciences
The following is an excerpt from this article: Parkinson’s disease was first described and named Paralysis Agitans in 1817 by British physician James Parkinson (Lieberman 2004). Later on, it took on its current name after Dr. Parkinson. Parkinson’s disease (PD) is a neurological disorder for which the cause is yet to be discovered. Like many other diseases, PD has numerous facets. Throughout all of its different stages, it presents with motor, as well as nonmotor, symptoms (Simuni et al. 2009). Though estimates of people affected by PD are constantly being made, it is difficult to determine a precise and accurate …
Functional Electrical Stimulation In Spinal Cord Injury Rehabilitation, 2012 Touro College
Functional Electrical Stimulation In Spinal Cord Injury Rehabilitation, Meir Hildeshaim
The Science Journal of the Lander College of Arts and Sciences
The following is an excerpt from the introduction to this article: Spinal cord injury is defined as a “disconnection syndrome” that results in a loss of ability of the spinal cord to communicate ascending and/or descending impulses (Hamid and Hayak 2008). Due to its role as the primary conduit of motor and sensory impulses, spinal cord injury is widely regarded as one of the most catastrophic, survivable injuries a person can suffer. Depending on the severity and placement of the injury, the patient can experience a wide range of disability or death. A mild injury may result in the patient …
Autophagy And Apoptotic Genes Implicated In Alzheimer’S Disease Are Modulated Following Infection Of Neuronal Cells With Chlamydia Pneumoniae, 2012 Philadelphia College of Osteopathic Medicine
Autophagy And Apoptotic Genes Implicated In Alzheimer’S Disease Are Modulated Following Infection Of Neuronal Cells With Chlamydia Pneumoniae, Denah M. Appelt, Ian Kohler, Annette K. Slutter, Juliana Zoga, Susan T. Hingley, Brian J. Balin
Scholarly Posters
Background: The focus of the current studies was to determine the relationship between the molecular mechanisms interconnecting autophagy and apoptosis following Chlamydia pneumoniae infection in neuronal cells. Dysfunctions in apoptosis and autophagy have been implicated in the neurodegeneration associated with Alzheimer’s disease (AD). Autophagy in AD pathogenesis has been shown to play a role in amyloid processing through the endosomal-lysosomal system. Apoptosis may contribute to the neuronal cell loss observed in AD; however, there is limited evidence of the apoptotic process proceeding to terminal completion. Although Aβ1-42 has been shown to induce apoptosis in neurons and may be an early …
The Effect Of Load On Movement Coordination During Sled Towing, 2012 University of New England
The Effect Of Load On Movement Coordination During Sled Towing, Michael Lawrence, Daniel Leib, Cara Masterson, Erin Hartigan
Daniel Leib
INTRODUCTION Towing sleds while walking is a popular resistance exercise for the healthy athlete. One reason for the popularity of sled towing is that it is widely believed to be a ‘functional’ exercise. Preliminary research suggests towing while walking can increases lower extremity moment impulses; however whether towing a sled utilizes the same coordination patterns as un-resisted walking is unknown. While altered patterns may not be as relevant to a healthy athlete, sled towing is also sometimes used in the rehabilitation of athletes who sustained a lower extremity injury (anterior cruciate ligament rupture) with the goal of regaining movement symmetry. …
Effects Of Fatigue On Golf Performance, 2012 Boise State University
Effects Of Fatigue On Golf Performance, Daniel J. Leib, Nicholas R. Higdon, W. Holmes Finch, Eric L. Dugan
Daniel Leib
No abstract provided.
Does Whole Body Vibration (Wbv) Therapy Positively Affect The Motor Skills Of Patients Who Have Been Diagnosed With Parkinson’S Disease?, 2012 Philadelphia College of Osteopathic Medicine
Does Whole Body Vibration (Wbv) Therapy Positively Affect The Motor Skills Of Patients Who Have Been Diagnosed With Parkinson’S Disease?, Courtney Forsyth
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether Whole Body Vibration (WBV) therapy positively affects the motor skills of patients who have been diagnosed with Parkinson’s disease.
STUDY DESIGN: Review of 3 English language primary studies. All three were randomized control trials; one was rater blinded and one double blinded with a placebo.
DATA SOURCES: All of the articles were Randomized Control Trials found using the PubMed database.
OUTCOMES MEASURED: Each of the three studies looked at the symptoms of Parkinson’s disease patients before and after Whole Body Vibration Therapy. Each study used the Unified Parkinson’s Disease …
Is 1.25 Mg Oral Fingolimod Effective In Reducing Relapses In Adults With Relapsing Multiple Sclerosis?, 2012 Philadelphia College of Osteopathic Medicine
Is 1.25 Mg Oral Fingolimod Effective In Reducing Relapses In Adults With Relapsing Multiple Sclerosis?, Caitlin M. Cook
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not is 1.25 mg oral fingolimod effective in reducing relapses in adults with relapsing multiple sclerosis.
STUDY DESIGN: Review of three English language primary studies published between 2006 and 2010.
DATA SOURCES: Randomized, double-blind, controlled clinical trials comparing daily 1.25 mg oral fingolimod to either identical placebo capsules or weekly intramuscular interferon beta-1a therapy were found using Pubmed and Cochrane Databases.
OUTCOMES MEASURED: Annualized relapse rate was assessed in all studies. Relapses were confirmed by neurologists and assessed using the Expanded Disability Status Scale (EDSS) to evaluate worsening …
Web-Based Assessment Of Visual And Visuospatial Symptoms In Parkinson's Disease, 2012 Bridgewater State University
Web-Based Assessment Of Visual And Visuospatial Symptoms In Parkinson's Disease, Melissa M. Amick, Ivy N. Miller, Sandra Neargarder, Alice Cronin-Golomb
Psychology Faculty Publications
Visual and visuospatial dysfunction is prevalent in Parkinson’s disease (PD). To promote assessment of these often overlooked symptoms, we adapted the PD Vision Questionnaire for Internet administration. The questionnaire evaluates visual and visuospatial symptoms, impairments in activities of daily living (ADLs), and motor symptoms. PD participants of mild to moderate motor severity (n = 24) and healthy control participants (HC, n = 23) completed the questionnaire in paper and web-based formats. Reliability was assessed by comparing responses across formats. Construct validity was evaluated by reference to performance on measures of vision, visuospatial cognition, ADLs, and motor symptoms. The web-based …
Bi-Lateral Changes To Hippocampal Cholesterol Levels During Epileptogenesis And In Chronic Epilepsy Following Focal-Onset Status Epilepticus In Mice, 2012 Technological University Dublin
Bi-Lateral Changes To Hippocampal Cholesterol Levels During Epileptogenesis And In Chronic Epilepsy Following Focal-Onset Status Epilepticus In Mice, Steve Meaney, Maura Heverin, Tobias Engel, Eva Jimenez-Mateosa, Reza Al-Aaudia, David Henshall
Articles
Brain cholesterol homeostasis has been shown to be disrupted in neurodegenerative conditions such as Alzheimer's and Huntington's diseases. Investigations in animal models of seizure-induced brain injury suggest that brain cholesterol levels are altered by prolonged seizures (status epilepticus) and are a feature of the pathophysiology of temporal lobe epilepsy. The present study measured hippocampal sterol levels in a model of unilateral hippocampal injury triggered by focal-onset status epilepticus, and in chronically epileptic mice. Status epilepticus was induced by intra-amygdala microinjection of kainic acid and ipsilateral and contralateral hippocampus analyzed. No significant changes were found for ipsilateral or contralateral hippocampal levels …
The Cellular Nucleic Acid Binding Protein Regulates The Alzheimer’S Disease Β-Secretase Protein Bace1, 2012 University of Kentucky
The Cellular Nucleic Acid Binding Protein Regulates The Alzheimer’S Disease Β-Secretase Protein Bace1, Christopher J. Holler
Theses and Dissertations--Molecular and Cellular Biochemistry
Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the elderly population and is believed to be caused by the overproduction and accumulation of the toxic amyloid beta (Aβ) peptide in the brain. Aβ is produced by two separate enzymatic cleavage events of the larger membrane bound amyloid precursor protein, APP. The first, and rate-limiting, cleavage event is made by beta-secretase, or BACE1, and is thus an attractive therapeutic target. Our lab, as well as many others, has shown that BACE1 protein and activity are increased in late-stage sporadic AD. We have extended these findings to show that BACE1 …
Blast-Induced Brain Injury: Influence Of Shockwave Components, 2012 University of Kentucky
Blast-Induced Brain Injury: Influence Of Shockwave Components, Dexter V. Reneer
Theses and Dissertations--Neuroscience
Blast-induced traumatic brain injury (bTBI) has been described as the defining injury of Operations Enduring Freedom and Iraqi Freedom (OEF/OIF). Previously, most blast injury research has focused on the effects of blast on internal, gas filled organs due to their increased susceptibility. However, due to a change in enemy tactics combined with better armor and front-line medical care, bTBI has become one of the most common injuries due to blast. Though there has been a significant amount of research characterizing the brain injury produced by blast, a sound understanding of the contribution of each component of the shockwave to the …
Noninvasive Assessment And Modeling Of Diabetic Cardiovascular Autonomic Neuropathy, 2012 University of Kentucky
Noninvasive Assessment And Modeling Of Diabetic Cardiovascular Autonomic Neuropathy, Siqi Wang
Theses and Dissertations--Biomedical Engineering
Noninvasive assessment of diabetic cardiovascular autonomic neuropathy (AN): Cardiac and vascular dysfunctions resulting from AN are complications of diabetes, often undiagnosed. Our objectives were to: 1) determine sympathetic and parasympathetic components of compromised blood pressure regulation in patients with polyneuropathy, and 2) rank noninvasive indexes for their sensitivity in diagnosing AN. Continuous 12-lead electrocardiography (ECG), blood pressure (BP), respiration, regional blood flow and bio-impedance were recorded from 12 able-bodied subjects (AB), 7 diabetics without (D0), 7 with possible (D1) and 8 with definite polyneuropathy (D2), during 10 minutes supine control, 30 minutes 70-degree head-up tilt and 5 minutes supine recovery. …
Investigating The Impact Of Cd147 And Its Expression On Neurodegenaration And Alzheimer's Disease (Ad), 2012 Edith Cowan University
Investigating The Impact Of Cd147 And Its Expression On Neurodegenaration And Alzheimer's Disease (Ad), Limbikani J. Kanyenda
Theses: Doctorates and Masters
CD147, also known as basigin, extracellular matrix metalloproteinase inducer, neurothelin, tumour cell-derived collagenase stimulatory factor, M6, HT7, OX47 or gp42, is a transmembrane glycoprotein of the immunoglobulin super-family. It is expressed in many neuronal and non-neuronal tissues with high expression in the hippocampus, pre-frontal cortex, thyroid, heart, early erythroid, amygdala and placenta. This protein is involved in various cellular and biological functions such as lymphocyte migration and maturation, tissue repair, cancer progression, T and B lymphocyte activation and induction of extracellular matrix metalloproteinase. The CD147 protein interacts with with cyclophilin A, cyclophilin B, sterol carrier protein, caveolin-1 and integrins, and …