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Trunk And Respiratory Motor Control In Typically Developing Children And Its Implications In Children With Chronic Spinal Cord Injury., Goutam Singh 2017 University of Louisville

Trunk And Respiratory Motor Control In Typically Developing Children And Its Implications In Children With Chronic Spinal Cord Injury., Goutam Singh

Electronic Theses and Dissertations

Independent sitting is a major milestone and is also a prerequisite for optimal performance of activities of daily living (ADLs). Development of sitting posture control is a dynamic process involving control of degrees of freedom of head and trunk. Traditionally, trunk has been modeled as a single unit (segment). However, recent studies have suggested that it is made up multiple spinal units, controlled by a combination of trunk muscles. During typical development, posture control of trunk is different for different trunk segments. This motor development of trunk control is a complex process due to constant interaction between the nervous system ...


Allele-Selective Suppression Of Mutant Huntingtin In Primary Human Blood Cells, James R. C. Miller, Edith L. Pfister, Wanzhao Liu, Ralph Andre, Ulrike Trager, Lori A. Kennington, Kimberly Lo, Sipke Dijkstra, Douglas Macdonald, Gary R. Ostroff, Neil Aronin, Sarah J. Tabrizi 2017 University College London

Allele-Selective Suppression Of Mutant Huntingtin In Primary Human Blood Cells, James R. C. Miller, Edith L. Pfister, Wanzhao Liu, Ralph Andre, Ulrike Trager, Lori A. Kennington, Kimberly Lo, Sipke Dijkstra, Douglas Macdonald, Gary R. Ostroff, Neil Aronin, Sarah J. Tabrizi

Open Access Articles

Post-transcriptional gene silencing is a promising therapy for the monogenic, autosomal dominant, Huntington's disease (HD). However, wild-type huntingtin (HTT) has important cellular functions, so the ideal strategy would selectively lower mutant HTT while sparing wild-type. HD patients were genotyped for heterozygosity at three SNP sites, before phasing each SNP allele to wild-type or mutant HTT. Primary ex vivo myeloid cells were isolated from heterozygous patients and transfected with SNP-targeted siRNA, using glucan particles taken up by phagocytosis. Highly selective mRNA knockdown was achieved when targeting each allele of rs362331 in exon 50 of the HTT transcript; this selectivity was ...


Accessing Healthfulness Through Intrapersonal Communication: The Correlations Between Health Locus Of Control And Health Outcomes Behaviors, And Perceptions, Laura S. Gavin-Breier 2017 Olivet Nazarene University

Accessing Healthfulness Through Intrapersonal Communication: The Correlations Between Health Locus Of Control And Health Outcomes Behaviors, And Perceptions, Laura S. Gavin-Breier

Scholar Week 2016 - present

No abstract provided.


Cerebral Lactate Metabolism And Memory: Implications For Alzheimer's Disease, Richard Andrew Harris 2017 The University of Western Ontario

Cerebral Lactate Metabolism And Memory: Implications For Alzheimer's Disease, Richard Andrew Harris

Electronic Thesis and Dissertation Repository

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by amyloid plaques that are comprised of aggregated amyloid-beta peptides. These toxic proteins promote mitochondrial dysfunction and neuronal cell death. A shift in metabolism away from oxidative phosphorylation and toward aerobic glycolysis, with the concomitant production of lactate, affords neurons a survival advantage against amyloid-beta toxicity. Recent evidence now suggests that aerobic glycolysis in the brain plays a critical role in supporting synaptic plasticity, learning, and memory. However, the role of aerobic glycolysis and lactate metabolism in AD-mediated cognitive decline is unknown. My objective was to test the hypotheses that aerobic ...


Repetitive Finger Movement In Parkinson's Patients, Lindsay Ebeling, Amos Kotz, Abby Crimmins, Abby Crimmins 2017 Iowa State University

Repetitive Finger Movement In Parkinson's Patients, Lindsay Ebeling, Amos Kotz, Abby Crimmins, Abby Crimmins

Symposium on Undergraduate Research and Creative Expression

People with parkinson's disease demonstrate impairments in repetitive movement. Previous research has revealed that impairments in repetitive finger movement emerge at rates above 2 Hz. There remains a need to understand this impairment in a large population of people with parkinson's and how this impairment changes with disease progression. Participants completed a repetitive finger movement task in time with a tone paced from 1-3 Hz. Position of the index finger was collected. Results showed that in a large population of people with parkinson's disease, the impairment was present in 60% of the participants and remained present one ...


The Effects Of Acoustic Environment On The Gait Of Healthy Young Adults, Stephanie Masek, Andrew Deiter 2017 Iowa State University

The Effects Of Acoustic Environment On The Gait Of Healthy Young Adults, Stephanie Masek, Andrew Deiter

Symposium on Undergraduate Research and Creative Expression

This study examined how an individual's gait was affected by their acoustic environment. Participants were instructed to walk at a normal pace while listening to either a steady beat or a song of their choice, or in silence. A computer program called Pitch Switch was used to match the tempo of both the metronome and music to the participant's preferred walking speed, so that the pace of walking was always set by the participant. A number of physical parameters were measured with a Gait Rite system in all three acoustical conditions. These measurements included stride length and step ...


The Influence Of Parkinson's Disease Symptoms On Repetitive Toe Tapping At High And Low Frequencies., Alexandra Jeppesen, Callan Barrick, Alexa Badding, Thomas Berta 2017 Iowa State University

The Influence Of Parkinson's Disease Symptoms On Repetitive Toe Tapping At High And Low Frequencies., Alexandra Jeppesen, Callan Barrick, Alexa Badding, Thomas Berta

Symposium on Undergraduate Research and Creative Expression

People with Parkinson's Disease have impairments in repetitive movement. However, no one has quantified repetitive toe-tapping performance at different rates in persons with PD. Position of the toe and EMG of the tibialias anterior and gastrocnemius were collected while participants tapped at 70 beats per minute and 140 beats per minute. Results revealed that participants had greater impairment at the higher rate. The results of this data will inform future studies on the impact of impairments in repetitive movements on larger motor tasks such as gait.


The Use Of Rhyme, Rhythm, And Melody As A Form Of Repetition Priming To Aid In Encoding, Storage, And Retrieval Of Semantic Memories In Alzheimer’S Patients, Faiz Plastikwala 2017 Virginia Commonwealth University

The Use Of Rhyme, Rhythm, And Melody As A Form Of Repetition Priming To Aid In Encoding, Storage, And Retrieval Of Semantic Memories In Alzheimer’S Patients, Faiz Plastikwala

Virginias Collegiate Honors Council Conference

Treating Alzheimer’s disease, especially through non-pharmaceutical means, has become increasingly important over the past few decades. I examined the use of melody, rhyme, and rhythm as encoding mechanisms to aid in the retrieval of long term semantic information by juxtaposing previous experiments in the field. Melody, rhyme, and rhythm provide an organizational structure to facilitate the encoding of information. Specifically, chunking, the grouping of smaller units into larger ‘chunks’, helps facilitate long term encoding in patients, and is the byproduct of the organizational structure of a text. A major drawback of using these devices is the loss in the ...


Medical Resource Utilization Of Outpatient Care For Children With Neurofibromatosis Type 1, Rabia Idrees, Michael Fisher, Rachel Hachen, Brian Callaghan, Robert A. Avery 2017 George Washington University

Medical Resource Utilization Of Outpatient Care For Children With Neurofibromatosis Type 1, Rabia Idrees, Michael Fisher, Rachel Hachen, Brian Callaghan, Robert A. Avery

GW Research Days 2016 - Present

Background:

Neurofibromatosis Type 1 (NF1) is an autosomal dominant syndrome with manifestations affecting the central nervous system, musculoskeletal system, peripheral nervous system, and cognitive/behavioral functions. Many of these manifestations persist throughout life and require medical/surgical interventions.

The resource utilization and economic burden of caring for children with NF1 is unknown. Prior research has inherent selection bias and does not accurately reflect the incidence/resource utilization of morbidities. In order to identify which disease manifestations are in the most need of improved clinical algorithms and novel therapeutics, the frequency/type of resources utilized (i.e., diagnostic imaging and specialty ...


Differential Mrna Expression In Ectopic Germinal Centers Of Myasthenia Gravis Thymus, Manjistha Sengupta, Bi-Dar Wang, Norman H. Lee, Gary Cutter, Linda L. Kusner, Henry J. Kaminski 2017 George Washington University

Differential Mrna Expression In Ectopic Germinal Centers Of Myasthenia Gravis Thymus, Manjistha Sengupta, Bi-Dar Wang, Norman H. Lee, Gary Cutter, Linda L. Kusner, Henry J. Kaminski

GW Research Days 2016 - Present

Myasthenia gravis (MG) is an autoimmune neuromuscular disorder resulting in weakness of voluntary muscles. It is caused by antibodies directed against proteins present at the post-synaptic surface of neuromuscular junction (NMJ). A characteristic pathology of patients with early onset MG is thymic hyperplasia with ectopic germinal centers (GC). However, mechanisms that trigger and maintain thymic hyperplasia are poorly characterized.

In order to determine the central mechanisms involved in the pathology, thymus samples from MG patients were assessed by histology and grouped based on appearance of GC compared to samples without them. We assessed the differential mRNA expression profiles between the ...


Genetic Influences Of Prok2 Associated Genes Affecting Alzheimer’S Disease Outcomes, Valentina Pita Grisanti 2017 Iowa State University

Genetic Influences Of Prok2 Associated Genes Affecting Alzheimer’S Disease Outcomes, Valentina Pita Grisanti

Honors Projects and Posters

Background: Prokineticin (PROK2) is a secreted protein expressed in the small intestine. It has also been associated with protecting brain cells by stimulates neurons to produce more mitochondria. Methods: Exploratory analysis was conducted in PLINK to extract SNP’s in Chromosome 3 (location of PROK2) that are related to bioenergetics and metabolism from the ADNI data, which contains longitudinal data including demographic, cognitive, neuroimaging, and biochemical data. Afterwards, the minor allele information was obtained for each of the SNPs. Then, linear mixed modeling in SPSS 23 was done to test associations between these genes associated with PROK2 and Alzheimer’s ...


Hsp90 And Its Co-Chaperones Modify Tdp-43 Localization, Aggregation, And Toxicity, Lilian T. Lin 2017 The University of Western Ontario

Hsp90 And Its Co-Chaperones Modify Tdp-43 Localization, Aggregation, And Toxicity, Lilian T. Lin

Electronic Thesis and Dissertation Repository

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease associated with protein misfolding and protein aggregation. In particular, the TAR DNA-binding protein (TDP-43) is often found in the pathological inclusions in neurons of ALS patient brains and spinal cords. This phenomenon is known as TDP-43 proteinopathy, the mislocalization of TDP-43 from the cell nucleus and the formation of aggregates in the cytoplasm. Numerous mutations in the gene encoding TDP-43 have also been linked to familial cases of ALS (fALS) and cause TDP-43 proteinopathy. This study attempts to decipher how the molecular chaperone Hsp90 and its co-chaperones, Aha1, Sti1, and Cdc37, modulate ...


Use Of Porous Elastomer Foams To Support Long Term Three Dimensional Neuronal Cultures, Richard M. Cukelj, Elda Hegmann, Ernest Freeman, Jennifer McDonough, Robert Clements 2017 Kent State University - Kent Campus

Use Of Porous Elastomer Foams To Support Long Term Three Dimensional Neuronal Cultures, Richard M. Cukelj, Elda Hegmann, Ernest Freeman, Jennifer Mcdonough, Robert Clements

Undergraduate Research Symposium

In order to effectively study the interactions that occur between neurons found in the brain, spatially and after an extended period of time, it is necessary to have reliable, repeatable studies. This is difficult to accomplish through conventional two-dimensional cell culture techniques, but three dimensional (3D) elastomer foams satisfy these criteria. Here we present a platform to study complex neuronal networks for extended periods in vitro. Elastomer foams were constructed with pore sizes ranging from 150μm to 400μm with 40μm secondary pores which allowed human neuroblastoma cells (SH-SY5Y) to adhere and interact with the foam and be sustained for long ...


Alberta Stroke Program Early Ct Score Infarct Location Predicts Outcome Following M2 Occlusion, Muhib Khan, Grayson L. Baird, Richard P. Goddeau, Brian Silver, Nils Henninger 2017 Spectrum Health

Alberta Stroke Program Early Ct Score Infarct Location Predicts Outcome Following M2 Occlusion, Muhib Khan, Grayson L. Baird, Richard P. Goddeau, Brian Silver, Nils Henninger

Open Access Articles

BACKGROUND: Although it is generally thought that patients with distal middle cerebral artery (M2) occlusion have a favorable outcome, it has previously been demonstrated that a substantial minority will have a poor outcome by 90 days. We sought to determine whether assessing the Alberta Stroke Program Early CT Score (ASPECTS) infarct location allows for identifying patients at risk for a poor 90-day outcome.

METHODS: We retrospectively analyzed patients with isolated acute M2 occlusion admitted to a single academic center between January 2010 and August 2012. Infarct regions were defined according to ASPECTS system on the initial head computed tomography. Discriminant ...


P35. Investigating The Effect Of Maternal Immune Activation On Sensory Filtering, Social Behaviour And Attention, Faraj Haddad 2017 Western University

P35. Investigating The Effect Of Maternal Immune Activation On Sensory Filtering, Social Behaviour And Attention, Faraj Haddad

Western Research Forum

Background

Altered brain development is associated with many neuropsychiatric disorders like Autism Spectrum Disorder (ASD) and schizophrenia. Environmental insults can interfere with neurodevelopment, and a prominent example is maternal infection during pregnancy. Epidemiological studies show that children born to mothers who were infected during pregnancy display a higher risk of developing ASD and schizophrenia, and this effect is mainly due to the maternal immune response. Polyinosinic-polycytidilic acid (Poly I:C) is a double stranded RNA molecule that mimics viral markers and elicits an immune response. When injected in pregnant rodents, this model produces offspring that exhibit core symptoms of ASD ...


P30. Optimizing Current Steering In Deep Brain Stimulation For Treating Parkinsonian Axial Motor Symptoms, Daphne Hui 2017 Western University

P30. Optimizing Current Steering In Deep Brain Stimulation For Treating Parkinsonian Axial Motor Symptoms, Daphne Hui

Western Research Forum

Background: The proposed study will investigate deep brain stimulation (DBS), of the subthalamic nucleus (STN) to improve gait dysfunctions in advanced Parkinson’s Disease (PD). DBS requires implantation of electrodes into the brain that contain contacts where current traverses to stimulate neurons. Imprecise electrode implantations are inherent in surgical implantation; thus, contributing to the elusiveness of DBS on gait.

Methods: The proposed investigation will divide current between two contacts to receive 0, 30, 50, 70, or 100% of current, to find the best combination to improve gait. Gait changes associated with fractional combinations will be visually assessed with clinical scales ...


Parental Quality Of Life 10 Years After Their Child’S Epilepsy Diagnosis, Klajdi Puka, Kathy Nixon Speechley 2017 Western University

Parental Quality Of Life 10 Years After Their Child’S Epilepsy Diagnosis, Klajdi Puka, Kathy Nixon Speechley

Western Research Forum

Background: Although the long-term course of childhood epilepsy is favorable in terms of seizure control, patients often face debilitating cognitive and psychosocial deficits that persist even after seizure remission. Pediatric epilepsy also has a large impact on the family and has been shown to be associated with diminished quality of life (QOL) among parents. However, the long-term outcome of parental QOL is unknown. This study aimed to 1) evaluate parental QOL 10 years after their child was diagnosed with epilepsy and 2) identify epilepsy-, child- and family-related characteristics associated with diminished parental QOL.

Methods: Data were derived from the Health-Related ...


Als-Linked Fus Exerts A Gain Of Toxic Function Involving Aberrant P38 Mapk Activation, Reddy Ranjith Kumar Sama, Claudia Fallini, Rodolfo Gatto, Jeanne E. McKeon, Yuyu Song, Melissa S. Rotunno, Saul Penaranda, Izrail Abdurakhmanov, John E. Landers, Gerardo Morfini, Scott T. Brady, Daryl Bosco 2017 University of Massachusetts Medical School

Als-Linked Fus Exerts A Gain Of Toxic Function Involving Aberrant P38 Mapk Activation, Reddy Ranjith Kumar Sama, Claudia Fallini, Rodolfo Gatto, Jeanne E. Mckeon, Yuyu Song, Melissa S. Rotunno, Saul Penaranda, Izrail Abdurakhmanov, John E. Landers, Gerardo Morfini, Scott T. Brady, Daryl Bosco

Open Access Articles

Mutations in Fused in Sarcoma/Translocated in Liposarcoma (FUS) cause familial forms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive axonal degeneration mainly affecting motor neurons. Evidence from transgenic mouse models suggests mutant forms of FUS exert an unknown gain-of-toxic function in motor neurons, but mechanisms underlying this effect remain unknown. Towards this end, we studied the effect of wild type FUS (FUS WT) and three ALS-linked variants (G230C, R521G and R495X) on fast axonal transport (FAT), a cellular process critical for appropriate maintenance of axonal connectivity. All ALS-FUS variants impaired anterograde and retrograde FAT in squid ...


Levodopa-Induced Morot Behavior Alterations In Dosophila Larvae, James Stanton 2017 University of Nebraska at Omaha

Levodopa-Induced Morot Behavior Alterations In Dosophila Larvae, James Stanton

Student Research and Creative Activity Fair

Exposing L-Dopa to Drosophila Melanogaster larvae and recording their induced dyskinetic behavior


Als Surveillance In Massachusetts: A One-Of-A-Kind Registry For Tracking An Elusive Disease, Vannalyn Abille, Alicia Fraser, Robert Knorr 2017 Massachusetts Department of Public Health

Als Surveillance In Massachusetts: A One-Of-A-Kind Registry For Tracking An Elusive Disease, Vannalyn Abille, Alicia Fraser, Robert Knorr

Community Engagement and Research Symposia

Background: Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neuromuscular disease with an etiology not yet fully understood. The Massachusetts Argeo Paul Cellucci ALS Registry is a unique population-based surveillance system used to monitor the occurrence of ALS throughout the state and to explore possible environmental causes of the disease.

Methods: The Registry gathers annual reports of ALS cases from physicians, hospitals, and clinics in accordance with state regulations. Medical records are obtained and abstracted for each case, and eligible cases are reviewed by a consulting neurologist to confirm diagnosis. Necessary clinical and demographic information are recorded in a ...


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