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Nervous System Diseases Commons

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617 full-text articles. Page 27 of 27.

Band Heterotopia, M. S. Alam, N Naila 2010 Aga Khan University

Band Heterotopia, M. S. Alam, N Naila

Section of Internal Medicine

Band heterotopias are one of the rarest groups of congenital disorder that result in variable degree of structural abnormality of brain parenchyma. Band of heterotopic neurons result from a congenital or acquired deficiency of the neuronal migration. MRI is the examination of choice for demonstrating these abnormalities because of the superb gray vs. white matter differentiation, detail of cortical anatomy and ease of multiplanar imaging. We report a case of band heterotopia that showed a bilateral band of gray matter in deep white matter best demonstrated on T2 Wt. and FLAIR images.


Growing Burden Of Neurological Diseases In Pakistan � Need For A National Health Survey, Mohammad Wasay, Shaukat Ali 2010 Aga Khan University

Growing Burden Of Neurological Diseases In Pakistan � Need For A National Health Survey, Mohammad Wasay, Shaukat Ali

Department of Medicine

No abstract provided.


An Epitope From Acanthamoeba Castellanii That Cross-React With Proteolipid Protein 139-151-Reactive T Cells Induces Autoimmune Encephalomyelitis In Sjl Mice, Chandirasegaran Massilamany, David Steffan, Jay Reddy 2010 University of Nebraska - Lincoln

An Epitope From Acanthamoeba Castellanii That Cross-React With Proteolipid Protein 139-151-Reactive T Cells Induces Autoimmune Encephalomyelitis In Sjl Mice, Chandirasegaran Massilamany, David Steffan, Jay Reddy

Jay Reddy Publications

We report here that an epitope (aa, 83-95) derived from Acanthamoeba castellanii (ACA) induces clinical signs of experimental autoimmune encephalomyelitis (EAE) in SJL/J mice reminiscent of the disease induced with myelin proteolipid protein (PLP) 139-151. By using IAs/tetramers, we demonstrate that both ACA 83-95 and PLP 139-151 generate antigen-specific cross-reactive CD4 T cells and the T cells secrete identical patterns of cytokines and induce EAE with a similar severity. These results may provide insights into the pathogenesis of multiple sclerosis and ACA-induced granulomatous encephalitis.


Preliminary Exploration Of The Effect Of Background Color On The Speed And Accuracy Of Search For An Aided Symbol Target By Typically Developing Preschoolers, Krista M. Wilkinson, Bridgett Coombs 2010 University of Massachusetts Medical School

Preliminary Exploration Of The Effect Of Background Color On The Speed And Accuracy Of Search For An Aided Symbol Target By Typically Developing Preschoolers, Krista M. Wilkinson, Bridgett Coombs

Center for Health Policy and Research (CHPR) Publications

Aided augmentative and alternative communication can be used successfully with individuals with communication disabilities. Recent studies suggest that, where possible, arranging symbols based on internal color (placing red fruits together) facilitates search for a target symbol by children with and without Down syndrome (Wilkinson, Carlin, & Thistle, 2008). We explored whether color cuing of symbol background might offer similar benefits for symbols that cannot readily be arranged by internal color. Ten nondisabled preschoolers engaged in computer search tasks for line drawings representing common animals when the line drawings appeared on white backgrounds compared to color-saturated backgrounds that cued the subcategory to ...


Finding The Pill On The Floor: How Contrast Sensitivity Affects Daily Living Skills In Alzheimer’S Disease Patients, Marlyn Colon 2010 Bridgewater State University

Finding The Pill On The Floor: How Contrast Sensitivity Affects Daily Living Skills In Alzheimer’S Disease Patients, Marlyn Colon

Undergraduate Review

Alzheimer’s disease (AD) is a progressive brain disorder that gradually destroys an individual’s mental functioning and social capabilities, including the ability to carry out everyday activities. Although memory deficits affect AD patients’ ability to perform these activities, research suggests that visual perception impairments also contribute. One impaired visual perception ability, contrast sensitivity, enables one to distinguish an object from its immediate surroundings. The present project measured contrast sensitivity in a real-world task by having AD patients find a pill of various shades of gray on a tiled background. Results were compared to young and elderly control participants. Participants ...


Ischemic Stroke Care - Official Guidelines From The Pakistan Society Of Neurology, Ayeesha Kamran Kamal, Ahmed Itrat, Imama Naqvi, Maria Khan, Roomasa Channa, Ismail Khatri, Mohammad Wasay 2010 Aga Khan University

Ischemic Stroke Care - Official Guidelines From The Pakistan Society Of Neurology, Ayeesha Kamran Kamal, Ahmed Itrat, Imama Naqvi, Maria Khan, Roomasa Channa, Ismail Khatri, Mohammad Wasay

Department of Medicine

No abstract provided.


Genetic Connections Between Neurological Disorders And Cholesterol Metabolism, Ingemar Bjorkhem, Valerio Leoni, Steve Meaney 2010 Karolinska Institute

Genetic Connections Between Neurological Disorders And Cholesterol Metabolism, Ingemar Bjorkhem, Valerio Leoni, Steve Meaney

Articles

Cholesterol is an essential component of both the peripheral and central nervous systems of mammals. Over the last decade, evidence has accumulated that disturbances in cholesterol metabolism are associated with the development of various neurological conditions. In addition to genetically defined defects in cholesterol synthesis, which will be covered in another review in this Thematic Series, defects in cholesterol metabolism (cerebrotendinous xanthomatosis) and intracellular transport (Niemann Pick Syndrome) lead to neurological disease. A subform of hereditary spastic paresis (type SPG5) and Huntington's disease are neurological diseases with mutations in genes that are of importance for cholesterol metabolism. Neurodegeneration is ...


Gene And Stem Cell Therapies For Treating Epilepsy., Janice R. Naegele, Xu Maisano 2010 Wesleyan University

Gene And Stem Cell Therapies For Treating Epilepsy., Janice R. Naegele, Xu Maisano

Division III Faculty Publications

No abstract provided.


Pkc Inhibition Increases Gap Junction Intercellular Communication And Cell Adhesion In Human Neuroblastoma, M. Morley, C. Jones, M. Sidhu, V. Gupta, S. Bernier, W. Rushlow, Daniel Belliveau 2009 The University of Western Ontario

Pkc Inhibition Increases Gap Junction Intercellular Communication And Cell Adhesion In Human Neuroblastoma, M. Morley, C. Jones, M. Sidhu, V. Gupta, S. Bernier, W. Rushlow, Daniel Belliveau

Daniel J. Belliveau

Abstract Gap junction intercellular communication and cell–cell adhesion are essential for maintaining a normal cellular phenotype, including the control of growth and proliferation. Loss of either cell–cell adhesion or communication is common in cancers, while restoration of function is associated with tumor suppression. Protein kinase C (PKC) isozymes regulate a broad spectrum of cellular functions including growth and proliferation, and their overexpression has been correlated with carcinogenesis. Consequently, PKC inhibitors are currently undergoing clinical trials as an anti-cancer agents although the precise cellular alterations induced by PKC inhibitors remain to be elucidated. In the current study, the effects ...


Muscular Fatigue Increases Ground Reaction Loading Rate During Walking, Henry Wang, Jeff Frame, Elicia Ozimek, Cara Reedstrom, Daniel Leib, Eric Dugan 2009 Ball State University

Muscular Fatigue Increases Ground Reaction Loading Rate During Walking, Henry Wang, Jeff Frame, Elicia Ozimek, Cara Reedstrom, Daniel Leib, Eric Dugan

Daniel Leib

No abstract provided.


Influences Of Load Carriage And Fatigue On Lower Extremity Kinetics During Walking, Cara Reedstrom, Henry Wang, Jeff Frame, Elicia Ozimek, Daniel Leib, Eric Dugan 2009 Ball State University

Influences Of Load Carriage And Fatigue On Lower Extremity Kinetics During Walking, Cara Reedstrom, Henry Wang, Jeff Frame, Elicia Ozimek, Daniel Leib, Eric Dugan

Daniel Leib

No abstract provided.


An Integrated Modeling Method For Tibia Strain Analysis, Daniel Leib, Henry Wang 2009 Boise State University

An Integrated Modeling Method For Tibia Strain Analysis, Daniel Leib, Henry Wang

Daniel Leib

No abstract provided.


An Integrated Modeling Method For Bone Strain Analysis, Daniel Leib, Henry Wang, Eric Dugan 2009 Boise State University

An Integrated Modeling Method For Bone Strain Analysis, Daniel Leib, Henry Wang, Eric Dugan

Daniel Leib

No abstract provided.


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