Contribution Of Wfs1 To Pancreatic Beta Cell Survival And Adaptive Alterations In Wfs1 Deficiency: A Dissertation, 2012 University of Masschusetts Medical School
Contribution Of Wfs1 To Pancreatic Beta Cell Survival And Adaptive Alterations In Wfs1 Deficiency: A Dissertation, Bryan M. O'Sullivan-Murphy
GSBS Dissertations and Theses
Diabetes mellitus comprises a cohort of genetic and metabolic diseases which are characterized by the hallmark symptom of hyperglycemia. Diabetic subtypes are based on their pathogenetic origins: the most prevalent subtypes are the autoimmune-mediated type 1 diabetes mellitus (T1DM) and the metabolic disease of type 2 diabetes mellitus (T2DM). Genetic factors are major contributory aspects to diabetes development, particularly in T2DM where there is close to 80% concordance rates between monozygotic twins. However, the functional state of the pancreatic β cell is of paramount importance to the development of diabetes. Perturbations that lead to β cell dysfunction impair insulin production ...
Er Stress As A Trigger For Beta-Cell Dysfunction And Autoimmunity In Type 1 Diabetes, 2012 University of Massachusetts Medical School
Er Stress As A Trigger For Beta-Cell Dysfunction And Autoimmunity In Type 1 Diabetes, Bryan M. O'Sullivan-Murphy, Fumihiko Urano
Program in Gene Function and Expression Publications and Presentations
Comment on: Tersey SA, Nishiki Y, Templin AT, Cabrera SM, Stull ND, Colvin SC, Evans-Molina C, Rickus JL, Maier B, Mirmira RG. Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes. 2012 Apr;61(4):818-27.
Polycystic Ovary Syndrome: Pathogenesis, Health Consequences, And Treatment Of Pcos In Relation To Insulin Resistance, 2012 University of New Hampshire - Main Campus
Polycystic Ovary Syndrome: Pathogenesis, Health Consequences, And Treatment Of Pcos In Relation To Insulin Resistance, Danielle Bernier
Honors Theses and Capstones
The purpose of this paper is to present a review of the current research on polycystic ovary syndrome (PCOS). PCOS is one of the most common endocrine disorders in women of reproductive age, affecting 5-10% of the population. Despite its prevalence, PCOS remains largely under unknown. This review has been broken down into two separate chapters. The first is the pathogenesis and related health consequences of PCOS. This chapter focuses on the diagnosis of PCOS as well as the prevalence and incidence of the disease. It then delves into the pathogenesis with a focus on genetics, obesity, insulin resistance and ...
Endocrine Complications In Patients Of Beta Thalassemia Major In A Tertiary Care Hospital In Pakistan, 2012 Aga Khan University
Endocrine Complications In Patients Of Beta Thalassemia Major In A Tertiary Care Hospital In Pakistan, Amina Adil, Zain A. Sobani, Abdul Jabbar, Salman N Adil, Safia Awan
Section of Diabetes, Endocrinology and Metabolism
OBJECTIVE: To determine the major endocrine complications present in patients of Thalassemia major presenting to a tertiary care center in Karachi, Pakistan.
METHODS: Records of all thallasemia major patients at a Haematology Department in a tertiary care hospital of Karachi were retrospectively reviewed from May to August 2009 with specific focus on endocrine data and investigations. The patients' data was recorded in a questionnaire and analyzed using SPSS v.17, frequencies and percentages along with corresponding 95% confidence interval were computed.
RESULTS: Our data revealed that a significantly small percentage of those under care received regular endocrine follow-up. Male hypo-gonadal ...
Are Population-Based Diabetes Models Useful For Individual Risk Estimation, 2012 University of Massachusetts Medical School
Are Population-Based Diabetes Models Useful For Individual Risk Estimation, Barry Saver, J. Hargraves, Kathleen Mazor
Kathleen M. Mazor
BACKGROUND: Predictive models are increasingly used in guidelines and informed decision-making interventions. We compared predictions from 2 prominent models for diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) outcomes model and the Archimedes-based Diabetes Personal Health Decisions (PHD) model. METHODS: Ours was a simulation study comparing 10-year and 20-year model predictions for risks of myocardial infarction (MI), stroke, amputation, blindness, and renal failure for representative test cases. RESULTS: The Diabetes PHD model predicted substantially higher risks of MI and stroke in most cases, particularly for stroke and for 20-year outcomes. In contrast, the UKPDS model predicted risks of amputation and ...
Antipsychotic Medication Use Among Children And Risk Of Diabetes Mellitus, 2012 University of Massachusetts Medical School
Antipsychotic Medication Use Among Children And Risk Of Diabetes Mellitus, Susan Andrade, Joan Lo, Douglas Roblin, Hassan Fouayzi, Daniel Connor, Robert Penfold, Malini Chandra, George Reed, Jerry Gurwitz
Jerry H. Gurwitz
OBJECTIVE: To assess whether the risk of incident diabetes was increased with the use of second-generation antipsychotics (SGAs) in a large diverse cohort of children.
METHODS: A retrospective study was conducted by using the administrative databases of 3 health plans participating in the Health Maintenance Organization Research Network. Children 5 to 18 years of age who initiated SGA therapy between January 2001 and December 2008 and 2 comparison groups, namely, nonusers of psychotropic drugs and users of antidepressant medications, were identified. Diagnoses from inpatient and outpatient records, pharmacy dispensings, and outpatient laboratory results were used to identify incident cases of ...
Brazilian Longitudinal Study Of Adult Health (Elsa-Brasil): Objectives And Design., 2012 Universidade de São Paulo
Brazilian Longitudinal Study Of Adult Health (Elsa-Brasil): Objectives And Design., Paulo A. Lotufo
Paulo A Lotufo
The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography ...
Type 2 Diabetes Science And American Indian / Alaska Native Culture: Creating A National K-12 Curriculum Prevention Strategy For Native Youth, 2012 University of Nevada, Las Vegas
Type 2 Diabetes Science And American Indian / Alaska Native Culture: Creating A National K-12 Curriculum Prevention Strategy For Native Youth, Carolee Dodge Francis, Michelle Chino
Environmental & Occupational Health Faculty Publications
Preventing and reducing the onset of type 2 diabetes among American Indian/Alaska Native youth requires educational strategies to affect knowledge, attitudes, and cognitive decision-making skills. In an unparalleled effort to address the growing epidemic of type 2 diabetes in tribal communities, eight tribal colleges and three federal agencies collaborated to develop and implement a kindergarten-through-twelfth-grade (K–12) Diabetes Education in Tribal Schools curriculum. This article outlines the scientific and cultural development of a comprehensive K–12 science curriculum as a targeted health prevention strategy.
A Reappraisal In São Paulo, Brazil (2008) Of "The Ecology Of Medical Care:" The "One Per Thousand's Rule"., 2012 Universidade de Sao Paulo
A Reappraisal In São Paulo, Brazil (2008) Of "The Ecology Of Medical Care:" The "One Per Thousand's Rule"., Adriana Roncoletta, Gustavo D. Gusso, Isabela M. Bensenor, Paulo A. Lotufo
Paulo A Lotufo
This paper reassessed in Brazil, the concept of "Medical ecology" i introduced in 1961 to describe the relationship and utilization of health care services by a given population. This was a cross-sectional telephone survey among a random sample of people enrolled in a private HMO. We interviewed a random sample of non-pregnant adults over age 18 using 10 questions about symptoms and health care use during the month prior to interview. The final sample consisted of 1,065 participants (mean age 68 years, 68% female). From this sample, 424 (39.8%) reported the presence of symptoms, 311 (29.2%) had ...
Hypothyroidism In The Elderly, 2012 Universidade de São Paulo
Hypothyroidism In The Elderly, Paulo A. Lotufo
Paulo A Lotufo
An overview adressing observational and randomized clinical trials about hypothyroidism in the elderly.
Chronic Non-Communicable Diseases In Brazil: Priorities For Disease Management And Research, 2012 Universidade de São Paulo
Chronic Non-Communicable Diseases In Brazil: Priorities For Disease Management And Research, Bruce B. Duncan, Dora Chor, Estela M. Aquino, Isabela M. Bensenor, J.Geraldo Mill, M.Ines Schmidt, Paulo A. Lotufo, Alvaro Vigo, Sandhi M. Barreto
Paulo A Lotufo
Chronic Non-Communicable Diseases are the main source of disease burden in Brazil. In 2011, the Brazilian Ministry of Health launched the Strategic Plan of Action for Management of Chronic Non-Communicable Diseases focusing on population-based interventions to manage cardiovascular diseases, diabetes, cancer, and chronic respiratory diseases mainly through fi ghting tobacco use, unhealthy diets, physical inactivity and the harmful use of alcohol. Although a signifi cant number of scientifi c studies on chronic diseases and their risk factors have been undertaken in Brazil, few are of cohort design. In this context, the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), a cohort ...
Insulin Pump School: Back To The Basics Of Pump Therapy, 2012 Philadelphia College of Osteopathic Medicine
Insulin Pump School: Back To The Basics Of Pump Therapy, Sara Wilson Reece, Cheryl Williams
The Longstreet Clinic (TLC), P.C. is a regional multidisciplinary physician practice. The Internal Medicine (IM) and Family Medicine (FM) departments are located in Gainesville and Oakwood (Hall County), Georgia. • Hall County is located in Northeast Georgia 50 miles northeast of Atlanta. It lies at the southern edge of the Chattahoochee National Forest and the foothills of the Blue Ridge Mountains. The population of Hall County is approximately 187,700. • Diabetes Education and Medical Nutritional Therapy department provides diabetes education and management services for IM and FM patients with diabetes. • Team of CDEs: RN, RD, PharmD • RN and PharmD are ...
Primary Cilia Regulates The Directional Migration And Barrier Integrity Of Endothelial Cells Through The Modulation Of Hsp27 Dependent Actin Cytoskeletal Organization, Thomas J. Jones, Ravi K. Adapala, Werner J. Geldenhuys, Chris Bursley, Wissam A. Aboualaiwi, Surya M. Nauli, Charles K. Thodeti
Pharmacy Faculty Articles and Research
Cilia are mechanosensing organelles that communicate extracellular signals into intracellular responses. Altered functions of primary cilia play a key role in the development of various diseases including polycystic kidney disease. Here, we show that endothelial cells from the oak ridge polycystic kidney (Tg737orpk/orpk) mouse, with impaired cilia assembly, exhibit a reduction in the actin stress fibers and focal adhesions compared to wild type. In contrast, endothelial cells from polycystin-1 deficient mice (pkd1null/null), with impaired cilia function, display robust stress fibers and focal adhesion assembly. We found that the Tg737orpk/orpk cells exhibit impaired directional migration and endothelial cell ...
Correlates Of Morbidity And Mortality In Severe Necrotizing Pancreatitis, 2012 Aga Khan University
Correlates Of Morbidity And Mortality In Severe Necrotizing Pancreatitis, K. M. Pal, Pashtoon Murtaza Kasi, Mohammad Tayyeb, S. M. Faisal Mosharraf, Zafar Fatmi
Community Health Sciences
Acute severe pancreatitis is associated with a high morbidity and mortality and frequently is accompanied by underlying pancreatic parenchymal necrosis. Patients with pancreatic necrosis must be identified, because the morbidity and mortality rate in this subgroup is much higher. Our objective was to compare the clinical outcomes of these patients based on the degree of pancreatic necrosis. A total of 35 patients were noted to have pancreatic necrosis. These were divided into 2 groups based on extent of necrosis: group A had less than 50% necrosis and group B had more than 50% necrosis. The rate of mortality (5% versus ...
Post Gastric Bypass Hypoglycemia: Four Cases Treated Successfully With Alphaglucosidase Inhibitor Therapy, 2012 Lehigh Valley Health Network
Post Gastric Bypass Hypoglycemia: Four Cases Treated Successfully With Alphaglucosidase Inhibitor Therapy, Shavon S. Frankhouser Do, Aakif N. Ahmad Do, Gretchen A. Perilli Md, Benjamin J. Quintana Md, Marc A. Vengrove Do, Facp
Department of Medicine
No abstract provided.
Noninvasive Assessment And Modeling Of Diabetic Cardiovascular Autonomic Neuropathy, 2012 University of Kentucky
Noninvasive Assessment And Modeling Of Diabetic Cardiovascular Autonomic Neuropathy, Siqi Wang
Theses and Dissertations--Biomedical Engineering
Noninvasive assessment of diabetic cardiovascular autonomic neuropathy (AN): Cardiac and vascular dysfunctions resulting from AN are complications of diabetes, often undiagnosed. Our objectives were to: 1) determine sympathetic and parasympathetic components of compromised blood pressure regulation in patients with polyneuropathy, and 2) rank noninvasive indexes for their sensitivity in diagnosing AN. Continuous 12-lead electrocardiography (ECG), blood pressure (BP), respiration, regional blood flow and bio-impedance were recorded from 12 able-bodied subjects (AB), 7 diabetics without (D0), 7 with possible (D1) and 8 with definite polyneuropathy (D2), during 10 minutes supine control, 30 minutes 70-degree head-up tilt and 5 minutes supine recovery ...
Volume Measures Using A Digital Image Analysis System Are Reliable In Diabetic Foot Ulcers, 2011 University of Iowa
Volume Measures Using A Digital Image Analysis System Are Reliable In Diabetic Foot Ulcers, Sue Gardner, Rita Frantz, Stephen Hillis, Thomas Blodgett, Lorraine Femino, Shannon Lehman
Reliable measures of wound size are critical to wound healing research and clinical management. Measurement of full-thickness wounds is increasingly being done using digital images and photogrammetric software, such as VeVMD (Vista Medical, Winnipeg, Manitoba, Canada), to estimate wound volume. The reliability of VeVMD in determining wound volume is unknown. The present study sought to examine the reliability of wound volume measurements obtained using VeVMD.
Compound 49b: A Novel Beta-Adrenergic Receptor Agonist In The Treatment Of Diabetic Retinopathy, 2011 University of Tennessee Health Science Center
Compound 49b: A Novel Beta-Adrenergic Receptor Agonist In The Treatment Of Diabetic Retinopathy, Kimberly Williams-Guy
Theses and Dissertations (ETD)
Diabetic retinopathy is the leading cause of blindness in working Americans. While there are therapeutic regimens for the disease, more effective methods are needed. We have previously shown that a non-specific beta-adrenergic receptor agonist, isoproterenol, was effective in preventing functional and morphological changes associated with diabetic retinopathy in the rat. Isoproterenol also produced left ventricle remodeling suggesting it entered the systemic circulation. We therefore synthesized various novel beta-adrenergic receptor compounds and screened these compounds in vitro for their ability to reduce markers of inflammation and apoptosis. Of the various compounds tested, Compound 49b was able to reduce both inflammation and ...
Trail And Dcr1 Expressions Are Differentially Regulated In The Pancreatic Islets Of Stz- Versus Cy-Applied Nod Mice, 2011 Harvard Medical School
Trail And Dcr1 Expressions Are Differentially Regulated In The Pancreatic Islets Of Stz- Versus Cy-Applied Nod Mice, Ercument Dirice, Sevin Kahraman, Gulsum Ozlem Elpek, Cigdem Aydin, Mustafa Kemal Balci, Abdulkadir Omer, Salih Sanlioglue, Ahter Dilsad Sanlioglue
Open Access Articles
TNF-related apoptosis-inducing ligand (TRAIL) is an important component of the immune system. Although it is well acknowledged that it also has an important role in Type 1 Diabetes (T1D) development, this presumed role has not yet been clearly revealed. Streptozotocin (STZ) and Cyclophosphamide (CY) are frequently used agents for establishment or acceleration of T1D disease in experimental models, including the non-obese diabetic (NOD) mice. Although such disease models are very suitable for diabetes research, different expression patterns for various T1D-related molecules may be expected, depending on the action mechanism of the applied agent. We accelerated diabetes in female NOD mice ...
Elsa-Brasil: Historico [In Portuguese], 2011 Universidade de São Paulo
Elsa-Brasil: Historico [In Portuguese], Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.