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Multiple Protein Kinases Determine The Phosphorylated State Of The Small Heat Shock Protein, Hsp27, In Sh-Sy5y Neuroblastoma Cells, Linda A. Dokas, Amy M. Malone, Frederick E. Williams, Surya M. Nauli, William S. Messer Jr. 2011 University of Toledo

Multiple Protein Kinases Determine The Phosphorylated State Of The Small Heat Shock Protein, Hsp27, In Sh-Sy5y Neuroblastoma Cells, Linda A. Dokas, Amy M. Malone, Frederick E. Williams, Surya M. Nauli, William S. Messer Jr.

Pharmacy Faculty Articles and Research

In SH-SY5Y human neuroblastoma cells, the cholinergic agonist, carbachol, stimulates phosphorylation of the small heat shock protein 27 (HSP27). Carbachol increases phosphorylation of both Ser-82 and Ser-78 while the phorbol ester, phorbol-12, 13-dibutyrate (PDB) affects only Ser-82. Muscarinic receptor activation by carbachol was confirmed by sensitivity of Ser-82 phosphorylation to hyoscyamine with no effect of nicotine or bradykinin. This response to carbachol is partially reduced by inhibition of protein kinase C (PKC) with GF 109203X and p38 mitogen-activated protein kinase (MAPK) with SB 203580. In contrast, phosphorylation produced by PDB is completely reversed by GF 109203X or CID 755673, an ...


Predictors Of 1-Year Survival After Ischemic Stroke And Intracerebral Haemorrhage: Results From The Stroke Mortality And Morbidity Study (The Emma Study)., Paulo Lotufo 2011 Universidade de São Paulo

Predictors Of 1-Year Survival After Ischemic Stroke And Intracerebral Haemorrhage: Results From The Stroke Mortality And Morbidity Study (The Emma Study)., Paulo Lotufo

Paulo A Lotufo

Socioeconomic status plays an important role for stroke trends in developing countries. We aimed to analyze predictors of 1-year survival after ischemic stroke (IS) and intracerebral haemorrhage (ICH) among participants of the EMMA study. Hypothesis: to verify if there aredifferences in predictors of 1-year survival according to stroke subtypes. Methods: we prospectively ascertained consecutive first-ever stroke (IS and ICH) registered between April 2006 and December 2008, using the standardized World Health Organization (WHO)´s stepwise approach to stroke surveillance, in a hospital located in a deprived area in the city of Sao Paulo, Brazil. Results: From a total of 430 ...


Functional Dependence Among Ischemic Stroke Survivors: Six-Month Follow-Up In The Stroke Mortality And Morbidity Study (The Emma Study), Paulo Lotufo 2011 Universidade de São Paulo

Functional Dependence Among Ischemic Stroke Survivors: Six-Month Follow-Up In The Stroke Mortality And Morbidity Study (The Emma Study), Paulo Lotufo

Paulo A Lotufo

There are controversies about the role of socioeconomic status (SES), clinical risk factors and medical care post-stroke recovery. We aimed to investigate the predictors of functional dependence during six-month follow-up in ischemic stroke (IS) Hypothesis: to verify if there is an influence of SES, clinical and hospital characteristics at 28-day and sixmonth IS recovery. Methods: We investigated the predictors of functional dependence among IS survivors admitted from April 2006 to December 2009 in a community hospital located in a deprived area in the city of Sao Paulo, Brazil. Patients were classified as independent or dependent according to their functional status ...


Income Inequality And Suicide In Sao Paulo, Brazil (1996 To 2009)., Paulo Lotufo 2011 Universidade de São Paulo

Income Inequality And Suicide In Sao Paulo, Brazil (1996 To 2009)., Paulo Lotufo

Paulo A Lotufo

To describe the characteristics of suicide in the city of Sa˜o Paulo according to socioeconomic status. The city is organized into 96 districts that were classified into three areas according to family income. From 1996 to 2009, a total of 6,123 suicides (for area: wealthiest, 1,193; middle-income, 1,996; poorest area, 2, 934) were adjudicated. In the poorest area the age-adjusted rates were 6.1 (men) and 1.6 (women); in the middle, 6.7 (men) and 1.5 (women), and the wealthiest 8.0 (men), and 2.8 (women). In the city, the suicide rates declined ...


Transient Acute Lateral Wall St Elevation Myocardial Infarction Caused By ‘Benign’ Circunflex Coronary Artery Anomaly Originating From The Right Coronary Artery, Paulo Lotufo 2011 Universidade de São Paulo

Transient Acute Lateral Wall St Elevation Myocardial Infarction Caused By ‘Benign’ Circunflex Coronary Artery Anomaly Originating From The Right Coronary Artery, Paulo Lotufo

Paulo A Lotufo

No abstract provided.


Gene Expression Profiling Of Islet Cell Subtypes, David M. Blodgett, Susanne Pechhold, Klaus Pechhold, David Harlan 2011 University of Massachusetts Medical School

Gene Expression Profiling Of Islet Cell Subtypes, David M. Blodgett, Susanne Pechhold, Klaus Pechhold, David Harlan

UMass Center for Clinical and Translational Science Research Retreat

Abstract

Pancreatic endocrine cells are co-located into clusters called the islets of Langerhans that are comprised of glucagon producing alpha cells, insulin secreting beta cells, somatostatin generating delta cells, and other cell types. Type 1 diabetes results from an autoimmune process in which autoreactive T cells destroy the insulin producing beta cells, requiring the patient to inject insulin to regulate their blood glucose levels. Thus far, attempts to cure diabetes via islet transplantation have been limited by insufficient donor supply, inconsistent isolated islet quality, continued autoimmunity, alloimmune rejection, and limited beta cell regeneration. Diabetes research has focused on preventing the ...


Strategies To Reduce Disease Burden From Diabetes And Hypertension In Developing World, Waris Qidwai 2011 Aga Khan University

Strategies To Reduce Disease Burden From Diabetes And Hypertension In Developing World, Waris Qidwai

Department of Family Medicine

No abstract provided.


Effect Of Screening And Management Of Diabetes During Pregnancy On Stillbirths, Madiha Syed, Hasan Javed, Mohammad Yawar Yakoob, Zulfiqar Ahmed Bhutta 2011 Aga Khan University

Effect Of Screening And Management Of Diabetes During Pregnancy On Stillbirths, Madiha Syed, Hasan Javed, Mohammad Yawar Yakoob, Zulfiqar Ahmed Bhutta

Woman and Child Health

Background:Diabetes during pregnancy is associated with significant risk of complications to the mother, fetus and newborn. We reviewed the potential impact of early detection and control of diabetes mellitus during pregnancy on stillbirths for possible inclusion in the Lives Saved Tool (LiST).

Methods:

A systematic literature search up to July 2010 was done to identify all published randomized controlled trials and observational studies. A standardized data abstraction sheet was employed and data were abstracted by two independent authors. Meta-analyses were performed with different sub-group analyses. The analyses were graded according to the CHERG rules using the adapted GRADE criteria ...


Can We Stop The Stroke Epidemic In Pakistan?, Ismail A. Khatri, Mohammad Wasay 2011 Shifa International Hospital

Can We Stop The Stroke Epidemic In Pakistan?, Ismail A. Khatri, Mohammad Wasay

Department of Medicine

No abstract provided.


Acute Inferolateral St-Elevation Myopericarditis Diagnosed By Delayed Enhancement Cardiac Computed Tomography, Paulo Lotufo 2011 Universidade de São Paulo

Acute Inferolateral St-Elevation Myopericarditis Diagnosed By Delayed Enhancement Cardiac Computed Tomography, Paulo Lotufo

Paulo A Lotufo

A 20-year-old man with no previous medical history presented to the Emergency Department (ED) complaining of 3 h of chest pressure. He denied drug abuse or risk factors for coronary artery disease. He had no symptoms of viral infection. Physical examination was unremarkable. The first electrocardiogram (ECG) showed a 4 mm ST-segment elevation in the inferior leads and no PR depression. His troponin and CK-MB levels were abnormal. Urgent coronary angiography showed no lesions. Echocardiography was normal. The patient was investigated with cardiac computed tomography (CT) and late enhancement imaging. Cardiac anatomy and coronary arteries were normal in the first ...


Epidemiologia: Uma Abordagem Prática [Portuguese], Isabela Bensenor, Paulo Lotufo 2011 Universidade de Sao Paulo

Epidemiologia: Uma Abordagem Prática [Portuguese], Isabela Bensenor, Paulo Lotufo

Paulo A Lotufo

Basic Epidemiology for undergraduate students, medical residents and health professionals.


Spurious Hyperkalaemia: An Insight, Khawaja Salman Zaki, Uzma Majid, Najmul Islam 2011 Aga Khan University

Spurious Hyperkalaemia: An Insight, Khawaja Salman Zaki, Uzma Majid, Najmul Islam

Section of Diabetes, Endocrinology and Metabolism

Hyperkalaemia is a common electrolyte disorder with potentially lethal consequences and can lead to life-threatening cardiac dysrhythmias. Spurious hyperkalaemia, also known as pseudohyperkalaemia or factitious hyperkalaemiais, is also quite common in clinical practice and it's a source of avoidable emergency department visits or hospital admissions. We report a case in which alarming hyperkalaemia was found in a patient having Chronic Monomyelocytic Leukaemia on two different occasions, later diagnosed to be spurious.


Diabetic Ketoacidosis Associated With Tacrolimus In Solid Organ Transplant Recipients, Muhammad Qamar Masood, Madiha Rabbani, Wasim Jafri, Manal Habib, Taimur Saleem 2011 Aga Khan University

Diabetic Ketoacidosis Associated With Tacrolimus In Solid Organ Transplant Recipients, Muhammad Qamar Masood, Madiha Rabbani, Wasim Jafri, Manal Habib, Taimur Saleem

Section of Diabetes, Endocrinology and Metabolism

Diabetic ketoacidosis in patients receiving tacrolimus in the post-transplant setting is rare. We describe two such cases in solid-organ transplant recipients. The first patient, a 17-year-old male, presented with severe diabetic ketoacidosis and was managed with intravenous fluids and insulin infusion. He was a known case of Laurence-Moon-Bardet-Biedl syndrome and had received a renal transplant 2 years ago and was receiving tacrolimus since then. Although diabetic ketoacidosis resolved in 24 hours, large doses of subcutaneous insulin (upto 130 units per day) were needed to keep serum glucose within the normal range. Substitution of tacrolimus with cyclosporine obviated the need for ...


Cardiovascular Risk Factors Associated With Migraine Among The Elderly With A Low Income: The Sao Paulo Ageing & Health Study (Spah), Paulo Lotufo 2011 Universidade de São Paulo

Cardiovascular Risk Factors Associated With Migraine Among The Elderly With A Low Income: The Sao Paulo Ageing & Health Study (Spah), Paulo Lotufo

Paulo A Lotufo

BACKGROUND: To investigate the association between cardiovascular risk-factor profile and migraine in the elderly, we evaluated a population sample of ageing men and women (65 years or more) living in a low-income area in the city of São Paulo, Brazil. PATIENTS AND METHODS: We investigated migraine status and cardiovascular profile from a baseline of 1450 participants (65-102 years of age) of the São Paulo Ageing & Health Study (SPAH), a longitudinal population-based study with low-income elderly in Brazil. The following age and sex-adjusted cardiovascular risk factors were analyzed: blood pressure, pulse pressure, serum total and high-density lipoprotein cholesterol, body mass index, smoking, history of hypertension, diabetes and the 10-year risk of myocardial infarction or coronary heart disease death based on the Framingham Risk Score. RESULTS: The overall prevalence of migraine was 11.4%, and it was 3 times more frequent among women than men (15.3% vs 5.4%; P < 0.0001). Migraineurs were younger than non-migraineurs (mean age 70.6 years vs 72.1 years; P = 0.001, respectively). There was no statistically significant difference regarding the cardiovascular risk-factor profile after adjustment for age and sex among migraineurs and non-migraineurs. Only a decrease in the risk of hypertension among women (OR 0.58; 95% CI 0.38-0.90; P = 0.01) was also observed even after adjustment for age. CONCLUSIONS:Overall, we did not find a worse cardiovascular risk profile among elderly migraineurs. An inverse association between hypertension and migraine in women warrants further investigation


Sertraline Vs. Electrical Current Therapy For Treating Depression Clinical Trial - Select Tdcs: Design, Rationale And Objectives, Paulo Lotufo 2010 Universidade de São Paulo

Sertraline Vs. Electrical Current Therapy For Treating Depression Clinical Trial - Select Tdcs: Design, Rationale And Objectives, Paulo Lotufo

Paulo A Lotufo

Despite significant advancements in psychopharmacology, treating major depressive disorder (MDD) is still a challenge considering the efficacy, tolerability, safety, and economical costs of most antidepressant drugs. One approach that has been increasingly investigated is modulation of cortical activity with tools of non-invasive brain stimulation - such as transcranial magnetic stimulation and transcranial direct current stimulation (tDCS). Due to its profile, tDCS seems to be a safe and affordable approach. METHODS AND DESIGN: The SELECT TDCS trial aims to compare sertraline vs. tDCS in a double-blinded, randomized, factorial trial enrolling 120 participants to be allocated to four groups to receive sertraline+tDCS ...


Periodontal Disease Contributes To The Occurrence Of Cardiovascular Events? A Meta-Analysis Of Case Control Studies, Julita Coelho, Paulo Lotufo, Mauricio Barreto 2010 Universidade Estadual de Feira de Santana

Periodontal Disease Contributes To The Occurrence Of Cardiovascular Events? A Meta-Analysis Of Case Control Studies, Julita Coelho, Paulo Lotufo, Mauricio Barreto

Paulo A Lotufo

Source: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH Volume: 65 Supplement: 1 Pages: A231-A232 DOI: 10.1136/jech.2011.142976h.80 Published: AUG 201


Prevalence Of Thyroid Disorders Among Older People: Results From The São Paulo Ageing & Health Study, Paulo A. Lotufo 2010 Universidade de São Paulo

Prevalence Of Thyroid Disorders Among Older People: Results From The São Paulo Ageing & Health Study, Paulo A. Lotufo

Paulo A Lotufo

This study aimed to estimate prevalence of thyroid disorders in the São Paulo Ageing & Health Study, an epidemiological study addressing several health-adverse outcomes among elderly people living in a poor area of São Paulo, Brazil. All participants answered a questionnaire and had a blood sample collected to assess levels of tireotropic hormone and free-thyroxine. Among 1,373 people (60.8% women), prevalence rates (95% confidence interval) for thyroid dysfunction (%) were: overt hyperthyroidism, 0.7% (0.2-1.1) [women: 0.8% (0.2-1.5); men: 0.4% (0.01-0.9)]; overt hypothyroidism, 5.7% (4.5-6.9) [women: 5.9% (4.3-7.5); men: 5.4% (3.5-7.3)]; subclinical hyperthyroidism, 2.4% (1.6-3.2) [women: 2.8% (1.6-3.9); men: 1.9% (0.7-3.0)]; and subclinical hypothyroidism, 6.5% (5.2-7.8) [women: 6.7% (5.0- 8.4); men: 6.1% (4.1-8.2)]. There was no difference in prevalence rates according to gender, but almost 40% of women were diagnosed and under treatment compared ...


Self-Glucose Monitoring And Glycaemic Control At A Tertiary Care University Hospital, Karachi, Pakistan, Khurshid Khowaja, Humaira Waheed 2010 Aga Khan University

Self-Glucose Monitoring And Glycaemic Control At A Tertiary Care University Hospital, Karachi, Pakistan, Khurshid Khowaja, Humaira Waheed

Section of Diabetes, Endocrinology and Metabolism

OBJECTIVE: To explore the association between Self Monitoring of Blood Glucose (SMBG) levels and improved glycemic control (HbA1c level) among type 2 diabetic patients, receiving oral hypoglycaemic agents and insulin, and to ascertain the factors influencing SMBG.

METHOD: Using Comparative cross sectional study design five hundred Type 2 diabetes patients through convenient sampling between 30-70 years were interviewed through a structured questionnaire in year 2006 and 2007 at AKUH Ambulatory setting. These 500 subjects were divided as 250 in case (doing SMBG) and 250 in control (not doing SMBG) groups.

RESULTS: We identified that HbA1c value was maintained at good ...


Energy Webs And Nursing Praxis: Patterning In The Lived Experience Of Type 2 Diabetes, Karen Marcus Glasenapp 2010 St. Catherine University

Energy Webs And Nursing Praxis: Patterning In The Lived Experience Of Type 2 Diabetes, Karen Marcus Glasenapp

Doctor of Nursing Practice Systems Change Projects

Diabetes is an illness best described as costly, complex, chronic, and epidemic in the United States, affecting nearly 24 million children and adults; 90% of who have type 2 diabetes (Centers for Disease Control and Prevention, 2008). On average, every 20 seconds in the United States, an individual 20 years of age and older receives a diagnosis of diabetes; yet, an estimated 6 million people with the disease remain undiagnosed (American Diabetes Association, 2010b). The financial burden of this disease, the inconsistent effectiveness of well-intentioned diabetes programs to educate and actualize change behavior, and the limited resources of millions of ...


Clinician Driven Disparities In The Care Of Black/African American Patients With Diabetes: Low Density Lipoproteins In An Urban Clinic, Louise Carter Winter 2010 St. Catherine University

Clinician Driven Disparities In The Care Of Black/African American Patients With Diabetes: Low Density Lipoproteins In An Urban Clinic, Louise Carter Winter

Doctor of Nursing Practice Systems Change Projects

This quantitative, non-experimental, retrospective chart review investigated the possible presence of clinician driven disparities in the care of Black/African American patients with diabetes at an urban clinic. The study was a response to the Institute of Medicine’s call to address patient, system, and clinician issues that negatively impact management of patients with chronic diseases including diabetes. The goal is to improve patient outcomes using system wide care guidelines to increase success at meeting the nationally accepted Diabetes 5 (D5) measures. During a twelve month period, clinician response to elevated low density lipoproteins (LDLs) was assessed while considering patient ...


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