Development Of A Multi-Site Phase Ii Clinical Trial Of Valproic Acid For Retinitis Pigmentosa, 2010 University of Massachusetts Medical School
Development Of A Multi-Site Phase Ii Clinical Trial Of Valproic Acid For Retinitis Pigmentosa, Christine Moulton Clemson
GSBS Dissertations and Theses
The body of work presented here is a compendium of the multiple steps required for an investigator initiated trial of an existing medication (Valproic Acid- VPA) for a new indication (Retinitis Pigmentosa – RP). The chapters are listed in logical and chronological order of the process. In order to access patient records an expedited Institutional Review Board (IRB) application for retrospective chart review was submitted (Chapter 1). These records enabled the statistical analysis which not only laid the framework for the trial design, but also became the basis for two manuscripts (Chapter 2). Protocol development informed by the preliminary human studies ...
Age- And Sex-Associated Changes In Mrna Expression Of Neurodegenerative Disorder-Related Molecules In The Hippocampus And Cerebellum Of Rat Brain, Srinivasarao Thulluri
Theses, Dissertations and Capstones
Age-associated oxidative stress is involved in neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases, and sex-associated differences may also affect the risk for these neurodegenerative diseases. We compared the effects of aging and sex on the mRNA expression of five molecules that are closely related to oxidative stress, along with Alzheimer’s and Parkinson’s diseases in the hippocampus of both male and female Fischer 344xBrown Norway (F344BN) rats. The reverse transcription polymerase chain reaction was used to determine the mRNA expression level of superoxide dismutase 2 (SOD2), heme oxygenase 1 (HO1), amyloid precursor protein (APP), -site APP-cleaving ...
Preliminary Exploration Of The Effect Of Background Color On The Speed And Accuracy Of Search For An Aided Symbol Target By Typically Developing Preschoolers, 2010 University of Massachusetts Medical School
Preliminary Exploration Of The Effect Of Background Color On The Speed And Accuracy Of Search For An Aided Symbol Target By Typically Developing Preschoolers, Krista M. Wilkinson, Bridgett Coombs
Center for Health Policy and Research (CHPR) Publications
Aided augmentative and alternative communication can be used successfully with individuals with communication disabilities. Recent studies suggest that, where possible, arranging symbols based on internal color (placing red fruits together) facilitates search for a target symbol by children with and without Down syndrome (Wilkinson, Carlin, & Thistle, 2008). We explored whether color cuing of symbol background might offer similar benefits for symbols that cannot readily be arranged by internal color. Ten nondisabled preschoolers engaged in computer search tasks for line drawings representing common animals when the line drawings appeared on white backgrounds compared to color-saturated backgrounds that cued the subcategory to ...
Fas Behavioral Survey Of Traits: Screening For Effects Of Prenatal Exposure To Alcohol, 2010 George Fox University
Fas Behavioral Survey Of Traits: Screening For Effects Of Prenatal Exposure To Alcohol, Glena Andrews, C. Joe Robins
Faculty Publications - Grad School of Clinical Psychology
The FAS BeST was developed by parents and educators of children with Fetal Alcohol Syndrome rating behaviors characteristic of FASD including; easily influenced by others, difficulty learning from experience, appearing and declaring innocence even when confronted with evidence to the contrary, and experiencing difficulties in other domains. The FAS BeST differentiates between children with PEA, dysgenesis of the corpus callosum (DCC), and attention deficit hyperactivity disorder (ADHD; Porter & Andrews, 2004). The sample included 294 participants. Using the cutoff score suggested by Porter and Andrews (2004) the accuracy rates were 78% for FAS/E, 100% for controls, 85% for DCC, and ...
Spirituality And Organised Religion In Supporting Parents Of Children With Down Syndrome And Intellectual Disability, 2010 Edith Cowan University
Spirituality And Organised Religion In Supporting Parents Of Children With Down Syndrome And Intellectual Disability, Divia Pillay
Theses : Honours
Background: Raising a child with an intellectual disability can present parents with many challenges. Factors that have been demonstrated to positively impact on the mental and physical health of parents of children with an intellectual disability include greater clinical, family and social supports. One avenue of support that has been rarely explored is the role of spirituality and organised religion in supporting parents of children with an intellectual disability. Aim: The aim of this literature review was to investigate the role of spirituality and organised religion in the lives of parents of children with intellectual disability, specifically Down syndrome. Methods ...