History Of Periodontitis Diagnosis And Edentulism As Predictors Of Cardiovascular Disease, Stroke, And Mortality In Postmenopausal Women, Michael J. Lamonte, Robert J. Genco, Kathleen M. Hovey, Robert B. Wallace, Jo L. Freudenheim, Dominique S. Michaud, Xiaodan Mai, Lesley Tinker, Christian R. Salazar, Christopher A. Andrews, Wenjun Li, Charles Eaton, Lisa W. Martin, Jean Wactawski-Wende
University of Massachusetts Medical School Faculty Publications
BACKGROUND: Few studies have reported associations between periodontitis and cardiovascular disease (CVD) risk in older women, which is the objective of the present investigation.
METHODS AND RESULTS: Participants were 57 001 postmenopausal women ages 55 to 89 years (mean 68 years; > 85% 60 and older) who were enrolled (1993-1998) in the Women's Health Initiative Observational Study, and were without known CVD when history of periodontitis and edentulism was assessed by questionnaire at study Year-5 (1998-2003). There were 3589 incident CVD events and 3816 total deaths during a mean follow-up of 6.7 years. In multivariable analysis, periodontitis was not ...
Secondary Prevention And Cognitive Function After Stroke: A Study Protocol For A 5-Year Follow-Up Of The Aspire-S Cohort, 2017 Royal College of Surgeons in Ireland
Secondary Prevention And Cognitive Function After Stroke: A Study Protocol For A 5-Year Follow-Up Of The Aspire-S Cohort, Daniela Rohde, David Williams, Eva Gaynor, Kathleen E. Bennett, Eamon Dolan, Elizabeth Callaly, Margaret Large, Anne Hickey
Introduction Cognitive impairment is common following stroke and can increase disability and levels of dependency of patients, potentially leading to greater burden on carers and the healthcare system. Effective cardiovascular risk factor control through secondary preventive medications may reduce the risk of cognitive decline. However, adherence to medications is often poor and can be adversely affected by cognitive deficits. Suboptimal medication adherence negatively impacts secondary prevention targets, increasing the risk of recurrent stroke and further cognitive decline. The aim of this study is to profile cognitive function and secondary prevention, including adherence to secondary preventive medications and healthcare usage, 5 ...
Delineating A Cardioprotective Pathway For Trp Channel-Induced Nitric Oxide Production In Diabetic Cardiomyocytes, 2017 Kent State University - Kent Campus
Delineating A Cardioprotective Pathway For Trp Channel-Induced Nitric Oxide Production In Diabetic Cardiomyocytes, Erik Hopkins, Spencer R. Andrei, Manasi A. Agrawal, Monica Ghosh, Derek Damron Dr.
Undergraduate Research Symposium
Background: Transient Receptor Potential (TRP) channel stimulation induces the up-regulation of several downstream mediators that are well understood to be cardioprotective in response to ischemic injury in the heart. However, since the discovery of this cardioprotective pathway is completely novel in nature, the extent to which it is modified in the setting of diabetes presents an intriguing translational interest. We hypothesized that the TRP-induced upregulation of this cardioprotective axis is compromised in diabetes.
Methods: CMs isolated from normal and diabetic mice were treated with the TRPA1 agonist, AITC, or the TRPV1 agonist, capsaicin, in the presence or absence of TRPA1 ...
Trpa1 Activation Elicits Post-Translational Modifications Of Akt And Enos In Cardiomyocytes, 2017 Kent State University
Trpa1 Activation Elicits Post-Translational Modifications Of Akt And Enos In Cardiomyocytes, Ryan Pasquino, Spencer Andrei, Monica Ghosh, Manasi Agrawal, Derek Damron
Undergraduate Research Symposium
Background: Recently, our lab was the first to identify the functional presence of transient receptor potential (TRP) channels of the ankyrin 1 subtype (TRPA1) in mouse cardiomyocytes (CMs). However, the extent to which TRPA1 mediates signaling events in cardiac tissue has yet to be fully determined. Based upon investigations completed in other tissue types in the body, we hypothesized that TRPA1 activation will lead to Akt and eNOS activation in CMs.
Methods: CMs were untreated or treated with the TRPA1-specific agonist, allyl isothiocyanate (AITC), in the presence of absence of Akt inhibitor (LY294002) or eNOS inhibitor (L-NAME) and prepared for ...
Nitric Oxide Bioavailability In Diabetic Cardiomyocytes: The Role Of Propofol In Superoxide Scavenging, 2017 Kent State University
Nitric Oxide Bioavailability In Diabetic Cardiomyocytes: The Role Of Propofol In Superoxide Scavenging, Kayla N. Hamdan, Spencer R. Andrei, Derek S. Damron
Undergraduate Research Symposium
Background: The reaction of NO with superoxide anion to form peroxynitrite has been implicated as a potential mechanism contributing to the limited NO bioavailability observed in diabetes. Furthermore, there is little evidence outlining the effects of intravenous anesthetic, propofol, on NO bioavailability in cardiomyocytes (CMs) isolated from diabetic mice. We hypothesized that propofol would act as a superoxide scavenger, thereby increasing NO bioavailability.
Methods: For NO, superoxide and peroxynitrite measurements, freshly isolated control and diabetic CMs were incubated in the presence or absence of propofol with NO, superoxide (DHE) or peroxynitrite (HKG) fluorescent probes. Fluorescence was measured using either fluorescence ...
Venoarterial Extracorporeal Membrane Oxygenation For Cardiogenic Shock: A Retrospective Analysis Based On The Etiology Of Shock, Andrew Burchett, Thomas Tribble, Richard Charnigo, Susan Smyth, Maya Guglin
The VAD Journal
Background: We performed a retrospective analysis to evaluate the efficacy of VA-ECMO support in cardiogenic shock based on various etiologies.
Methods: We retrospectively analyzed 99 patients supported with VA-ECMO from January 1, 2012 to January 1, 2015. Outcomes included survival to discontinuation of VA-ECMO support and survival to hospital discharge. The etiologies of cardiogenic shock included cardiac arrest (CPR), acute myocardial infarction (AMI), decompensated congestive heart failure (CHF), pulmonary embolism (PE), right ventricular failure (RVF) not secondary to an acute pulmonary embolism, and post-cardiotomy syndrome (PCS). The PCS group was used as a reference group; odds ratios were estimated ...
P23. Elucidation Of The Signaling Pathway Of Mertk, 2017 Western University
P23. Elucidation Of The Signaling Pathway Of Mertk, Kyle Taruc
Western Research Forum
Mer Tyrosine Kinase (MERTK) is a receptor which mediates efferocytosis – removal of apoptotic cells by phagocytes such as macrophages. MERTK plays a critical role in homeostasis, with mutations in MERTK associated with the development and progression of atherosclerosis, the buildup of cholesterol-laden plaque in the sub-arterial space. Indeed, one MERTK allele is associated with 66% (heterozygous) to 75% (homozygous) protection from atherosclerosis, while other alleles and SNP’s pre-dispose to atherosclerosis and autoimmunity. Complications resulting from atherosclerosis, including heart attack and stroke, are currently the second leading cause of mortality in Canada. Despite the importance of MERTK in atherosclerosis ...
Using Heart Models For Physiology Teaching And Learning, 2017 Illinois Mathematics and Science Academy
Using Heart Models For Physiology Teaching And Learning, Sowmya Anjur
Over the last few decades, there has been a shift in the classroom from a teacher-centered learning environment, with its emphasis on content delivery, to a student-centered environment focused on inquiry learning (http://www.nsta.org/docs/ PositionStatement_Scienti cInquiry.pdf). With the Next Generation Science Standards (NGSS, 2012) being adopted by many states, students are no longer passive listeners, but actively participate in and initiate class discussions (Weimar, 2013). Additionally, recent technological advances have allowed students to acquire information from sources such as the internet which no longer necessitates the teacher giving lectures (Silver- thorn, 2006). The more student-centered learning ...
Gastrointestinal-Renal Axis: Role In The Regulation Of Blood Pressure., 2017 George Washington University
Gastrointestinal-Renal Axis: Role In The Regulation Of Blood Pressure., Jian Yang, Pedro A Jose, Chunyu Zeng
Medicine Faculty Publications
Hypertension is one of the most common and important health problems worldwide.1 It has been estimated that 29% of the world's adult population, or 1.56 billion people, will have hypertension by the year 2025.2The prevalence of high blood pressure and its adverse consequences result in a heavy burden for hypertensive patients from high‐, middle‐, and low‐income countries.2, 3 Many monogenic causes of hypertension have been reported. However, determining the causes of essential hypertension has been hampered because it is a complex disorder with genetic, epigenetic, and environmental determinants. Among numerous environmental factors, sodium ...
Up-Regulation Of Junctophilin-2 Prevents Er Stress And Apoptosis In Hypoxia/Reoxygenation-Stimulated H9c2 Cells, 2017 The University of Western Ontario
Up-Regulation Of Junctophilin-2 Prevents Er Stress And Apoptosis In Hypoxia/Reoxygenation-Stimulated H9c2 Cells, Zijun Su
Electronic Thesis and Dissertation Repository
Ischemic heart disease is the leading cause of death, and reperfusion which can restore blood flow is the primary therapy. However, reperfusion can induce further damage to cardiomyocytes, a condition described as ischemia-reperfusion (I/R) injury. I/R is now recognized as a combination determining the final myocardial infarction size. Although the mechanisms underlying I/R-induced cardiac injury remain incompletely understood, emerging evidence suggests that intracellular Ca2+ mishandling during I/R plays a key role in cell death. Junctophilin-2 (JPH2) is a junctional membrane-binding structural protein. It mechanically maintains the fixed distance between the T-tubule and the sarcoplasmic reticulum ...
Messenger Rna And Microrna Transcriptomic Signatures Of Cardiometabolic Risk Factors, 2017 University of Massachusetts Medical School
Messenger Rna And Microrna Transcriptomic Signatures Of Cardiometabolic Risk Factors, David D. Mcmanus, Jian Rong, Tianxiao Huan, Sean Lacey, Kahraman Tanriverdi, Peter J. Munson, Martin G. Larson, Roby Joehanes, Venkatesh Murthy, Ravi Shah, Jane E. Freedman, Daniel Levy
UMass Center for Clinical and Translational Science Supported Publications
BACKGROUND: Cardiometabolic (CM) risk factors are heritable and cluster in individuals. We hypothesized that CM risk factors are associated with multiple shared and unique mRNA and microRNA (miRNA) signatures. We examined associations of mRNA and miRNA levels with 6 CM traits: body mass index, HDL-cholesterol and triglycerides, fasting glucose, and systolic and diastolic blood pressures through cross-sectional analysis of 2812 Framingham Heart Study who had whole blood collection for RNA isolation for mRNA and miRNA expression studies and who consented to genetic research. We excluded participants taking medication for hypertension, dyslipidemia, or diabetes. We measured mRNA (n = 17,318; using ...
Neighborhood Environment Correlates Of Physical Activity And Sedentary Behavior Among Latino Adults In Massachusetts, 2017 University of Massachusetts Medical School
Neighborhood Environment Correlates Of Physical Activity And Sedentary Behavior Among Latino Adults In Massachusetts, Valerie J. Silfee, Milagros C. Rosal, Meera Sreedhara, Vilma Lora, Stephenie C. Lemon
Stephenie C. Lemon
BACKGROUND: U.S. Latinos experience high rates of cardio-metabolic diseases and have high rates of physical inactivity and sedentary behavior. Understanding the environmental factors associated with physical activity and sedentary behaviors among Latinos could inform future interventions. The purpose of this study is to explore the neighborhood environment correlates of physical activity and sedentary behavior in a sample of U.S. Latino adults.
METHODS: Cross-sectional study of 602 Latino adults in Lawrence, MA. Survey assessments of physical activity, sedentary behavior, and neighborhood environment were verbally administered. The neighborhood environment scale assessed violence, safety, aesthetic quality, walkability, availability of healthy foods ...
Beta-Blocker Use Is Associated With Impaired Left Atrial Function In Hypertension, 2017 University of Massachusetts Medical School
Beta-Blocker Use Is Associated With Impaired Left Atrial Function In Hypertension, Mayank Sardana, Amer Ahmed Syed, Zeba Hashmath, Timothy S. Phan, Maheswara R. Koppula, Uzma Kewan, Zoubair Ahmed, Ravikantha Chandamuri, Swapna Varakantam, Ejaz Shah, Ryan Gorz, Scott R. Akers, Julio A. Chirinos
Open Access Articles
BACKGROUND: Impaired left atrial (LA) mechanical function is present in hypertension and likely contributes to various complications, including atrial arrhythmias, stroke, and heart failure. Various antihypertensive drug classes exert differential effects on central hemodynamics and left ventricular function. However, little is known about their effects on LA function.
METHODS AND RESULTS: We studied 212 subjects with hypertension and without heart failure or atrial fibrillation. LA strain was measured from cine steady-state free-precession cardiac MRI images using feature-tracking algorithms. In multivariable models adjusted for age, sex, race, body mass index, blood pressure, diabetes mellitus, LA volume, left ventricular mass, and left ...
Junctional Ectopic Tachycardia Secondary To Myocarditis Associated With Sudden Cardiac Arrest, 2017 George Washington University
Junctional Ectopic Tachycardia Secondary To Myocarditis Associated With Sudden Cardiac Arrest, Michael E. A. Cunningham, Robin W. Doroshow, Laura Oliveri, Jeffrey P. Moak
Pediatrics Faculty Publications
No abstract provided.
Anakinra Reduces Blood Pressure And Renal Fibrosis In One Kidney/Doca/Salt-Induced Hypertension, 2017 Monash University
Anakinra Reduces Blood Pressure And Renal Fibrosis In One Kidney/Doca/Salt-Induced Hypertension, Yeong Hann Ling, Shalini M. Krishnan, Christopher T. Chan, Henry Diep, Dorota Ferens, Jaye Chin-Dusting, Barbara K. Kemp-Harper, Chrishan S. Samuel, Timothy D. Hewitson, Eicke Latz, Ashley Mansell, Christopher G. Sobey, Grant R. Drummond
Open Access Articles
OBJECTIVE: To determine whether a clinically-utilised IL-1 receptor antagonist, anakinra, reduces renal inflammation, structural damage and blood pressure (BP) in mice with established hypertension. METHODS: Hypertension was induced in male mice by uninephrectomy, deoxycorticosterone acetate (2.4mg/d,s.c.) and replacement of drinking water with saline (1K/DOCA/salt). Control mice received uninephrectomy, a placebo pellet and normal drinking water. 10days post-surgery, mice commenced treatment with anakinra (75mg/kg/d, i.p.) or vehicle (0.9% saline, i.p.) for 11 days. Systolic BP was measured by tail cuff while qPCR, immunohistochemistry and flow cytometry were used to measure ...
A Mediterranean Diet To Improve Cardiovascular And Cognitive Health: Protocol For A Randomised Controlled Intervention Study., 2017 University of South Australia
A Mediterranean Diet To Improve Cardiovascular And Cognitive Health: Protocol For A Randomised Controlled Intervention Study., Alexandra T. Wade, Courtney R. Davis, Kathryn A. Dyer, Jonathan M. Hodgson, Richard J. Woodman, Hannah A.D. Keage, Karen J. Murphy
ECU Publications Post 2013
The Mediterranean diet has demonstrated efficacy for improving cardiovascular and cognitive health. However, a traditional Mediterranean diet delivers fewer serves of dairy and less dietary calcium than is currently recommended in Australia, which may limit long-term sustainability. The present study aims to evaluate whether a Mediterranean diet with adequate dairy and calcium can improve cardiovascular and cognitive function in an at-risk population, and thereby reduce risk of cardiovascular disease (CVD) and cognitive decline. A randomised, controlled, parallel, crossover design trial will compare a Mediterranean diet supplemented with dairy foods against a low-fat control diet. Forty participants with systolic blood pressure ...
Race And Place Differences In Patients Hospitalized With An Acute Coronary Syndrome: Is There Double Jeopardy? Findings From Trace-Core, 2017 University of Massachusetts Medical School
Race And Place Differences In Patients Hospitalized With An Acute Coronary Syndrome: Is There Double Jeopardy? Findings From Trace-Core, Robert J. Goldberg, Joel M. Gore, David D. Mcmanus, Richard H. Mcmanus, Mayra Tisminetzky, Darleen M. Lessard, Jerry H. Gurwitz, David C. Parish, Jeroan J. Allison, Connie Ng Hess, Tracy Wang, Catarina I. Kiefe
University of Massachusetts Medical School Faculty Publications
The objectives of this longitudinal study were to examine differences between whites and blacks, and across two geographical regions, in the socio-demographic, clinical, and psychosocial characteristics, hospital treatment practices, and post-discharge mortality for hospital survivors of an acute coronary syndrome (ACS). In this prospective cohort study, we performed in-person interviews and medical record abstractions for patients discharged from the hospital after an ACS at participating sites in Central Massachusetts and Central Georgia during 2011-2013. Among the 1143 whites in Central Massachusetts, 514 whites in Central Georgia, and 277 blacks in Central Georgia, we observed a gradient of socioeconomic position with ...
Zero-Fluoroscopy Cavotricuspid Isthmus Ablation Using Carto Mapping System As Sole Guiding Method, 2017 Aurora Health Care
Zero-Fluoroscopy Cavotricuspid Isthmus Ablation Using Carto Mapping System As Sole Guiding Method, Wassim Ballany, Indrajit Choudhuri, Mohamed Djelmami-Hani, Ryan L. Cooley
Aurora Electrophysiology Fellows
Background: Catheter ablation of the cavotricuspid isthmus (CTI) is traditionally performed using fluoroscopy and electroanatomical mapping systems. Zero-fluoroscopy approaches have recently been studied, mostly using the EnSite® mapping system (St. Jude Medical Inc., St. Paul, MN). We studied the feasibility and efficacy of zero-fluoroscopic mapping and ablation of the CTI using the Carto® 3 system (Biosense Webster Inc., South Diamond Bar, CA).
Purpose: To evaluate the efficacy and safety of a zero-fluoroscopic approach to CTI ablation.
Methods: We included 9 patients with typical atrial flutter for whom mapping and ablation of the CTI was done using Carto mapping as the ...
We Have No Real Evidence Related To Anticoagulation Plus Aspirin For Stroke Prevention In Atrial Fibrillation, 2017 wayne state university school of medicine
We Have No Real Evidence Related To Anticoagulation Plus Aspirin For Stroke Prevention In Atrial Fibrillation, Yuxiang Wang
Clinical Research in Practice: The Journal of Team Hippocrates
A critical appraisal and clinical application of Flaker GC, Gruber M, Connolly SJ, et al. Risks and benefits of combining aspirin with anticoagulant therapy in patients with atrial fibrillation: an exploratory analysis of stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials. Am Heart J. 2006;152:967-973. doi: 10.1016/j.ahj.2006.06.024
Von Willebrand Disease, 2017 Liberty University
Von Willebrand Disease, Ramon Misla David
Von Willebrand Disease (VWD) is a blood clotting disorder characterized by low levels of the Von Willebrand Factor (VWF) in the blood. VWF is functions to bind platelets and promote clotting of the blood when vascular injury occurs. Therefore, VWD leads to decreased or impaired clotting. There are three main types and four subtypes of VWD (type 1, 2A, 2B, 2N, 2M, and 3). Each type of VWD increases in severity. VWD is diagnosed preliminarily through a personal and family history and physical examination. Upon indications toward the possibility of a bleeding disorder, an initial hemostasis evaluation is performed followed ...