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Cardiovascular Diseases Commons

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Risk Factors For Major Early Adverse Events Related To Cardiac Catheterization In Children And Young Adults With Pulmonary Hypertension: An Analysis Of Data From The Impact (Improving Adult And Congenital Treatment) Registry., Michael L O'Byrne, Kevin F Kennedy, Joshua P Kanter, John T Berger, Andrew C Glatz 2018 George Washington University

Risk Factors For Major Early Adverse Events Related To Cardiac Catheterization In Children And Young Adults With Pulmonary Hypertension: An Analysis Of Data From The Impact (Improving Adult And Congenital Treatment) Registry., Michael L O'Byrne, Kevin F Kennedy, Joshua P Kanter, John T Berger, Andrew C Glatz

Pediatrics Faculty Publications

BACKGROUND: Cardiac catheterization is the gold standard for assessment and follow-up of patients with pulmonary hypertension (PH). To date, there are limited data about the factors that influence the risk of catastrophic adverse events after catheterization in this population.

METHODS AND RESULTS: A retrospective multicenter cohort study was performed to measure risk of catastrophic adverse outcomes after catheterization in children and young adults with PH and identify risk factors for these outcomes. All catheterizations in children and young adults, aged 0 to 21 years, with PH at hospitals submitting data to the IMPACT (Improving Adult and Congenital Treatment) registry between ...


Review Of Kawasaki Disease, Rani Shah, Hisham Hirzallah, Munes Fares, Ashwini Mallad, Gudjon Karlsson, Mehiar El-Hamdani 2018 Marshall University

Review Of Kawasaki Disease, Rani Shah, Hisham Hirzallah, Munes Fares, Ashwini Mallad, Gudjon Karlsson, Mehiar El-Hamdani

Mehiar El Hamdani, MD

Abstract

Background: Kawasaki disease is one of the leading causes of acquired heart disease in children. It is an acute self-limited vasculitis that predominantly affects infants and children younger than 5 years of age. These patients present with nonspecific symptoms, such as fever and lymphadenopathy, making the diagnosis challenging. This disease can have serious and potentially fatal outcomes, and prompt recognition of this disease is vital to the patient’s outcome. We present a complete review of the disease, including the epidemiology, pathophysiology, diagnosis and management of acute Kawasaki disease, the natural history of this disease, and follow up of ...


Review Of Kawasaki Disease, Rani Shah, Hisham Hirzallah, Munes Fares, Ashwini Mallad, Gudjon Karlsson, Mehiar El-Hamdani 2018 Marshall University

Review Of Kawasaki Disease, Rani Shah, Hisham Hirzallah, Munes Fares, Ashwini Mallad, Gudjon Karlsson, Mehiar El-Hamdani

Marshall Journal of Medicine

Abstract

Background: Kawasaki disease is one of the leading causes of acquired heart disease in children. It is an acute self-limited vasculitis that predominantly affects infants and children younger than 5 years of age. These patients present with nonspecific symptoms, such as fever and lymphadenopathy, making the diagnosis challenging. This disease can have serious and potentially fatal outcomes, and prompt recognition of this disease is vital to the patient’s outcome. We present a complete review of the disease, including the epidemiology, pathophysiology, diagnosis and management of acute Kawasaki disease, the natural history of this disease, and follow up of ...


Pilot Study To Assess Visualization And Therapy Of Inflammatory Mechanisms After Vessel Reopening In A Mouse Stroke Model, Ebba Beller, Laura Reuter, Anne Kluge, Christine Preibisch, Ute Lindauer, Alexei A. Bogdanov Jr., Friederike Lammer, Claire Delbridge, Kaspar Matiasek, Benedikt J. Schwaiger, Tobias Boeckh-Behrens, Claus Zimmer, Alexandra S. Gersing 2018 Klinikum rechts der Isar der Technischen Universität München

Pilot Study To Assess Visualization And Therapy Of Inflammatory Mechanisms After Vessel Reopening In A Mouse Stroke Model, Ebba Beller, Laura Reuter, Anne Kluge, Christine Preibisch, Ute Lindauer, Alexei A. Bogdanov Jr., Friederike Lammer, Claire Delbridge, Kaspar Matiasek, Benedikt J. Schwaiger, Tobias Boeckh-Behrens, Claus Zimmer, Alexandra S. Gersing

Radiology Publications and Presentations

After reperfusion therapy in stroke patients secondary inflammatory processes may increase cerebral damage. In this pilot study, effects of anti-inflammatory therapy were assessed in a middle cerebral artery occlusion (MCAO) mouse model after reperfusion. 1 hour after MCAO, the artery was reopened and tacrolimus or NaCl were administered intra-arterially. Perfusion-weighted (PWI) and diffusion-weighted images (DWI) were obtained by MRI during MCAO. DWI, T2- and T1-weighted images with and without Bis-5HT-DTPA administration were obtained 24 hours after MCAO. Neutrophils, Myeloperoxidase-positive-(MPO+)-cells and microglia, including M1 and M2 phenotypes, were assessed immunohistochemically. Treatment with tacrolimus led to significantly smaller apparent diffusion ...


Long-Term Exposure Of Fine Particulate Matter Causes Hypertension By Impaired Renal D1 Receptor-Mediated Sodium Excretion Via Upregulation Of G-Protein-Coupled Receptor Kinase Type 4 Expression In Sprague-Dawley Rats., Xi Lu, Zhengmeng Ye, Shuo Zheng, Hongmei Ren, Jing Zeng, Xinquan Wang, Pedro A Jose, Ken Chen, Chunyu Zeng 2018 George Washington University

Long-Term Exposure Of Fine Particulate Matter Causes Hypertension By Impaired Renal D1 Receptor-Mediated Sodium Excretion Via Upregulation Of G-Protein-Coupled Receptor Kinase Type 4 Expression In Sprague-Dawley Rats., Xi Lu, Zhengmeng Ye, Shuo Zheng, Hongmei Ren, Jing Zeng, Xinquan Wang, Pedro A Jose, Ken Chen, Chunyu Zeng

Medicine Faculty Publications

BACKGROUND: Epidemiological evidence supports an important association between air pollution exposure and hypertension. However, the mechanisms are not clear.

METHODS AND RESULTS: Our present study found that long-term exposure to fine particulate matter (PM2.5) causes hypertension and impairs renal sodium excretion, which might be ascribed to lower D1 receptor expression and higher D1 receptor phosphorylation, accompanied with a higher G-protein-coupled receptor kinase type 4 (GRK4) expression. The in vivo results were confirmed in in vitro studies (ie, PM2.5 increased basal and decreased D1 receptor mediated inhibitory effect on Na+-K+ ATPase activity, decreased D1 receptor expression, and increased ...


Bulgaria: Brucellosis, Austin Wheeler 2018 Augustana College, Rock Island Illinois

Bulgaria: Brucellosis, Austin Wheeler

Global Public Health

In this brief we will discuss how a disease called Brucellosis has affected the country of Bulgaria. Bulgaria is a European country located towards the South Eastern part of Europe. A few points mentioned in the brief are what the disease can do to your body, through education of the disease we can show what a serious problem it is. The brief will also cover how you can contract the disease through animals, and how you can prevent contraction from occurring. The brief also includes a lot about the religious background of the country. This should hopefully be used to ...


Chile: Air Pollution, Kara Eder 2018 Augustana College, Rock Island Illinois

Chile: Air Pollution, Kara Eder

Global Public Health

Chile faces a constant issue of air pollution, reaping respiratory health problems for citizens in urban areas. While the many cases over the past century have increased officials to take action on the issue, the growing infrastructure and economy of the country makes it difficult to regulate harmful emissions. Wood-burning heaters within urban residential areas also contribute to the unhealthy smog. Ingestion of these forms of matter in the air causes respiratory symptoms such as bronchitis and cardiovascular disease. Bans on such heaters and taxes on vehicle emissions were placed in order to prevent the severity of pollutants in the ...


Halting Progression Of Stasis Dermatitis: Community Perspectives And Strategies For Prevention, Allison B. Robbins 2018 University of Vermont

Halting Progression Of Stasis Dermatitis: Community Perspectives And Strategies For Prevention, Allison B. Robbins

Family Medicine Clerkship Student Projects

Complications of stasis dermatitis including venous ulcers, osteomyelitis, and cellulitis all significantly increase morbidity and mortality of disease. Progression beyond stasis dermatitis and avoidance of the aforementioned complications are preventable with patient education and adherence to basic therapies including compression stockings and lifestyle modification. Therefore the goals of this project were to: assess the community’s understanding of stasis dermatitis and their awareness of its complications; use this information to help healthcare providers tailor their preventative health counseling accordingly; and provide education for patients on stasis dermatitis, its complications, and therapies/behavioral changes to prevent disease progression.


Grenada: Cardiovascular Disease, Talayah Lemon 2018 Augustana College, Rock Island Illinois

Grenada: Cardiovascular Disease, Talayah Lemon

Global Public Health

Grenada has a population of 109,011 people. This public health brief encompasses cardiovascular disease and its impact in the country of Grenada. The country suffers from high level of AIDS/HIV, obesity, diabetes, etc. However, Cardiovascular disease is very prevalent in Grenada. About 34% of the population suffer from the disease. Cardiovascular disease affects the blood supply flow to the heart. Grenada’s health system has provided solutions such as providing adequate health care, but lack some healthcare services, such as cardiology and vascular surgeries. Cardiovascular disease has a huge impact on the population, but Grenada works towards ways ...


Panama: Ischemic Heart Disease, Alexander R. Ligeza 2018 Augustana College, Rock Island Illinois

Panama: Ischemic Heart Disease, Alexander R. Ligeza

Global Public Health

This public health brief draws attention to the issue of ischemic heart disease that is currently plaguing Panama. Due largely to the dietary culture of the country, ischemic heart disease remains the number one health-related killer of Panamanians. Over the past few decades, there has been a stark increase in the amount of processed foods that are becoming a large part of the diets of western nations, and Panama has become no stranger to this trend. Although there have been great strides made in the treatment of ischemic heart disease, Panama still has a long road ahead of itself before ...


Tonga: Chronic Diseases, Muhammad Taimoor 2018 Augustana College, Rock Island Illinois

Tonga: Chronic Diseases, Muhammad Taimoor

Global Public Health

Tonga is an Archipelago in the south Pacific Ocean, south of Samoa. The public health brief project is on chronic diseases in Tonga. The total population of Tonga was 107,122 in 2010. The Free Wesleyan Church of Tonga is the established religion in Tonga. Tongan’s make up the majority of the population but there are other ethnicities such as Euromericans and Europeans too. The major challenges faced by Tonga are decaying infrastructure, low economy, and political corruption. The widespread of non-communicable diseases such as cancer is a major health issue in Tonga. 74% of all adults in Tonga ...


Hungary: Cardiovascular Disease, Taylor Steger 2018 Augustana College, Rock Island Illinois

Hungary: Cardiovascular Disease, Taylor Steger

Global Public Health

Hungary faces many public health issues. In particular, cardiovascular disease has impacted the majority of the Hungarian people with a mortality rate of 50-60%. The high consumption of fattening food, excessive alcohol drinking, smoking habits and tobacco use impact the entire population’s health status. This disease impacts blood vessels and causes them to narrow or be blocked. This blockage causes blood flow from the heart to be suppressed which can cause heart attacks, strokes etc. Hungary has the highest amount of people with cardiovascular disease out of all European countries. The most impacted people are in the urban areas ...


Cuba: Coronary Heart Disease, Michaela Loizzi 2018 Augustana College, Rock Island Illinois

Cuba: Coronary Heart Disease, Michaela Loizzi

Global Public Health

Cuba has a strong health care system with universal health care for their citizens over 40 years old. Despite the strong health care system Cuba lacks the resources necessary to treat coronary heart disease, the leading cause of death in the country. The country’s whole population is affected by coronary heart disease however the most affected is the lower class due unaffordable treatment. The primary causes of coronary heart disease includes their daily lifestyle such as, physical inactivity, diet, and excessive smoking. It is important to note that the major factors in Cuba leading to coronary heart disease are ...


Bahrain: Cardiovascular Disease, Sandra Morales 2018 Augustana College, Rock Island Illinois

Bahrain: Cardiovascular Disease, Sandra Morales

Global Public Health

A beautiful island in the Arabian Gulf (Persian Gulf), east of Saudi Arabia, north of Qatar, Bahrain is home to over 1.5 million people. The diverse population consists of Muslims, Hindus, Christians, Asians, Africans, and so much more. Bahrain is a constitutional monarchy. The current commander of the Bahrain defense force is Khalifa bin Salman Al Khalifa. For the most part, Bahrainis have political freedoms. However, one major problem Bahrainis face, in particular men, is cardiovascular disease. Cardiovascular disease accounted for 34% of deaths in 2002. It is a major cause of morbidity and mortality in Bahrain. Obesity and ...


Adrenergic Stimulation In Acute Hyperglycemia: Effects On Cellular And Tissue Level Murine Cardiac Electrophysiology, Sridevi Thyagarajan 2018 University of Kentucky

Adrenergic Stimulation In Acute Hyperglycemia: Effects On Cellular And Tissue Level Murine Cardiac Electrophysiology, Sridevi Thyagarajan

Theses and Dissertations--Biomedical Engineering

Cardiovascular complications associated with elevated levels of glucose in the blood (Hyperglycemia, HG) is a growing health concern. HG is known to be associated with a variety of cardiovascular morbidities including higher incidence of electrical disturbances. Although effects of chronic HG have been widely investigated, electrophysiological effects of acute hyperglycemia are relatively less known. Further, hyperglycemic effects on adrenergic response is not widely investigated. We used excised ventricular tissues from mice to record trans-membrane potentials during a variety of pacing protocols to investigate cellular/tissue level electrophysiological effects of acute hyperglycemia and adrenergic stimulation (1µM Isoproterenol, a β-adrenergic agonist). A ...


Ten-Year (2001-2011) Trends In The Incidence Rates And Short-Term Outcomes Of Early Versus Late Onset Cardiogenic Shock After Hospitalization For Acute Myocardial Infarction, Hoa L. Nguyen, Jorge L. Yarzebski, Darleen M. Lessard, Joel M. Gore, David D. McManus, Robert J. Goldberg 2017 University of Massachusetts Medical School

Ten-Year (2001-2011) Trends In The Incidence Rates And Short-Term Outcomes Of Early Versus Late Onset Cardiogenic Shock After Hospitalization For Acute Myocardial Infarction, Hoa L. Nguyen, Jorge L. Yarzebski, Darleen M. Lessard, Joel M. Gore, David D. Mcmanus, Robert J. Goldberg

Jorge L. Yarzebski

BACKGROUND: Cardiogenic shock (CS) is a serious complication of acute myocardial infarction, and the time of onset of CS has a potential role in influencing its prognosis. Limited contemporary data exist on this complication, however, especially from a population-based perspective. Our study objectives were to describe decade-long trends in the incidence, in-hospital mortality, and factors associated with the development of CS in 3 temporal contexts: (1) before hospital arrival for acute myocardial infarction (prehospital CS); (2) within 24 hours of hospitalization (early CS); and (3) > /=24 hours after hospitalization (late CS). METHODS AND RESULTS: The study population consisted of 5782 ...


Magnitude And Characteristics Of Patients Who Survived An Acute Myocardial Infarction, Mayra Tisminetzky, Tracy Y. Wang, Jerry H. Gurwitz, Lisa A. Kaltenbach, David D. McManus, Joel M. Gore, Eric Peterson, Robert J. Goldberg 2017 University of Massachusetts Medical School

Magnitude And Characteristics Of Patients Who Survived An Acute Myocardial Infarction, Mayra Tisminetzky, Tracy Y. Wang, Jerry H. Gurwitz, Lisa A. Kaltenbach, David D. Mcmanus, Joel M. Gore, Eric Peterson, Robert J. Goldberg

Jerry H. Gurwitz

BACKGROUND: The purpose of this study was to describe the magnitude and characteristics of patients who did not experience any significant major adverse cardiovascular event early (within 6 weeks) and late (during the first year) after hospital discharge for an acute myocardial infarction (AMI).

METHODS AND RESULTS: Data from 12 243 patients discharged after an AMI from 233 sites across the United States in the TRANSLATE-ACS (Treatment With ADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) study were analyzed. Multivariable adjusted regression analyses modeled factors associated with 6-week and 1-year survivors who did not ...


Magnitude And Characteristics Of Patients Who Survived An Acute Myocardial Infarction, Mayra Tisminetzky, Tracy Y. Wang, Jerry H. Gurwitz, Lisa A. Kaltenbach, David D. McManus, Joel M. Gore, Eric Peterson, Robert J. Goldberg 2017 University of Massachusetts Medical School

Magnitude And Characteristics Of Patients Who Survived An Acute Myocardial Infarction, Mayra Tisminetzky, Tracy Y. Wang, Jerry H. Gurwitz, Lisa A. Kaltenbach, David D. Mcmanus, Joel M. Gore, Eric Peterson, Robert J. Goldberg

David D. McManus

BACKGROUND: The purpose of this study was to describe the magnitude and characteristics of patients who did not experience any significant major adverse cardiovascular event early (within 6 weeks) and late (during the first year) after hospital discharge for an acute myocardial infarction (AMI).

METHODS AND RESULTS: Data from 12 243 patients discharged after an AMI from 233 sites across the United States in the TRANSLATE-ACS (Treatment With ADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) study were analyzed. Multivariable adjusted regression analyses modeled factors associated with 6-week and 1-year survivors who did not ...


Ten-Year (2001-2011) Trends In The Incidence Rates And Short-Term Outcomes Of Early Versus Late Onset Cardiogenic Shock After Hospitalization For Acute Myocardial Infarction, Hoa L. Nguyen, Jorge L. Yarzebski, Darleen M. Lessard, Joel M. Gore, David D. McManus, Robert J. Goldberg 2017 University of Massachusetts Medical School

Ten-Year (2001-2011) Trends In The Incidence Rates And Short-Term Outcomes Of Early Versus Late Onset Cardiogenic Shock After Hospitalization For Acute Myocardial Infarction, Hoa L. Nguyen, Jorge L. Yarzebski, Darleen M. Lessard, Joel M. Gore, David D. Mcmanus, Robert J. Goldberg

Robert J. Goldberg

BACKGROUND: Cardiogenic shock (CS) is a serious complication of acute myocardial infarction, and the time of onset of CS has a potential role in influencing its prognosis. Limited contemporary data exist on this complication, however, especially from a population-based perspective. Our study objectives were to describe decade-long trends in the incidence, in-hospital mortality, and factors associated with the development of CS in 3 temporal contexts: (1) before hospital arrival for acute myocardial infarction (prehospital CS); (2) within 24 hours of hospitalization (early CS); and (3) > /=24 hours after hospitalization (late CS). METHODS AND RESULTS: The study population consisted of 5782 ...


Magnitude And Characteristics Of Patients Who Survived An Acute Myocardial Infarction, Mayra Tisminetzky, Tracy Y. Wang, Jerry H. Gurwitz, Lisa A. Kaltenbach, David D. McManus, Joel M. Gore, Eric Peterson, Robert J. Goldberg 2017 University of Massachusetts Medical School

Magnitude And Characteristics Of Patients Who Survived An Acute Myocardial Infarction, Mayra Tisminetzky, Tracy Y. Wang, Jerry H. Gurwitz, Lisa A. Kaltenbach, David D. Mcmanus, Joel M. Gore, Eric Peterson, Robert J. Goldberg

Robert J. Goldberg

BACKGROUND: The purpose of this study was to describe the magnitude and characteristics of patients who did not experience any significant major adverse cardiovascular event early (within 6 weeks) and late (during the first year) after hospital discharge for an acute myocardial infarction (AMI).

METHODS AND RESULTS: Data from 12 243 patients discharged after an AMI from 233 sites across the United States in the TRANSLATE-ACS (Treatment With ADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) study were analyzed. Multivariable adjusted regression analyses modeled factors associated with 6-week and 1-year survivors who did not ...


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