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Expression Of Human Tissue Kallikreins (Klks) In Polymorphous Low Grade Adenocarcinoma (Plga), Jacqueline M. Cox 2017 The University of Western Ontario

Expression Of Human Tissue Kallikreins (Klks) In Polymorphous Low Grade Adenocarcinoma (Plga), Jacqueline M. Cox

Electronic Thesis and Dissertation Repository

Polymorphous low grade adenocarcinoma (PLGA) is the second most common malignant salivary gland tumour of the minor salivary glands. Human tissue kallikreins (KLKs) are a family of highly conserved serine proteases expressed by various tissues throughout the body. KLKs have become powerful tumour markers for the diagnosis of the cancer patient (e.g. PSA (KLK3)). The literature demonstrates a link between KLKs and salivary gland neoplasms. The purpose of this study is to determine levels of KLK mRNA in tissue samples of formalin fixed paraffin embedded polymorphous low grade adenocarcinoma (PLGA). Secondly, we wish to determine if KLK expression is ...


Expression Of Zeb Factors In Oral Squamous Cell Carcinoma., Saira Ahmed 2017 University of Louisville

Expression Of Zeb Factors In Oral Squamous Cell Carcinoma., Saira Ahmed

Electronic Theses and Dissertations

Objectives: The ZEB family of transcription factors (ZEB1 and ZEB2) have been demonstrated to play a role in metastatic progression of several cancers, and may also influence the initial transformation and generation of cancer stem cells. However, the expression pattern of ZEB proteins in the development of oral squamous cell carcinoma has not been investigated. The purpose of this study was to define changes in expression and subcellular localization of the ZEB family in both precancerous lesions and different grades of OSCC. Materials and Methods: Seventy-nine tongue biopsies were subjected to immunohistochemistry and immunofluorescence to determine the expression and subcellular ...


Using An Audience Response System To Calibrate Dental Faculty Assessing Student Clinical Competence., Sean A. Aiken 2017 University of Louisville

Using An Audience Response System To Calibrate Dental Faculty Assessing Student Clinical Competence., Sean A. Aiken

Electronic Theses and Dissertations

In order to best prepare students to become competent and confident practitioners in a clinical environment upon graduating dental school, it is imperative for them to receive consistent and productive feedback from the supervising faculty. Through academic engagement, and more specifically faculty calibration, it may be possible to eliminate the disconnect that sometimes exists between faculty expectations and terminology, and those of the students. In terms of definitions, academic engagement reflects faculty scholarly development activities that support integration of relevant, current theory of best practices consistent with the school's mission, expected learner outcomes, and supporting strategies.1-6, 32 The ...


Student Self-Assessment Of Operative Dentistry Experiences : A Time Dependent Exercise In Best Practice Outcomes., Celine Joyce Cornelius Timothius 2017 University of Louisville

Student Self-Assessment Of Operative Dentistry Experiences : A Time Dependent Exercise In Best Practice Outcomes., Celine Joyce Cornelius Timothius

Electronic Theses and Dissertations

Purpose: The purpose of this project was to evaluate student self-assessment of operative dentistry experiences. Methods: First, a retrospective analysis of student self-assessment and faculty assessment grade sheets were evaluated for mean differences and correlations across time. Both preclinical (D2: n=120) and clinical (D3: n=120; D4: n=120) grades sheets were evaluated. Secondly, twenty-five (n=25) students from each of the D1, D2, D3 and D4 classes were asked to evaluate dentoform work. Twenty-five (n=25) operative calibrated faculty graded the same two dentoforms. Results: D2 student’s self-assessment scores were significantly higher than the faculty assessment scores ...


Inhibition Of Chemotherapeutic-Induced Apoptosis In Esophageal Squamous Cancer Cells By The Keystone Periodontal Pathogen, Porphyromonas Gingivalis., Atul Kumar Agrawal 2017 University of Louisville

Inhibition Of Chemotherapeutic-Induced Apoptosis In Esophageal Squamous Cancer Cells By The Keystone Periodontal Pathogen, Porphyromonas Gingivalis., Atul Kumar Agrawal

Electronic Theses and Dissertations

Recent evidence has shown that P. gingivalis, a Gram-negative, anaerobic oral bacterium, is negatively associated with the presence and outcome of esophageal squamous cell carcinoma (ESCC). While potential underlying mechanisms are yet to be established, P. gingivalis infection is known to inhibit apoptosis in gingival epithelial cells. Therefore, we hypothesized that P. gingivalis may also inhibit of the induction of apoptosis in human ESCC cells exposed to the commonly employed anti-ESCC chemotherapeutic agent, cisplatin. The capacity of P. gingivalis, at variant multiplicities of infection, to suppress cisplatin-induced necrosis and apoptosis in EC9706 ESCC cells was established by lactate dehydrogenase (LDH ...


Prevalence, Incidence And Risk Factors For Dental Caries In Preschool And School-Aged African American Children: A Prospective Cohort Study, Tariq Ghazal 2017 University of Iowa

Prevalence, Incidence And Risk Factors For Dental Caries In Preschool And School-Aged African American Children: A Prospective Cohort Study, Tariq Ghazal

Theses and Dissertations

My PhD projects were secondary analyses of data from a prospective study conducted at the University of Alabama at Birmingham. Two cohorts of low socioeconomic status, African-American children from Perry County, Alabama, were invited to participate. Children in the 1st Cohort (Cohort 1, n=98) were approximately six years old at baseline and followed for 6 years, while children in the 2nd Cohort (Cohort 2, n=95) were approximately one-year-old at baseline and followed for five years.

For the first dissertation project, the prevalence and incidence of dental decay were assessed for children in Cohort 1. The findings of this ...


Mechanical Preparation Of Oval-Shaped Root Canals In Mandibular Premolars With The Trushape 3d Conforming File: A Micro-Computed Tomography Study, Lauren Elizabeth Jensen 2017 University of Iowa

Mechanical Preparation Of Oval-Shaped Root Canals In Mandibular Premolars With The Trushape 3d Conforming File: A Micro-Computed Tomography Study, Lauren Elizabeth Jensen

Theses and Dissertations

The TRUShape 3D Conforming File (TRUShape), a novel, S-shaped nickel-titanium (NiTi) rotary file, was developed to facilitate cleaning and shaping of irregular-shaped root canals. The purpose of this study was to evaluate the shaping ability of TRUShape compared to Vortex Blue (VB) when used in non-round, oval-shaped root canals by micro-computed tomography (MCT).

Thirty single-rooted human mandibular premolar teeth with radiographically similar root canal size and curvature were randomly allocated to two groups (N=15), and mechanically prepared with TRUShape or VB. Each tooth was submitted to MCT at 20 μm resolution at three time intervals: before shaping, and after ...


The Use Of Topical Subgingival Application Of Simvastatin Gel In Treatment Of Peri Implant Mucisitis : A Pilot Study, Ahmed Mahrous 2017 University of Iowa

The Use Of Topical Subgingival Application Of Simvastatin Gel In Treatment Of Peri Implant Mucisitis : A Pilot Study, Ahmed Mahrous

Theses and Dissertations

Dentistry has come a long way from its humble beginnings. Like all other healthcare specialties, dentistry has evolved through the years. The understanding of physiology of dental health and disease has evolved allowing us to treat dental diseases much more efficiently. However not all dental problems are fully understood.

Diseases that affect the bone and soft tissue around teeth and dental implants, also known as “periodontal” and peri-implant” diseases respectively, have proven to be among the least understood and challenging dental diseases to treat. Recent advancements in microbiology and immunology have revealed that periodontal and peri implant disease have a ...


Management Of Initial Caries Lesions: Iowa Survey, Amira Elgreatly 2017 University of Iowa

Management Of Initial Caries Lesions: Iowa Survey, Amira Elgreatly

Theses and Dissertations

The purpose of this study was to investigate factors related to Iowa dentists’ management of initial caries lesions for low, moderate and high-risk patients and their agreement with the International Caries Classification and Management System (ICCMS) Guidelines.

A survey with three patient scenarios (low, moderate and high-risk) was electronically sent to 916 University of Iowa alumni dentists who were in active practice. Information on dentists’ demographics and practice characteristics were also collected in the survey. Descriptive statistics were conducted to profile the variables of interest. Bivariate analyses were performed to assess the factors associated with the management of initial caries ...


Esthetic Blending: Visual Vs. Spectrophotometric Data Analysis For Different Bevels In Class Iv Dental Composite Direct Restorations, Tracy A. D'Antonio 2017 University of Iowa

Esthetic Blending: Visual Vs. Spectrophotometric Data Analysis For Different Bevels In Class Iv Dental Composite Direct Restorations, Tracy A. D'Antonio

Theses and Dissertations

The purpose of this study was to determine which type of bevel in a class IV dental composite restoration is the most esthetic and has the best blend to natural tooth structure via clinical and spectrophotometric evaluations. The null hypotheses were as follows: (1) there is no difference in visual evaluation rank scores among five groups of evaluators for each type of bevel; (2) there is no agreement in the visual evaluation rank scores of the seven groups of bevels among all evaluators or within each group of evaluators; (3) there is no difference in the lightness values among seven ...


Comparative Assessment Of Conventional Vs. Cad/Cam Complete Denture Fabrication Techniques On Patient Satisfaction, Quality Of Life And Prosthesis Biofilm, Wissanee Jia-mahasap 2017 University of Iowa

Comparative Assessment Of Conventional Vs. Cad/Cam Complete Denture Fabrication Techniques On Patient Satisfaction, Quality Of Life And Prosthesis Biofilm, Wissanee Jia-Mahasap

Theses and Dissertations

Objectives: The primary objective was to assess the impact of two denture fabrication techniques, conventional and CAD/CAM, on oral health-related quality of life (OHRQoL) and patient satisfaction in complete denture wearers. The secondary objective was to compare the level of microorganisms present on complete dentures from the two fabrication techniques.

Methods: Twenty-eight completely edentulous subjects (16 men and 21 women, age range from 49 to 87 years old.), who had been edentulous for at least 6 months, were wearing ill-fitting complete dentures, or unsatisfied with their existing complete dentures were recruited. Subjects were randomized to conventional and computer-aided design ...


An Investigation Of Surface Characteristics Of Enamel Treated With Infiltrative Resin: A Scanning Electron Microscopy Study, Danielle E. Easterly 2017 Virginia Commonwealth University

An Investigation Of Surface Characteristics Of Enamel Treated With Infiltrative Resin: A Scanning Electron Microscopy Study, Danielle E. Easterly

Theses and Dissertations

AN INVESTIGATION OF SURFACE CHARACTERISTICS OF ENAMEL TREATED WITH INFILTRATIVE RESIN: A SCANNING ELECTRON MICROSCOPY STUDY

Danielle E. Easterly, Doctorate of Dental Surgery.

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at Virginia Commonwealth University.

Virginia Commonwealth University. 2017.

Director: Dr. Eser Tüfekçi

D.D.S., M.S., Ph.D., M.S.H.A.

Objective: To evaluate the microstructural changes of a resin infiltrant (ICON®, DMG America LLC, Englewood, NJ) after six months of simulated toothbrushing.

Materials and Methods: Ten extracted third molars (n=10) were collected. Artificial white spot ...


A Comparative Study Of Intraradicular Enterococcus Faecalis Biofilm Removal With Three Root Canal Treatment Systems: A Scanning Electron Microscopy Evaluation, Cyrous Ardalan 2017 Virginia Commonwealth University

A Comparative Study Of Intraradicular Enterococcus Faecalis Biofilm Removal With Three Root Canal Treatment Systems: A Scanning Electron Microscopy Evaluation, Cyrous Ardalan

Theses and Dissertations

The objective of this study was to evaluate the biofilm removal efficacy of three root canal treatment systems: ProUltra® PiezoFlow™, traditional needle irrigation, and the GentleWave® system in an ex-vivo benchtop study. Twenty-four extracted maxillary and mandibular molars were selected. Teeth were all instrumented to a master apical file size #25 with 4% taper. Teeth were then randomly divided into four experimental groups and two control groups. The root canals were inoculated with a culture of Enterococcus faecalis and incubated for five weeks to form a biofilm. Each group was then treated with one of the different root canal treatment ...


Oral Health: The Need For Both Conventional Microbial And Molecular Characterization, Elisheva Friedman, Negin Alizadeh, Zvi G. Loewy 2017 Touro College of Pharmacy

Oral Health: The Need For Both Conventional Microbial And Molecular Characterization, Elisheva Friedman, Negin Alizadeh, Zvi G. Loewy

Touro College of Pharmacy (New York) Publications and Research

This study aims to consider the microbial distribution in oral disease, as well as gene analysis and expression, in elucidating: 1, the fundamental underpinnings of oral disease, and 2, the potential relationship between oral diseases and systemic health. A key focus is identifying the microbiota associated with oral disease manifestations characterized by both conventional microbiological and molecular methods. Variations in the observed microbial populations characterized by conventional and molecular approaches have been identified for caries, periodontitis, peri-implantitis, and stomatitis. The discovery of therapeutic approaches for oral disease will require comprehensive microbial and genomic analysis. This study evaluated the current state ...


Mechanism Of Interaction Of Peptide Modified Nanoparticles With Porphyromonas Gingivalis., Ankita Jain 2016 University of Louisville

Mechanism Of Interaction Of Peptide Modified Nanoparticles With Porphyromonas Gingivalis., Ankita Jain

Electronic Theses and Dissertations

Studies suggest that P. gingivalis functions as a keystone pathogen and interacts with primary colonizers in the supragingival biofilm such as S. gordonii. This interaction contributes to the initial colonization of the oral cavity by P. gingivalis and thus represents a potential target for therapeutic intervention. We have identified a peptide (BAR) derived from the streptococcal SspB protein that functions to inhibit P. gingivalis adherence to S. gordonii. In addition, we showed that nanoparticles (NPs) functionalized with BAR inhibit this interaction more potently than free soluble peptide, possibly by promoting interaction with P. gingivalis at higher valency than free peptide ...


Peptoanaerobacter Stomatis Interactions With Neutrophils., Emeri Jimenez Flores 2016 University of Louisville

Peptoanaerobacter Stomatis Interactions With Neutrophils., Emeri Jimenez Flores

Electronic Theses and Dissertations

Peptoanaerobacter stomatis is a newly appreciated taxon, present in high numbers in oral biofilms from periodontal patients. However, little is known about this organism’s potential virulence and its interaction with the host immune response. Therefore, to better understand the role of P. stomatis in periodontitis, we studied its interactions with neutrophils. Human neutrophils were challenged with P. stomatis strain CM2 or S. aureus AF488 (positive control) for 30 min. Bacterial internalization was examined by ImageStreamX imaging flow cytometry. Bacterial viability was assessed by colony-forming unit assays and Baclight assays. Phagocytosis-stimulated respiratory burst response was measured by flow cytometry. The ...


Characterization Of Pg1604 (Porz) As An Essential Component Of Type 9 Secretion System In Porphyromonas Gingivalis., Apurva Tadimari Prabhakar 2016 University of Louisville

Characterization Of Pg1604 (Porz) As An Essential Component Of Type 9 Secretion System In Porphyromonas Gingivalis., Apurva Tadimari Prabhakar

Electronic Theses and Dissertations

Background: The numerous virulence factors of Porphyromonas gingivalis are essential for the organism to invade host tissues while escaping immune responses [1, 2]. Some of these factors, like major proteases referred to as gingipains, are secreted by a unique secretion system called PerioGate or Type IX Secretion System (T9SS). T9SS consists of a number of membrane and periplasmic proteins, which provide transportation only for proteins that possess a conserved C-terminal domain (CTD). The CTD functions as a specific recognition signal for the T9SS. PG1604 of P. gingivalis W83 is a CTD-containing protein, which has been shown in our initial studies ...


Comparison Of Two Different Surgical Approaches To Increase Peri-Implant Mucosa Thickness: A Randomized Controlled Clinical Trial, Christopher G. Hutton 2016 University of Iowa

Comparison Of Two Different Surgical Approaches To Increase Peri-Implant Mucosa Thickness: A Randomized Controlled Clinical Trial, Christopher G. Hutton

Theses and Dissertations

Objectives: Tooth replacement therapy using endosseous implants has become an essential component of contemporary dental practice. While a plethora of factors determine clinical success, the bucco-lingual and apico-coronal dimensions of the peri-implant mucosa play an important role in both esthetics and the maintenance of peri-implant health. Studies, most of which treat mucogingival defects in the natural dentition, comparing acellular dermal matrix (ADM) and autologous subepithelial connective tissue grafts (sCTG) have shown similar clinical outcomes. The purpose of this non-inferiority trial is to determine the clinical efficacy of ADM in the augmentation of peri-implant mucosa thickness (PMT) as compared to an ...


Longterm Quality Of Life After Oncologic Surgery And Microvascular Free Flap Reconstruction In Patients With Oral Squamous Cell Carcinoma, Andre Peisker, Gregor F. Raschke, Arndt Guentsch, Korosh Roshanghias, Francy Eichmann, Stefan Schultze-Mosgau 2016 Friedrich Schiller University of Jena

Longterm Quality Of Life After Oncologic Surgery And Microvascular Free Flap Reconstruction In Patients With Oral Squamous Cell Carcinoma, Andre Peisker, Gregor F. Raschke, Arndt Guentsch, Korosh Roshanghias, Francy Eichmann, Stefan Schultze-Mosgau

School of Dentistry Faculty Research and Publications

Background: Quality of life (QoL) has become increasingly important in cancer treatment. It refers to the patient’s perception of the effects of the disease and therapy, and their impact on daily functioning and general feeling of well being. Material and Methods: In this prospective study, a total of 100 patients treated at our institution, completed the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire and the specific EORTC QLQ-H&N35 module. The questionnaires were distributed to the patients between 12 and 60 months postoperatively. Results: Global QoL score was 58.3 and mean score for functioning ...


Filifactor Alocis, A Newly Appreciated Oral Pathogen, Fails To Induce The Respiratory Burst Response Of Human Neutrophils., Jacob S. Edmisson 2016 University of Louisville

Filifactor Alocis, A Newly Appreciated Oral Pathogen, Fails To Induce The Respiratory Burst Response Of Human Neutrophils., Jacob S. Edmisson

College of Arts & Sciences Senior Honors Theses

Almost 50% of adult Americans suffer from periodontitis which is a bacterially induced inflammation of the tissue that surround and support the tooth. The accumulation of neutrophils, a critical cell component of the innate immune system, in the gingival crevice contributes to tissue damage. Filifactor alocis is a newly appreciated pathogen present in oral biofilms at periodontal disease sites. Studying the interactions between neutrophils and F. alocis will provide valuable information for delineating the role of this bacterium in periodontal disease and enhance our understanding of bacterial strategies to evade leukocytes’ antimicrobial mechanisms. The hypothesis that F. alocis modulates human ...


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