Synthesis, Including Microwave Promotion, Of Selected Cyclopropyl Derivatives As Stereochemically Rigid Probes Of Certain Pharmalogical Receptors, Grace Hohn
Honors Program Projects
Pharmacologic intervention with stereochemical probes allows for the treatment of medical conditions by affecting receptors in the body and causing receptors to respond to the presence of the probe. Novel cyclopropyl derivatives were synthesized could serve as a stereochemically rigid probes of certain pharmacological receptors and could have potential use as a drug. A probe is a molecule or ligand that can bind to and interact with a receptor in the human body. This interaction triggers a desirable response by increasing or decreasing the presence of a compound (e.g. dopamine for depression) in order to repair a chemical imbalance ...
Structure Activity Relationship Studies Of Novel Diarylpentanoid Analogs Targeting The Androgen Receptor In Prostate Cancer Cells, Haili Coffin, Marco Bisoffi
Student Research Day Abstracts and Posters
The development of prostate cancer (PCa) relies strongly on the activation of the androgen receptor (AR) signaling pathway by its natural ligand dihydrotestosterone. Furthermore, PCa progression to metastatic disease represents oncogene addiction to AR activity. Androgen ablation therapy is thus a mainstay therapy against this disease, but the development of ligand-independent AR activation and persisting AR expression eventually leads to castration resistant PCa (CRPC). Therefore, down-regulation of AR expression in PCa cells may be an effective therapeutic modality. The diarylpentanoid ca27 has previously been shown to down-regulate AR expression by an unknown mechanism of action. The present work represents a ...
Antiemetic Use Among Pregnant Women In The United States: The Escalating Use Of Ondansetron, 2017 US Food and Drug Administration
Antiemetic Use Among Pregnant Women In The United States: The Escalating Use Of Ondansetron, Lockwood G. Taylor, Steven T. Bird, Leyla Sahin, Melissa S. Tassinari, Patty Greene, Marsha Reichman, Susan E. Andrade, Katherine Haffenreffer, Sengwee Toh
University of Massachusetts Medical School Faculty Publications
PURPOSE: To examine ondansetron use in pregnancy in the context of other antiemetic use among a large insured United States population of women delivering live births. METHODS: We assessed ondansetron and other antiemetic use among pregnant women delivering live births between 2001 and 2015 in 15 data partners contributing data to the Mini-Sentinel Distributed Database. We identified live birth pregnancies using a validated algorithm, and all forms of ondansetron and other available antiemetics were identified using National Drug Codes or procedure codes. We assessed the prevalence of antiemetic use by trimester, calendar year, and formulation. RESULTS: In over 2.3 ...
Compromised External Validity: Federally Produced Cannabis Does Not Reflect Legal Markets, Daniela Vergara, L. Cinnamon Bidwell, Steep Hill, Kent E. Hutchison, Nolan C. Kane
University Libraries Open Access Fund Supported Publications
As the most widely used illicit drug worldwide, and as a source of numerous under-studied pharmacologically-active compounds, a precise understanding of variability in psychological and physiological effects of Cannabis varieties is essential. The National Institute on Drug Abuse (NIDA) is designated as the sole legal producer of Cannabis for use in US research studies. We sought to compare the chemical profiles of Cannabis varieties that are available to consumers in states that have statelegalized use versus what is available to researchers interested in studying the plant and its effects. Our results demonstrate that the federally-produced Cannabis has significantly less variety ...
Internal Medicine Resident Perspectives Regarding Broad-Spectrum Antibiotic Usage., 2017 George Washington University
Internal Medicine Resident Perspectives Regarding Broad-Spectrum Antibiotic Usage., Ann M Laake, Gayle Bernabe, James Peterson, Angelike P Liappis
Medicine Faculty Publications
Focus groups held with internal medicine residents discussed their perspectives regarding broad-spectrum antibiotic (BSA) usage. Residents knew of BSA-associated adverse events, but they did not associate such events with increased patient morbidity and mortality, and they were more likely to use BSA in situations with diagnostic uncertainty and sick patients.
Medical Marijuana Education For Medical Students, 2017 University of Massachusetts Medical School
Medical Marijuana Education For Medical Students, Patrick Mcguire
As the nationwide discourse on medical marijuana evolves, with 28 out of 50 states approving its use, University of Massachusetts Medical School graduates will need to be prepared to discuss medical marijuana (MMJ) with their patients. There is currently no formal medical school education on MMJ. This project set out to understand the curriculum gap and provide a learning session to interested students. The presentation was created using research done by the author during the first three years of medical school, including visits to private MMJ clinics. Utilizing a pre/post-session online assessment of a group of twenty-six students, we ...
Session D-2: Don’T Overdose The Patient: A Unit Conversion Literacy Project, 2017 Northern Illinois University
Session D-2: Don’T Overdose The Patient: A Unit Conversion Literacy Project, Gary M. Baker, David Anim-Addo, Patrick Young
Professional Learning Day
General chemistry for non-science majors is often a prerequisite course for students pursuing degree programs in allied health fields, such as nursing. A core nursing skill is medicine management, which includes correctly calculating drug dosage volumes administered by I.V. or injection. Such calculations are nothing more than general chemistry problems involving concentration units and dilution. Our data show, however, that more than 90% of students lack this skill after taking a traditional general chemistry course. This presentation will focus on documenting this curricular gap and how we, as teachers, can address it.
Effect Of Immediate Initiation Of Antiretroviral Therapy On Risk Of Severe Bacterial Infections In Hiv-Positive People With Cd4 Cell Counts Of More Than 500 Cells Per Μl: Secondary Outcome Results From A Randomised Controlled Trial., 2017 George Washington University
Effect Of Immediate Initiation Of Antiretroviral Therapy On Risk Of Severe Bacterial Infections In Hiv-Positive People With Cd4 Cell Counts Of More Than 500 Cells Per Μl: Secondary Outcome Results From A Randomised Controlled Trial., Jemma O'Connor, Michael J Vjecha, Andrew N Phillips, Brian Angus, David Cooper, Fred Gordin, +Several Additional Authors
Medicine Faculty Publications
BACKGROUND: The effects of antiretroviral therapy on risk of severe bacterial infections in people with high CD4 cell counts have not been well described. In this study, we aimed to quantify the effects of immediate versus deferred ART on the risk of severe bacterial infection in people with high CD4 cell counts in a preplanned analysis of the START trial.
METHODS: The START trial was a randomised controlled trial in ART-naive HIV-positive patients with CD4 cell count of more than 500 cells per μL assigned to immediate ART or deferral until their CD4 cell counts were lower than 350 cells ...
The Autocrine Role Of Proteoglycan-4 (Prg4) In Modulating Osteoarthritic Synoviocyte Proliferation And Expression Of Matrix Degrading Enzymes, Ali Alquraini, Maha Jamal, Ling Zhang, Tannin Schmidt, Gregory D. Jay, Khaled A. Elsaid
Pharmacy Faculty Articles and Research
Background: Lubricin/proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. Recently, we showed that recombinant human PRG4 (rhPRG4) is a putative ligand for CD44 receptor. rhPRG4-CD44 interaction inhibits cytokine-induced rheumatoid arthritis synoviocyte proliferation. The objective of this study is to decipher the autocrine function of PRG4 in regulating osteoarthritic synoviocyte proliferation and expression of catabolic and pro-inflammatory mediators under basal and interleukin-1 beta (IL-1β)- stimulated conditions.
Methods: Cytosolic and nuclear levels of nuclear factor kappa B (NFκB) p50 and p65 subunits in Prg4+/+ and Prg4-/- synoviocytes were studied using western blot. Nuclear translocation ...
The [E]Motionless Body No Longer: Tracing The Historical Intersections Of Mental Illness And Movement In The American Asylum, Holly Adele Herzfeld
Senior Projects Spring 2017
Senior Project submitted to The Division of Multidisciplinary Studies of Bard College.
Risk Of Gastrointestinal Bleeding Among Dabigatran Users – A Self Controlled Case Series Analysis, 2017 George Washington University
Risk Of Gastrointestinal Bleeding Among Dabigatran Users – A Self Controlled Case Series Analysis, Wenze Tang, Hsien-Yen Chang, Meijia Zhou, Sonal Singh
Epidemiology and Biostatistics Faculty Publications
This article aims to evaluate the real world risk of gastrointestinal bleeding among users naïve to dabigatran. We adopted a self-controlled case series design. We sampled 1215 eligible adult participants who were continuous insured users between July 1, 2010 and March 31, 2012 with use of dabigatran and at least one gastrointestinal bleeding episode. We used a conditional Poisson regression to estimate incidence rate ratios. The population consisted of 64.69% of male and 60.25% patients equal to or greater than age 65 at start of observation. After adjustment for time-variant confounders, the incidence rate of gastrointestinal bleeding was ...
Molecular Modeling Of Novel Tryptamine Analogs With Antibiotic Potential Through Their Inhibition Of Tryptophan Synthase, 2017 Claremont McKenna College
Molecular Modeling Of Novel Tryptamine Analogs With Antibiotic Potential Through Their Inhibition Of Tryptophan Synthase, Jared Schattenkerk
CMC Senior Theses
The growing prevalence of antibiotic-resistant bacteria is a global health crisis that threatens the effectiveness of antibiotics in medical treatment. Increases in the number of antibiotic-resistant bacteria and a drop in the pharmaceutical development of novel antibiotics have combined to form a situation that is rapidly increasing the likelihood of a post-antibiotic era. The development of antibiotics with novel enzymatic targets is critical to stall this growing crisis. In silico methods of molecular modeling and drug design were utilized in the development of novel tryptamine analogs as potential antibiotics through their inhibition of the bacterial enzyme tryptophan synthase. Following the ...
Unmasking Of Myoclonus By Lacosamide In Generalized Epilepsy, 2017 George Washington University
Unmasking Of Myoclonus By Lacosamide In Generalized Epilepsy, Daniel Birnbaum, Mohamad Z. Koubeissi
Neurology Faculty Publications
Lacosamide is a new-generation antiseizure medication that is approved for use as an adjunctive treatment and monotherapy in focal epilepsy. Its use in generalized epilepsy, however, has not been adequately evaluated in controlled trials. We report a 67-year-old woman who experienced new-onset myoclonic seizures after initiation of lacosamide. We presume that she had an undiagnosed generalized epilepsy syndrome, likely juvenile myoclonic epilepsy. Myoclonic seizures were not reported before introducing lacosamide and completely resolved after lacosamide was discontinued. This suggests that lacosamide may have the potential to worsen myoclonus, similar to what has been reported with another sodium channel agent, lamotrigine ...
Addressing Antibiotic Resistance From Farm-Raised Fish Imported To The United States, Nicholas Ali
Bard Center for Environmental Policy
Misuse of medically important antibiotics in animal production threatens the effectiveness of drugs that are vital in combating disease and infections. Recently, the FDA implemented regulations to limit the use of and access to veterinary drugs. However, these regulations only affect domestic production operations. Because over 90% of seafood consumed in the U.S. is imported from countries with different regulatory standards and because the U.S. has an import inspection rate of less than 1%, antibiotic resistance stemming from imported aquaculture is still a risk that is not sufficiently accounted for. This research investigates how the U.S. has ...
Characterization Of Physicochemical And Thermal Properties Of Biofield Treated Ethyl Cellulose And Methyl Cellulose, Mahendra Trivedi
Mahendra Kumar Trivedi
Characterization Of Physicochemical And Thermal Properties Of Biofield Treated Ethyl Cellulose And Methyl Cellulose, Mahendra Trivedi, Dahryn Trivedi
Mahendra Kumar Trivedi
A New Sv2a Ligand For Epilepsy, 2016 University of California - Davis
A New Sv2a Ligand For Epilepsy, Michael A. Rogawski
Michael A. Rogawski
Profile Interview With Faculty Mentor Jane Krause, 2016 Purdue University
Profile Interview With Faculty Mentor Jane Krause, Elizabeth J. Dowell, Ashley M. Schinker
Purdue Journal of Service-Learning and International Engagement
No abstract provided.
There Is A Trend Favoring Vancomycin Vs. Metronidazole In Treating Severe C. Difficile Infection, 2016 Wayne State University School of Medicine
There Is A Trend Favoring Vancomycin Vs. Metronidazole In Treating Severe C. Difficile Infection, Dean D. Fouchia
Clinical Research in Practice: The Journal of Team Hippocrates
A critical appraisal and clinical application of Johnson S, Louie TJ, Gerding DN, et al. Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials. Clin Infect Dis. 2014;59(3):345-354. doi: 10.1093/cid/ciu313
Synthesis And Development Of Long-Acting Abacavir Prodrug Nanoformulations, 2016 University of Nebraska Medical Center
Synthesis And Development Of Long-Acting Abacavir Prodrug Nanoformulations, Dhirender Singh
Theses & Dissertations
Over the past decade, work from our laboratory has demonstrated the potential of targeted nanoformulated antiretroviral therapy (nanoART) to produce sustained high plasma and tissue drug concentrations for weeks following a single intramuscular (IM) administration that can suppress ongoing viral replication and mitigate dose associated viral resistance. While progress has occurred towards developing long-acting nanoformulations for protease and nonnucleoside reverse transcriptase (RT) inhibitors, development of nanoformulations of hydrophilic nucleoside RT inhibitor drugs have remained elusive. Abacavir (ABC); a hydrophilic molecule exhibited limited utilities to develop into long-acting nanoformulation platform. Furthermore, inefficient conversion of ABC to its biological active metabolites; carbovir ...