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Diverse Repertoire Of Human Adipocyte Subtypes Develops From Transcriptionally Distinct Mesenchymal Progenitor Cells, So Yun Min, Anand Desai, Zinger Yang, Agastya Sharma, Tiffany DeSouza, Ryan Genga, Alper Kucukural, Lawrence M. Lifshitz, Soren Nielsen, Camilla Scheele, Rene Maehr, Manuel Garber, Silvia Corvera 2019 University of Massachusetts Medical School

Diverse Repertoire Of Human Adipocyte Subtypes Develops From Transcriptionally Distinct Mesenchymal Progenitor Cells, So Yun Min, Anand Desai, Zinger Yang, Agastya Sharma, Tiffany Desouza, Ryan Genga, Alper Kucukural, Lawrence M. Lifshitz, Soren Nielsen, Camilla Scheele, Rene Maehr, Manuel Garber, Silvia Corvera

Open Access Articles

Single-cell sequencing technologies have revealed an unexpectedly broad repertoire of cells required to mediate complex functions in multicellular organisms. Despite the multiple roles of adipose tissue in maintaining systemic metabolic homeostasis, adipocytes are thought to be largely homogenous with only 2 major subtypes recognized in humans so far. Here we report the existence and characteristics of 4 distinct human adipocyte subtypes, and of their respective mesenchymal progenitors. The phenotypes of these distinct adipocyte subtypes are differentially associated with key adipose tissue functions, including thermogenesis, lipid storage, and adipokine secretion. The transcriptomic signature of "brite/beige" thermogenic adipocytes reveals mechanisms for ...


Oral Administration Of An Anti-Cfae Secretory Iga Antibody Protects Against Enterotoxigenic Escherichia Coli Diarrheal Disease In A Non-Human Primate Model, Matteo Stoppato, Carlos Gaspar, James Regeimbal, Gladys Nunez, Serena Giuntini, Melissa A. Gawron, Jessica R. Pondish, Joseph C. Martin III, Matthew Schneider, Zachary A. Schiller, Mark S. Klempner, Lisa A. Cavacini, Yang Wang 2019 University of Massachusetts Medical School

Oral Administration Of An Anti-Cfae Secretory Iga Antibody Protects Against Enterotoxigenic Escherichia Coli Diarrheal Disease In A Non-Human Primate Model, Matteo Stoppato, Carlos Gaspar, James Regeimbal, Gladys Nunez, Serena Giuntini, Melissa A. Gawron, Jessica R. Pondish, Joseph C. Martin Iii, Matthew Schneider, Zachary A. Schiller, Mark S. Klempner, Lisa A. Cavacini, Yang Wang

University of Massachusetts Medical School Faculty Publications

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea-associated illness in developing countries. There is currently no vaccine licensed to prevent ETEC and the development of an efficacious prophylaxis would provide an intervention with significant impact. Recent studies suggested that effective protection could be achieved by inducing immunity to block colonization of ETEC. Here, we evaluated the efficacy of secretory (s) IgA2 and dimeric (d) IgA2 of an anti-colonization factor antigen antibody, 68-61, in the Aotus nancymaae non-human primate (NHP) ETEC challenge model via oral and parental delivery. Thirty-nine animals were distributed across 3 groups of 13, and challenged ...


Leptin Promotes Expression Of Emt-Related Transcription Factors And Invasion In A Src And Fak-Dependent Pathway In Mcf10a Mammary Epithelial Cells, Monserrat Olea-Flores, Miriam Zuñiga-Eulogio, Arvey Tacuba-Saavedra, Magdalena Bueno-Salgado, Andrea Sánchez-Carvajal, Yovani Vargas-Santiago, Miguel A. Mendoza-Catalán, Eduardo Pérez Salazar, Alejandra García-Hernández, Teresita Padilla-Benavides, Napoleón Navarro-Tito 2019 Autonomous University of Guerrero

Leptin Promotes Expression Of Emt-Related Transcription Factors And Invasion In A Src And Fak-Dependent Pathway In Mcf10a Mammary Epithelial Cells, Monserrat Olea-Flores, Miriam Zuñiga-Eulogio, Arvey Tacuba-Saavedra, Magdalena Bueno-Salgado, Andrea Sánchez-Carvajal, Yovani Vargas-Santiago, Miguel A. Mendoza-Catalán, Eduardo Pérez Salazar, Alejandra García-Hernández, Teresita Padilla-Benavides, Napoleón Navarro-Tito

University of Massachusetts Medical School Faculty Publications

Leptin is one of the main adipokines secreted in breast tissue, and has been associated with epithelial-mesenchymal transition (EMT) and tumor progression in breast cancer. Leptin promotes EMT, cell migration and invasion in epithelial breast cells, leading to tumor progression. However, the molecular mechanism that underlies these events is not fully understood; however, the activation of different signaling pathways appears to be essential. In this sense, the effect of leptin on the activation of kinases like Src and FAK, which regulate signaling pathways that activate the EMT program, has not been completely described. Therefore, we investigated the involvement of these ...


Micro-Rnas Are Related To Epicardial Adipose Tissue In Participants With Atrial Fibrillation: Data From The Mirhythm Study, Khanh-Van T. Tran, Jordan Majka, Saket Sanghai, Mayank Sardana, Darleen M. Lessard, Zachary J. Milstone, Kahraman Tanriverdi, Jane E. Freedman, Timothy P. Fitzgibbons, David D. McManus 2019 University of Massachusetts Medical School

Micro-Rnas Are Related To Epicardial Adipose Tissue In Participants With Atrial Fibrillation: Data From The Mirhythm Study, Khanh-Van T. Tran, Jordan Majka, Saket Sanghai, Mayank Sardana, Darleen M. Lessard, Zachary J. Milstone, Kahraman Tanriverdi, Jane E. Freedman, Timothy P. Fitzgibbons, David D. Mcmanus

Open Access Articles

Introduction: Epicardial adipose tissue (EAT) has been linked to incidence and recurrence of atrial fibrillation (AF), but the underlying mechanisms that mediate this association remain unclear. Circulating microRNAs (miRNAs) contribute to the regulation of gene expression in cardiovascular diseases, including AF. Thus, we sought to test the hypothesis that circulating miRNAs relate to burden of EAT.

Methods: We examined the plasma miRNA profiles of 91 participants from the miRhythm study, an ongoing study examining associations between miRNA and AF. We quantified plasma expression of 86 unique miRNAs commonly expressed in cardiomyocytes using quantitative reverse transcriptase polymerase chain reaction (qPCR). From ...


Investigating Potential Biomarkers In Autism Spectrum Disorder, Carolyn Bridgemohan, David E. Cochran, Andrew W. Zimmerman, Roula N. Choueiri, Jean A. Frazier 2019 Harvard Medical School

Investigating Potential Biomarkers In Autism Spectrum Disorder, Carolyn Bridgemohan, David E. Cochran, Andrew W. Zimmerman, Roula N. Choueiri, Jean A. Frazier

Open Access Articles

Background: Early identification and treatment of individuals with autism spectrum disorder (ASD) improves outcomes, but specific evidence needed to individualize treatment recommendations is lacking. Biomarkers that could be routinely measured within the clinical setting could potentially transform clinical care for patients with ASD. This demonstration project employed collection of biomarker data during regular autism specialty clinical visits and explored the relationship of biomarkers with clinical ASD symptoms.

Methods: Eighty-three children with ASD, aged 5-10 years, completed a multi-site feasibility study integrating the collection of biochemical (blood serotonin, urine melatonin sulfate excretion) and clinical (head circumference, dysmorphology exam, digit ratio, cognitive ...


Plasma Phospholipid Fatty Acids And Coronary Heart Disease Risk: A Matched Case-Control Study Within The Women's Health Initiative Observational Study, Qing Liu, Nirupa R. Matthan, JoAnn E. Manson, Barbara V. Howard, Lesley F. Tinker, Marian L. Neuhouser, Linda V. Van Horn, Jacques E. Rossouw, Matthew A. Allison, Lisa W. Martin, Wenjun Li, Linda G. Snetselaar, Lu Wang, Alice H. Lichtenstein, Charles B. Eaton 2019 Brown University

Plasma Phospholipid Fatty Acids And Coronary Heart Disease Risk: A Matched Case-Control Study Within The Women's Health Initiative Observational Study, Qing Liu, Nirupa R. Matthan, Joann E. Manson, Barbara V. Howard, Lesley F. Tinker, Marian L. Neuhouser, Linda V. Van Horn, Jacques E. Rossouw, Matthew A. Allison, Lisa W. Martin, Wenjun Li, Linda G. Snetselaar, Lu Wang, Alice H. Lichtenstein, Charles B. Eaton

Open Access Articles

BACKGROUND AND AIMS: The association of fatty acids with coronary heart disease (CHD) has been examined, mainly through dietary measurements, and has generated inconsistent results due to measurement error. Large observational studies and randomized controlled trials have shown that plasma phospholipid fatty acids (PL-FA), especially those less likely to be endogenously synthesized, are good biomarkers of dietary fatty acids. Thus, PL-FA profiles may better predict CHD risk with less measurement error.

METHODS: We performed a matched case-control study of 2428 postmenopausal women nested in the Women's Health Initiative Observational Study. Plasma PL-FA were measured using gas chromatography and expressed ...


Gms-Classifier1 Does Not Predict Disability Progression In Multiple Sclerosis, Johannis A. van Rossum, Joep Killestein, Luisa M. Villar, Peter N. Riskind, Mark S. Freedman, Charlotte Teunissen 2019 Vrije Universiteit Amsterdam

Gms-Classifier1 Does Not Predict Disability Progression In Multiple Sclerosis, Johannis A. Van Rossum, Joep Killestein, Luisa M. Villar, Peter N. Riskind, Mark S. Freedman, Charlotte Teunissen

Open Access Articles

Several clinical, immunological and radiological biomarkers have been shown to predict the disease course of multiple sclerosis (MS).One potential serum marker is the gMS-Classifier1, which is composed of IgM anti-Glc antibodies, namely anti-GAGA 2,3,4 and 6. Previous work demonstrated that the gMS-Classifier1 could not predict early conversion to clinically definite MS in a cohort of clinically isolated syndrome (CIS) patients, but predicted Expanded Disability Status Scale (EDSS) progression. Significance, however, was dependent on covariates, and confirmation in an independent study was required. The aim of this study was to test if the gMS-Classifier1 could predict early disability ...


Dysfunction In Serotonergic And Noradrenergic Systems And Somatic Symptoms In Psychiatric Disorders, Yi Liu, Jingping Zhao, Xiaoduo Fan, Wenbin Guo 2019 The Second Xiangya Hospital of Central South University

Dysfunction In Serotonergic And Noradrenergic Systems And Somatic Symptoms In Psychiatric Disorders, Yi Liu, Jingping Zhao, Xiaoduo Fan, Wenbin Guo

Open Access Articles

Somatic symptoms include a range of physical experiences, such as pain, muscle tension, body shaking, difficulty in breathing, heart palpitation, blushing, fatigue, and sweating. Somatic symptoms are common in major depressive disorder (MDD), anxiety disorders, and some other psychiatric disorders. However, the etiology of somatic symptoms remains unclear. Somatic symptoms could be a response to emotional distress in patients with those psychiatric conditions. Increasing evidence supports the role of aberrant serotoninergic and noradrenergic neurotransmission in somatic symptoms. The physiological alterations underlying diminished serotonin (5-HT) and norepinephrine (NE) signaling may contribute to impaired signal transduction, reduced 5-HT, or NE release from ...


Plasma Indoleamine 2,3-Dioxygenase Activity As A Potential Biomarker For Early Diagnosis Of Multidrug-Resistant Tuberculosis In Tuberculosis Patients, Wen Shi, Juan Wu, Qi Tan, Chun-Mei Hu, Xia Zhang, Hong-Qiu Pan, Zhen Yang, Meng-Yu He, Min Yu, Bo Zhang, Wei-Ping Xie, Hong Wang 2019 The First Affiliated Hospital of Nanjing Medical University

Plasma Indoleamine 2,3-Dioxygenase Activity As A Potential Biomarker For Early Diagnosis Of Multidrug-Resistant Tuberculosis In Tuberculosis Patients, Wen Shi, Juan Wu, Qi Tan, Chun-Mei Hu, Xia Zhang, Hong-Qiu Pan, Zhen Yang, Meng-Yu He, Min Yu, Bo Zhang, Wei-Ping Xie, Hong Wang

Open Access Articles

Purpose: Multidrug-resistant tuberculosis (MDR-TB) remains a challenge of global TB control, with difficulty in early detection of drug-sensitive tuberculosis (DS-TB). We investigate the diagnostic significance of IDO as a potential biomarker to discriminate MDR patients among the TB patients.

Patients and methods: Plasma indoleamine 2,3-dioxygenase (IDO) was measured by the ratio of kynurenine (Kyn) to tryptophan (Trp) concentrations, using high performance liquid chromatography-mass spectrometry (LC-MS/MS). Chest computed tomography (CT) imaging signs from TB patients were collected and analyzed in 18 DS-TB patients, 16 MDR-TB patients, 6 lung cancer (LC) patients, and 11 healthy individuals. Lung imaging signs from ...


Circulating Micrornas Mir-331 And Mir-195 Differentiate Local Luminal A From Metastatic Breast Cancer, Peter McAnena, Kahraman Tanriverdi, Catherine Curran, K. Gilligan, Jane E. Freedman, James A. L. Brown, Michael J. Kerin 2019 National University of Ireland, Galway

Circulating Micrornas Mir-331 And Mir-195 Differentiate Local Luminal A From Metastatic Breast Cancer, Peter Mcanena, Kahraman Tanriverdi, Catherine Curran, K. Gilligan, Jane E. Freedman, James A. L. Brown, Michael J. Kerin

Open Access Articles

BACKGROUND: Breast cancer is the leading cause of cancer related death in women, with metastasis the principle cause of mortality. New non-invasive prognostic markers are needed for the early detection of metastasis, facilitating treatment decision optimisation. MicroRNA (miRNA) are small, non-coding RNAs regulating gene expression and involved in many cellular processes, including metastasis. As biomarkers, circulating miRNAs (in blood) hold great promise for informing diagnosis or monitoring treatment responses.

METHODS: Plasma extracted RNA from age matched local Luminal A (n = 4) or metastatic disease (n = 4) were profiled using Next Generation Sequencing. Selected differentially expressed miRNA were validated on a ...


Implications Of Genetic Variation Of Common Drug Metabolizing Enzymes And Abc Transporters Among The Pakistani Population, Nasir Ali Afsar, Henrike Bruckmueller, Anneke Nina Werk, Muhammad Kashif Nisa, H R. Ahmad, Ingolf Cascorbi 2019 Jinnah Medical and Dental College, Sohail University, Karachi, Pakistan

Implications Of Genetic Variation Of Common Drug Metabolizing Enzymes And Abc Transporters Among The Pakistani Population, Nasir Ali Afsar, Henrike Bruckmueller, Anneke Nina Werk, Muhammad Kashif Nisa, H R. Ahmad, Ingolf Cascorbi

Department of Biological & Biomedical Sciences

Genetic polymorphism of drug metabolizing enzymes and transporters may influence drug response. The frequency varies substantially between ethnicities thus having implications on appropriate selection and dosage of various drugs in different populations. The distribution of genetic polymorphisms in healthy Pakistanis has so far not been described. In this study, 155 healthy adults (98 females) were included from all districts of Karachi. DNA was extracted from saliva and genotyped for relevant SNVs in CYP1A1, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 as well as ALDH3A1, GSTA1, ABCB1 and ABCC2. About 64% of the participants were born to parents who were unrelated ...


Proteomics Profiling And Risk Of New-Onset Atrial Fibrillation: Framingham Heart Study, Darae Ko, Mark D. Benson, Debby Ngo, Qiong Yang, Martin G. Larson, Thomas J. Wang, Ludovic Trinquart, David D. McManus, Steven A. Lubitz, Patrick T. Ellinor, Ramachandran S. Vasan, Robert E. Gerszten, Emelia J. Benjamin, Honghuang Lin 2019 Boston University

Proteomics Profiling And Risk Of New-Onset Atrial Fibrillation: Framingham Heart Study, Darae Ko, Mark D. Benson, Debby Ngo, Qiong Yang, Martin G. Larson, Thomas J. Wang, Ludovic Trinquart, David D. Mcmanus, Steven A. Lubitz, Patrick T. Ellinor, Ramachandran S. Vasan, Robert E. Gerszten, Emelia J. Benjamin, Honghuang Lin

Open Access Articles

Background: Prior studies relating proteomics markers to incident AF screened for limited numbers of proteins.

Methods and Results: We performed proteomics assays among participants from the Framingham Heart Study Offspring attending their fifth examination. Plasma protein levels (n=1373) were measured by the SOMAscan proteomic profiling platform. We used robust inference for the Cox proportional hazards model to relate each protein level with incident AF. In addition, we examined the association between AF-related genetic loci and levels of proteins associated with AF. Our study included 1885 participants (mean age 55+/-10 years, 54% women) who had proteomic profiles measured. A ...


Viral Infection Or Ifn-Alpha Alters Mitotic Spindle Orientation By Modulating Pericentrin Levels, William M. McDougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, Abraham L. Brass 2019 University of Massachusetts Medical School

Viral Infection Or Ifn-Alpha Alters Mitotic Spindle Orientation By Modulating Pericentrin Levels, William M. Mcdougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, Abraham L. Brass

Open Access Articles

Congenital microcephaly occurs in utero during Zika virus (ZIKV) infection. The single-gene disorder, Majewski osteodysplastic primordial dwarfism type II (MOPDII), also leads to microcephaly and is concomitant with a decrease in the centrosomal protein, pericentrin (PCNT). This protein is a known contributor of mitotic spindle misorientation and ultimately, microcephaly. Similar to MOPDII, either viral infection or interferon (IFN)-alpha exposure reduced PCNT levels at the mitotic spindle poles. We unexpectedly found that infection of cells with any one of a diverse set of viruses, such as ZIKV, dengue virus, cytomegalovirus, influenza A virus, or hepatitis B virus, or treatment of ...


The Neutrophil-To-Lymphocyte And Monocyte-To-Lymphocyte Ratios Are Independently Associated With Neurological Disability And Brain Atrophy In Multiple Sclerosis, Christopher C. Hemond, Bonnie I. Glanz, Rohit Bakshi, Tanuja Chitnis, Brian C. Healy 2019 University of Massachusetts Medical School

The Neutrophil-To-Lymphocyte And Monocyte-To-Lymphocyte Ratios Are Independently Associated With Neurological Disability And Brain Atrophy In Multiple Sclerosis, Christopher C. Hemond, Bonnie I. Glanz, Rohit Bakshi, Tanuja Chitnis, Brian C. Healy

Open Access Articles

BACKGROUND: Serum hematological indices such as the neutrophil-lymphocyte ratio (NLR) or monocyte-lymphocyte ratio (MLR) have been used as biomarkers of pathogenic inflammation and prognostication in multiple areas of medicine; recent evidence shows correlation with psychological parameters as well.

OBJECTIVES/AIMS: To characterize clinical, neuroimaging, and psycho-neuro-immunological associations with NLR and MLR in persons with multiple sclerosis (MS).

METHODS: We identified a large cohort of clinically well-defined patients from our longitudinal database that included MS-related outcomes, disease-modifying therapy, patient-reported outcome (PRO) measures, and quantified cerebral MRI at 1.5 T. We queried hospital records for complete blood counts within 2 months ...


Interferon-Induced Transmembrane Protein 3 Blocks Fusion Of Sensitive But Not Resistant Viruses By Partitioning Into Virus-Carrying Endosomes, Krishna C. Suddala, Christine C. Lee, Paul Meraner, Mariana Marin, Ruben M. Markosyan, Tanay M. Desai, Fredric S. Cohen, Abraham L. Brass, Gregory B. Melikyan 2019 Emory University

Interferon-Induced Transmembrane Protein 3 Blocks Fusion Of Sensitive But Not Resistant Viruses By Partitioning Into Virus-Carrying Endosomes, Krishna C. Suddala, Christine C. Lee, Paul Meraner, Mariana Marin, Ruben M. Markosyan, Tanay M. Desai, Fredric S. Cohen, Abraham L. Brass, Gregory B. Melikyan

Open Access Articles

Late endosome-resident interferon-induced transmembrane protein 3 (IFITM3) inhibits fusion of diverse viruses, including Influenza A virus (IAV), by a poorly understood mechanism. Despite the broad antiviral activity of IFITM3, viruses like Lassa virus (LASV), are fully resistant to its inhibitory effects. It is currently unclear whether resistance arises from a highly efficient fusion machinery that is capable of overcoming IFITM3 restriction or the ability to enter from cellular sites devoid of this factor. Here, we constructed and validated a functional IFITM3 tagged with EGFP or other fluorescent proteins. This breakthrough allowed live cell imaging of virus co-trafficking and fusion with ...


Leucine Supplementation In Cuprizone-Induced Oligodendrocyte Toxicity, Michael Ley 2019 The University of Akron

Leucine Supplementation In Cuprizone-Induced Oligodendrocyte Toxicity, Michael Ley

Williams Honors College, Honors Research Projects

Cuprizone is a copper chelator that induces demyelination in the central nervous system when fed to mice. This compound is thought to target Complex IV and disrupt mitochondrial metabolism leading to loss of myelin-producing oligodendrocytes. In this proposal, we further examine the chemical and toxicological properties of cuprizone. Immunofluorescence imaging and microarray data on MO3.13 cells treated with cuprizone revealed the possibility of alterations in lysosomal function, as well as mitochondrial disruption via mTOR and Electron Transport Chain (ETC) related pathways. Cell viability assays conducted suggest that addition of Branched-Chain Amino Acids, most commonly used from literature, leucine, can ...


Eralpha Isoforms Modulate The Tumorigenicity Of 24r,25(Oh)2d3 In Estrogen-Responsive Cancer, Anjali Verma 2019 Virginia Commonwealth University

Eralpha Isoforms Modulate The Tumorigenicity Of 24r,25(Oh)2d3 In Estrogen-Responsive Cancer, Anjali Verma

Theses and Dissertations

Over 200,000 cases of breast cancer are diagnosed every year. Nearly 20% of these patients supplement their diets with some form of vitamin D. This high frequency of vitamin D supplement use may be due in part to research suggesting that cancer patients with higher serum vitamin D3 levels have better prognoses than patients with low serum vitamin D3. However, double-blind clinical trials on the efficacy of vitamin D3 supplementation in breast cancer have been inconclusive. A recent meta-analysis showed evidence of reduced cancer recurrence in patients taking vitamin D3 supplements who had ‘estrogen receptor ...


Intron-Containing Rna From The Hiv-1 Provirus Activates Type I Interferon And Inflammatory Cytokines, Sean M. McCauley, Kyusik Kim, Anetta Nowosielska, Ann Dauphin, Leonid Yurkovetskiy, William E. Diehl, Jeremy Luban 2018 University of Massachusetts Medical School

Intron-Containing Rna From The Hiv-1 Provirus Activates Type I Interferon And Inflammatory Cytokines, Sean M. Mccauley, Kyusik Kim, Anetta Nowosielska, Ann Dauphin, Leonid Yurkovetskiy, William E. Diehl, Jeremy Luban

Open Access Articles

HIV-1-infected people who take drugs that suppress viremia to undetectable levels are protected from developing AIDS. Nonetheless, HIV-1 establishes proviruses in long-lived CD4(+) memory T cells, and perhaps other cell types, that preclude elimination of the virus even after years of continuous antiviral therapy. Here we show that the HIV-1 provirus activates innate immune signaling in isolated dendritic cells, macrophages, and CD4(+) T cells. Immune activation requires transcription from the HIV-1 provirus and expression of CRM1-dependent, Rev-dependent, RRE-containing, unspliced HIV-1 RNA. If rev is provided in trans, all HIV-1 coding sequences are dispensable for activation except those cis-acting sequences required ...


Signaling Pathways Induced By Leptin During Epithelial(-)Mesenchymal Transition In Breast Cancer, Monserrat Olea-Flores, Juan Carlos Juarez-Cruz, Miguel A. Mendoza-Catalan, Teresita Padilla-Benavides, Napoleon Navarro-Tito 2018 Autonomous University of Guerrero

Signaling Pathways Induced By Leptin During Epithelial(-)Mesenchymal Transition In Breast Cancer, Monserrat Olea-Flores, Juan Carlos Juarez-Cruz, Miguel A. Mendoza-Catalan, Teresita Padilla-Benavides, Napoleon Navarro-Tito

Open Access Articles

Leptin is an adipokine that is overexpressed in obese and overweight people. Interestingly, women with breast cancer present high levels of leptin and of its receptor ObR. Leptin plays an important role in breast cancer progression due to the biological processes it participates in, such as epithelial(-)mesenchymal transition (EMT). EMT consists of a series of orchestrated events in which cell(-)cell and cell(-)extracellular matrix interactions are altered and lead to the release of epithelial cells from the surrounding tissue. The cytoskeleton is also re-arranged, allowing the three-dimensional movement of epithelial cells into the extracellular matrix. This transition provides ...


Recombinant Human Proteoglycan-4 Reduces Phagocytosis Of Urate Crystals And Downstream Nuclear Factor Kappa B And Inflammasome Activation And Production Of Cytokines And Chemokines In Human And Murine Macrophages, Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Wendy Wong, Anthony M. Reginato, Changqi Sun, Tannin A. Schmidt 2018 Chapman University

Recombinant Human Proteoglycan-4 Reduces Phagocytosis Of Urate Crystals And Downstream Nuclear Factor Kappa B And Inflammasome Activation And Production Of Cytokines And Chemokines In Human And Murine Macrophages, Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Wendy Wong, Anthony M. Reginato, Changqi Sun, Tannin A. Schmidt

Pharmacy Faculty Articles and Research

Microbial biofilms are organized communities of cells that are associated with a wide spectrum of resistant and chronic infections that lead to the treatment failure. Accordingly, there is an urgent demand to create novel effective therapeutic drugs that can inhibit biofilm formation with new mechanisms of action to surmount the current escalating resistance. In this study, in silico hybrid model was utilized to develop three novel short linear peptides (4, 5, and 6) with potential biofilm inhibiting activities (scores > 1.0). The peptides were composed of cationic and hydrophobic residues. They were synthesized using solid-phase strategy. Synthesized peptides were purified ...


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