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Network Analyses Of Glomerular Capillaries, Jason Cory Brunson, Justin Sardi, Mark Terasaki 2019 UConn Health

Network Analyses Of Glomerular Capillaries, Jason Cory Brunson, Justin Sardi, Mark Terasaki

Biology and Medicine Through Mathematics Conference

No abstract provided.


Evaluation Of Prophylactic Dosages Of Enoxaparin In Non-Surgical Elderly Patients With Renal Impairment, Nibal Chamoun, Hady Ghanem, Ahmad Hachem, Essa Hariri, Christelle Lteif, Hanine Mansour, Hani Dimassi, Richard Zalloum, Georges Ghanem 2019 Lebanese American University

Evaluation Of Prophylactic Dosages Of Enoxaparin In Non-Surgical Elderly Patients With Renal Impairment, Nibal Chamoun, Hady Ghanem, Ahmad Hachem, Essa Hariri, Christelle Lteif, Hanine Mansour, Hani Dimassi, Richard Zalloum, Georges Ghanem

Open Access Articles

BACKGROUND: Thromboprophylaxis dosing strategies using enoxaparin in elderly patients with renal disease are limited, while dose adjustments or monitoring of anti-Xa levels are recommended. We sought to evaluate the efficacy and safety of enoxaparin 20 mg versus 30 mg subcutaneously daily by comparing anti-Xa levels, thrombosis and bleeding.

METHODS: We conducted a prospective, single-blinded, single-center randomized clinical trial including non-surgical patients, 70 years of age or older, with renal disease requiring thromboprophylaxis. Patients were randomized to receive either 20 mg or 30 mg of enoxaparin. The primary endpoint was peak anti-Xa levels on day 3. Secondary endpoints included trough anti-Xa ...


Pharmacological Inhibition Of The Nlrp3 Inflammasome Reduces Blood Pressure, Renal Damage, And Dysfunction In Salt-Sensitive Hypertension, Shalini M. Krishnan, Eicke Latz, Grant R. Drummond 2019 Monash University

Pharmacological Inhibition Of The Nlrp3 Inflammasome Reduces Blood Pressure, Renal Damage, And Dysfunction In Salt-Sensitive Hypertension, Shalini M. Krishnan, Eicke Latz, Grant R. Drummond

Open Access Articles

AIMS: Renal inflammation, leading to fibrosis and impaired function is a major contributor to the development of hypertension. The NLRP3 inflammasome mediates inflammation in several chronic diseases by processing the cytokines pro-interleukin (IL)-1beta and pro-IL-18. In this study, we investigated whether MCC950, a recently-identified inhibitor of NLRP3 activity, reduces blood pressure (BP), renal inflammation, fibrosis and dysfunction in mice with established hypertension.

METHODS AND RESULTS: C57BL6/J mice were made hypertensive by uninephrectomy and treatment with deoxycorticosterone acetate (2.4 mg/day, s.c.) and 0.9% NaCl in the drinking water (1K/DOCA/salt). Normotensive controls were uninephrectomized ...


The “Benefits,” Risks, And Costs Of Routine Infant Circumcision, Stephanie Welch 2019 N/A

The “Benefits,” Risks, And Costs Of Routine Infant Circumcision, Stephanie Welch

Journal of Evolution and Health

No abstract provided.


Session 3 - Gastrointestinal Packet, SKMC Surface Anatomy 2019 Thomas Jefferson University

Session 3 - Gastrointestinal Packet, Skmc Surface Anatomy

Student Organizations

Learning Objectives

  1. Be able to identify which abdominal organs are located in each of the four quadrants
  2. Be able to identify which pathologies would be associated with pain in the RLQ, RUQ, LLQ, LUQ
  3. Describe the surface anatomy projections of the abdomen
  4. Discuss the differences between direct and indirect inguinal hernias
  5. Describe abdominal pathologies that can be determined from abdominal inspection on physical exam
  6. Identify where pain from abdominal organs will refer to


Writing Ourselves Into Existence: Healing Through Collaborative Curriculum Development, Bianca Ivette Laureano, Sara C. Flowers DrPH 2018 Woman of Color Sexual Health Network & ANTE UP! Professional Development

Writing Ourselves Into Existence: Healing Through Collaborative Curriculum Development, Bianca Ivette Laureano, Sara C. Flowers Drph

Journal of Critical Thought and Praxis

Here we offer an open exchange / evaluation of our experience as facilitator and editor (Bianca) and writer and collaborator (Sara) during the inaugural Women of Color Sexual Health Network Curriculum Lab which took place November 2017 in New Orleans, LA. In two months, 7 women and femmes of color who are sexuality educators wrote a robust curriculum for our communities that centers pleasure, social emotional learning competencies as early Freedom Schools implemented, sex and pleasure positive, using an intersectional framework and praxis, disability justice framework, inclusive of LGBTQ communities, and does not assume HIV negative status. This is one of ...


Proteomic Profiling Of Serum Derived Exosomes From Prostate Cancer Patients, David Turay 2018 Selected Works

Proteomic Profiling Of Serum Derived Exosomes From Prostate Cancer Patients, David Turay

David Turay, MD

Touted among the major achievements in the diagnosis and management of Prostate cancer (PCa) in the past few decades has been, the dramatic decline of men with advanced/metastatic PCa at diagnosis coupled with a significant improvement ( >90%) in the five and ten year survival rates of the disease. Non-palpable PCa (potentially clinically treatable disease) now accounts for 70-80% of all newly diagnosed cases of PCa. Preceding these changes by about a decade was the introduction of Prostatic Specific Antigen (PSA) into clinical practice; first as biomarker for monitoring response to therapy and subsequently as a complementary screening tool. It ...


Congenital Heart Defects And Ciliopathies Associated With Renal Phenotypes, George C. Gabriel, Gregory J. Pazour, Cecilia W. Lo 2018 University of Pittsburgh

Congenital Heart Defects And Ciliopathies Associated With Renal Phenotypes, George C. Gabriel, Gregory J. Pazour, Cecilia W. Lo

Open Access Articles

Congenital heart disease (CHD) is one of the most common birth defects, and recent studies indicate cilia-related mutations play a central role in the genetic etiology of CHD. As cilia are also known to have important roles in kidney development and disease, it is not surprising that renal anomalies were found to be enriched among CHD mutant mice recovered in a large-scale mouse forward genetic screen. Indeed 42% of mutations identified to cause both CHD and renal anomalies were cilia-related. Many of these cilia mutations comprise cilia transition zone or inversin compartment components, consistent with the known role of these ...


Improving Techniques To Study Equine Cervical Mucociliary Clearance, Melissa A. Hawkes 2018 University of Maine

Improving Techniques To Study Equine Cervical Mucociliary Clearance, Melissa A. Hawkes

Electronic Theses and Dissertations

Bacterial uterine infections inflict major losses on the equine breeding industry. These infections usually arise from bacteria introduced at breeding. Micro-currents propelled by ciliated cells between the folds of the uterus and cervix have been proposed as a means by which contaminants are expelled. Previous data have shown possible ciliary micro-currents propelling carbon particles, occasionally rotating, through cervical folds. However, adherence to the epithelium may have interfered with movement of carbon in these studies. Therefore, we tested potentially non-adherent substances to reveal ciliary micro-currents on the equine cervix under high magnification video-endoscopy. We hypothesized that polyethylene green microspheres 1 - 5 ...


Identifying What Matters To Hysterectomy Patients: Postsurgery Perceptions, Beliefs, And Experiences, Andrew S. Bossick, Roopina Sangha, Heather Olden, Gwen L. Alexander, Ganesa Wegienka 2018 Henry Ford Health System

Identifying What Matters To Hysterectomy Patients: Postsurgery Perceptions, Beliefs, And Experiences, Andrew S. Bossick, Roopina Sangha, Heather Olden, Gwen L. Alexander, Ganesa Wegienka

Journal of Patient-Centered Research and Reviews

Purpose: Hysterectomy is the most common nonobstetrical surgery for women in the United States. Few investigations comparing hysterectomy surgical approaches include patient-centered outcomes.

Methods: The study was performed at Henry Ford Health System (Detroit, MI) between February 2015 and May 2015. A total of 1,038 eligible women — those 18 to 65 years of age and who had an electronic medical record-documented Current Procedural Terminology (CPT®) code or an International Statistical Classification of Diseases, Ninth Edition (ICD-9) code of hysterectomy between December 2012 and December 2014 — were selected and recruited. A question guide was developed to investigate women’s experiences ...


The Needs Of Women Treated For Ovarian Cancer: Results From A #Gyncsm Twitter Chat, Teresa Hagan Thomas, Karin Nauth-Shelley, Michael A. Thompson, Deanna J. Attai, Matthew S. Katz, David Graham, Dee Sparacio, Christina Lizaso, Audun Utengen, Don S. Dizon 2018 University of Pittsburgh School of Nursing

The Needs Of Women Treated For Ovarian Cancer: Results From A #Gyncsm Twitter Chat, Teresa Hagan Thomas, Karin Nauth-Shelley, Michael A. Thompson, Deanna J. Attai, Matthew S. Katz, David Graham, Dee Sparacio, Christina Lizaso, Audun Utengen, Don S. Dizon

Journal of Patient-Centered Research and Reviews

Purpose: Ovarian cancer is the most fatal of all gynecologic cancers, with a high relapse rate regardless of stage. Women treated for ovarian cancer, therefore, likely have supportive care needs that extend well beyond the time frame of first-line therapy. Unfortunately, there is minimal data describing these needs. The purpose of this qualitative study is to understand the supportive care needs of women with ovarian care at the end of treatment.

Methods: To better understand the issues faced by women with ovarian cancer, we conducted a public Twitter chat in collaboration with gynecologic cancer social media (#gyncsm). Both quantitative and ...


Why American Parents Circumcise Their Sons: An Integrative Review Of Literature, Lacy Lauber 2017 DePaul University

Why American Parents Circumcise Their Sons: An Integrative Review Of Literature, Lacy Lauber

Grace Peterson Nursing Research Colloquium

Background: Since medical evidence supports both pros and cons of routine neonatal male circumcision, expectant and new parents are left to make the decision to circumcise their sons on their own. There is limited research as to why American parents choose to circumcise their newborn sons.

Objectives: The purpose of this integrative literature review is to identify the reasons behind parental decision making in neonatal male circumcision in the United States. Understanding motivating factors in parental decision-making can highlight areas of prenatal education for expectant parents.

Method: An integrative literature review was conducted utilizing these online databases: PubMed, The Cumulative ...


Robustness Of A Newly Proposed Risk Schema For Lymphatic Dissemination In Endometrioid Endometrial Cancer, Danielle M. Greer, Jessica J.F. Kram, Callie M. Cox Bauer, Scott A. Kamelle 2017 Aurora University of Wisconsin Medical Group; Center for Urban Population Health

Robustness Of A Newly Proposed Risk Schema For Lymphatic Dissemination In Endometrioid Endometrial Cancer, Danielle M. Greer, Jessica J.F. Kram, Callie M. Cox Bauer, Scott A. Kamelle

Journal of Patient-Centered Research and Reviews

Background: Surgical management for endometrioid endometrial cancer (EEC) includes complete lymph node dissection for all patients at risk of lymphatic dissemination. The standard risk schema, defined by Mayo Clinic, identifies low-risk patients as those with grade 1/2 EEC, myometrial invasion (MI) ≤ 50%, and tumor diameter (TD) ≤ 2 cm. We recently proposed (and published) a risk schema containing modified forms of grade, MI and TD that suggests a significant decrease in false-negative rate and need for lymphadenectomy in low-risk women.

Purpose: Evaluate robustness of our proposed schema for lymphatic dissemination risk stratification in a subsequent EEC patient cohort.

Methods: We ...


Maternal Intuition Of Fetal Gender, Michael McFadzen, David P. Dielentheis, Ronda Kasten, Maharaj Singh, Joe Grundle 2017 Obstetrics/Gynecology, Aurora Sheboygan Clinic, Aurora Health Care

Maternal Intuition Of Fetal Gender, Michael Mcfadzen, David P. Dielentheis, Ronda Kasten, Maharaj Singh, Joe Grundle

Journal of Patient-Centered Research and Reviews

Purpose: Fetal gender speculation is a preoccupation of many expecting parents, and pregnant women commonly profess to intuitively know the gender of their unborn babies. This study objectively compared pregnant mothers’ perceptions of fetal gender to sonographically proven gender determinations. Also, success rates from previously published studies, noninvasive prenatal testing and a myriad of gender determination methods were observed and reported for context.

Methods: All pregnant women presenting for second-trimester screening ultrasound (at 17–23 weeks gestation) in the obstetrics department of a single health center were asked to participate. A medical sonographer described the ultrasound examination, obtained appropriate consent ...


Is It Really Possible To Enlarge The Penis Naturally With Exercises.Docx, David Trust 2017 Andrology Institute

Is It Really Possible To Enlarge The Penis Naturally With Exercises.Docx, David Trust

David Trust

According to studies over the years, approximately 90 to 95% of men are not comfortable with the size of their penis. Despite all the polemics, it is known that 90% of penises are the same length when erect, around 15 centimetres. But, no man is completely satisfied with belonging only to that part of the "average", they always want a little more.
Currently, there is a lot of information about penis enlargement, and there are also several methods that claim to be effective at increasing penis enlargement. We will show you the most popular methods to increase the length and ...


Chat Expression In Chlamydia Muridarum-Infected Female Murine Genital Tract, Hallie Sartain 2017 East Tennessee State University

Chat Expression In Chlamydia Muridarum-Infected Female Murine Genital Tract, Hallie Sartain

Undergraduate Honors Theses

Chlamydia trachomatis is the most prevalent agent of bacterial sexually transmitted infections in the world. However, a profuse number of cases are unreported, as the infection is often asymptomatic. Sequelae such as pelvic inflammatory disease, an increased risk of cervical cancer, premature birth, and perinatal infections in pregnant women can occur. Inflammation occurs in the body in response to infection or injury. Although inflammation can lead to some unwanted secondary effects, such as pain, it serves to return the body to homeostasis by restoring injured tissues and eliminating pathogens. One recently identified connection between the central nervous system and the ...


Cytoplasmic Induction And Over-Expression Of Cyclooxygenase-2 In Human Prostate Cancer: Implications For Prevention And Treatment, S. Madaan, P. D. Abel, K. S. Chaudhary, R. Hewitt, M. A. Stott, G. W.H. Stamp, El-Nasir Lalani 2016 Imperial College School of Medicine

Cytoplasmic Induction And Over-Expression Of Cyclooxygenase-2 In Human Prostate Cancer: Implications For Prevention And Treatment, S. Madaan, P. D. Abel, K. S. Chaudhary, R. Hewitt, M. A. Stott, G. W.H. Stamp, El-Nasir Lalani

El Nasir Lalani

Objective: To assess the level and morphological distribution of cyclooxygenase (COX)-1 and -2 in human prostates and to determine any association with the Gleason grade of prostate cancer.

Materials and Methods: The study comprised 30 samples from patients with benign prostatic hyperplasia (BPH) and 82 with prostate cancer. Immunohistochemistry was used to assess the expression of COX-1 and -2, and 13 samples were also assessed using immunoblotting (six BPH and seven cancers).

Results: For both BPH and prostate cancer, COX-1 expression was primarily in the fibromuscular stroma, with variable weak cytoplasmic expression in glandular/neoplastic epithelial cells. In contrast ...


Store Operated Calcium Entry In Glomerular Mesangial Cells And Diabetic Nephropathy, Sarika Chaudhari 2016 University of North Texas Health Science Center at Fort Worth

Store Operated Calcium Entry In Glomerular Mesangial Cells And Diabetic Nephropathy, Sarika Chaudhari

Theses and Dissertations

Glomerular mesangial cells (MCs) are the major source of extracellular matrix (ECM). One of the early pathological changes in diabetic nephropathy (DN) is accumulation of ECM in glomeruli. Multifunctional store-operated Ca2+ entry (SOCE) regulates MC function. However, whether and how SOCE in MCs contributes to pathophysiology of DN remains unknown. The aim of the study was to investigate association of SOCE in MCs with ECM protein expression and the underlying mechanism using both in vitro and in vivo systems.

Study I was to determine the effect of diabetes on SOCE. In cultured human MCs, we found that prolonged high ...


Ultrasonography Of The Scrotum In Adults, Anna L. Kuhn, Eduardo Scortegagna, Kristina M. Nowitzki, Young H. Kim 2016 University of Massachusetts Medical School

Ultrasonography Of The Scrotum In Adults, Anna L. Kuhn, Eduardo Scortegagna, Kristina M. Nowitzki, Young H. Kim

Radiology Publications and Presentations

Ultrasonography is the ideal noninvasive imaging modality for evaluation of scrotal abnormalities. It is capable of differentiating the most important etiologies of acute scrotal pain and swelling, including epididymitis and testicular torsion, and is the imaging modality of choice in acute scrotal trauma. In patients presenting with palpable abnormality or scrotal swelling, ultrasonography can detect, locate, and characterize both intratesticular and extratesticular masses and other abnormalities. A 12-17 MHz high frequency linear array transducer provides excellent anatomic detail of the testicles and surrounding structures. In addition, vascular perfusion can be easily assessed using color and spectral Doppler analysis. In most ...


Proteomic Profiling Of Serum Derived Exosomes From Prostate Cancer Patients, David Turay 2016 Loma Linda University

Proteomic Profiling Of Serum Derived Exosomes From Prostate Cancer Patients, David Turay

Loma Linda University Electronic Theses, Dissertations & Projects

Touted among the major achievements in the diagnosis and management of Prostate cancer (PCa) in the past few decades has been, the dramatic decline of men with advanced/metastatic PCa at diagnosis coupled with a significant improvement ( >90%) in the five and ten year survival rates of the disease. Non-palpable PCa (potentially clinically treatable disease) now accounts for 70-80% of all newly diagnosed cases of PCa. Preceding these changes by about a decade was the introduction of Prostatic Specific Antigen (PSA) into clinical practice; first as biomarker for monitoring response to therapy and subsequently as a complementary screening tool. It ...


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