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Robustness Of A Newly Proposed Risk Schema For Lymphatic Dissemination In Endometrioid Endometrial Cancer, Danielle M. Greer, Jessica J.F. Kram, Callie M. Cox Bauer, Scott A. Kamelle 2017 Aurora University of Wisconsin Medical Group; Center for Urban Population Health

Robustness Of A Newly Proposed Risk Schema For Lymphatic Dissemination In Endometrioid Endometrial Cancer, Danielle M. Greer, Jessica J.F. Kram, Callie M. Cox Bauer, Scott A. Kamelle

Journal of Patient-Centered Research and Reviews

Background: Surgical management for endometrioid endometrial cancer (EEC) includes complete lymph node dissection for all patients at risk of lymphatic dissemination. The standard risk schema, defined by Mayo Clinic, identifies low-risk patients as those with grade 1/2 EEC, myometrial invasion (MI) ≤ 50%, and tumor diameter (TD) ≤ 2 cm. We recently proposed (and published) a risk schema containing modified forms of grade, MI and TD that suggests a significant decrease in false-negative rate and need for lymphadenectomy in low-risk women.

Purpose: Evaluate robustness of our proposed schema for lymphatic dissemination risk stratification in a subsequent EEC patient cohort.

Methods: We ...


Maternal Intuition Of Fetal Gender, Michael McFadzen, David P. Dielentheis, Ronda Kasten, Maharaj Singh, Joe Grundle 2017 Obstetrics/Gynecology, Aurora Sheboygan Clinic, Aurora Health Care

Maternal Intuition Of Fetal Gender, Michael Mcfadzen, David P. Dielentheis, Ronda Kasten, Maharaj Singh, Joe Grundle

Journal of Patient-Centered Research and Reviews

Purpose: Fetal gender speculation is a preoccupation of many expecting parents, and pregnant women commonly profess to intuitively know the gender of their unborn babies. This study objectively compared pregnant mothers’ perceptions of fetal gender to sonographically proven gender determinations. Also, success rates from previously published studies, noninvasive prenatal testing and a myriad of gender determination methods were observed and reported for context.

Methods: All pregnant women presenting for second-trimester screening ultrasound (at 17–23 weeks gestation) in the obstetrics department of a single health center were asked to participate. A medical sonographer described the ultrasound examination, obtained appropriate consent ...


Is It Really Possible To Enlarge The Penis Naturally With Exercises.Docx, David Trust 2017 Andrology Institute

Is It Really Possible To Enlarge The Penis Naturally With Exercises.Docx, David Trust

David Trust

According to studies over the years, approximately 90 to 95% of men are not comfortable with the size of their penis. Despite all the polemics, it is known that 90% of penises are the same length when erect, around 15 centimetres. But, no man is completely satisfied with belonging only to that part of the "average", they always want a little more.
Currently, there is a lot of information about penis enlargement, and there are also several methods that claim to be effective at increasing penis enlargement. We will show you the most popular methods to increase the length and ...


Ethnic Disparity In 21-Hydroxylase Gene Mutations Identified In Pakistani Congenital Adrenal Hyperplasia Patient, Aysha Habib Khan, Muniba Aban, Jamal Raza, Naeem ul Haq, Abdul Jabbar, Tariq Moatter 2016 Aga Khan University

Ethnic Disparity In 21-Hydroxylase Gene Mutations Identified In Pakistani Congenital Adrenal Hyperplasia Patient, Aysha Habib Khan, Muniba Aban, Jamal Raza, Naeem Ul Haq, Abdul Jabbar, Tariq Moatter

Aysha Habib

Background: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders caused by defects in the steroid 21 hydroxylase gene (CYP21A2). We studied the spectrum of mutations in CYP21A2 gene in a multi-ethnic population in Pakistan to explore the genetics of CAH. Methods: A cross sectional study was conducted for the identification of mutations CYP21A2 and their phenotypic associations in CAH using ARMS-PCR assay. Results: Overall, 29 patients were analyzed for nine different mutations. The group consisted of two major forms of CAH including 17 salt wasters and 12 simple virilizers. There were 14 phenotypic males and 15 females ...


Ultrasonography Of The Scrotum In Adults, Anna L. Kuhn, Eduardo Scortegagna, Kristina M. Nowitzki, Young H. Kim 2016 University of Massachusetts Medical School

Ultrasonography Of The Scrotum In Adults, Anna L. Kuhn, Eduardo Scortegagna, Kristina M. Nowitzki, Young H. Kim

Radiology Publications and Presentations

Ultrasonography is the ideal noninvasive imaging modality for evaluation of scrotal abnormalities. It is capable of differentiating the most important etiologies of acute scrotal pain and swelling, including epididymitis and testicular torsion, and is the imaging modality of choice in acute scrotal trauma. In patients presenting with palpable abnormality or scrotal swelling, ultrasonography can detect, locate, and characterize both intratesticular and extratesticular masses and other abnormalities. A 12-17 MHz high frequency linear array transducer provides excellent anatomic detail of the testicles and surrounding structures. In addition, vascular perfusion can be easily assessed using color and spectral Doppler analysis. In most ...


Proteomic Profiling Of Serum Derived Exosomes From Prostate Cancer Patients, David Turay 2016 Loma Linda University

Proteomic Profiling Of Serum Derived Exosomes From Prostate Cancer Patients, David Turay

Loma Linda University Electronic Theses, Dissertations & Projects

Touted among the major achievements in the diagnosis and management of Prostate cancer (PCa) in the past few decades has been, the dramatic decline of men with advanced/metastatic PCa at diagnosis coupled with a significant improvement ( >90%) in the five and ten year survival rates of the disease. Non-palpable PCa (potentially clinically treatable disease) now accounts for 70-80% of all newly diagnosed cases of PCa. Preceding these changes by about a decade was the introduction of Prostatic Specific Antigen (PSA) into clinical practice; first as biomarker for monitoring response to therapy and subsequently as a complementary screening tool. It ...


Current And Past Menstrual Status Is An Important Determinant Of Femoral Neck Geometry In Exercising Women, Rebecca J. Mallinson, Nancy I. Williams, Jenna C. Gibbs, Karsten Koehler, Heather C.M. Allaway, Emily Southmayd, M. J. De Souza 2016 The Pennsylvania State University

Current And Past Menstrual Status Is An Important Determinant Of Femoral Neck Geometry In Exercising Women, Rebecca J. Mallinson, Nancy I. Williams, Jenna C. Gibbs, Karsten Koehler, Heather C.M. Allaway, Emily Southmayd, M. J. De Souza

Nutrition and Health Sciences -- Faculty Publications

Menstrual status, both past and current, has been established as an important determinant of bone mineral density (BMD) in young exercising women. However, little is known regarding the association between the cumulative effect of menstrual status and indices of bone health beyond BMD, such as bone geometry and estimated bone strength.

Purpose: This study explores the association between cumulative menstrual status and indices of bone health assessed using dualenergy x-ray absorptiometry (DXA), including femoral neck geometry and strength and areal BMD (aBMD), in exercising women.

Methods: 101 exercising women (22.0 ± 0.4 years, BMI 21.0 ± 0.2 kg ...


Medical Help-Seeking For Sexual Concerns In Prostate Cancer Survivors, Melissa K. Hyde, Leah Zajdlewicz, Addie C. Wootten, Christian J. Nelson, Anthony Lowe, Jeff Dunn, Suzanne K. Chambers 2016 Edith Cowan University

Medical Help-Seeking For Sexual Concerns In Prostate Cancer Survivors, Melissa K. Hyde, Leah Zajdlewicz, Addie C. Wootten, Christian J. Nelson, Anthony Lowe, Jeff Dunn, Suzanne K. Chambers

ECU Publications Post 2013

Introduction: Although sexual dysfunction is common after prostate cancer, men's decisions to seek help for sexual concerns are not well understood.

Aim: Describe predictors of actual prior help-seeking and intended future medical help-seeking for sexual dysfunction in prostate cancer survivors.

Methods: A cross-sectional survey of 510 prostate cancer survivors assessed masculine beliefs, attitudes, support/approval from partner/peer networks (subjective norm), and perceived control as predictors of medical help-seeking for sexual concerns. A theory of planned behavior (TPB) perspective was used to examine actual prior and planned future behavior and contributing factors. Statistical analyses included multiple and logistic regressions ...


Gating Of The Polycystin Ion Channel Signaling Complex In Neurons And Kidney Cells, Patrick Delmas, Surya Nauli, Xiaogang Li, Bertrand Coste, Nancy Osorio, Marcel Crest, David Brown, Jing Zhou 2015 IFR Jean Roche

Gating Of The Polycystin Ion Channel Signaling Complex In Neurons And Kidney Cells, Patrick Delmas, Surya Nauli, Xiaogang Li, Bertrand Coste, Nancy Osorio, Marcel Crest, David Brown, Jing Zhou

David C. Brown

Mutations in either polycystin-2 (PC2) or polycystin-1 (PC1) proteins cause severe, potentially lethal, kidney disorders and multiple extrarenal (including brain) disease phenotypes. PC2, a member of the transient receptor potential channel superfamily, and PC1, an orphan membrane receptor of largely unknown function, are thought to be part of a common signaling pathway. Here, we show that in rat sympathetic neurons and kidney cells, coassembly of full-length PC1 with PC2 forms a plasmalemmal ion channel signaling complex in which PC1 stimulation simultaneously activates PC2 ion channels and G(i/o)-proteins. PC2 activation occurs through a structural rearrangement of PC1, independent ...


Tiki_Goddess 2015 Biotechniques, May Issue Cover, George McNamara 2015 M.D. Anderson Cancer Center

Tiki_Goddess 2015 Biotechniques, May Issue Cover, George Mcnamara

George McNamara

May 2015 Biotechniques cover

http://www.biotechniques.com/BiotechniquesJournal/2015/May/

Cover: "Tiki Goddess" trichrome stained frontal baby mouse tissue section. Image courtesy of George McNamara, L.J.N Cooper Lab, M.D Anderson Cancer Center, Houston, TX. Cover design Genevieve McCarthy.

More images of Tiki_Goddess, at a lot higher resolution, is available at the following web pages:

Tiki_Goddess (small file, with back story)

http://home.earthlink.net/~tiki_goddess/

Tiki_Goddess ("full size" for 2000, The full size version is 8.8 Mb, JPEG quality 10 saved with Photoshop CS)

http://home.earthlink.net/~tiki_goddess/TikiGoddess.jpg

Tiki_Goddess on ThorLabs Digital ...


Interstitial Cystitis: The Estrogen Connection, Heather G. Kuruvilla 2015 Cedarville University

Interstitial Cystitis: The Estrogen Connection, Heather G. Kuruvilla

The Research and Scholarship Symposium

Interstitial cystitis (IC), or painful bladder syndrome, is an autoimmune condition with an unknown etiology. Common symptoms include urinary urgency, frequency, and bladder and urethral pain and burning. This condition, like many autoimmune disorders, disproportionately affects females; therefore, female sex hormones are hypothesized to play a role in the disorder. My hypothesis is that estrogen, both endogenous and synthetic, affects the severity of IC symptoms. Through surveying the available literature on interstitial cystitis, I have found that IC symptoms often correlate with low estrogen. My hope is that by understanding more about how hormones affect IC, we can come up ...


Posterior Approach To Kidney Dissection: An Old Surgical Approach For Integrated Medical Curricula, Frank J. Daly, David L. Bolender, Deepali Jain, Sheryl Uyeda, Todd M. Hoagland 2015 University of New England

Posterior Approach To Kidney Dissection: An Old Surgical Approach For Integrated Medical Curricula, Frank J. Daly, David L. Bolender, Deepali Jain, Sheryl Uyeda, Todd M. Hoagland

Biomedical Sciences Faculty Publications

Integrated medical curricular changes are altering the historical regional anatomy approach to abdominal dissection. The renal system is linked physiologically and biochemically to the cardiovascular and respiratory systems, yet anatomist often approach the urinary system as part of the abdomen and pelvic regions. As part of an integrated curriculum, the renal system must be covered relatively quickly after the thorax in the cadaver lab, often without the opportunity to fully appreciate the rest of the abdominal contents. This paper provides dissection instructions that follow the one of the historical surgical approaches for nephrectomy, including preservation of the posterior abdominal wall ...


Urinary Dna Lesions As A Biomarker For Assessing Male Reproductive Health, Hueiwang Anna Jeng, Chih-Hung Pan, Chao Mu-Rong 2015 Old Dominion University

Urinary Dna Lesions As A Biomarker For Assessing Male Reproductive Health, Hueiwang Anna Jeng, Chih-Hung Pan, Chao Mu-Rong

Community & Environmental Health Faculty Publications

The study aimed to examine whether urinary 8-hydroxy-2’-deoxyguanosine (8-OHdG) could serve as a biomarker for assessing sperm DNA integrity. Urine and semen samples were collected from 124 coke-oven workers, who had chronically been exposed to polycyclic aromatic hydrocarbons (PAHs), from a steel plant in Kaohsiung, Taiwan. The coke-oven workers were divided into two subgroups: topside-oven workers and side-oven workers. Sperm DNA integrity was assessed in terms of DNA fragmentation and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo). Urine samples were used to detect 1-hydroxypyrene (1-OHP) and urinary 8-OHdG, which served to assess exposure to PAHs and the whole body oxidative stress, respectively ...


Measurement Of 8-Oxo-7, 8-Dihydro-2' Deoxyguanosine In Human Semen And Urine By Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry With On-Line Solid Phase Extraction: Comparison With A Commercial Available Enzyme-Linked Immunosorbent Assay, Hueiwang A. Jeng, Mu R. Chao, Ruei N. Li, Chih H. Pan, Wen Y. Lin 2015 Old Dominion University

Measurement Of 8-Oxo-7, 8-Dihydro-2' Deoxyguanosine In Human Semen And Urine By Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry With On-Line Solid Phase Extraction: Comparison With A Commercial Available Enzyme-Linked Immunosorbent Assay, Hueiwang A. Jeng, Mu R. Chao, Ruei N. Li, Chih H. Pan, Wen Y. Lin

Community & Environmental Health Faculty Publications

This study aimed to assess the correlation between 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxo-dGuo) in semen and urine, and to compare the analytical methods of the isotope-diluted liquid chromatograph-tandem mass spectrometry (LC-MS/MS) coupled with an on-line Solid-Phase Extraction (SPE) and commercial Enzyme- Linked Immunosorbent Assay (ELISA) used for detecting 8-oxo-dGuo as an oxidative DNA damage marker. Semen and urine samples were simultaneously collected from 85 apparently healthy human subjects. An optimized DNA extraction method was employed to extract DNA from sperm while minimizing oxidation of DNA. All of the biological samples were analyzed by LC-MS/MS and ELISA. All of the ...


Effect Of Age On Uterine And Ovarian Morphology With Polycystic Ovaries, Ambreen Usmani, Rehana Rehman, Aisha Qamar 2014 Bahria University

Effect Of Age On Uterine And Ovarian Morphology With Polycystic Ovaries, Ambreen Usmani, Rehana Rehman, Aisha Qamar

Department of Biological & Biomedical Sciences

Abstract

Objective: To measure the outcome of age on ovarian and uterine morphology in primary infertile women with

polycystic ovaries.

Methods: The observational cross-sectional study was conducted from January 2009 to March 2010, and the

subjects were recruited from Ziauddin Hospital, Nazimabad, Karachi. The primary infertile subjects with polycystic

ovaries were subdivided into two age groups:20-30 years (group I), and 31-40 years (group II). Both groups had equal

number of subjects. The ovarian volume, follicles count and size, uterine area and endometrial thickness were

determined by transabdominal and transvaginal scans. Shapiro-Wilk's test and Mann-Whitney test were applied,

with ...


Intravenous Pyruvate To Prevent Renal Injury Following Cardiac Arrest And Resuscitation, Roger A. Hollrah M.S. 2014 University of North Texas Health Science Center of Fort Worth

Intravenous Pyruvate To Prevent Renal Injury Following Cardiac Arrest And Resuscitation, Roger A. Hollrah M.S.

Theses and Dissertations

Introduction: Cardiac arrest followed by resuscitation and recovery of spontaneous circulation (ROSC) produces systemic ischemia reperfusion (I/R), affecting all internal organs, including the kidney. This type of stress generates both a robust increase in reactive oxygen and nitrogen species (RONS) and an intense inflammatory response, which can result in renal cell death. The glycoprotein erythropoietin (EPO) has been shown to combat renal I/R injury by offering cyto-protection against inflammation and oxidative damage, as well as inhibiting apoptosis. The endogenous intermediary metabolite pyruvate has been observed to stabilize specific genetic machinery responsible for the production of EPO. This study ...


Roles Of Dopamine Receptor On Chemosensory And Mechanosensory Primary Cilia In Renal Epithelial Cells, Viralkumar S. Upadhyay, Brian S. Muntean, Samred H. Kathem, Jangyoun J. Hwang, Wissam A. AbouAlaiwi, Surya M. Nauli 2014 University of Toledo

Roles Of Dopamine Receptor On Chemosensory And Mechanosensory Primary Cilia In Renal Epithelial Cells, Viralkumar S. Upadhyay, Brian S. Muntean, Samred H. Kathem, Jangyoun J. Hwang, Wissam A. Aboualaiwi, Surya M. Nauli

Pharmacy Faculty Articles and Research

Dopamine plays a number of important physiological roles. However, activation of dopamine receptor type-5 (DR5) and its effect in renal epithelial cells have not been studied. Here, we show for the first time that DR5 is localized to primary cilia of LLCPK kidney cells. Renal epithelial cilia are mechanosensory organelles that sense and respond to tubular fluid-flow in the kidney. To determine the roles of DR5 and sensory cilia, we used dopamine to non-selectively and fenoldopam to selectively activate ciliary DR5. Compared to mock treatment, dopamine treated cells significantly increases the length of cilia. Fenoldopam further increases the length of ...


The Hormones Of The Placenta, Shaya Oratz 2014 Touro College

The Hormones Of The Placenta, Shaya Oratz

The Science Journal of the Lander College of Arts and Sciences

The human pregnancy begins with fertilization and implantation. As the embryo evolves and develops within the uterus of the mother, the placenta is formed. The placenta is a transient organ that develops to meet and accommodate specific needs during pregnancy. Its two major functions are the exchange of nutrients and gases between the mother and fetus and its role as an endocrine unit. Through the production and release of many hormones the placenta works to regulate the many necessary physiological changes in the mother in order to maintain the pregnancy, meet the needs of the developing fetus and prepare the ...


3,4,5-Trichloroaniline Nephrotoxicity In Vitro.Pdf, 2013 Selected Works

3,4,5-Trichloroaniline Nephrotoxicity In Vitro.Pdf

Deborah L Preston

Chloroanilines are widely used in the manufacture of drugs, pesticides and industrial intermediates. Among the trichloroanilines, 3,4,5-trichloroaniline (TCA) is the most potent nephrotoxicant in vivo. The purpose of this study was to examine the nephrotoxic potential of TCA in vitro and to determine if renal biotransformation and/or free radicals contributed to TCA cytotoxicity using isolated renal cortical cells (IRCC) from male Fischer 344 rats as the animal model. IRCC (~4 million cells/mL; 3 mL) were incubated with TCA (0, 0.1, 0.25, 0.5 or 1.0 mM) for 60–120 min. In some experiments ...


The Roles Of Primary Cilia In Polycystic Kidney Disease, Samred H. Kathem, Ashraf M. Mohieldin, Surya M. Nauli 2013 Chapman University

The Roles Of Primary Cilia In Polycystic Kidney Disease, Samred H. Kathem, Ashraf M. Mohieldin, Surya M. Nauli

Pharmacy Faculty Articles and Research

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited genetic disorder that results in progressive renal cyst formation with ultimate loss of renal function and other systemic disorders. These systemic disorders include abnormalities in cardiovascular, portal, pancreatic and gastrointestinal systems. ADPKD is considered to be among the ciliopathy diseases due to the association with abnormal primary cilia function. In order to understand the full course of primary cilia and its association with ADPKD, the structure, functions and role of primary cilia have been meticulously investigated. As a result, the focus on primary cilia has emerged to support the vital roles ...


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