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Intranasal Colonization By Streptococcus Pneumoniae Induces Immunological Protection From Pulmonary And Systemic Infection: A Dissertation, Nang H. Maung 2011 University of Massachusetts Medical School

Intranasal Colonization By Streptococcus Pneumoniae Induces Immunological Protection From Pulmonary And Systemic Infection: A Dissertation, Nang H. Maung

GSBS Dissertations and Theses

Given that Streptococcus pneumoniae can cause life-threatening pulmonary and systemic infection, an apparent paradox is that the bacterium resides, usually harmlessly, in the nasopharynx of many people. Humoral immunity is thought to be the primary defense against serious pneumococcal infection, and we hypothesized that nasopharyngeal colonization of mice results in the generation of an antibody response that provides long-term protection against lung infection. We found that survival of of C57L/6 mice after intranasal inoculation with wild-type serotype 4 strain TIGR4 pneumococci required B cells but not T cells, suggesting that nasopharyngeal colonization elicited a protective humoral immune response. In ...


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