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Distortion In Body Schema: The Influence Of Body Fat And Mass On Perceptions Of Personal Size, Katarina Ann Ferrucci 2017 Bard College

Distortion In Body Schema: The Influence Of Body Fat And Mass On Perceptions Of Personal Size, Katarina Ann Ferrucci

Senior Projects Spring 2017

Obesity has been linked with a myriad of negative outcomes for both physical and mental health including feeding and eating disorders and cognitive impairments that affect perception of body size. Understanding the cognitive mechanisms and physiological factors that contribute to perception of body size may help us to comprehend how obesity impacts the construction and development of one’s mental body representations. Previous research by Scarpina, Castelnuovo, and Molinari (2014) suggests that, compared to those with a normal Body Mass Index, individuals with a BMI greater than 30 (obese) not only inaccurately estimate tactile and mental distances on their own ...


Contributions Of Myd88-Dependent Receptors And Cd11c-Positive Cells To Corneal Epithelial Barrier Function Against Pseudomonas Aeruginosa, Matteo M. E. Metruccio, Connie Tam, David J. Evans, Anna L. Xie, Michael E. Stern, Suzanne M. J. Fleiszig 2017 Touro University California

Contributions Of Myd88-Dependent Receptors And Cd11c-Positive Cells To Corneal Epithelial Barrier Function Against Pseudomonas Aeruginosa, Matteo M. E. Metruccio, Connie Tam, David J. Evans, Anna L. Xie, Michael E. Stern, Suzanne M. J. Fleiszig

College of Pharmacy (TUC) Publications and Research

Previously we reported that corneal epithelial barrier function against Pseudomonas aeruginosa was MyD88-dependent. Here, we explored contributions of MyD88-dependent receptors using vital mouse eyes and confocal imaging. Uninjured IL-1R (−/−) or TLR4 (−/−) corneas, but not TLR2 (−/−), TLR5 (−/−), TLR7 (−/−), or TLR9 (−/−), were more susceptible to P. aeruginosa adhesion than wild-type (3.8-fold, 3.6-fold respectively). Bacteria adherent to the corneas of IL-1R (−/−) or TLR5 (−/−) mice penetrated beyond the epithelial surface only if the cornea was superficially-injured. Bone marrow chimeras showed that bone marrow-derived cells contributed to IL-1R-dependent barrier function. In vivo, but not ex vivo, stromal CD11c+ cells responded to bacterial challenge ...


An Investigation Into Spike-Based Neuromorphic Approaches For Artificial Olfactory Systems, Anup Vanarse, Adam Osseiran, Alexander Rassau 2017 Edith Cowan University

An Investigation Into Spike-Based Neuromorphic Approaches For Artificial Olfactory Systems, Anup Vanarse, Adam Osseiran, Alexander Rassau

ECU Publications Post 2013

The implementation of neuromorphic methods has delivered promising results for vision and auditory sensors. These methods focus on mimicking the neuro-biological architecture to generate and process spike-based information with minimal power consumption. With increasing interest in developing low-power and robust chemical sensors, the application of neuromorphic engineering concepts for electronic noses has provided an impetus for research focusing on improving these instruments. While conventional e-noses apply computationally expensive and power-consuming data-processing strategies, neuromorphic olfactory sensors implement the biological olfaction principles found in humans and insects to simplify the handling of multivariate sensory data by generating and processing spike-based information. Over ...


Youth Recreational Firearm User’S Shooting Habits, Use Of Hearing Protection Devices And Self-Assessed Auditory Status, Kayla Howerton 2016 University of Northern Colorado

Youth Recreational Firearm User’S Shooting Habits, Use Of Hearing Protection Devices And Self-Assessed Auditory Status, Kayla Howerton

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

No abstract provided.


“My Logic Is Undeniable”: Replicating The Brain For Ideal Artificial Intelligence, Samuel C. Adams 2016 Liberty University

“My Logic Is Undeniable”: Replicating The Brain For Ideal Artificial Intelligence, Samuel C. Adams

Senior Honors Theses

Alan Turing asked if machines can think, but intelligence is more than logic and reason. I ask if a machine can feel pain or joy, have visions and dreams, or paint a masterpiece. The human brain sets the bar high, and despite our progress, artificial intelligence has a long way to go. Studying neurology from a software engineer’s perspective reveals numerous uncanny similarities between the functionality of the brain and that of a computer. If the brain is a biological computer, then it is the embodiment of artificial intelligence beyond anything we have yet achieved, and its architecture is ...


Complementary Control Of Sensory Adaptation By Two Types Of Cortical Interneurons, Ryan G. Natan, John J. Briguglio, Laetitia Mwilambwe-Tshilobo, Sara I. Jones, Mark Aizenberg, Ethan M. Goldberg, Maria N. Geffen 2015 University of Pennsylvania

Complementary Control Of Sensory Adaptation By Two Types Of Cortical Interneurons, Ryan G. Natan, John J. Briguglio, Laetitia Mwilambwe-Tshilobo, Sara I. Jones, Mark Aizenberg, Ethan M. Goldberg, Maria N. Geffen

BBB Major Publications

Reliably detecting unexpected sounds is important for environmental awareness and survival. By selectively reducing responses to frequently, but not rarely, occurring sounds, auditory cortical neurons are thought to enhance the brain's ability to detect unexpected events through stimulus-specific adaptation (SSA). The majority of neurons in the primary auditory cortex exhibit SSA, yet little is known about the underlying cortical circuits. We found that two types of cortical interneurons differentially amplify SSA in putative excitatory neurons. Parvalbumin-positive interneurons (PVs) amplify SSA by providing non-specific inhibition: optogenetic suppression of PVs led to an equal increase in responses to frequent and rare ...


Hdac I Inhibition In The Dorsal And Ventral Hippocampus Differentially Modulates Predator-Odor Fear Learning And Generalization, Robin K. Yuan, Jenna C. Hebert, Arthur S. Thomas, Ellen G. Wann, Isabel A. Muzzio 2015 University of Pennsylvania

Hdac I Inhibition In The Dorsal And Ventral Hippocampus Differentially Modulates Predator-Odor Fear Learning And Generalization, Robin K. Yuan, Jenna C. Hebert, Arthur S. Thomas, Ellen G. Wann, Isabel A. Muzzio

BBB Major Publications

Although predator odors are ethologically relevant stimuli for rodents, the molecular pathways and contribution of some brain regions involved in predator odor conditioning remain elusive. Inhibition of histone deacetylases (HDACs) in the dorsal hippocampus has been shown to enhance shock-induced contextual fear learning, but it is unknown if HDACs have differential effects along the dorso-ventral hippocampal axis during predator odor fear learning. We injected MS-275, a class I HDAC inhibitor, bilaterally in the dorsal or ventral hippocampus of mice and found that it had no effects on innate anxiety in either region. We then assessed the effects of MS-275 at ...


Neuroprotective Effects Of Brn3b In Pc12 Cells And Retinal Ganglion Cells Under Glaucomatous Conditions, Nitasha R. Phatak 2015 University of North Texas Health Science Center at Fort Worth

Neuroprotective Effects Of Brn3b In Pc12 Cells And Retinal Ganglion Cells Under Glaucomatous Conditions, Nitasha R. Phatak

Theses and Dissertations

Glaucoma is a group of chronic progressive optic neuropathies commonly characterized by elevated intraocular pressure (IOP) (a subset of glaucoma patients display neurodegenerative effects at ‘normal’ IOP) leading to axonal degeneration, optic nerve head cupping and apoptosis of retinal ganglion cell death (RGCs), which result in visual field defects and blindness. While there are medications available to lower IOP, there is an unmet need for neuroprotective treatments for glaucoma, since some neurodegenerative effects persist despite lowering IOP.

The main focus of this study was on the class 4 POU domain transcription factor, Brn3b, which has been shown to play a ...


Interaction Among Gustation, Olfaction, And Vision In Flavor Identification, Michael Lauth 2015 California Polytechnic State University San Luis Obispo

Interaction Among Gustation, Olfaction, And Vision In Flavor Identification, Michael Lauth

Michael Lauth

Even though the senses of taste, smell, and sight are distinct, there is a significant overlap among them in our perceptions of objects that helps us understand and differentiate the world. Everyone has experienced, when his or her nose gets congested, that his or her sense of taste changes as well. Many individuals do not equally understand the top-down processing with taste when someone sees objects they are about to eat. In the replicated study by our principle investigator, a random convenience sample of young adults (n=162) were recruited and tested to determine if they could taste four Jelly ...


Tiki_Goddess 2015 Biotechniques, May Issue Cover, George McNamara 2015 M.D. Anderson Cancer Center

Tiki_Goddess 2015 Biotechniques, May Issue Cover, George Mcnamara

George McNamara

May 2015 Biotechniques cover

http://www.biotechniques.com/BiotechniquesJournal/2015/May/

Cover: "Tiki Goddess" trichrome stained frontal baby mouse tissue section. Image courtesy of George McNamara, L.J.N Cooper Lab, M.D Anderson Cancer Center, Houston, TX. Cover design Genevieve McCarthy.

More images of Tiki_Goddess, at a lot higher resolution, is available at the following web pages:

Tiki_Goddess (small file, with back story)

http://home.earthlink.net/~tiki_goddess/

Tiki_Goddess ("full size" for 2000, The full size version is 8.8 Mb, JPEG quality 10 saved with Photoshop CS)

http://home.earthlink.net/~tiki_goddess/TikiGoddess.jpg

Tiki_Goddess on ThorLabs Digital ...


Olfactory Thresholds Of The U.S. Population Of Home-Dwelling Older Adults: Development And Validation Of A Short, Reliable Measure, David W. Kern, L Phillip Schumm, Kristen E. Wroblewski, Jayant M. Pinto, Thomas Hummel 2015 Northeastern Illinois University

Olfactory Thresholds Of The U.S. Population Of Home-Dwelling Older Adults: Development And Validation Of A Short, Reliable Measure, David W. Kern, L Phillip Schumm, Kristen E. Wroblewski, Jayant M. Pinto, Thomas Hummel

Psychology & Gerontology Faculty Publications

Current methods of olfactory sensitivity testing are logistically challenging and therefore infeasible for use in in-home surveys and other field settings. We developed a fast, easy and reliable method of assessing olfactory thresholds, and used it in the first study of olfactory sensitivity in a nationally representative sample of U.S. home-dwelling older adults. We validated our method via computer simulation together with a model estimated from 590 normosmics. Simulated subjects were assigned n-butanol thresholds drawn from the estimated normosmic distribution and based on these and the model, we simulated administration of both the staircase and constant stimuli methods ...


Hearing Loss From Traumatic Brain Injury, Nathan Young 2015 Parkland College

Hearing Loss From Traumatic Brain Injury, Nathan Young

A with Honors Projects

Traumatic brain injury to the parts of the brain responsible for processing auditory information can result in hearing loss that is difficult to assess and treat. Symptoms can include difficulty in filtering background noises or filtering out specific sounds, confusion, and disorientation or nausea. Treatment of this type of hearing loss varies, but primarily consists of psychological treatment focused around rehabilitation and coping.


Olfactory Dysfunction Predicts 5-Year Mortality In Older Adults, Jayant M. Pinto, Kristen E. Wroblewski, David W. Kern, L Phillip Schumm, Martha K. McClintock 2014 University of Chicago

Olfactory Dysfunction Predicts 5-Year Mortality In Older Adults, Jayant M. Pinto, Kristen E. Wroblewski, David W. Kern, L Phillip Schumm, Martha K. Mcclintock

Psychology & Gerontology Faculty Publications

Prediction of mortality has focused on disease and frailty, although antecedent biomarkers may herald broad physiological decline. Olfaction, an ancestral chemical system, is a strong candidate biomarker because it is linked to diverse physiological processes. We sought to determine if olfactory dysfunction is a harbinger of 5-year mortality in the National Social Life, Health and Aging Project [NSHAP], a nationally representative sample of older U.S. adults. 3,005 community-dwelling adults aged 57–85 were studied in 2005–6 (Wave 1) and their mortality determined in 2010–11 (Wave 2). Olfactory dysfunction, determined objectively at Wave 1, was used to ...


Atypical Multisensory Integration In Niemann-Pick Type C Disease – Towards Potential Biomarkers, Gizely N. Andrade, Sophie Molholm, John S. Butler, Alice Brown Brandwein, Steven U. Walkley, John J. Foxe 2014 CUNY Graduate Center

Atypical Multisensory Integration In Niemann-Pick Type C Disease – Towards Potential Biomarkers, Gizely N. Andrade, Sophie Molholm, John S. Butler, Alice Brown Brandwein, Steven U. Walkley, John J. Foxe

Publications and Research

Background: Niemann-Pick type C (NPC) is an autosomal recessive disease in which cholesterol and glycosphingolipids accumulate in lysosomes due to aberrant cell-transport mechanisms. It is characterized by progressive and ultimately terminal neurological disease, but both pre-clinical studies and direct human trials are underway to test the safety and efficacy of cholesterol clearing compounds, with good success already observed in animal models. Key to assessing the effectiveness of interventions in patients, however, is the development of objective neurobiological outcome measures. Multisensory integration mechanisms present as an excellent candidate since they necessarily rely on the fidelity of long-range neural connections between the ...


Cx3cl1 (Fractalkine) Protein Expression In Normal And Degenerating Mouse Retina: In Vivo Studies, Marina Zieger, Peter K. Ahnelt, Pavel Uhrin 2014 University of Massachusetts Medical School

Cx3cl1 (Fractalkine) Protein Expression In Normal And Degenerating Mouse Retina: In Vivo Studies, Marina Zieger, Peter K. Ahnelt, Pavel Uhrin

Open Access Articles

We aimed to investigate fractalkine (CX3CL1) protein expression in wild type (wt) retina and its alterations during retinal degeneration in mouse model (rd10) of retinitis pigmentosa. Forms of retinal protein CX3CL1, total protein and mRNA levels of CX3CL1 were analyzed at postnatal days (P) 5, 10, 14, 22, 30, 45, and 60 by Western blotting and real-time PCR. Cellular sources of CX3CL1 were investigated by in situ hybridization histochemistry (ISH) and using transgenic (CX3CL1cherry) mice. The immunoblots revealed that in both, wt and rd10 retinas, a membrane integrated approximately 100 kDa CX3CL1 form and a cleaved approximately 85 kDa CX3CL1 ...


Involvement Of Caspase-7 In Photoreceptor And Retinal Ganglion Cell Death, Shreyasi Choudhury M.S. 2014 University of North Texas Health Science Center of Fort Worth

Involvement Of Caspase-7 In Photoreceptor And Retinal Ganglion Cell Death, Shreyasi Choudhury M.S.

Theses and Dissertations

Apoptosis has been implicated in retinal cell death during both retinal differentiation and degeneration. In diseases such as retinitis pigmentosa, glaucoma, age-related macular degeneration, diabetic retinopathy and traumatic optic neuropathy, retinal cell apoptosis plays an important role.

Caspases, a family of cysteine proteases, are major players of apoptosis. Thus, one obvious target for modulating apoptosis is the caspase family of proteins. The role of initiator caspases (caspase-1, -2, -8, -9) and effector caspases (caspase-3, -6) in retinal neuronal apoptosis has been studied previously. But the role of a unique effector caspase, caspase-7, has never been studied before. The purpose of ...


Interaction Among Gustation, Olfaction, And Vision In Flavor Identification, Michael J. Lauth 2014 California Polytechnic State University San Luis Obispo

Interaction Among Gustation, Olfaction, And Vision In Flavor Identification, Michael J. Lauth

Symposium

Even though the senses of taste, smell, and sight are distinct, there is a significant overlap among them in our perceptions of objects that helps us understand and differentiate the world. Everyone has experienced, when his or her nose gets congested, that his or her sense of taste changes as well. Many individuals do not equally understand the top-down processing with taste when someone sees objects they are about to eat. In the replicated study by our principle investigator, a random convenience sample of young adults (n=162) were recruited and tested to determine if they could taste four Jelly ...


Hearing Loss And The Structure Of The Ear, Molly Rannebarger 2014 Parkland College

Hearing Loss And The Structure Of The Ear, Molly Rannebarger

A with Honors Projects

This is a PowerPoint presentation given by a student on the structure of the ear, causes of hearing loss and available solutions.


Sensing A Sensor: Identifying The Mechanosensory Function Of Primary Cilia, Rahul M. Prasad, Xingjian Jin, Surya M. Nauli 2014 University of Kentucky

Sensing A Sensor: Identifying The Mechanosensory Function Of Primary Cilia, Rahul M. Prasad, Xingjian Jin, Surya M. Nauli

Pharmacy Faculty Articles and Research

Over the past decade, primary cilia have emerged as the premier means by which cells sense and transduce mechanical stimuli. Primary cilia are sensory organelles that have been shown to be vitally involved in the mechanosensation of urine in the renal nephron, bile in the hepatic biliary system, digestive fluid in the pancreatic duct, dentin in dental pulp, lacunocanalicular fluid in bone and cartilage, and blood in vasculature. The prevalence of primary cilia among mammalian cell types is matched by the tremendously varied disease states caused by both structural and functional defects in cilia. In the process of delineating the ...


The Role Of Ral-Interacting Protein Of 76 Kda (Rlip76) In Development Of Ocular Tissues, Mukesh K. Sahu 2013 University of North Texas Health Science Center of Fort Worth

The Role Of Ral-Interacting Protein Of 76 Kda (Rlip76) In Development Of Ocular Tissues, Mukesh K. Sahu

Theses and Dissertations

Mukesh Kumar Sahu. THE ROLE OF RAL-INTERACTING PROTEIN OF 76 kDa (RLIP76) IN THE DEVELOPMENT OF OCULAR TISSUES. August 2013. Total number of pages – 114; 17 illustrations; 4 tables; 137 references. Abstract: RalBP1/RLIP76 is a ubiquitously expressed protein, involved in the promotion and regulation of functions initiated by Ral and R-Ras small GTPases. Presence of multiple domains in its structure enables RLIP76 to be involved in a number of physiological processes such as endocytosis, exocytosis, mitochondrial fission, actin cytoskeleton remodeling, and transport of exogenous and endogenous toxicants. Previous studies in Dr. Awasthi’s laboratory have established that RLIP76 provides ...


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