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3,968 full-text articles. Page 7 of 137.

Extracapsular Hepatocellular Adenoma: A Diagnostic Dilemma, iIsin Y. Comba, Richard Henriquez, Sundeep Kumar, Ruthvik Srinvasa-Murthy, Maria Wallis-Crespo, Olga Karasik, Lakhinder Bhatia, Dong Xu 2019 HCA Healthcare

Extracapsular Hepatocellular Adenoma: A Diagnostic Dilemma, Iisin Y. Comba, Richard Henriquez, Sundeep Kumar, Ruthvik Srinvasa-Murthy, Maria Wallis-Crespo, Olga Karasik, Lakhinder Bhatia, Dong Xu

Gastroenterology

Introduction: Hepatocellular adenoma (HCA) is a benign tumor of the liver and almost always located intracapsular. Bleeding (25%), and malignant transformation (5%) can complicate the disease course if left untreated. Herein, we present a case of extracapsular HCA of ectopic liver in the omentum complicated with intraperitoneal hemorrhage.

Case Description/Methods: A 43-year-old lady with no past medical history presented to emergency department with two-day history of left shoulder pain and epigastric discomfort. Her only medication was an oral contraceptive pill (OCP). On physical exam, the patient had persistent sinus tachycardia, and epigastric tenderness. Initial labs were unremarkable except for ...


Point-Of-Care Ultrasound For The Pediatric Limp, Lucas Friedman MD 2019 HCA Healthcare

Point-Of-Care Ultrasound For The Pediatric Limp, Lucas Friedman Md

Pediatrics

Objectives

  • Describe the technique and use of POCUS in the Limping Child
  • Describe the use of POCUS in the diagnosis and treatment of Septic arthritis


Bta-Mir-24-3p Controls The Myogenic Differentiation And Proliferation Of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells By Targeting Acvr1b, Xin Hu, Yishen Xing, Ling Ren, Yahui Wang, Qian Li, Xing Fu, Qiyuan Yang, Lingyang Xu, Luc Willems, Junya Li, Lupei Zhang 2019 University of Liège

Bta-Mir-24-3p Controls The Myogenic Differentiation And Proliferation Of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells By Targeting Acvr1b, Xin Hu, Yishen Xing, Ling Ren, Yahui Wang, Qian Li, Xing Fu, Qiyuan Yang, Lingyang Xu, Luc Willems, Junya Li, Lupei Zhang

Open Access Articles

MicroRNAs modulate a variety of cellular events, including skeletal muscle development, but the molecular basis of their functions in fetal bovine skeletal muscle development is poorly understood. In this study, we report that bta-miR-24-3p promotes the myogenic differentiation of fetal bovine PDGFRalpha(-) progenitor cells. The expression of bta-miR-24-3p increased during myogenic differentiation. Overexpression of bta-miR-24-3p significantly promoted myogenic differentiation, but inhibited proliferation. A dual-luciferase assay identified ACVR1B as a direct target of bta-miR-24-3p. Similarly, knocking down ACVR1B by RNA interference also significantly inhibited proliferation and promoted the differentiation of bovine PDGFRalpha(-) progenitor cells. Thus, our study provides a mechanism in ...


Severe Bradycardia During A Spinal Cord Stimulator Procedure, Marc Blanchard MD, Ettore Crimi MD, Stephen Pyles MD 2019 HCA Healthcare

Severe Bradycardia During A Spinal Cord Stimulator Procedure, Marc Blanchard Md, Ettore Crimi Md, Stephen Pyles Md

Anesthesiology

We report a case of severe bradycardia during spinal cord implantation. A 43 year old female with a history of chronic refractory lumbar back pain presented for revision of spinal cord stimulator. Preoperative assessment was positive only for bilateral lower extremity radiculopathy. During the procedure, surgeon’s attempt to advance the lead through scar tissue elicited severe bradycardia (HR 28) resolved with glycopyrrolate. Compression of spinal cord secondary to difficult lead placement could be the cause of this cardiovascular event. Anesthesiologists need to be aware that severe bradycardia can occur during spinal cord implantation.


Chromatin Profiling Of Cortical Neurons Identifies Individual Epigenetic Signatures In Schizophrenia, Fedor E. Gusev, Denis A. Reshetov, Amanda C. Mitchell, Tatiana V. Andreeva, Aslihan Dincer, Anastasia P. Grigorenko, Gennady Fedonin, Tobias Halene, Maria Aliseychik, Elena Filippova, Zhiping Weng, Schahram Akbarian, Evgeny I. Rogaev 2019 Russian Academy of Sciences

Chromatin Profiling Of Cortical Neurons Identifies Individual Epigenetic Signatures In Schizophrenia, Fedor E. Gusev, Denis A. Reshetov, Amanda C. Mitchell, Tatiana V. Andreeva, Aslihan Dincer, Anastasia P. Grigorenko, Gennady Fedonin, Tobias Halene, Maria Aliseychik, Elena Filippova, Zhiping Weng, Schahram Akbarian, Evgeny I. Rogaev

Open Access Articles

Both heritability and environment contribute to risk for schizophrenia. However, the molecular mechanisms of interactions between genetic and non-genetic factors remain unclear. Epigenetic regulation of neuronal genome may be a presumable mechanism in pathogenesis of schizophrenia. Here, we performed analysis of open chromatin landscape of gene promoters in prefrontal cortical (PFC) neurons from schizophrenic patients. We cataloged cell-type-based epigenetic signals of transcriptional start sites (TSS) marked by histone H3-K4 trimethylation (H3K4me3) across the genome in PFC from multiple schizophrenia subjects and age-matched control individuals. One of the top-ranked chromatin alterations was found in the major histocompatibility (MHC) locus on chromosome ...


Reduced Brain Activity In The Right Putamen As An Early Predictor For Treatment Response In Drug-Naive, First-Episode Schizophrenia, Renrong Wu, Yangpan Ou, Feng Liu, Jindong Chen, Huabing Li, Jingping Zhao, Wenbin Guo, Xiaoduo Fan 2019 The Second Xiangya Hospital of Central South University

Reduced Brain Activity In The Right Putamen As An Early Predictor For Treatment Response In Drug-Naive, First-Episode Schizophrenia, Renrong Wu, Yangpan Ou, Feng Liu, Jindong Chen, Huabing Li, Jingping Zhao, Wenbin Guo, Xiaoduo Fan

Open Access Articles

Antipsychotic medications can have a significant effect on brain function after only several days of treatment. It is unclear whether such an acute effect can serve as an early predictor for treatment response in schizophrenia. Thirty-two patients with drug-naive, first-episode schizophrenia and 32 healthy controls underwent resting-state functional magnetic resonance imaging. Patients were treated with olanzapine and were scanned at baseline and 1 week of treatment. Healthy controls were scanned once at baseline. Symptom severity was assessed within the patient group using the Positive and Negative Syndrome Scale (PANSS) at three time points (baseline, 1 week of treatment, and 8 ...


Control Of Cellular Responses To Mechanical Cues Through Yap/Taz Regulation, Ishani Dasgupta, Dannel McCollum 2019 University of Massachusetts Medical School

Control Of Cellular Responses To Mechanical Cues Through Yap/Taz Regulation, Ishani Dasgupta, Dannel Mccollum

Open Access Articles

To perceive their three-dimensional environment, cells and tissues must be able to sense and interpret various physical forces like shear, tensile, and compression stress. These forces can be generated both internally and externally in response to physical properties, like substrate stiffness, cell contractility, and forces generated by adjacent cells. Mechanical cues have important roles in cell fate decisions regarding proliferation, survival, differentiation as well as the processes of tissue regeneration and wound repair (1). Aberrant remodeling of the extracellular space and/or defects in properly responding to mechanical cues likely contributes to various disease states such as fibrosis, muscle diseases ...


Common Nodes Of Virus-Host Interaction Revealed Through An Integrated Network Analysis, Korbinian Bosl, Richard K. Kandasamy 2019 Norwegian University of Science and Technology

Common Nodes Of Virus-Host Interaction Revealed Through An Integrated Network Analysis, Korbinian Bosl, Richard K. Kandasamy

Open Access Articles

Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways and evade innate immune response by modulating key host factors and signaling pathways. A collective view of these multiple studies could advance our understanding of virus-host interactions and provide new therapeutic perspectives for the treatment of viral diseases. Here, we performed an integrative meta-analysis to elucidate the 17 different host-virus interactomes. Network and bioinformatics analyses showed how viruses with small genomes efficiently achieve ...


The Genome-Wide Multi-Layered Architecture Of Chromosome Pairing In Early Drosophila Embryos, Jelena Erceg, Jumana AlHaj Abed, Anton Goloborodko, Bryan R. Lajoie, Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Ruth B. McCole, Son C. Nguyen, Wren Saylor, Eric F. Joyce, T. Niroshini Senaratne, Mohammed A. Hannan, Guy Nir, Job Dekker, Leonid A. Mirny, C-Ting Wu 2019 Harvard Medical School

The Genome-Wide Multi-Layered Architecture Of Chromosome Pairing In Early Drosophila Embryos, Jelena Erceg, Jumana Alhaj Abed, Anton Goloborodko, Bryan R. Lajoie, Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Ruth B. Mccole, Son C. Nguyen, Wren Saylor, Eric F. Joyce, T. Niroshini Senaratne, Mohammed A. Hannan, Guy Nir, Job Dekker, Leonid A. Mirny, C-Ting Wu

Program in Systems Biology Publications

Genome organization involves cis and trans chromosomal interactions, both implicated in gene regulation, development, and disease. Here, we focus on trans interactions in Drosophila, where homologous chromosomes are paired in somatic cells from embryogenesis through adulthood. We first address long-standing questions regarding the structure of embryonic homolog pairing and, to this end, develop a haplotype-resolved Hi-C approach to minimize homolog misassignment and thus robustly distinguish trans-homolog from cis contacts. This computational approach, which we call Ohm, reveals pairing to be surprisingly structured genome-wide, with trans-homolog domains, compartments, and interaction peaks, many coinciding with analogous cis features. We also find a ...


Evaluation Of Il-1 Blockade As A Host-Directed Therapy For Tuberculosis In Mice And Macaques, Caylin G. Winchell, Bibhuti B. Mishra, University of Massachusetts Medical School, Samantha J. Nelson, Christopher M. Sassetti, JoAnne L. Flynn 2019 University of Pittsburgh

Evaluation Of Il-1 Blockade As A Host-Directed Therapy For Tuberculosis In Mice And Macaques, Caylin G. Winchell, Bibhuti B. Mishra, University Of Massachusetts Medical School, Samantha J. Nelson, Christopher M. Sassetti, Joanne L. Flynn

University of Massachusetts Medical School Faculty Publications

In 2017, there were over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB), emphasizing a need for new treatment strategies. Linezolid (LZD) is a potent antibiotic for antibiotic-resistant Gram-positive infections and is an effective treatment for TB. However, extended LZD use can lead to LZD-associated host toxicities, most commonly bone marrow suppression. LZD toxicities may be mediated by IL-1, a pathway important for early immunity during M. tuberculosis infection that later contributes to pathology. We hypothesized LZD efficacy could be enhanced by modulation of IL-1 pathway to reduce BM toxicity and TB associated-inflammation. We used two ...


Anatomy And Physiology I & Ii (Abac), Leslie Pryor McIntosh, DeLoris Hesse, Andrew McIntosh, Heather Cathcart, Arielle Hunt, Kingsley Dunkley 2019 Philadelphia College of Osteopathic Medicine

Anatomy And Physiology I & Ii (Abac), Leslie Pryor Mcintosh, Deloris Hesse, Andrew Mcintosh, Heather Cathcart, Arielle Hunt, Kingsley Dunkley

Biological Sciences Grants Collections

This Grants Collection for Anatomy and Physiology I & II was created under a Spring 2018 Pilot for G2C and Scaling Up OER Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Each collection contains the following materials:

  • Linked Syllabus or Syllabi
  • Initial Proposal
  • Final Report


Uga Laboratory Manual For Functional Human Anatomy, Rob Nichols 2019 University of Georgia

Uga Laboratory Manual For Functional Human Anatomy, Rob Nichols

Biological Sciences Open Textbooks

This lab manual was created for Functional Human Anatomy at the University of Georgia under a Textbook Transformation Grant and revised through a Scaling Up OER Pilot Grant.

http://oer.galileo.usg.edu/biology-collections/12/

The manual contains the following labs:

  • Introduction to Anatomical Terminology
  • Back: Skeletal Framework
  • Back Muscles
  • Skeletal Framework of the Upper Limb
  • Muscles of the Upper Limb
  • Skeletal Framework of the Lower Limb
  • Skeletal Framework of the Thorax
  • Body Cavities and Mesenteries


Uga Anatomy And Physiology 2 Lab Manual, 3rd Edition, Ann Massey, Lindsey Beebe, DeLoris Hesse 2019 University of Georgia

Uga Anatomy And Physiology 2 Lab Manual, 3rd Edition, Ann Massey, Lindsey Beebe, Deloris Hesse

Biological Sciences Open Textbooks

This lab manual was created for Anatomy and Physiology II at the University of Georgia under a Textbook Transformation Grant and revised through a Scaling Up OER Pilot Grant.

http://oer.galileo.usg.edu/biology-collections/12/

The manual contains the following labs:

  • Blood Composition
  • Blood Typing
  • Heart Anatomy
  • Cardiovascular Physiology
  • Systemic Blood Vessels
  • Anatomy of the Respiratory System
  • Physiology of the Respiratory System
  • Renal Anatomy
  • Urinalysis
  • Digestive System Anatomy
  • Digestive Physiology
  • Male Reproductive System
  • Female Reproductive System

Accessible files with optical character recognition (OCR) and auto-tagging provided by the Center for Inclusive Design and Innovation.


Anatomy And Physiology I & Ii (Uga, Scaling Up Oer), DeLoris Hesse, Lindsey Beebe, Ann Massey, Daniel McNabney, Rob Nichols 2019 University of Georgia

Anatomy And Physiology I & Ii (Uga, Scaling Up Oer), Deloris Hesse, Lindsey Beebe, Ann Massey, Daniel Mcnabney, Rob Nichols

Biological Sciences Grants Collections

This Grants Collection for Anatomy and Physiology I & II was created under a Spring 2018 Pilot for G2C and Scaling Up OER Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Each collection contains the following materials:

  • Linked Syllabus or Syllabi
  • Initial Proposal
  • Final Report


Transplantation Of Renal Allograft After Removal Of Renal Cell Carcinoma: Case Report And Review Of The Literature, Anthony P. Tran, Paulo N.A. Martins, Zachary G. Papazian, Vijay K. Vanguri, Babak Movahedi, Pang-Yen Fan, Kenneth A. Bodziak, Jennifer K. Yates, Mitchell H. Sokoloff, Adel Bozorgzadeh 2019 University of Massachusetts Medical School

Transplantation Of Renal Allograft After Removal Of Renal Cell Carcinoma: Case Report And Review Of The Literature, Anthony P. Tran, Paulo N.A. Martins, Zachary G. Papazian, Vijay K. Vanguri, Babak Movahedi, Pang-Yen Fan, Kenneth A. Bodziak, Jennifer K. Yates, Mitchell H. Sokoloff, Adel Bozorgzadeh

Open Access Articles

With the rising incidence of end-stage renal disease in the United States, patients needing renal transplants are waiting longer for increasingly scarce grafts. Formerly, the general practice was to avoid organs with tumors for transplant because of the risk of malignancy transmission to the recipient. However, with comprehensive donor selection and a small-sized primary tumor, the positive outcomes of transplant outweigh the risks of transmission after a partial nephrectomy. In our case, a 31-year-old woman, the daughter of the recipient, underwent a laparoscopic nephrectomy with an existing 8-mm tumor later confirmed as renal cell carcinoma. An ex vivo tumor enucleation ...


Plasma Eicosanoid Levels In Tuberculosis And Tuberculosis-Diabetes Co-Morbidity Are Associated With Lung Pathology And Bacterial Burden, Nathella Pavan Kumar, Kadar Moideen, Arul Nancy, Vijay Viswanathan, Basavaradhya S. Shruthi, Sivakumar Shanmugam, Syed Hissar, Hardy Kornfeld, Subash Babu 2019 National Institutes of Health

Plasma Eicosanoid Levels In Tuberculosis And Tuberculosis-Diabetes Co-Morbidity Are Associated With Lung Pathology And Bacterial Burden, Nathella Pavan Kumar, Kadar Moideen, Arul Nancy, Vijay Viswanathan, Basavaradhya S. Shruthi, Sivakumar Shanmugam, Syed Hissar, Hardy Kornfeld, Subash Babu

Open Access Articles

Host eicosanoids are lipid mediators of inflammation that are commonly accepted as important modulators of the host immune response in Mycobacterium tuberculosis infection. During active tuberculosis (TB), eicosanoids may play an important role in the regulation of inflammatory responses. However, a detailed investigation of the relationship of eicosanoids in TB and TB-diabetes comorbidity (TB-DM) and association to disease pathology or bacterial burdens has not been studied. To study this, we examined the plasma levels of Lipoxin A4 (LXA4), 15-epi-LXA4, Leukotriene B4 (LTB4), and Prostaglandin E2 (PGE2) in individuals with either TB-DM, TB, diabetes mellitus (DM) or healthy controls (HC). Plasma ...


Myofascial Release, Colin S. Hetherington 2019 Gettysburg College

Myofascial Release, Colin S. Hetherington

Student Publications

Fascia represents an intricate system of connective tissue that permeates throughout the human body. Its matrix of continuous fibers support, protect, divide and suspend both superficial and deep anatomical structures. While once thought to be a passive mesh network, new evidence suggests fascia is much more complicated. Now recognized as an active physiological component of the human body, myofascial health and function has been given much attention clinically. Of the techniques aimed to treat and restore fascial structure and function, myofascial release has been found to promote stability, increase range of motion and most importantly alleviate musculoskeletal pain. This form ...


Leptin Induces Cell Migration And Invasion In A Fak-Src- Dependent Manner In Breast Cancer Cells, Juan Carlos Juarez-Cruz, Miriam Daniela. Zuniga-Eulogio, Monserrat Olea-Flores, Eduardo Castaneda-Saucedo, Miguel Angel. Mendoza-Catalan, Carlos Ortuno-Pineda, Ma Elena. Moreno-Godinez, Socrates Villegas-Comonfort, Teresita Padilla-Benavides, Napoleon Navarro-Tito 2019 Autonomous University of Guerrero

Leptin Induces Cell Migration And Invasion In A Fak-Src- Dependent Manner In Breast Cancer Cells, Juan Carlos Juarez-Cruz, Miriam Daniela. Zuniga-Eulogio, Monserrat Olea-Flores, Eduardo Castaneda-Saucedo, Miguel Angel. Mendoza-Catalan, Carlos Ortuno-Pineda, Ma Elena. Moreno-Godinez, Socrates Villegas-Comonfort, Teresita Padilla-Benavides, Napoleon Navarro-Tito

Open Access Articles

Breast cancer is the most common invasive neoplasia, and the second leading cause of the cancer deaths in women worldwide. Mammary tumorigenesis is severely linked to obesity, one potential connection is leptin. Leptin is a hormone secreted by adipocytes, which contributes to the progression of breast cancer. Cell migration, metalloproteases secretion, and invasion are cellular processes associated with various stages of metastasis. These processes are regulated by the kinases FAK and Src. In this study, we utilized the breast cancer cell lines MCF7 and MDA-MB-231 to determine the effect of leptin on FAK and Src kinases activation, cell migration, metalloprotease ...


A Small Peptide Antagonist Of The Fas Receptor Inhibits Neuroinflammation And Prevents Axon Degeneration And Retinal Ganglion Cell Death In An Inducible Mouse Model Of Glaucoma, Anitha Krishnan, Andrew J. Kocab, David N. Zacks, Ann Marshak-Rothstein, Meredith Gregory-Ksander 2019 Harvard Medical School

A Small Peptide Antagonist Of The Fas Receptor Inhibits Neuroinflammation And Prevents Axon Degeneration And Retinal Ganglion Cell Death In An Inducible Mouse Model Of Glaucoma, Anitha Krishnan, Andrew J. Kocab, David N. Zacks, Ann Marshak-Rothstein, Meredith Gregory-Ksander

Open Access Articles

BACKGROUND: Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration. We demonstrated previously that FasL-Fas signaling was required for axon degeneration and death of RGCs in chronic and inducible mouse models of glaucoma and that Fas activation triggered RGC apoptosis, glial activation, and inflammation. Here, we investigated whether targeting the Fas receptor with a small peptide antagonist, ONL1204, has anti-inflammatory and neuroprotective effects in a microbead-induced mouse model of glaucoma.

METHODS: Intracameral injection of microbeads was used to elevate intraocular pressure (IOP) in ...


Pollen-Derived Rnas Are Found In The Human Circulation, Milka Koupenova-Zamor, Eric O. Mick, Heather A. Corkrey, Anupama Singh, Selim E. Tanriverdi, Olga Vitseva, Daniel Levy, Allison M. Keeler, Marzieh Ezzaty Mirhashemi, Mai K. Elmallah, Mark Gerstein, Joel Rozowsky, Kahraman Tanriverdi, Jane E. Freedman 2019 University of Massachusetts Medical School

Pollen-Derived Rnas Are Found In The Human Circulation, Milka Koupenova-Zamor, Eric O. Mick, Heather A. Corkrey, Anupama Singh, Selim E. Tanriverdi, Olga Vitseva, Daniel Levy, Allison M. Keeler, Marzieh Ezzaty Mirhashemi, Mai K. Elmallah, Mark Gerstein, Joel Rozowsky, Kahraman Tanriverdi, Jane E. Freedman

Open Access Articles

The presence of nonhuman RNAs in man has been questioned and it is unclear if food-derived miRNAs cross into the circulation. In a large population study, we found nonhuman miRNAs in plasma by RNA sequencing and validated a small number of pine-pollen miRNAs by RT-qPCR in 2,776 people. The presence of these pine-pollen miRNAs associated with hay fever and not with overt cardiovascular or pulmonary disease. Using in vivo and in vitro models, we found that transmission of pollen-miRNAs into the circulation occurs via pulmonary transfer and this transfer was mediated by platelet-pulmonary vascular cell interactions and platelet pollen-DNA ...


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