A Fatal Rectus Sheath Hematoma After A Myasthenia Crisis Case Report, 2020 Tufts University School of Medicine - Maine Track Program
A Fatal Rectus Sheath Hematoma After A Myasthenia Crisis Case Report, Robert G. Michaud, Lesley B. Gordon
Journal of Maine Medical Center
Introduction: Rectus sheath hematomas (RSH) generally occur due to damage to the inferior epigastric artery. They are rare causes of abdominal pain or acute blood loss anemia, but are an important diagnostic consideration because they can be cryptic and are potentially fatal.
Clinical Findings: An 85-year-old female who had been admitted to the hospital for 10 days with a myasthenia crisis was found to be abruptly hypotensive with a tender abdominal mass in the left lower quadrant subtly crossing midline. She was on prophylactic anticoagulation during her hospitalization.
Main diagnosis, therapeutics, interventions, and outcomes: The patient was initially stabilized with ...
Visualization Of Brown Fat Using X-Ray Dark Field Imaging, 2020 Louisiana State University and Agricultural and Mechanical College
Visualization Of Brown Fat Using X-Ray Dark Field Imaging, Troy D. Jacobs
LSU Master's Theses
Introduction: Obesity has become a major societal issue. Many researchers are looking for ways to combat this growing epidemic. Brown adipose tissue (BAT) might be a way to help individuals overcome the challenges associated with weight loss and maintenance of weight loss, but a better understanding of BAT and how to control and utilize it is needed. BAT differs from white adipose tissue (WAT) in that BAT is rich with mitochondria and therefore is metabolically active. BAT is a source of non-shivering thermogenesis and can be activated both by cold exposure and pharmacologically. Current methods of assessing BAT activity are ...
Anatomy And Function Of Autonomic Innervation Of The Liver, 2020 University of Central Florida
Anatomy And Function Of Autonomic Innervation Of The Liver, Kennan Negrete
The Pegasus Review: UCF Undergraduate Research Journal (URJ)
The liver is one of the most important regulatory organs, and its extensive influence upon homeostatic balance is well-documented. However, the role of autonomic innervation in the control and regulation of hepatic function is poorly understood relative to the other organs of the digestive system. Furthermore, the neuroanatomical layout of the liver remains an incomplete puzzle with various missing pieces. The scarcity of information concerning such a critical organ presents an interesting conundrum for the scientific and biomedical communities alike, especially given the prevalence of liver degeneracy and disease in the modern clinical setting. A more complete understanding of the ...
A Comparison Of Denoising Methods In Onset Determination In Medial Gastrocnemius Muscle Activations During Stance, 2020 Machine Learning Algorithms Team
A Comparison Of Denoising Methods In Onset Determination In Medial Gastrocnemius Muscle Activations During Stance, Jian Zhang, Rahul Soangra, Thurmon Lockhart
Physical Therapy Faculty Articles and Research
One of the most basic pieces of information gained from dynamic electromyography is accurately defining muscle action and phase timing within the gait cycle. The human gait relies on selective timing and the intensity of appropriate muscle activations for stability, loading, and progression over the supporting foot during stance, and further to advance the limb in the swing phase. A common clinical practice is utilizing a low-pass filter to denoise integrated electromyogram (EMG) signals and to determine onset and cessation events using a predefined threshold. However, the accuracy of the defining period of significant muscle activations via EMG varies with ...
Myo/Nog Cells Expressing Muscle Proteins Are Present In Preretinal Membranes From Patients With Proliferative Vitreoretinopathy., 2020 Philadelphia College of Osteopathic Medicine
Myo/Nog Cells Expressing Muscle Proteins Are Present In Preretinal Membranes From Patients With Proliferative Vitreoretinopathy., Jacquelyn Gerhart, Nathan Morrison, Lindsay Gugerty, David Telander, Arturo Bravo Nuevo, Mindy George-Weinstein
PCOM Scholarly Papers
Proliferative vitreoretinopathy (PVR) is a complication of rhegmatogenous retinal detachment and ocular trauma. The disease is characterized by development of membranes that may apply traction to the retina and cause redetachment. Membrane contractions are attributed to myofibroblasts arising from retinal pigment epithelial cells, glia and fibroblasts. The progenitors of myofibrobasts in the lens are Myo/Nog cells that express the skeletal muscle transcription factor MyoD and bone morphogenetic protein inhibitor Noggin. The retina and choroid also contain Myo/Nog cells that respond to stress. We examined preretinal PVR membranes from three ocular trauma patients with retinal detachment for Myo/Nog ...
Potential Role Of Platelets In Covid‐19: Implications For Thrombosis, 2020 University of Massachusetts Medical School
Potential Role Of Platelets In Covid‐19: Implications For Thrombosis, Milka Koupenova
COVID-19 Publications by UMMS Authors
For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets ...
Assisting Children With Velocardiofacial Syndrome Who Have Developmental Disabilities And Delays Associated With Speech, Communication, And Education, Mckenzie K. Holty
Children with velocardiofacial syndrome (VCFS) have a variety of complex needs. Research shows that VCFS is characterized by a combination of medical problems, developmental delays, and learning disabilities, which vary from child to child. This syndrome also puts adolescents at a higher risk for developing psychiatric and psychotic disorders. The complexity of symptoms that can arise from VCFS can influence the ability of these children to communicate, socialize, and learn effectively. This literature review aims to discuss literature for caregivers, educators, and physicians to aid children effectively and understand their challenges relating to speech, communication, and education. This topic is ...
Quadriceps Muscle Layer Thickness In Kidney Transplant Recipients: A Potential Measure Of Frailty And Sarcopenia, 2020 The University of Western Ontario
Quadriceps Muscle Layer Thickness In Kidney Transplant Recipients: A Potential Measure Of Frailty And Sarcopenia, Max A. Levine
Electronic Thesis and Dissertation Repository
Introduction: Frailty and sarcopenia are related concepts that can impact outcomes after kidney transplantation. Measures of these two entities and new/emerging metrics of sarcopenia remain to be validated.
Methods: In a prospective cohort study, kidney and kidney-pancreas transplant recipients were assessed at the time of transplant with the Physical Frailty Phenotype, bioimpedance analysis, quadriceps muscle layer thickness (QMLT), and CT. The impact on length of stay (LOS), prediction of frailty/sarcopenia, and relative concordance of metrics were analyzed.
Results: Low QMLT, a putative surrogate of sarcopenia/frailty, was more frequently associated with longer LOS (>14 days) after transplant. Additionally ...
Coffee And Tea Consumption In The Early Adult Lifespan And Left Ventricular Function In Middle Age: The Cardia Study, 2020 Johns Hopkins University
Coffee And Tea Consumption In The Early Adult Lifespan And Left Ventricular Function In Middle Age: The Cardia Study, Chike C. Nwabuo, Aisha S. Betoko, Jared P. Reis, Henrique T. Moreira, Henrique D. Vasconcellos, Eliseo Guallar, Christopher Cox, Stephen Sidney, Bharath Ambale-Venkatesh, Cora E. Lewis, Pamela J. Schreiner, Donald Lloyd-Jones, Catarina I. Kiefe, Samuel S. Gidding, Joao A. C. Lima
Open Access Articles
AIMS: The long-term impact of coffee or tea consumption on subclinical left ventricular (LV) systolic or diastolic function has not been previously studied. We examined the association between coffee or tea consumption beginning in early adulthood and cardiac function in midlife.
METHODS AND RESULTS: We investigated 2735 Coronary Artery Risk Development in Young Adults (CARDIA) study participants with long-term total caffeine intake, coffee, and tea consumption data from three visits over a 20 year interval and available echocardiography indices at the CARDIA Year-25 exam (2010-2011). Linear regression models were used to assess the association between caffeine intake, tea, and coffee ...
Incidental Diagnosis Of Dual Arterial Supply Of The Right Lower Lobe, 2020 Children's Mercy Kansas City
Incidental Diagnosis Of Dual Arterial Supply Of The Right Lower Lobe, Christopher Mathis
No abstract provided.
Emergence, Mechanics, And Development: How Behavior And Geometry Underlie Cowrie Seashell Form, 2020 University of California Berkeley
Emergence, Mechanics, And Development: How Behavior And Geometry Underlie Cowrie Seashell Form, Michael G. Levy, Michael R. Deweese
Biology and Medicine Through Mathematics Conference
No abstract provided.
Angiopoietin 1 Protects Against Lps-Induced Acute Lung Injury And Alveolar Remodeling In Neonatal Mice, 2020 Childrens Mercy Hospital
Angiopoietin 1 Protects Against Lps-Induced Acute Lung Injury And Alveolar Remodeling In Neonatal Mice, Umar Salimi
No abstract provided.
Yap1/Taz Drives Ependymoma-Like Tumour Formation In Mice, 2020 The Francis Crick Institute
Yap1/Taz Drives Ependymoma-Like Tumour Formation In Mice, Noreen Eder, Federico Roncaroli, Marie-Charlotte Dolmart, Stuart Horswell, Felipe Andreiuolo, Helen R. Flynn, Andre T. Lopes, Suzanne Claxton, John-Paul Kilday, Lucy Collinson, Junhao Mao, Torsten Pietsch, Barry Thompson, Ambrosius P. Snijders, Sila K. Ultanir
Open Access Articles
YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to drive brain tumour formation in mice. Neuronal differentiation is inhibited in the hippocampus. Deletion of YAP1's negative regulators LATS1 and LATS2 kinases in NEX-Cre lineage in double conditional knockout mice also generates similar tumours, which are rescued by deletion of YAP1 and its paralog TAZ. YAP1/TAZ-induced mouse tumours display molecular and ultrastructural characteristics of human ependymoma. RNA sequencing and quantitative proteomics of ...
The Snakeskin-Mesh Complex Of Smooth Septate Junction Restricts Yorkie To Regulate Intestinal Homeostasis In Drosophila, 2020 University of Massachusetts Medical School
The Snakeskin-Mesh Complex Of Smooth Septate Junction Restricts Yorkie To Regulate Intestinal Homeostasis In Drosophila, Hsi-Ju Chen, Qi Li, Niraj K. Nirala, Y. Tony Ip
Open Access Articles
Tight junctions in mammals and septate junctions in insects are essential for epithelial integrity. We show here that, in the Drosophila intestine, smooth septate junction proteins provide barrier and signaling functions. During an RNAi screen for genes that regulate adult midgut tissue growth, we found that loss of two smooth septate junction components, Snakeskin and Mesh, caused a hyperproliferation phenotype. By examining epitope-tagged endogenous Snakeskin and Mesh, we demonstrate that the two proteins are present in the cytoplasm of differentiating enteroblasts and in cytoplasm and septate junctions of mature enterocytes. In both enteroblasts and enterocytes, loss of Snakeskin and Mesh ...
Assessment Of Antebrachial And Carpal Muscle Activity During Smartphone Use: Is “Selfie Wrist” A Real Phenomenon?, 2020 University of Mississippi
Assessment Of Antebrachial And Carpal Muscle Activity During Smartphone Use: Is “Selfie Wrist” A Real Phenomenon?, Monica Stacy
Reports in the media by celebrities have sparked an interest in a phenomenon being called “selfie-wrist,” in which smartphone users develop symptoms traditionally associated with carpal tunnel syndrome (CTS). There has been no research to date which investigates the claims of “selfie wrist.” The primary aim of this study was to address the validity of “selfie wrist” claims. The secondary aim of this study was to further investigate the effects of texting on musculoskeletal health, taking into account the differences between texting one-handed versus two-handed, and the effect of using a grip device while texting.
The experiment consisted of an ...
A Runx2 Stabilization Pathway Mediates Physiologic And Pathologic Bone Formation, 2020 University of Massachusetts Medical School
A Runx2 Stabilization Pathway Mediates Physiologic And Pathologic Bone Formation, Jung-Min Kim, Yeon-Suk Yang, Xianpeng Ge, Matthew B. Greenblatt, Jae-Hyuck Shim
Open Access Articles
The osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly regulated, as inadequate bone formation results in low bone mass and skeletal fragility, and over-exuberant osteogenesis results in heterotopic ossification (HO) of soft tissues. RUNX2 is essential for tuning this balance, but the mechanisms of posttranslational control of RUNX2 remain to be fully elucidated. Here, we identify that a CK2/HAUSP pathway is a key regulator of RUNX2 stability, as Casein kinase 2 (CK2) phosphorylates RUNX2, recruiting the deubiquitinase herpesvirus-associated ubiquitin-specific protease (HAUSP), which stabilizes RUNX2 by diverting it away from ubiquitin-dependent proteasomal degradation. This pathway is important ...
The Effects Of Acute Exercise And Psychological Stress On Episodic Memory, 2020 University of Mississippi
The Effects Of Acute Exercise And Psychological Stress On Episodic Memory, Lauren Koehler
Research has suggested that exercise has an effect on memory function. Studies have also shown that exercise mitigates the effects of stress. The relationship between exercise and stress in regard to memory function is noteworthy. There has been little research on this relationship in young adults. This thesis discusses the effects of acute exercise on the episodic memory of young adults when they are exposed to a psychosocial stressor. The results of the research study show that acute aerobic exercise before memory encoding or consolidation was not associated with memory function after exposure to a stressor. Future research in this ...
Neuroligin3 Splice Isoforms Shape Inhibitory Synaptic Function In The Mouse Hippocampus, 2020 University of Massachusetts Medical School
Neuroligin3 Splice Isoforms Shape Inhibitory Synaptic Function In The Mouse Hippocampus, Motokazu Uchigashima, Ming Leung, Takuya Watanabe, Amy Cheung, Timmy Le, Sabine Pallat, Alexandre Luis Marques Dinis, Masahiko Watanabe, Yuka Imamura Kawasawa, Kensuke Futai
Open Access Articles
Synapse formation is a dynamic process essential for the development and maturation of the neuronal circuitry in the brain. At the synaptic cleft, transsynaptic protein-protein interactions are major biological determinants of proper synapse efficacy. The balance of excitatory and inhibitory synaptic transmission (E-I balance) stabilizes synaptic activity, and dysregulation of the E-I balance has been implicated in neurodevelopmental disorders, including autism spectrum disorders. However, the molecular mechanisms underlying the E-I balance remain to be elucidated. Here, using single-cell transcriptomics, immunohistochemistry and electrophysiology approaches to murine CA1 pyramidal neurons obtained from organotypic hippocampal slice cultures, we investigate Neuroligin (Nlgn) genes that ...
The Current Neuroscientific Understanding Of Alzheimer's Disease, 2020 University of Tennessee, Knoxville
The Current Neuroscientific Understanding Of Alzheimer's Disease, Rachel A. Brandes
Pursuit - The Journal of Undergraduate Research at the University of Tennessee
Alzheimer’s disease is a degenerative neurological illness characterized by the deterioration of brain regions implicated in memory and cognitive function. While researchers have yet to find a cure or effective treatment, they have gained a better understanding of its pathology and development. Through years of neuroscience research, scientists have discovered much of what happens in the brain during Alzheimer’s disease onset and how this causes its symptoms; many hypotheses regarding this aspect of the illness involve temporal lobe atrophy, neurofibrillary tangles, and amyloid plaques. Although Alzheimer’s disease affects millions of people every day, it seems that most ...
Analyzing Leadership Opportunities Through Participant Perspective, 2020 University of Nebraska at Omaha
Analyzing Leadership Opportunities Through Participant Perspective, Cathryn Yaggie Heinen
The Anatomy Academic Assistant (AAA) practicum is a peer-mentoring program that helps participants further develop leadership skills. The goal of this research was to analyze leadership qualities through participant perspective and analyze the effectiveness of the AAA practicum in enhancing these leadership qualities. A 25-question survey, measuring participant perspective, was designed to include both rating-scale questions and free response questions. Rating-scale questions used a Likert scale with a corresponding assigned value. Free response questions also provided qualitative data that was grouped into overarching themes in a generated word cloud. The assigned value averages showed that participants largely agreed with the ...