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Endocrine System Commons

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The Effect Of Care Coordination On Hemoglobin A1c For Type 2 Diabetes Patients, Lee Ann Hinsky 2020 Abilene Christian University

The Effect Of Care Coordination On Hemoglobin A1c For Type 2 Diabetes Patients, Lee Ann Hinsky

Electronic Theses and Dissertations

The purpose of the study was to test the impact of care coordinator visits by primary care registered nurses on serum hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes. In the study, the researcher compared 2 groups of type 2 diabetes patients—those who had care coordinator visits from registered nurses and those who did not—through retrospective data collection and analysis from the patients’ electronic medical record from July 2018 through December 2018. An independent samples t test was used to compare the means of the intervention and control groups’ change in HbA1c levels. The intervention and ...


Oral Contraceptives As Possible Acl Injury Prevention Method, Haley Schweizer 2020 Arcadia University

Oral Contraceptives As Possible Acl Injury Prevention Method, Haley Schweizer

Capstone Showcase

ABSTRACT

Introduction: Anterior Cruciate Ligament (ACL) injuries are an upsetting setback for many athletes that require a long and costly recovery process. The injury rates are four times greater in women than men. Preventative measures that help to prevent ACL injuries are limited to stretching and strengthening. Therefore, this review aims to investigate if oral contraceptive [I] usage provides a possible new avenue for prevention of ACL injury [O] in young female athletes (ages 18-30) [P] compared to those that do not take oral contraceptives [C].

Methods: A literature review was performed though PubMed, Google Scholar, SCOPUS Database, and ClinicalKey ...


Leptin Effects On Bone Metabolism, Elizabeth Bark 2020 The University of Akron

Leptin Effects On Bone Metabolism, Elizabeth Bark

Williams Honors College, Honors Research Projects

Scales from adult zebrafish, Danio rerio, are an established model for studying osteoblast and osteoclast activity. In this study, scales in a cell culture were used to determine if the hormone leptin has an effect on activity of these bone remodeling scales. Alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) activities of zebrafish scales were measured and compared with and without leptin treatment. There was no statistically significant difference between leptin treatments in terms of ALP and TRAP activity. Differences between TRAP values between days 1 and 2 did look promising although they were not statistically significant. This study could ...


Intestinal Neurod1 Expression Impairs Paneth Cell Differentiation And Promotes Enteroendocrine Lineage Specification, Joyce H. Li, Subir Ray, Ning Pan, Jody Haigh, Bernd Fritzsch, Andrew B. Leiter 2019 University of Massachusetts Medical School

Intestinal Neurod1 Expression Impairs Paneth Cell Differentiation And Promotes Enteroendocrine Lineage Specification, Joyce H. Li, Subir Ray, Ning Pan, Jody Haigh, Bernd Fritzsch, Andrew B. Leiter

Open Access Articles

Transcription factor Neurod1 is required for enteroendocrine progenitor differentiation and maturation. Several earlier studies indicated that ectopic expression of Neurod1 converted non- neuronal cells into neurons. However, the functional consequence of ectopic Neurod1 expression has not been examined in the GI tract, and it is not known whether Neurod1 can similarly switch cell fates in the intestine. We generated a mouse line that would enable us to conditionally express Neurod1 in intestinal epithelial cells at different stages of differentiation. Forced expression of Neurod1 throughout intestinal epithelium increased the number of EECs as well as the expression of EE specific transcription ...


An Analysis Of Abdominal Stability Following Hyperthermic Exercise In Euhydrated And Dehydrated Conditions, Carli Ceckanowicz 2019 University of Connecticut

An Analysis Of Abdominal Stability Following Hyperthermic Exercise In Euhydrated And Dehydrated Conditions, Carli Ceckanowicz

Honors Scholar Theses

Core stability is essential for maintaining safety and optimizing performance during exercise and sport. The purpose of this study is to analyze how heat and hydration status (euhydrated USG<1.025 or dehydrated USG>1.025) can impair trunk stability in males and females (in both follicular and luteal phases) using the Trunk Stability Test (TST). Participants complete three blocks of 30 minutes of hyperthermic (35±1.299 oC and 49.418±5.0329% relative humidity) treadmill exercise. Exercise intensity is equivalent to 15 minutes at either 11W/kg or 7W/kg and the following 15 minutes at either 7W/kg or 4W/kg ...


Hemoglobin A1c Levels And Sport Participation In Children With Type 1 Diabetes., Amy Kozerski 2019 University of Louisville

Hemoglobin A1c Levels And Sport Participation In Children With Type 1 Diabetes., Amy Kozerski

Electronic Theses and Dissertations

This study’s purpose was to determine a possible difference in hemoglobin A1c levels and sport participation in children with type 1 diabetes. Patients with provided consent via an iPad electronic informed consent/assent (preamble) completed a physical activity and sport participation survey. The survey was linked to their medical chart including demographic and diabetes medical history (e.g. HbA1c). The analyses provided a sample of 120 participants, 40 in the no sport participation group and 78 in the sport participation group with 56 females and 64 males, with an average age12.94±2.8 years. An independent sample t ...


Functionality Of The Kidneys, Amber Jourdan 2019 Grand Valley State University

Functionality Of The Kidneys, Amber Jourdan

Honors Projects

This project is an informative research paper on the role of the kidneys in the urinary system, as well as issues that arise in the kidneys. A brief introduction is given to explain the general function of the urinary system and the importance of the kidneys. Following that, a section of Acute Kidney Injury explains the disease and possible treatments. Additionally, there is a section on kidney stones, how they are formed, and how treatments are administered when a patient presents with this ailment. This paper is not the only piece of this project. In addition, a visual aid will ...


The Influence Of Pre- And Post Meal Exercise In Relation To Postprandial Blood Glucose Levels In Type Ii Diabetics, Jessica Johnson 2019 Fort Hays State University

The Influence Of Pre- And Post Meal Exercise In Relation To Postprandial Blood Glucose Levels In Type Ii Diabetics, Jessica Johnson

Master's Theses

The purpose of this study was to investigate the relationship of pre and post evening meal exercise in relation to postprandial blood glucose levels in type II diabetics. Fifteen participants diagnosed with type II diabetes volunteered to participate in this 21 day study. During the first seven days, participants were told to change nothing about their daily routine. Throughout the study they were asked to track all food consumption in the MyFitnessPal application and to record their blood glucose levels fasting, before their evening meal, and 120 minutes after their evening meal. At the end of day seven, each participant ...


Hdl In Endocrine Carcinomas: Biomarker, Drug Carrier, And Potential Therapeutic, Emily E. Morin, Xiang-An Li, Anna Schwendeman 2018 University of Michigan

Hdl In Endocrine Carcinomas: Biomarker, Drug Carrier, And Potential Therapeutic, Emily E. Morin, Xiang-An Li, Anna Schwendeman

Physiology Faculty Publications

High-density lipoprotein (HDL) have long been studied for their protective role against cardiovascular diseases, however recently relationship between HDL and cancer came into focus. Several epidemiological studies have shown an inverse correlation between HDL-cholesterol (HDL-C) and cancer risk, and some have even implied that HDL-C can be used as a predictive measure for survival prognosis in for specific sub-population of certain types of cancer. HDL itself is an endogenous nanoparticle capable of removing excess cholesterol from the periphery and returning it to the liver for excretion. One of the main receptors for HDL, scavenger receptor type B-I (SR-BI), is highly ...


Glimepiride Administered In Chow Reversibly Impairs Glucose Tolerance In Mice, Dana M. Niedowicz, Sabire Özcan, Peter T. Nelson 2018 University of Kentucky

Glimepiride Administered In Chow Reversibly Impairs Glucose Tolerance In Mice, Dana M. Niedowicz, Sabire Özcan, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

Sulfonylureas are a class of antidiabetes medications prescribed to millions of individuals worldwide. Rodents have been used extensively to study sulfonylureas in the laboratory. Here, we report the results of studies treating mice with a sulfonylurea (glimepiride) in order to understand how the drug affects glucose homeostasis and tolerance. We tested the effect of glimepiride on fasting blood glucose, glucose tolerance, and insulin secretion, using glimepiride sourced from a local pharmacy. We also examined the effect on glucagon, gluconeogenesis, and insulin sensitivity. Unexpectedly, glimepiride exposure in mice was associated with fasting hyperglycemia, glucose intolerance, and decreased insulin. There was no ...


Cystic Fibrosis-Related Diabetes Is Caused By Islet Loss And Inflammation, Nathaniel J. Hart, Jenny Aurielle B. Babon, Megan E. DeNicola, Sally C. Kent, Alvin C. Powers 2018 Vanderbilt University Medical Center

Cystic Fibrosis-Related Diabetes Is Caused By Islet Loss And Inflammation, Nathaniel J. Hart, Jenny Aurielle B. Babon, Megan E. Denicola, Sally C. Kent, Alvin C. Powers

Open Access Articles

Cystic fibrosis-related (CF-related) diabetes (CFRD) is an increasingly common and devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the underlying causes of CFRD are unclear. Here, we examined cystic fibrosis transmembrane conductance regulator (CFTR) islet expression and whether the CFTR participates in islet endocrine cell function using murine models of beta cell CFTR deletion and normal and CF human pancreas and islets. Specific deletion of CFTR from murine beta cells did not affect beta cell function. In human islets, CFTR mRNA was minimally expressed, and CFTR protein and electrical activity were not detected. Isolated CF/CFRD ...


Regulation Of Extra-Pituitary Prolactin In Monocytes And Macrophages, Richard Barrett 2018 University of Central Florida

Regulation Of Extra-Pituitary Prolactin In Monocytes And Macrophages, Richard Barrett

Electronic Theses and Dissertations, 2004-2019

Recently it has been shown that leukocytes are capable of producing prolactin (PRL). Evidence of extra-pituitary PRL (ePRL) production is so far been limited to primates and is not shared across other mammal species such as mice and rats. While ePRL is characterized as an identical protein to traditional pituitary PRL, it is controlled under an alternative promoter and is thus regulated differently from pituitary PRL. Little is known about what regulates ePRL or its direct role in human physiology, but given that PRL has well over 300 described functions, it is likely that the autocrine and paracrine effects of ...


The Effects Of Continuous Insulin Pump Therapy On Glycemic Control In Pregnant Type 1 Diabetics, Kimberly Kelsey 2017 Dominican University of California

The Effects Of Continuous Insulin Pump Therapy On Glycemic Control In Pregnant Type 1 Diabetics, Kimberly Kelsey

Senior Theses and Capstone Projects

Type 1 Diabetics have various ways of managing their diabetes that have been studied for their effectiveness. Pregnancy in the Type 1 Diabetic has been understudied. It is known that Diabetics in general have poorer pregnancy outcomes because of poor glycemic control. This coupled with the fact that the body needs 3-4 times more insulin as pregnancy comes to an end makes managing blood glucose levels challenging for diabetics (Lowdermilk, 2016, p. 689). For the Type 1 Diabetic, there are two main ways to control diabetes: multiple daily injections using at least two type of insulin and continuous subcutaneous insulin ...


Epigenetic Impact Of Endocrine Disrupting Chemicals On Lipid Homeostasis And Atherosclerosis: A Pregnane X Receptor-Centric View, Robert N. Helsley, Changcheng Zhou 2017 University of Kentucky

Epigenetic Impact Of Endocrine Disrupting Chemicals On Lipid Homeostasis And Atherosclerosis: A Pregnane X Receptor-Centric View, Robert N. Helsley, Changcheng Zhou

Pharmacology and Nutritional Sciences Faculty Publications

Despite the major advances in developing diagnostic techniques and effective treatments, atherosclerotic cardiovascular disease (CVD) is still the leading cause of mortality and morbidity worldwide. While considerable progress has been achieved to identify gene variations and environmental factors that contribute to CVD, much less is known about the role of “gene–environment interactions” in predisposing individuals to CVD. Our chemical environment has significantly changed in the last few decades, and there are more than 100,000 synthetic chemicals in the market. Recent large-scale human population studies have associated exposure to certain chemicals including many endocrine disrupting chemicals (EDCs) with increased ...


Distortion In Body Schema: The Influence Of Body Fat And Mass On Perceptions Of Personal Size, Katarina Ann Ferrucci 2017 Bard College

Distortion In Body Schema: The Influence Of Body Fat And Mass On Perceptions Of Personal Size, Katarina Ann Ferrucci

Senior Projects Spring 2017

Obesity has been linked with a myriad of negative outcomes for both physical and mental health including feeding and eating disorders and cognitive impairments that affect perception of body size. Understanding the cognitive mechanisms and physiological factors that contribute to perception of body size may help us to comprehend how obesity impacts the construction and development of one’s mental body representations. Previous research by Scarpina, Castelnuovo, and Molinari (2014) suggests that, compared to those with a normal Body Mass Index, individuals with a BMI greater than 30 (obese) not only inaccurately estimate tactile and mental distances on their own ...


Sugar Consumption Alters Perception Of And Response To Stress In Undergraduate Students: Understanding The "Freshmen Fifteen", Katherine M Keever 2016 Union College - Schenectady, NY

Sugar Consumption Alters Perception Of And Response To Stress In Undergraduate Students: Understanding The "Freshmen Fifteen", Katherine M Keever

Honors Theses

Psychological stress is a common part in everyday life that directly affects the body through the nervous system and neuroendocrine hormones. A perceived stressor leads to the activation of the hypothalamic-pituitary-adrenal (HPA) axis, and the synthesis and release of the glucocorticoid hormone cortisol from the adrenal cortex. Studies have linked the release of cortisol during high-stress periods to an increased intake of sugary and fatty foods, consistent with a suspected glucocorticoid-metabolic-brain- negative pathway, with high sugar consumption leading to lower stress and subsequently cortisol levels. In this study, undergraduate students’ diets were supplemented with either a high sugar drink or ...


Point Mutations Of The Putative Follitropin Receptor Caveolin Interaction Motif Do Not Disrupt Receptor Function, Stanley Soroka 2016 Union College - Schenectady, NY

Point Mutations Of The Putative Follitropin Receptor Caveolin Interaction Motif Do Not Disrupt Receptor Function, Stanley Soroka

Honors Theses

Human follicle stimulating hormone (hFSH) is a hormone found in humans that is synthesized and secreted by the anterior pituitary and targets the ovaries and testes. This specificity of targeting is accomplished by the interaction of hFSH with its receptor (hFSHR) on target cells. hFSHR is a G protein-coupled receptor that localizes to domains in the cell membrane known as lipid rafts. The mechanism of translocation of the hFSHR into lipid rafts is unknown. Our hypothesis is that translocation occurs through interaction of hFSHR with the protein caveolin via a specific sequence in the hFSHR; a putative caveolin interaction motif ...


Measurement Of The Absolute Magnitude And Time Courses Of Mitochondrial Membrane Potential In Primary And Clonal Pancreatic Beta-Cells, Akos Gerencser, Shona A. Mookerjee, Martin Jastroch, Martin D. Brand 2016 Touro University California

Measurement Of The Absolute Magnitude And Time Courses Of Mitochondrial Membrane Potential In Primary And Clonal Pancreatic Beta-Cells, Akos Gerencser, Shona A. Mookerjee, Martin Jastroch, Martin D. Brand

Faculty Publications & Research of the TUC College of Pharmacy

The aim of this study was to simplify, improve and validate quantitative measurement of the mitochondrial membrane potential (ΔψM) in pancreatic β-cells. This built on our previously introduced calculation of the absolute magnitude of ΔψM in intact cells, using time-lapse imaging of the non-quench mode fluorescence of tetramethylrhodamine methyl ester and a bis-oxonol plasma membrane potential (ΔψP) indicator. ΔψM is a central mediator of glucose-stimulated insulin secretion in pancreatic β-cells. ΔψM is at the crossroads of cellular energy production and demand, therefore precise assay of its magnitude is a valuable tool to study how these processes interplay in insulin secretion ...


Occupational Exposure To Endocrine-Disrupting Chemicals And Birth Weight And Length Of Gestation: A European Meta-Analysis, Laura Birks, Maribel Casas, Ana M. Garcia, Jan Alexander, Henrique Barros, Anna Bergstrom, Jens Peter Bonde, Alex Burdorf, Nathalie Costet, Asta Danileviciute, Merete Eggesbø, Mariana F. Fernandez, M. Carmen Gonzalez-Galarzo, Regina Grazuleviciene, Wojciech Hanke, Vincent W. V. Jaddoe, Manolis Kogevinas, Inger Kull, Aitana Lertxundi, Vasiliki Melaki, Anne-Marie Nybo Andersen, Nicolas Olea, Kinga Polanska, Franca Rusconi, Loreto Santa-Marina, Ana Cristina Santos, Tanja Vrijkotte, Daniela Zugna, Mark Nieuwenhuijsen, Sylvaine Cordier, Martine Vrijheid 2016 Australian Catholic University

Occupational Exposure To Endocrine-Disrupting Chemicals And Birth Weight And Length Of Gestation: A European Meta-Analysis, Laura Birks, Maribel Casas, Ana M. Garcia, Jan Alexander, Henrique Barros, Anna Bergstrom, Jens Peter Bonde, Alex Burdorf, Nathalie Costet, Asta Danileviciute, Merete Eggesbø, Mariana F. Fernandez, M. Carmen Gonzalez-Galarzo, Regina Grazuleviciene, Wojciech Hanke, Vincent W. V. Jaddoe, Manolis Kogevinas, Inger Kull, Aitana Lertxundi, Vasiliki Melaki, Anne-Marie Nybo Andersen, Nicolas Olea, Kinga Polanska, Franca Rusconi, Loreto Santa-Marina, Ana Cristina Santos, Tanja Vrijkotte, Daniela Zugna, Mark Nieuwenhuijsen, Sylvaine Cordier, Martine Vrijheid

Faculty of Health Sciences Publications

Background:
Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth.
Objectives:
We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery.
Methods:
Using individual participant data from 133,957 mother–child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For ...


Capillary Endothelia From Two Adpkd Patients Are Polyploidy, Sarmed H. Kathem, Wissam A. AbouAlaiwi, Xiaolin Zi, Surya M. Nauli 2016 Chapman University

Capillary Endothelia From Two Adpkd Patients Are Polyploidy, Sarmed H. Kathem, Wissam A. Aboualaiwi, Xiaolin Zi, Surya M. Nauli

Pharmacy Faculty Articles and Research

Bilateral renal cyst formation is the main feature of autosomal dominant polycystic kidney disease (ADPKD). We and other laboratories have previously shown that cystlining epithelia of kidneys from ADPKD patients are characterized by polyploidy. In this report, we show that endothelia from the renal capillary beds of two ADPKD patients are also polyploidy. Spectral karyotyping study further confirms our flow cytometry analyses. We suggest that polyploidy may be used as a potential cellular marker in ADPKD.


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