Do Induced Pluripotent Stem Cells Resolve The Ethical And Legal Issues Generated By Human Embryonic Stem Cells?, 2015 Royal College of Surgeons in Ireland
Do Induced Pluripotent Stem Cells Resolve The Ethical And Legal Issues Generated By Human Embryonic Stem Cells?, Samantha J. Henson
Masters theses/dissertations - taught courses
The field of stem cell technology has seen an exponential growth over the last decade. Due to this, little attention has been paid as to whether this new technology adequately improves on previous research models, or indeed if it causes any ethical or legal issues itself. Of particular interest is whether Induced Pluripotent Stem Cells resolve the ethical and legal issues which have been generated by Human Embryonic Stem Cells. The ethical issues of note relate to the definition of personhood and moral status, the debate on when these can be ascribed, the consequences of utilising embryos for research, and ...
The Effects Of 17Α-Ethynylestradiol (Ee2) On Gonadal Development And Differentiation In The Estuarine Killifish, Fundulus Heteroclitus, Ibrahim Chehade
Theses and Dissertations (Comprehensive)
Endocrine disrupting substances (EDSs) comprise a wide variety of chemicals that perturb normal endocrine function including developmental and reproductive processes in vertebrates. The synthetic estrogen 17α-ethynylestradiol (EE2) is a commonly-used model EDS because of its environmental relevance and its effects on the reproductive endocrine system. Early life-stage exposure of fish to estrogenic EDSs causes effects such as intersex (ovotestes in males) and feminization. This study aims to confirm the period of gonadal differentiation in the estuarine killifish or mummichog (Fundulus heteroclitus) and to determine the sensitivity of gonadal development to EE2. Artificially-regressed mummichog were spawned, and fertilized eggs ...
The Role Of Sonic Hedgehog In The Hypothalamus, 2011 University of Pennsylvania
The Role Of Sonic Hedgehog In The Hypothalamus, Solsire E. Zevallos
Publicly Accessible Penn Dissertations
THE REQUIREMENT OF SONIC HEDGEHOG IN THE HYPOTHALAMUS
Solsire E. Zevallos
Douglas J. Epstein
Sonic hedgehog (Shh) is a morphogen secreted during early development that is required for the formation of the ventral neural tube, including the ventral forebrain. The prechordal source of Shh underlying the forebrain is required early to bifurcate the cerebral hemispheres and eye vesicles as well as to specify a rostroventral forebrain region, the hypothalamus. We hypothesized that Shh expressed later in the hypothalamus may be required for other known functions of Shh, such as patterning within a region, cell proliferation, cell specification, and axon ...