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Knee Range Of Motion: Reliability And Agreement Of 3 Measurement Methods, Paul G. Peters, Michael A. Herbenick, Philip A. Anloague, Ronald J. Markert, L. Joseph Rubino 2019 Wright State University - Main Campus

Knee Range Of Motion: Reliability And Agreement Of 3 Measurement Methods, Paul G. Peters, Michael A. Herbenick, Philip A. Anloague, Ronald J. Markert, L. Joseph Rubino

Ronald Markert

We conducted a study to compare 3 methods of measuring knee range of motion: visual estimation by physicians, hand goniometry by physical therapists, and radiographic goniometry. We hypothesized that reliability would be high within and across all techniques. We found intrarater and interrater reliability to be satisfactory for visual estimation, hand goniometry, and radiographic goniometry. Interrater reliability across methods did not agree satisfactorily. Between-methods differences in estimating knee range of motion may result from variations in technique among physicians and physical therapists.


Mixed Methods To Explore Factors Associated With The Decline Of Patients In The Methadone Maintenance Treatment Program In Shanghai, China, Lei Zhang, Jiayi Bao, Amy L. Harrington, Xiaoduo Fan, Zhen Ning, Jingying Zhang, Daqing Shi, Manji Hu, Zhirong Zhou, Zhengyi Cai, Min Zhao, Jiang Du 2019 Shanghai Jiao Tong University

Mixed Methods To Explore Factors Associated With The Decline Of Patients In The Methadone Maintenance Treatment Program In Shanghai, China, Lei Zhang, Jiayi Bao, Amy L. Harrington, Xiaoduo Fan, Zhen Ning, Jingying Zhang, Daqing Shi, Manji Hu, Zhirong Zhou, Zhengyi Cai, Min Zhao, Jiang Du

Open Access Articles

BACKGROUND: This study was to characterize the Methadone Maintenance Treatment (MMT) in Shanghai, China, and to explore factors associated with the decline of patients in MMT during 2005-2016.

METHODS: Both qualitative and quantitative methods were used in this study. Based on the data from Shanghai Centers for Disease Control (CDC), we described the changes in the number of patients who received MMT, and new enrollment each year from 2005 to 2016. Focus groups were conducted with 22 patients, and in-depth interviews were conducted with 9 service providers.

RESULTS: Quantitative data demonstrate that the number of new enrollment began to decline ...


Serum Deprivation Of Mesenchymal Stem Cells Improves Exosome Activity And Alters Lipid And Protein Composition, Reka A. Haraszti, Rachael Miller, Michelle L. Dubuke, Andrew H. Coles, Marie C. Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John D. Leszyk, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Rachel Wollacott, Yan Wang, Scott A. Shaffer, Neil Aronin, Anastasia Khvorova 2019 University of Massachusetts Medical School

Serum Deprivation Of Mesenchymal Stem Cells Improves Exosome Activity And Alters Lipid And Protein Composition, Reka A. Haraszti, Rachael Miller, Michelle L. Dubuke, Andrew H. Coles, Marie C. Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John D. Leszyk, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Rachel Wollacott, Yan Wang, Scott A. Shaffer, Neil Aronin, Anastasia Khvorova

Open Access Articles

Exosomes can serve as delivery vehicles for advanced therapeutics. The components necessary and sufficient to support exosomal delivery have not been established. Here we connect biochemical composition and activity of exosomes to optimize exosome-mediated delivery of small interfering RNAs (siRNAs). This information is used to create effective artificial exosomes. We show that serum-deprived mesenchymal stem cells produce exosomes up to 22-fold more effective at delivering siRNAs to neurons than exosomes derived from control cells. Proteinase treatment of exosomes stops siRNA transfer, indicating that surface proteins on exosomes are involved in trafficking. Proteomic and lipidomic analyses show that exosomes derived in ...


Plasma Indoleamine 2,3-Dioxygenase Activity As A Potential Biomarker For Early Diagnosis Of Multidrug-Resistant Tuberculosis In Tuberculosis Patients, Wen Shi, Juan Wu, Qi Tan, Chun-Mei Hu, Xia Zhang, Hong-Qiu Pan, Zhen Yang, Meng-Yu He, Min Yu, Bo Zhang, Wei-Ping Xie, Hong Wang 2019 The First Affiliated Hospital of Nanjing Medical University

Plasma Indoleamine 2,3-Dioxygenase Activity As A Potential Biomarker For Early Diagnosis Of Multidrug-Resistant Tuberculosis In Tuberculosis Patients, Wen Shi, Juan Wu, Qi Tan, Chun-Mei Hu, Xia Zhang, Hong-Qiu Pan, Zhen Yang, Meng-Yu He, Min Yu, Bo Zhang, Wei-Ping Xie, Hong Wang

Open Access Articles

Purpose: Multidrug-resistant tuberculosis (MDR-TB) remains a challenge of global TB control, with difficulty in early detection of drug-sensitive tuberculosis (DS-TB). We investigate the diagnostic significance of IDO as a potential biomarker to discriminate MDR patients among the TB patients.

Patients and methods: Plasma indoleamine 2,3-dioxygenase (IDO) was measured by the ratio of kynurenine (Kyn) to tryptophan (Trp) concentrations, using high performance liquid chromatography-mass spectrometry (LC-MS/MS). Chest computed tomography (CT) imaging signs from TB patients were collected and analyzed in 18 DS-TB patients, 16 MDR-TB patients, 6 lung cancer (LC) patients, and 11 healthy individuals. Lung imaging signs from ...


Bridging From Intramuscular To Limb Perfusion Delivery Of Raav: Optimization In A Non-Human Primate Study, Alisha Gruntman, Gwladys Gernoux, Qiushi Tang, Guo-Jie Ye, Dave R. Knop, Gensheng Wang, Janet Benson, Kristen E. Coleman, Allison M. Keeler, Christian Mueller, Louis G. Chicoine, Jeffrey D. Chulay, Terence R. Flotte 2019 University of Massachusetts Medical School

Bridging From Intramuscular To Limb Perfusion Delivery Of Raav: Optimization In A Non-Human Primate Study, Alisha Gruntman, Gwladys Gernoux, Qiushi Tang, Guo-Jie Ye, Dave R. Knop, Gensheng Wang, Janet Benson, Kristen E. Coleman, Allison M. Keeler, Christian Mueller, Louis G. Chicoine, Jeffrey D. Chulay, Terence R. Flotte

Christian Mueller

Phase 1 and phase 2 gene therapy trials using intramuscular (IM) administration of a recombinant adeno-associated virus serotype 1 (rAAV1) for replacement of serum alpha-1 antitrypsin (AAT) deficiency have shown long-term (5-year) stable transgene expression at approximately 2% to 3% of therapeutic levels, arguing for the long-term viability of this approach to gene replacement of secreted serum protein deficiencies. However, achieving these levels required 100 IM injections to deliver 135 mL of vector, and further dose escalation is limited by the scalability of direct IM injection. To further advance the dose escalation, we sought to bridge the rAAV-AAT clinical development ...


Repetitive Transcranial Magnetic Stimulation As An Adjunctive Treatment For Negative Symptoms And Cognitive Impairment In Patients With Schizophrenia: A Randomized, Double-Blind, Sham-Controlled Trial, Kaiming Zhuo, Yingying Tang, Zhenhua Song, Yingchan Wang, Junjie Wang, Zhenying Qian, Hui Li, Qiong Xiang, Tianyi Chen, Zhilei Yang, Yifeng Xu, Xiaoduo Fan, Jijun Wang, Dengtang Liu 2019 Shanghai Jiao Tong University

Repetitive Transcranial Magnetic Stimulation As An Adjunctive Treatment For Negative Symptoms And Cognitive Impairment In Patients With Schizophrenia: A Randomized, Double-Blind, Sham-Controlled Trial, Kaiming Zhuo, Yingying Tang, Zhenhua Song, Yingchan Wang, Junjie Wang, Zhenying Qian, Hui Li, Qiong Xiang, Tianyi Chen, Zhilei Yang, Yifeng Xu, Xiaoduo Fan, Jijun Wang, Dengtang Liu

Open Access Articles

Purpose: Effective treatment options for negative symptoms and cognitive impairment in patients with schizophrenia are still to be developed. The present study was to examine potential benefits of repetitive transcranial magnetic stimulation (rTMS) to improve negative symptoms and cognition in this patient population.

Methods: The study was a 4-week, randomized, double-blind sham-controlled trial. Patients with schizophrenia were treated with adjunctive 20-Hz rTMS for 4 weeks or sham condition to the left dorsolateral prefrontal cortex (DLPFC). Negative symptoms were measured using the Scale for the Assessment of Negative Symptoms (SANS) and the Positive and Negative symptom scale (PANSS) negative subscale at ...


Changes In Anticoagulant Utilization Among United States Nursing Home Residents With Atrial Fibrillation From 2011 To 2016, Matthew Alcusky, David D. McManus, Anne L. Hume, Marc Fisher, Jennifer Tjia, Kate L. Lapane 2019 University of Massachusetts Medical School

Changes In Anticoagulant Utilization Among United States Nursing Home Residents With Atrial Fibrillation From 2011 To 2016, Matthew Alcusky, David D. Mcmanus, Anne L. Hume, Marc Fisher, Jennifer Tjia, Kate L. Lapane

Open Access Articles

Background: Nursing home residents with atrial fibrillation are at high risk for ischemic stroke and bleeding events. The most recent national estimate (2004) indicated less than one third of this high-risk population was anticoagulated. Whether direct-acting oral anticoagulant ( DOAC ) use has disseminated into nursing homes and increased anticoagulant use is unknown.

Methods and Results: A repeated cross-sectional design was used to estimate the point prevalence of oral anticoagulant use on July 1 and December 31 of calendar years 2011 to 2016 among Medicare fee-for-service beneficiaries with atrial fibrillation residing in long-stay nursing homes. Nursing home residence was determined using Minimum ...


Evaluation Of Prophylactic Dosages Of Enoxaparin In Non-Surgical Elderly Patients With Renal Impairment, Nibal Chamoun, Hady Ghanem, Ahmad Hachem, Essa Hariri, Christelle Lteif, Hanine Mansour, Hani Dimassi, Richard Zalloum, Georges Ghanem 2019 Lebanese American University

Evaluation Of Prophylactic Dosages Of Enoxaparin In Non-Surgical Elderly Patients With Renal Impairment, Nibal Chamoun, Hady Ghanem, Ahmad Hachem, Essa Hariri, Christelle Lteif, Hanine Mansour, Hani Dimassi, Richard Zalloum, Georges Ghanem

Open Access Articles

BACKGROUND: Thromboprophylaxis dosing strategies using enoxaparin in elderly patients with renal disease are limited, while dose adjustments or monitoring of anti-Xa levels are recommended. We sought to evaluate the efficacy and safety of enoxaparin 20 mg versus 30 mg subcutaneously daily by comparing anti-Xa levels, thrombosis and bleeding.

METHODS: We conducted a prospective, single-blinded, single-center randomized clinical trial including non-surgical patients, 70 years of age or older, with renal disease requiring thromboprophylaxis. Patients were randomized to receive either 20 mg or 30 mg of enoxaparin. The primary endpoint was peak anti-Xa levels on day 3. Secondary endpoints included trough anti-Xa ...


Innovative Care Of Individuals In The Athletic Training Room: A Case Series, Kathryn E. Young 2019 James Madison University

Innovative Care Of Individuals In The Athletic Training Room: A Case Series, Kathryn E. Young

Senior Honors Projects, 2010-current

This work follows three unique cases of athletic injuries and/or injuries in patients. These cases were selected because of the innovative nature of the rehabilitation process conducted by the sports medicine team via the athletic training room or the unique nature of the injury/case.

The first is a concussion sustained from a motor vehicle accident in a collegiate female thrower. This is unique because it’s a non-sport related concussion handled as an athletic trainer would handle a sports related concussion. It also demonstrates a new unique protocol for concussion management.

The second case is a patient with ...


Regional Vitiligo Induced By Imiquimod Treatment For In-Transit Melanoma Metastases, Elizabeth Tkachenko, Jennifer Y. Lin, Rebecca I. Hartman 2019 University of Massachusetts Medical School

Regional Vitiligo Induced By Imiquimod Treatment For In-Transit Melanoma Metastases, Elizabeth Tkachenko, Jennifer Y. Lin, Rebecca I. Hartman

Open Access Articles

Imiquimod is a topical immunomodulator used for the treatment of viral warts and superficial basal cell carcinoma and as an emerging therapy for lentigo maligna and cutaneous melanoma metastases. Vitiligo-like depigmentation has been described as a local adverse effect of topical imiquimod therapy for melanoma1 and at distant sites in patients treated with combination topical monobenzone-imiquimod for metastatic melanoma.2 We present a case in which topical imiquimod resulted in both the resolution of in-transit metastatic melanoma and the depigmentation of local and regional skin, suggesting a regional lymphatic effect of this localized topical treatment.


Exploiting Unique Biological Features Of Leukemia Stem Cells For Therapeutic Benefit, Haojian Zhang, Shaoguang Li 2019 Wuhan University

Exploiting Unique Biological Features Of Leukemia Stem Cells For Therapeutic Benefit, Haojian Zhang, Shaoguang Li

Open Access Articles

Cancer stem cells play a critical role in disease initiation and insensitivity to chemotherapy in numerous hematologic malignancies and some solid tumors, and these stem cells need to be eradicated to achieve a cure. Key to successful targeting of cancer stem cells is to identify and functionally test critical target genes and to fully understand their associated molecular network in these stem cells. Human chronic myeloid leukemia (CML) is well accepted as one of the typical types of hematopoietic malignancies that are derived from leukemia stem cells (LSCs), serving as an excellent model disease for understanding the biology of LSCs ...


A Highly Expressed Intestinal Cysteine Protease Of Ancylostoma Ceylanicum Protects Vaccinated Hamsters From Hookworm Infection, Jason B. Noon, Erich M. Schwarz, Gary R. Ostroff, Raffi V. Aroian 2019 University of Massachusetts Medical School

A Highly Expressed Intestinal Cysteine Protease Of Ancylostoma Ceylanicum Protects Vaccinated Hamsters From Hookworm Infection, Jason B. Noon, Erich M. Schwarz, Gary R. Ostroff, Raffi V. Aroian

Open Access Articles

BACKGROUND: Human hookworms (Necator americanus, Ancylostoma duodenale, and Ancylostoma ceylanicum) are intestinal blood-feeding parasites that infect ~500 million people worldwide and are among the leading causes of iron-deficiency anemia in the developing world. Drugs are useful against hookworm infections, but hookworms rapidly reinfect people, and the parasites can develop drug resistance. Therefore, having a hookworm vaccine would be of tremendous benefit.

METHODOLOGY/PRINCIPAL FINDINGS: We investigated the vaccine efficacy in outbred Syrian hamsters of three A. ceylanicum hookworm antigen candidates from two classes of proteins previously identified as promising vaccine candidates. These include two intestinally-enriched, putatively secreted cathepsin B cysteine ...


The Healthcare Systems Research Network (Hcsrn) As An Environment For Dissemination And Implementation Research: A Case Study Of Developing A Multi-Site Research Study In Precision Medicine, Alanna Kulchak Rahm, Ilene Ladd, Andrea N. Burnett-Hartman, Mara M. Epstein, Jan T. Lowery, Christine Y. Lu, Pamala A. Pawloski, Ravi N. Sharaf, Su-Ying Liang, Jessica Ezzell. Hunter 2019 Geisinger

The Healthcare Systems Research Network (Hcsrn) As An Environment For Dissemination And Implementation Research: A Case Study Of Developing A Multi-Site Research Study In Precision Medicine, Alanna Kulchak Rahm, Ilene Ladd, Andrea N. Burnett-Hartman, Mara M. Epstein, Jan T. Lowery, Christine Y. Lu, Pamala A. Pawloski, Ravi N. Sharaf, Su-Ying Liang, Jessica Ezzell. Hunter

Open Access Articles

Context: In existence for nearly 25 years, the Healthcare Systems Research Network (HCSRN) is an established and sustainable network of health care systems that serves as a "real world" laboratory to enable the integration of research findings into practice. The objective of this paper is to demonstrate how the HCSRN serves as an ideal environment for studying dissemination and implementation of evidence-based practices into health care systems through the example of developing a multi-site study on the implementation of evidence-based precision medicine practices.

Case description: The "Implementing Universal Lynch Syndrome Screening (IMPULSS)" study (NIH R01CA211723) involves seven HCSRN health care ...


Therapeutic Peptide Sequences And Gatekeepers Loaded With Mesoporous Silica Nanoparticles, Dursitu Hassen 2019 Kansas State university

Therapeutic Peptide Sequences And Gatekeepers Loaded With Mesoporous Silica Nanoparticles, Dursitu Hassen

Kansas State University Undergraduate Research Conference

The research community is developing and looking into new ways of effectively delivering anti-cancer treatment. According to National Cancer Institute over 1.5 million new cases of cancer are predicted in the United States, just alone in 2018. The major hurdles that have been identified by scientists are finding mechanisms that assist in decreasing the side effects of cancer treatment and to increase the effectiveness of the drug. In our lab, a highly toxic peptide sequence, SA-K6L9-AS is encapsulated in MSNs (mesoporous silica nanoparticles) and capped with a gatekeeper. The function of a gatekeeper is preventing ...


Comparing The Effects Of Tissue Flossing And Instrument Assisted Soft Tissue Mobilization On Ankle Dorsiflexion, Sean Carlson, Garrett Rife, Zachary Williams 2019 Cedarville University

Comparing The Effects Of Tissue Flossing And Instrument Assisted Soft Tissue Mobilization On Ankle Dorsiflexion, Sean Carlson, Garrett Rife, Zachary Williams

The Research and Scholarship Symposium

Purpose: The purpose of this study is to evaluate the claimed effects of a new technique called Tissue Flossing and compare those effects with Instrument Assisted Soft Tissue Mobilization, or IASTM. Background: Tissue flossing is a relatively new technique that utilizes a large rubber band that is wrapped around the involved joint. Once applied, range of motion exercises are completed, and the band is removed. The goal is to increase joint range of motion. IASTM involves using a specialized tool to scrape an effected muscle or tendon of the body. The goal is to reduce any adhesions or scar tissue ...


Prophylactic Use Of Lmwh Vs Ufh In Pe Patients, Kyleigh Grieshaber, Barbara McClaskey 2019 Pittsburg State University

Prophylactic Use Of Lmwh Vs Ufh In Pe Patients, Kyleigh Grieshaber, Barbara Mcclaskey

Posters

As a result of deep vein thrombosis (DVT), a pulmonary embo­lism (PE) can occur which creates a blockage in the body’s pulmonary circulation, leading to cell death. PE is the third leading cause of death in the U.S., while being the most common, most preventable cause of death in hospitalized patients. Understanding the signs and symptoms of PE is essential in order to save patients’ lives. The objective of this research study was to compare the prophylactic use of Unfractionated Heparin (UFH) and Low Molecular Weight Heparin (LMWH) in patients effected with PE. Information for this research ...


Tamsulosin Use After Shock Wave Lithotripsy: A Systematic Review, Katherine Harte 2019 University of Rhode Island

Tamsulosin Use After Shock Wave Lithotripsy: A Systematic Review, Katherine Harte

Senior Honors Projects

Urolithiasis, or the formation of stones in the urinary tract, is a potentially painful process that impacts many people across the world. However, the results of clinical trials disagree on the proper treatment and management of kidney stones. One way to help those who have kidney stones is to perform extracorporeal shock wave lithotripsy (SWL), a medical procedure in which shock waves are directed towards kidney stones to prevent them from migrating and causing pain. Following SWL, patients are sometimes given additional medications, such as alpha blockers (e.g., tamsulosin), to aid in the passage of the stones. However, the ...


Impact Of Pharmacogenomics On Clinical Outcomes In Major Depressive Disorder In The Guided Trial: A Large, Patient- And Rater-Blinded, Randomized, Controlled Study, John F. Greden, Anthony J. Rothschild 2019 University of Michigan-Ann Arbor

Impact Of Pharmacogenomics On Clinical Outcomes In Major Depressive Disorder In The Guided Trial: A Large, Patient- And Rater-Blinded, Randomized, Controlled Study, John F. Greden, Anthony J. Rothschild

Open Access Articles

Current prescribing practices for major depressive disorder (MDD) produce limited treatment success. Although pharmacogenomics may improve outcomes by identifying genetically inappropriate medications, studies to date were limited in scope. Outpatients (N=1167) diagnosed with MDD and with a patient- or clinician-reported inadequate response to at least one antidepressant were enrolled in the Genomics Used to Improve DEpression Decisions (GUIDED) trial - a rater- and patient-blind randomized controlled trial. Patients were randomized to treatment as usual (TAU) or a pharmacogenomics-guided intervention arm in which clinicians had access to a pharmacogenomic test report to inform medication selections (guided-care). Medications were considered congruent ('use ...


Low Back Pain, A Comprehensive Review: Pathophysiology, Diagnosis, And Treatment (Poster), Ivan Urits, Aaron Burshtein, Medha Sharma, Lauren Testa, Peter A. Gold, Vwaire Orhurhu, Omar Viswanath, Mark R. Jones, Moises A. Sidransky, Alan D. Kaye 2019 Harvard Medical School

Low Back Pain, A Comprehensive Review: Pathophysiology, Diagnosis, And Treatment (Poster), Ivan Urits, Aaron Burshtein, Medha Sharma, Lauren Testa, Peter A. Gold, Vwaire Orhurhu, Omar Viswanath, Mark R. Jones, Moises A. Sidransky, Alan D. Kaye

Senior Scholars Program

Purpose of Review: Low back pain encompasses three distinct sources: axial lumbosacral, radicular, and referred pain. Annually, the prevalence of low back pain in the general U.S. adult population is 10-30%, and the lifetime prevalence of U.S. adults is as high as 65-80%.

Recent Findings: Patient history, physical exam, and diagnostic testing are important components to accurate diagnosis and identification of patient pathophysiology. Etiologies of low back pain include myofascial pain, facet joint pain, sacroiliac joint pain, discogenic pain, and spinal stenosis, and failed back surgery. In chronic back pain patients, a multidisciplinary, logical approach to treatment is ...


Women-Reported Barriers And Facilitators Of Adherence To Medications For Opioid Use Disorder, Alice Fiddian-Green, Aline C. Gubrium, Calla Harrington, Elizabeth Evans 2019 University of Massachusetts Amherst

Women-Reported Barriers And Facilitators Of Adherence To Medications For Opioid Use Disorder, Alice Fiddian-Green, Aline C. Gubrium, Calla Harrington, Elizabeth Evans

Community Engagement and Research Symposia

AIM: A poorly understood challenge is why many women with opioid use disorder do not remain engaged with medications for opioid use disorder (MOUD; e.g., methadone, buprenorphine, naltrexone) long enough to achieve sustained benefits. We aimed to identify barriers and facilitators that impact women's MOUD adherence.

METHODS: We conducted in-person interviews and focus groups with 20 women who had received MOUD for at least 90 days in Springfield and Holyoke, Massachusetts in 2018. Using grounded theory, we inductively identified major themes and selected illustrative quotations.

FINDINGS: Gender-specific barriers to treatment are shaped by MOUD-related stigma stemming from multiple ...


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