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Improved Methods Of Sepsis Case Identification And The Effects Of Treatment With Low Dose Steroids: A Dissertation, Huifang Zhao 2011 University of Massachusetts Medical School

Improved Methods Of Sepsis Case Identification And The Effects Of Treatment With Low Dose Steroids: A Dissertation, Huifang Zhao

GSBS Dissertations and Theses


Sepsis is the leading cause of death among critically ill patients and the 10th most common cause of death overall in the United States. The mortality rates increase with severity of the disease, ranging from 15% for sepsis to 60% for septic shock. Patient with sepsis can present varied clinical symptoms depending on the personal predisposition, causal microorganism, organ system involved, and disease severity. To facilitate sepsis diagnosis, the first sepsis consensus definitions was published in 1991 and then updated in 2001. Early recognition of a sepsis patient followed with timely and appropriate treatment and management strategies have been ...


Environmental Toxins: Biological, Chemical And Radiological Terrorism, Richard N. Bradley 2011 The University of Texas Health Science Center at Houston

Environmental Toxins: Biological, Chemical And Radiological Terrorism, Richard N. Bradley

Richard N Bradley

Children have greater risk of harm than adults after exposure to chemical, biological or radiological weapons, as may be seen following some acts of terrorism. This chapter reviews potential chemical agents, separating them into four categories: nerve agents, blister agents, cyanides, and choking agents. It reviews both recognition and treatment. The chapter also reviews symptoms, modes of transmission and treatment for the following biological agents: smallpox, plague, tularemia, anthrax, botulism, and viral hemorrhagic fevers.


Qualidade De Vida: Considerações Sobre Os Indicadores E Instrumentos De Medida / Quality Of Life: Consideration Of Indicators And Instruments Of Measure, Everton Fernando Alves 2010 Universidade Estadual de Maringá

Qualidade De Vida: Considerações Sobre Os Indicadores E Instrumentos De Medida / Quality Of Life: Consideration Of Indicators And Instruments Of Measure, Everton Fernando Alves

Everton Fernando Alves

Os instrumentos de medida são desenvolvidos para as mais diversas finalidades e indicações. Sua funcionalidade depende de escalas genéricas, do estado de saúde e escalas específicas a uma determinada situação. O presente estudo teve como objetivo discorrer sobre os aspectos importantes que permeiam a utilização dos instrumentos de medida e apresentar de forma sistematizada os indicadores e instrumentos de medida de QV, utilizados e validados no Brasil. Realizou-se um estudo de revisão narrativa do conhecimento disponível na literatura, com consulta às seguintes bases de dados: DEDALUS, LILACS, MEDLINE e Scielo, tendo como base os períodos de 1995-2008. Observou-se que os ...


Novel Amino Acid And Ethanolamine Derivatives As Potential Tumor Imaging Agents For Positron Emission Tomography, Limin Wang 2010 University of Pennsylvania

Novel Amino Acid And Ethanolamine Derivatives As Potential Tumor Imaging Agents For Positron Emission Tomography, Limin Wang

Publicly Accessible Penn Dissertations

Malignant tumors can be detected with high sensitivity and specificity by imaging their increased metabolic rate for glucose, amino acids and fatty acids. Positron emission tomography (PET) with glucose analog [18F]FDG, which utilizes increased glucose metabolism, has become a routine clinical test for diagnosis, staging and restaging a variety of cancers. Despite the tremendous success of PET-FDG, there are some well-known limitations of [18F]FDG such as high cerebral uptake, uptake in inflammatory tissues, high excretion through urinary tract and low or negligent uptake in certain type of tumors. Decades of nuclear medicine research have lead to development of ...


Desktop Medicine, Jason Karlawish 2010 University of Pennsylvania

Desktop Medicine, Jason Karlawish

Center for Bioethics Papers

No abstract provided.


Magnetic Resonance Imaging Of Neural And Pulmonary Vascular Function: A Dissertation, Ronn P. Walvick 2010 University of Massachusetts Medical School

Magnetic Resonance Imaging Of Neural And Pulmonary Vascular Function: A Dissertation, Ronn P. Walvick

GSBS Dissertations and Theses

Magnetic resonance imaging (MRI) has emerged as the imaging modality of choice in a wide variety experimental and clinical applications. In this dissertation, I will describe novel MRI techniques for the characterization of neural and pulmonary vascular function in preclinical models of disease.

In the first part of this dissertation, experimental results will be presented comparing the identification of ischemic lesions in experimental stroke using dynamic susceptibility contrast (DSC) and a well validated arterial spin labeling (ASL). We show that DSC measurements of an index of cerebral blood flow are sensitive to ischemia, treatment, and stroke subregions. Further, we derived ...


Evaluation Of The Quantitative Accuracy Of A Commercially-Available Positron Emission Mammography Scanner, Adam Springer 2010 University of Texas Graduate School of Biomedical Sciences at Houston

Evaluation Of The Quantitative Accuracy Of A Commercially-Available Positron Emission Mammography Scanner, Adam Springer

UT GSBS Dissertations and Theses (Open Access)

Objective: The PEM Flex Solo II (Naviscan, Inc., San Diego, CA) is currently the only commercially-available positron emission mammography (PEM) scanner. This scanner does not apply corrections for count rate effects, attenuation or scatter during image reconstruction, potentially affecting the quantitative accuracy of images. This work measures the overall quantitative accuracy of the PEM Flex system, and determines the contributions of error due to count rate effects, attenuation and scatter.

Materials and Methods: Gelatin phantoms were designed to simulate breasts of different sizes (4 – 12 cm thick) with varying uniform background activity concentration (0.007 – 0.5 μCi/cc), cysts ...


Perfil Dos Atendimentos Ambulatoriais Realizados Em Uma Clínica De Cirurgia Plástica No Sul Do Brasil / Outpatient Service Profile In A Plastic Surgery Clinic In Southern Brazil, Everton Fernando Alves 2010 Universidade Estadual de Maringá

Perfil Dos Atendimentos Ambulatoriais Realizados Em Uma Clínica De Cirurgia Plástica No Sul Do Brasil / Outpatient Service Profile In A Plastic Surgery Clinic In Southern Brazil, Everton Fernando Alves

Everton Fernando Alves

Objetivo: Descrever o perfil dos atendimentos ambulatoriais realizados em uma clínica de cirurgia plástica no sul do Brasil. Materiais e Métodos: Foi realizado um estudo descritivo, exploratório e de caráter quantitativo com o intuito de analisar a totalidade de atendimentos ambulatoriais (consultas e cirurgias) realizadas em uma clínica privada de cirurgia plástica no período de 01 de janeiro a 31 de dezembro de 2010. Resultados: Observou-se que, das 671 (60,5%) consultas novas, apenas 205 (18,5%) cirurgias foram realizadas. Março foi o mês com mais consultas (10%) e cirurgias (11,7%). Do total de consultas novas, as reparadoras foram ...


Hiv: Make The Diagnosis And Take The Next Step, Julie G. Stewart, Amy R. Weinberg 2010 Sacred Heart University

Hiv: Make The Diagnosis And Take The Next Step, Julie G. Stewart, Amy R. Weinberg

Nursing Faculty Publications

With the CDC urging screening for all willing patients, providers will be testing and managing a growing number of HIV-positive individuals.

The CDC estimates that with more than 40,000 new infections annually, more than 1.2 million people in the United States are living with HIV-and 24% to 27% may not be aware of their infection status.1 Studies have shown that HIV is often diagnosed late in the disease process, when the individual has already developed AIDS, which typically occurs 8 to 11 years after HIV infection.2 Research also points to missed opportunities to offer HIV testing ...


Qualidade De Vida No Trabalho: Indicadores E Instrumentos De Medidas / Quality Of Work Life: Indicators And Instruments Of Measure, Everton Fernando Alves 2010 Universidade Estadual de Maringá

Qualidade De Vida No Trabalho: Indicadores E Instrumentos De Medidas / Quality Of Work Life: Indicators And Instruments Of Measure, Everton Fernando Alves

Everton Fernando Alves

The measurement of Quality of Life at Work (QLW) has been emerging in the scientific community as an important tool for investigating and evaluating the occupational health of individuals in a holistic manner. The measurement instruments are developed for many different purposes and directions, being held by generic scales of health status and specific scales to a given situation. The objective of this study is to discuss important aspects related to QLW and present in a systematic concept, indicators and measurement instruments used and validated in Brazil. Was conducted a study of narrative review of available knowledge in the literature ...


Influence Of Anchoring On Miscarriage Risk Perception Associated With Amniocentesis, Regina A. Nuccio 2010 University of Texas Graduate School of Biomedical Sciences at Houston

Influence Of Anchoring On Miscarriage Risk Perception Associated With Amniocentesis, Regina A. Nuccio

UT GSBS Dissertations and Theses (Open Access)

INFLUENCE OF ANCHORING ON MISCARRIAGE RISK PERCEPTION ASSOCIATED WITH AMNIOCENTESIS Publication No. ___________ Regina Nuccio, BS Supervisory Professor: Claire N. Singletary, MS, CGC Amniocentesis is the most common invasive procedure performed during pregnancy (Eddleman, et al., 2006). One important factor that women consider when making a decision about amniocentesis is the risk of miscarriage associated with the procedure. People use heuristics such as anchoring, the action of using a prior belief regarding the magnitude of risk as a frame of reference for new information to be synthesized, to better understand risks that they encounter in their lives. This study aimed ...


Platelet Alpha- And Beta- Secretase Activities Are Not Significantly Affected By Dementia Or Mild Cognitive Impairment In Swedish Patients., Paul Gorham, Natalie Bark, Steve Meaney, Ingemar Bjorkhem, Milita Crisby 2010 Technological University Dublin

Platelet Alpha- And Beta- Secretase Activities Are Not Significantly Affected By Dementia Or Mild Cognitive Impairment In Swedish Patients., Paul Gorham, Natalie Bark, Steve Meaney, Ingemar Bjorkhem, Milita Crisby

Articles

The processing of the Amyloid Precursor Protein (APP) is a critical event in the formation of amyloid plaques which are composed of the 4kDa amyloid beta-peptide (Abeta). Processing of APP occurs through a non-amyloidogenic pathway, mediated by initial alpha-secretase cleavage or through an amyloidogenic pathway via sequential cleavage by beta- and gamma-secretase enzymes, which produces Abeta peptides. Currently, the diagnosis of probable or possible Alzheimer's disease (AD) is primarily based on neuropsychological and neuroradiological assessment. Recent reports indicate that platelet beta-secretase activity is moderately increased in patients with AD and mild cognitive impairment (MCI). To our knowledge platelet alpha-secretase ...


An Optical Machine Vision System For Applications In Cytopathology, Jonathan Blackledge, Dmitry Dubovitskiy 2010 Dublin Institute of Technology

An Optical Machine Vision System For Applications In Cytopathology, Jonathan Blackledge, Dmitry Dubovitskiy

Articles

This paper discusses a new approach to the processes of object detection, recognition and classification in a digital image focusing on problem in Cytopathology. A unique self learning procedure is presented in order to incorporate expert knowledge. The classification method is based on the application of a set of features which includes fractal parameters such as the Lacunarity and Fourier dimension. Thus, the approach includes the characterisation of an object in terms of its fractal properties and texture characteristics. The principal issues associated with object recognition are presented which include the basic model and segmentation algorithms. The self-learning procedure for ...


Evaluating Children With Otitis Media For Bacteremia Or Urinary Tract Infection., Daniel Yawman, Patrick Mahar, Aaron Blumkin, Gregory P. Conners 2010 Children's Mercy Hospital

Evaluating Children With Otitis Media For Bacteremia Or Urinary Tract Infection., Daniel Yawman, Patrick Mahar, Aaron Blumkin, Gregory P. Conners

Manuscripts, Articles, Book Chapters and Other Papers

Background. It is unclear if clinicians evaluate for concurrent bacteremia or UTI in young patients diagnosed with acute otitis media (AOM). Objectives. To describe how often, and under which circumstances, emergency providers investigate for bacteremia or UTI in 2-36 month olds with AOM. Methods. Cases of AOM were analyzed from the 2001-2004 National Hospital Ambulatory Medical Care Survey (NHAMCS)-Emergency Department dataset. Results. AOM was diagnosed in 17% of the 10,847 recorded visits of 2-36 month olds. Of these visits, laboratory testing included: CBC: 7%, Blood culture: 4%, urinalysis or urine culture: 5%, and any of these tests: 9 ...


Lost In Translation?: An Essay On Law And Neuroscience, Stephen J. Morse 2010 University of Pennsylvania

Lost In Translation?: An Essay On Law And Neuroscience, Stephen J. Morse

Faculty Scholarship at Penn Law

The rapid expansion in neuroscientific research fuelled by the advent of functional magnetic resonance imaging [fMRI] has been accompanied by popular and scholarly commentary suggesting that neuroscience may substantially alter, and perhaps will even revolutionize, both law and morality. This essay, a contribution to, Law and Neuroscience (M. Freeman, Ed. 2011), will attempt to put such claims in perspective and to consider how properly to think about the relation between law and neuroscience. The overarching thesis is that neuroscience may indeed make some contributions to legal doctrine, practice and theory, but such contributions will be few and modest for the ...


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