Screening For Intermediate And Severe Forms Of Thalassaemia In Discarded Red Blood Cells: Optimization And Feasibility, Maryanne Tan
Mary Anne Tan Jin Ai
Detection and quantification of Hb subtypes of human blood is integral to presumptive identification of thalassaemias. It has been used in neonatal screening of thalassaemia and Hb variants. The use of discarded red blood cells following processing of the cord blood for stem cells provides readily available diagnostic material for thalassaemia screening. In this study, we determined the range of Hb subtypes in 195 consecutive cord blood samples collected for cord blood banking. The `cord blood samples’ analysed were those of the remaining red blood cells after the cord blood was processed for stem cell storage. Quantification of Hb subtypes ...
Identifying And Co-Managing The Hiv-Infected Adult: A Guidebook For Primary Care Clinicians, 2011 Albert Einstein College of Medicine
Identifying And Co-Managing The Hiv-Infected Adult: A Guidebook For Primary Care Clinicians, Jason Leider, Susan F. Lelacheur, Julie G. Stewart Dnp, Mph
Nursing Faculty Publications
This guidebook was designed to help primary care clinicians improve their performance in terms of HIV identification and co-management. Surmounting barriers to opt-out screening, making an HIV diagnosis, and preventing transmission and opportunistic infections will be discussed, as will selection of initial therapy and considerations for patients receiving antiretroviral therapy (ART).
Pressure Pain Threshold Testing Demonstrates Predictive Ability In People With Acute Whiplash., 2011 The University of Western Ontario
Pressure Pain Threshold Testing Demonstrates Predictive Ability In People With Acute Whiplash., David Walton
No abstract provided.
In-Vivo Ct Dosimetry During Virtual Colonoscopy, 2011 The University of Texas Graduate School of Biomedical Sciences at Houston
In-Vivo Ct Dosimetry During Virtual Colonoscopy, Jonathon W. Mueller
UT GSBS Dissertations and Theses (Open Access)
Virtual colonoscopy (VC) is a minimally invasive means for identifying colorectal polyps and colorectal lesions by insufflating a patient’s bowel, applying contrast agent via rectal catheter, and performing multi-detector computed tomography (MDCT) scans. The technique is recommended for colonic health screening by the American Cancer Society but not funded by the Centers for Medicare and Medicaid Services (CMS) partially because of potential risks from radiation exposure. To date, no in‐vivo organ dose measurements have been performed for MDCT scans; thus, the accuracy of any current dose estimates is currently unknown.
In this study, two TLDs were affixed to ...
The Use Of Motion Analysis Technology As An Alternative Means Of Assessing Spinal Deformity In Patients With Adolescent Idiopathic Scoliosis, 2011 University of Connecticut - Storrs
The Use Of Motion Analysis Technology As An Alternative Means Of Assessing Spinal Deformity In Patients With Adolescent Idiopathic Scoliosis, Matthew J. Solomito
Adolescent Idiopathic Scoliosis (AIS) is a three dimensional deformity of the spine that causes abnormal curvatures in the coronal and sagittal planes and abnormal vertebral rotations. The gold standard for diagnosing and tracking the progression of the deformity is through the use of repeated radiography and a patient can receive upwards of fifteen radiographic series over the course of treatment, which exposes this population to an increased risk of radiation-dependent complications.
This thesis presents the necessary calculations and the marker set required to make the motion capture technology a viable alternative to radiographs, in an effort to reduce the patient ...
Investigation Of Emergency Medical Technicians Practice And Beliefs Regarding The Recognition And Treatment Of Exertional Heat Stroke, Kristin Applegate
Context: Current Evidence Based Practice (EBP) supports the use of rectal thermometry (Tre) for an accurate diagnosis and cold water-immersion (CWI) for the treatment of Exertional Heat Stroke (EHS) for an optimal outcome. Emergency Medical Services (EMS) play a critical role for the diagnosis and treatment of EHS as they may be the first to arrive on scene, however there is limited data regarding their implementation of EBP. Objective: Investigate current practice regarding EHS by EMS professionals and explore the relationship that exists between EMS and Athletic Trainers (ATs). Design: A basic qualitative design using in-person focus groups. Setting ...
Diagnosis Of Heart Failure In Primary Care, 2011 University of Birmingham
Diagnosis Of Heart Failure In Primary Care, F. D. R. Hobbs, Jenny Doust, Jonathan Mant, Martin R. Cowie
Extract: Heart failure is a syndrome resulting from a structural or functional cardiac disorder. For a diagnosis of heart failure to be made, there should be symptoms or signs, such as breathlessness, effort intolerance or fluid retention, together with objective evidence of cardiac dysfunction. Heart failure is an increasingly important chronic disease syndrome, associated with poor prognosis, poor quality of life for patients, and high healthcare costs. In the general population, where all grades of heart failure are represented, 5 year mortality is around 42%; however, where the diagnosis is established during a hospital admission, 5 year mortality is between ...
Application Of A High‑Resolution Computed Radiography System In Detecting An Iodinated X‑Ray Contrast Agent: Small Animal Phantom Study, 2011 University of Tennessee Health Science Center
Application Of A High‑Resolution Computed Radiography System In Detecting An Iodinated X‑Ray Contrast Agent: Small Animal Phantom Study, Anobel Maghsoodpour
Theses and Dissertations (ETD)
Tumor angiogenesis, the creation of new blood vessels, is the characteristic of solid tumors and crucial for their development. Iodinated contrast agents are used to increase the X‑ray detectability of zone of angiogenesis, and thus providing a means for tracking tumor growth.
The overall objective of this project was to evaluate the performance of Kodak CR 7400, a high‑resolution compact computed radiography (CR) system in detection of Omnipaque‑240, an iodinated contrast agent, in a phantom mimicking small animal tumor model.
The first phase of the project was dedicated to a comprehensive assessment of CR image quality by ...
Detection Of Folate Receptor From Fr+ Cancer Cells, 2011 Governors State University
Detection Of Folate Receptor From Fr+ Cancer Cells, Darpan Patel
All Capstone Projects
The aim was to detect cancer cells by using folate–PEG-Biotin probe with fluorescently labeled streptavidin for targeted drug delivery of anti-cancer drugs and diagnose cancer cells. Folate-PEG-Biotin (synthesized by Dr. Henne and Mr.Rohan Patel) was purified by HighPeformanceLiquidChromatography (HPLC) analysis and with the help of Liquid Chromatography/Mass Spectrometry (LC/MS) its identity was confirmed. Folate is a basic composition of cell metabolism in both synthesis of DNA and proteins. Growing cancer cells require high level of folic acid. Folate Receptor-α (FR-α) is a membrane bound protein having high affinity for folic acid and serves to transport of ...
Synthesis And Analytical Evaluation Of Folate Conjugates For Use In Cancer Cell Detection, 2011 Governors State University
Synthesis And Analytical Evaluation Of Folate Conjugates For Use In Cancer Cell Detection, Pradipkumar Koshiya
All Capstone Projects
Folate-targeted dyes have been used for the detection of tumor tissue and isolated cancer cells in both the animal tumor models as well as in human cancer patients. Folate receptors (FR) are abundantly present on several cancerous cell types but they are found less in normal human cells. There are several imaging agents that can be linked with folic acid and used for the detection of tumor. These imaging agents could be protein toxins, chemotherapeutic agents, gene therapy vectors, oligonucleotides, radioimaging agents, magnetic resonance imaging contrast agents and liposomes with entrapped drugs, radiotherapeutic agents and/or immunotherapeutic agents. This research ...
The Effect Of Glycemic Index And Glycemic Load On Glucose Control, Lipid Profiles And Anthropometrics Among Low-Income Latinos With Type 2 Diabetes: A Dissertation, 2011 University of Massachusetts Medical School
The Effect Of Glycemic Index And Glycemic Load On Glucose Control, Lipid Profiles And Anthropometrics Among Low-Income Latinos With Type 2 Diabetes: A Dissertation, Lauren A. Gellar
GSBS Dissertations and Theses
Background The incidence of type 2 diabetes has increased dramatically, particularly among Latinos. While several studies suggest the beneficial effect of lowering glycemic index and glycemic load in patients with type 2 diabetes, no data exists regarding this issue in the Latino population. The purpose of this study was to determine the effect of lowering glycemic index and glycemic load on diabetes control, lipid profiles and anthropometrics among Latinos with type 2 diabetes.
Methods Subjects participated in a 12 month randomized clinical trial. The intervention targeted diabetes knowledge, attitudes and behavioral capabilities related to diabetes self management with content including ...
Hemodynamics In The Stenosed Carotid Bifurcation With Plaque Ulceration, 2011 The University of Western Ontario
Hemodynamics In The Stenosed Carotid Bifurcation With Plaque Ulceration, Emily Y. Wong
Electronic Thesis and Dissertation Repository
The presence of irregular plaque surface morphology or ulceration of the atherosclerotic lesion has been identified as an independent risk factor for ischemic stroke. Doppler ultrasound (DUS) is the most commonly performed non-invasive technique used to assess patients suspected of having carotid artery disease, but currently does not incorporate the diagnosis of plaque ulceration. Advanced Doppler analyses incorporating quantitative estimates of flow disturbances may result in diagnostic indices that identify plaque ulcerative conditions. A technique for the fabrication of DUS-compatible flow phantoms was developed, using a direct-machining method that is amenable to comprehensive DUS investigations. In vitro flow studies in ...
Improved Methods Of Sepsis Case Identification And The Effects Of Treatment With Low Dose Steroids: A Dissertation, 2011 University of Massachusetts Medical School
Improved Methods Of Sepsis Case Identification And The Effects Of Treatment With Low Dose Steroids: A Dissertation, Huifang Zhao
GSBS Dissertations and Theses
Sepsis is the leading cause of death among critically ill patients and the 10th most common cause of death overall in the United States. The mortality rates increase with severity of the disease, ranging from 15% for sepsis to 60% for septic shock. Patient with sepsis can present varied clinical symptoms depending on the personal predisposition, causal microorganism, organ system involved, and disease severity. To facilitate sepsis diagnosis, the first sepsis consensus definitions was published in 1991 and then updated in 2001. Early recognition of a sepsis patient followed with timely and appropriate treatment and management strategies have been ...
Environmental Toxins: Biological, Chemical And Radiological Terrorism, 2011 The University of Texas Health Science Center at Houston
Environmental Toxins: Biological, Chemical And Radiological Terrorism, Richard N. Bradley
Richard N Bradley
Children have greater risk of harm than adults after exposure to chemical, biological or radiological weapons, as may be seen following some acts of terrorism. This chapter reviews potential chemical agents, separating them into four categories: nerve agents, blister agents, cyanides, and choking agents. It reviews both recognition and treatment. The chapter also reviews symptoms, modes of transmission and treatment for the following biological agents: smallpox, plague, tularemia, anthrax, botulism, and viral hemorrhagic fevers.
Qualidade De Vida: Considerações Sobre Os Indicadores E Instrumentos De Medida / Quality Of Life: Consideration Of Indicators And Instruments Of Measure, 2010 Universidade Estadual de Maringá
Qualidade De Vida: Considerações Sobre Os Indicadores E Instrumentos De Medida / Quality Of Life: Consideration Of Indicators And Instruments Of Measure, Everton Fernando Alves
Everton Fernando Alves
Os instrumentos de medida são desenvolvidos para as mais diversas finalidades e indicações. Sua funcionalidade depende de escalas genéricas, do estado de saúde e escalas específicas a uma determinada situação. O presente estudo teve como objetivo discorrer sobre os aspectos importantes que permeiam a utilização dos instrumentos de medida e apresentar de forma sistematizada os indicadores e instrumentos de medida de QV, utilizados e validados no Brasil. Realizou-se um estudo de revisão narrativa do conhecimento disponível na literatura, com consulta às seguintes bases de dados: DEDALUS, LILACS, MEDLINE e Scielo, tendo como base os períodos de 1995-2008. Observou-se que os ...
Novel Amino Acid And Ethanolamine Derivatives As Potential Tumor Imaging Agents For Positron Emission Tomography, 2010 University of Pennsylvania
Novel Amino Acid And Ethanolamine Derivatives As Potential Tumor Imaging Agents For Positron Emission Tomography, Limin Wang
Publicly Accessible Penn Dissertations
Malignant tumors can be detected with high sensitivity and specificity by imaging their increased metabolic rate for glucose, amino acids and fatty acids. Positron emission tomography (PET) with glucose analog [18F]FDG, which utilizes increased glucose metabolism, has become a routine clinical test for diagnosis, staging and restaging a variety of cancers. Despite the tremendous success of PET-FDG, there are some well-known limitations of [18F]FDG such as high cerebral uptake, uptake in inflammatory tissues, high excretion through urinary tract and low or negligent uptake in certain type of tumors. Decades of nuclear medicine research have lead to development of ...
Desktop Medicine, 2010 University of Pennsylvania
Desktop Medicine, Jason Karlawish
Center for Bioethics Papers
No abstract provided.
Magnetic Resonance Imaging Of Neural And Pulmonary Vascular Function: A Dissertation, 2010 University of Massachusetts Medical School
Magnetic Resonance Imaging Of Neural And Pulmonary Vascular Function: A Dissertation, Ronn P. Walvick
GSBS Dissertations and Theses
Magnetic resonance imaging (MRI) has emerged as the imaging modality of choice in a wide variety experimental and clinical applications. In this dissertation, I will describe novel MRI techniques for the characterization of neural and pulmonary vascular function in preclinical models of disease.
In the first part of this dissertation, experimental results will be presented comparing the identification of ischemic lesions in experimental stroke using dynamic susceptibility contrast (DSC) and a well validated arterial spin labeling (ASL). We show that DSC measurements of an index of cerebral blood flow are sensitive to ischemia, treatment, and stroke subregions. Further, we derived ...
Evaluation Of The Quantitative Accuracy Of A Commercially-Available Positron Emission Mammography Scanner, 2010 University of Texas Graduate School of Biomedical Sciences at Houston
Evaluation Of The Quantitative Accuracy Of A Commercially-Available Positron Emission Mammography Scanner, Adam Springer
UT GSBS Dissertations and Theses (Open Access)
Objective: The PEM Flex Solo II (Naviscan, Inc., San Diego, CA) is currently the only commercially-available positron emission mammography (PEM) scanner. This scanner does not apply corrections for count rate effects, attenuation or scatter during image reconstruction, potentially affecting the quantitative accuracy of images. This work measures the overall quantitative accuracy of the PEM Flex system, and determines the contributions of error due to count rate effects, attenuation and scatter.
Materials and Methods: Gelatin phantoms were designed to simulate breasts of different sizes (4 – 12 cm thick) with varying uniform background activity concentration (0.007 – 0.5 μCi/cc), cysts ...
Perfil Dos Atendimentos Ambulatoriais Realizados Em Uma Clínica De Cirurgia Plástica No Sul Do Brasil / Outpatient Service Profile In A Plastic Surgery Clinic In Southern Brazil, 2010 Universidade Estadual de Maringá
Perfil Dos Atendimentos Ambulatoriais Realizados Em Uma Clínica De Cirurgia Plástica No Sul Do Brasil / Outpatient Service Profile In A Plastic Surgery Clinic In Southern Brazil, Everton Fernando Alves
Everton Fernando Alves
Objetivo: Descrever o perfil dos atendimentos ambulatoriais realizados em uma clínica de cirurgia plástica no sul do Brasil. Materiais e Métodos: Foi realizado um estudo descritivo, exploratório e de caráter quantitativo com o intuito de analisar a totalidade de atendimentos ambulatoriais (consultas e cirurgias) realizadas em uma clínica privada de cirurgia plástica no período de 01 de janeiro a 31 de dezembro de 2010. Resultados: Observou-se que, das 671 (60,5%) consultas novas, apenas 205 (18,5%) cirurgias foram realizadas. Março foi o mês com mais consultas (10%) e cirurgias (11,7%). Do total de consultas novas, as reparadoras foram ...