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Therapeutic Options For Covid-19: Drug Repurposing Of Serine Protease Inhibitor Against Tmprss2, Mohammad Wildan Abiyyi, Surya Dwira, Arleni Bustami, Linda Erlina 2023 Master's Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia

Therapeutic Options For Covid-19: Drug Repurposing Of Serine Protease Inhibitor Against Tmprss2, Mohammad Wildan Abiyyi, Surya Dwira, Arleni Bustami, Linda Erlina

Indonesian Journal of Medical Chemistry and Bioinformatics

The SARS-Coronavirus 2 (SARS-CoV-2) outbreak is a serious global public health threat. Researchers around the world are conducting mass research to control this epidemic, starting from the discovery of vaccines, to new drugs that have specific activities as antivirals. Drug repurposing is a potential method of using drugs with known activity for reuse as COVID-19 therapy. This method has the advantage that it can reduce costs and also the duration in the development of potential drugs. The initial step in drug repurposing can be done computationally to determine the effectiveness and specificity of the drug on the target protein. Molecular …


A Focused Review Of Multidimensional Well-Being Assessments, Samantha Schonhardt, Stephanie Sullivan, Rebecca Shisler Marshall 2023 University of Georgia

A Focused Review Of Multidimensional Well-Being Assessments, Samantha Schonhardt, Stephanie Sullivan, Rebecca Shisler Marshall

Journal of Wellness

Introduction: Interest in the topic of well-being continues to grow and has resulted in the creation of a variety of well-being assessments. However, each assessment often brings its own terminology, theories, definitions, and dimensions. This creates a muddled research base that produces inconsistencies in the field of well-being. Therefore, the aim of this review was to identify assessments that measure multiple dimensions of well-being, catalogue and group the dimensions into categories, and develop definitions for the categories based on the conceptualizations in the literature. In doing so, the dimensionality of well-being portrayed in the literature can be better understood. …


Virtual Screening On Indonesian Herbal Compounds As Sars-Cov-2 Spike (S2) Glycoprotein Inhibitors: Pharmacophore Modelling & Molecular Docking Approaches, Syailendra Karuna Sugito, Artha Uli Cristina, Putri Saskia Harimurti, Gabriella Regita Cendani, Fauzi Azhar Insani, Linda Erlina, Rafika Indah Paramita, Fadilah Fadilah 2023 Universitas Indonesia

Virtual Screening On Indonesian Herbal Compounds As Sars-Cov-2 Spike (S2) Glycoprotein Inhibitors: Pharmacophore Modelling & Molecular Docking Approaches, Syailendra Karuna Sugito, Artha Uli Cristina, Putri Saskia Harimurti, Gabriella Regita Cendani, Fauzi Azhar Insani, Linda Erlina, Rafika Indah Paramita, Fadilah Fadilah

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: There are still no specific treatments for coronavirus disease (COVID-19) until present days. Several studies have been conducted to determine whether herbal medicine can be an option to be used as a definitive medicine for COVID-19. S2 subunit of spike protein which is responsible for SARS-CoV-2 entry to the host cell, is a potential drug target to inhibit the viral infection. In this study, we aimed to find some compounds from the HerbalDB database that have potential as SARS-CoV-2 spike (S2) glycoprotein inhibitor.

Methods: The 6LXT protein was used as the target protein. The procedure in this study consisted …


Mindfulness Based Stress Reduction Techniques In Chronic Illness, Anna Gil 2023 Abilene Christian University

Mindfulness Based Stress Reduction Techniques In Chronic Illness, Anna Gil

Electronic Theses and Dissertations

Abstract

Chronic stress and its effect on both physical and mental health have been a topic of increasing interest in the past several decades. There is mounting evidence that recurrent, persistent stress of both a physiologic and psychological nature leads to a dysfunction in the hypothalamic pituitary axis (HPA), the system which helps the body recover and adapt to short term stress. In long term stress, this HPA dysfunction leads to impairment of the immune and neuroendocrine systems resulting in chronic low-grade inflammation. This type of chronic inflammation acts as a precursor to several chronic illnesses such as diabetes, hypertension, …


Urban Land-Based Healing: A Northern Intervention Strategy, Nicole Redvers, Melanie Nadeau, Donald Prince 2023 University of North Dakota

Urban Land-Based Healing: A Northern Intervention Strategy, Nicole Redvers, Melanie Nadeau, Donald Prince

Indigenous Health Faculty Publications

Urban Indigenous populations face significant health and social disparities across Canada. With high rates of homelessness and substance abuse, there are often few options for urban Indigenous Peoples to access land-based healing programs despite the increasingly known and appreciated benefits. In May 2018, the first urban land-based healing camp opened in Yellowknife, Northwest Territories, Canada, one of the first to our knowledge in Canada or the United States. This camp may serve as a potential model for an Indigenous-led and Indigenous-based healing camp in an urban setting. We seek to present preliminary outcome data from the healing camp in a …


Mommy, Me, And We: Why Black Mothers Have Turned To Doulas, Janessa Harris 2023 University of Georgia

Mommy, Me, And We: Why Black Mothers Have Turned To Doulas, Janessa Harris

Crossings: Swarthmore Undergraduate Feminist Research Journal

Maternal mortality mates have disproportionately affected black mothers for far too long due to the lack of value that black bodies hold in medical spaces. Because of this concerns voiced by black people are often disregarded and ignored until the very last minute. But what if this was changed? This paper will focus on how black mothers have worked against Western medical systems that silence our voices, but instead turn to doulas who work to make these mothers feel seen, heard, and cared for. Through this, we make birthing a careful and collective effort to turn Mommy&Me to Mommy&We.


Determining Effects Of Holistic And Pharmaceutical Treatment Routes Taken By Physicians For Patients With Polycystic Ovary Syndrome, Erendira Martinez 2023 Dominican University of California

Determining Effects Of Holistic And Pharmaceutical Treatment Routes Taken By Physicians For Patients With Polycystic Ovary Syndrome, Erendira Martinez

Nursing | Senior Theses

Background

Polycystic ovarian syndrome is a hormonal disorder that affects women all over the world. Though a newly recognized diagnosis, that has not been researched extensively, it is clear that this reproductive and metabolic hinderance debilitates many aspects of women’s lives, negatively impacting their quality of life.

Objectives:

  • Discover the effects of physician determined treatment routes on patients with polycystic ovarian syndrome.
  • Explore insufficiency of research conducted regarding different routes of treatments for patients with polycystic ovarian syndrome.

Methods

A literature review was performed of primary research studies, utilizing databases provided by Dominican University of California. Six articles were reviewed …


Movement As Medicine: Dance/Movement Therapy For Individuals With Autism, Parkinson’S Disease, And Cancer, Alessia Zanobini 2023 Claremont McKenna College

Movement As Medicine: Dance/Movement Therapy For Individuals With Autism, Parkinson’S Disease, And Cancer, Alessia Zanobini

CMC Senior Theses

Dance/movement therapy (D/MT) is the psychotherapeutic use of expressive, creative movement to support holistic well-being. D/MT views the human being as a single body-mind unit and movement as a manifestation of life experiences. While typically practiced as a mental health intervention, D/MT can be adapted for a variety of populations. This thesis evaluates scientific data for the non-traditional use of D/MT for three conditions: autism, Parkinson’s disease, and cancer. For individuals on the autism spectrum, D/MT can strengthen attunement skills, provide creative communication outlets, and relieve harmful physical manifestations of autism. For individuals with Parkinson’s disease, D/MT can simultaneously ease …


Two Dimensions Of A Bodhisattva, Douglas Duckworth 2023 Temple University, Philadelphia, PA, USA

Two Dimensions Of A Bodhisattva, Douglas Duckworth

International Journal of Transpersonal Studies Advance Publication Archive

This paper presents two dimensions of a bodhisattva, the ideal of Maha- ya- na Buddhism. One dimension involves contemplative practices that disclose a pure nature that is always already present; this reality is unveiled after the obscurations that cloud it are removed. I refer to this as a “top-down” approach because it is based on qualities of awakening that are already there, yet lie beyond an ordinary being’s comprehension. The second dimension, which I refer to as a “bottom-up” approach, involves directed training and discipline. Unlike the top-down approach, this is not about “going with the flow” or simply letting …


Mindfulness Traps And The Entanglement Of Self: An Inquiry Into The Regime Of Mind, Richard Dixey, Ronald E. Purser 2023 Dharma College, Berkeley, CA, USA

Mindfulness Traps And The Entanglement Of Self: An Inquiry Into The Regime Of Mind, Richard Dixey, Ronald E. Purser

International Journal of Transpersonal Studies Advance Publication Archive

Mindfulness meditation can provide salutary therapeutic benefits, as well as lead advanced practitioners to states of calm and equanimity. In this paper, we argue that such forms of meditation may subtly entrap practitioners in circular, self-reflexive feedback loops. Because these meditation traps fail to clearly discern the operations of mind, they offer a temporary oasis of peace within an unaltered dualistic realm of mind that leaves the root delusion of self-identity intact. Drawing upon Tarthang Tulku’s seminal book Revelations of Mind, we present what he refers to as the “regime of mind,” the processes of cognition, identification and re-cognition in …


The Role Of Herbal Medicines In Central American Indigenous Communities; Improving Accessibility To Type 2 Diabetes Mellitus Treatment, Sarai Ortega 2023 Claremont Colleges

The Role Of Herbal Medicines In Central American Indigenous Communities; Improving Accessibility To Type 2 Diabetes Mellitus Treatment, Sarai Ortega

CMC Senior Theses

Indigenous communities in Central America have used various plant medications to treat illnesses and diseases for centuries. Clinicians must consider improving traditional healthcare methods that are intrinsic to indigenous communities in order to increase access to effective treatments, particularly for diseases that these communities are more at risk for. This work aims to propose a method to identify whether traditional preparations of five plants (Anacardium occidentale L., Hamelia patens Jacq., Momordica charantia L, Neurolaena lobota L. R. Br. Ex Cass., and Tecoma stans L. juss. ex Kunth) can reduce blood glucose levels in rats with type two diabetes. Additionally, …


Cognitive Illusion, Lucid Dreaming, And The Psychology Of Metaphor In Tibetan Buddhist Dzogchen Contemplative Practices, Michael R. Sheehy 2023 California Institute of Integral Studies

Cognitive Illusion, Lucid Dreaming, And The Psychology Of Metaphor In Tibetan Buddhist Dzogchen Contemplative Practices, Michael R. Sheehy

International Journal of Transpersonal Studies Advance Publication Archive

A classic set of eight similes of illusion (sgyu ma’i dpe brgyad) are employed recurrently throughout Indian and Tibetan Buddhist literature to illustrate the operations of cognition, its correlative perceptions, and experiences that emerge. To illustrate a Buddhist psychology of metaphor, the fourteenth century Tibetan scholar and synthesizer of the Dzogchen (rdzogs chen) or Great Perfection system, Longchen Rabjam Drimé Ödzer (1308-1363), composed his poetic text, Being at Ease with Illusion. This work on illusion is the third volume in Longchenpa’s Trilogy of Being at Ease (Ngal gso skor gsum) in which he presents a series of Dzogchen instructions on …


Authentic Mindfulness Within Mindfulness-Based Interventions: A Qualitative Study Of Participants' Experiences, Supakyada Sapthiang, Edo Shonin, Paul Barrows, William Van Gordon 2023 Awake to Wisdom Centre for Meditation and Mindfulness Research, Nottingham, UK

Authentic Mindfulness Within Mindfulness-Based Interventions: A Qualitative Study Of Participants' Experiences, Supakyada Sapthiang, Edo Shonin, Paul Barrows, William Van Gordon

International Journal of Transpersonal Studies Advance Publication Archive

There are concerns that participants of some modern mindfulness-based interventions (MBIs) are receiving a superficial form of mindfulness training. However, empirical investigation of this issue according to participants’ first-hand experiences has been limited. Thus, this qualitative study aimed to capture the first-hand perspectives relating to authentic mindfulness of participants who had recently attended an MBI in the UK. Ten adults completed a recorded, online semistructured interview. Based on a thematic analysis, the following four master themes were identified: (a) authentic mindfulness as a construct, (b) positive aspects of the training, (c) something missing, and (d) recommendations for authenticity. Although all …


The Potencial Of Ginger (Zingiber Officinale R.) As A Standardized Herbal Product In North Sumatera, Rahmad Syukur Siregar, Rika Ampuh Hadiguna, Insannul Kamil, Novizar Nazir, Nofialdi Nofialdi 2022 Universitas Andalas, Padang, West Sumatera, Indonesia and Faculty of Agricultural, Universitas Muhammadiyah Sumatera Utara, Medan, North Sumatera, Indonesia

The Potencial Of Ginger (Zingiber Officinale R.) As A Standardized Herbal Product In North Sumatera, Rahmad Syukur Siregar, Rika Ampuh Hadiguna, Insannul Kamil, Novizar Nazir, Nofialdi Nofialdi

Journal of Environmental Science and Sustainable Development

Indonesia has more than 9,609 plant species which have medicinal properties that is spread across various regions in Indonesia. Ginger is a group of medicinal plants that are therapeutic. Ginger has been cultivated on a large scale with the highest harvested area, total production and demand in Indonesia, including the Province of North Sumatra. The use of ginger as a medicinal plant has been carried out on the scale of the Traditional Medicine Industry (IOT), of which there are 135 IOTs in Indonesia and one of them is in North Sumatra, namely in the city of Medan. This article uses …


Research Highlights, Noopur Kumari, Babita Rani Kondle 2022 Central Council for Research in Homoeopathy, New Delhi, India

Research Highlights, Noopur Kumari, Babita Rani Kondle

Indian Journal of Research in Homoeopathy

Summary of the studies has been highlighted from Sep till Nov 2022.


Covid-19 Vaccination: Hesitancy, Side Effects And Homoeopathy, Subhash Kaushik 2022 Central Council for Research in Homoeopathy, New Delhi, India

Covid-19 Vaccination: Hesitancy, Side Effects And Homoeopathy, Subhash Kaushik

Indian Journal of Research in Homoeopathy

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Lycopodium Clavatum As An Inhibitor Of Monosodium Urate Crystallisation In Gout: An In Vitro Study, Sithara Perveen P, KR Mansoor Ali, Sheeba Veluthoor, Jijith U.S, Nithya T, Afiya alloor, Shijil V K 2022 Department of Case Taking and Repertorisation, Government Homoeopathic Medical College, Kozhikode (Kerala University of Health Sciences, Thrissur), Kerala, India

Lycopodium Clavatum As An Inhibitor Of Monosodium Urate Crystallisation In Gout: An In Vitro Study, Sithara Perveen P, Kr Mansoor Ali, Sheeba Veluthoor, Jijith U.S, Nithya T, Afiya Alloor, Shijil V K

Indian Journal of Research in Homoeopathy

Background: Hyperuricaemia plays a significant role in the development and pathogenesis of several metabolic and systemic disorders including metabolic syndrome, hypertension, stroke and atherosclerosis. Lycopodium clavatum is the most widely used drug in homoeopathy for treating hyperuricaemia and gout. However, its mechanism of action in reducing serum uric acid remains uncertain. Objective: The objective of the study was to study the potential role of homoeopathic preparation of Lycopodium clavatum in different potencies on monosodium urate crystallisation in vitro. Methods: Spectrophotometric crystallisation assay was carried out on a stock solution of 5 ml of uric acid after its …


Scope Of Homoeopathy In The Treatment Of Depression: A Narrative Synthesis, Karunakara Moorthi, Radhika P, Manu Chandran, K.C. Muraleedharan 2022 National Homoeopathy Research Institute in Mental Health, Kerala, India

Scope Of Homoeopathy In The Treatment Of Depression: A Narrative Synthesis, Karunakara Moorthi, Radhika P, Manu Chandran, K.C. Muraleedharan

Indian Journal of Research in Homoeopathy

Background: Depression is a disorder of major public health importance, in terms of its prevalence and suffering, dysfunction, morbidity and economic burden. Depression is one of the most common conditions for which people seek homoeopathic treatment. Objective: This study is aimed to understand the scope of homoeopathy in depression based on the results of previous studies. Methods: A study was done to evince the scope of homoeopathic medicines in the treatment of depression. Searches were done in both general and specialised databases. The data were collected from peer-reviewed journals published between January 2001 and January 2021. Efforts …


Covid-19 Vaccines And Homoeopathy – An Integrative Review, Deepthi Gilla, S R Sreelakshmy, BSJ Raja Kumar 2022 National Homoeopathy Research Institute in Mental Health, Kerala, India

Covid-19 Vaccines And Homoeopathy – An Integrative Review, Deepthi Gilla, S R Sreelakshmy, Bsj Raja Kumar

Indian Journal of Research in Homoeopathy

Background: The COVID-19 pandemic has brought millions of people at risk. Clinical trials of several known antiviral drugs and vaccines have been done. Homoeopathy is known to be effective in the prevention and treatment of infectious diseases as well as in overcoming some adverse effects of vaccination. Objectives: The objectives of this review were to identify the adverse effects of COVID-19 vaccination from the published literature and doing homoeopathic repertorisation to find out indicated remedies for alleviating the ill effects of COVID-19 vaccines. Methods: Published literature was searched for ‘Covid-19’, ‘Vaccination’ and ‘Adverse events’ in PubMed between …


Homeopathic Management Of Reinke’S Edema In A Non-Smoker: A Case Report, Aditya Pareek 2022 Pareek Hospital, Agra, Uttar Pradesh, India

Homeopathic Management Of Reinke’S Edema In A Non-Smoker: A Case Report, Aditya Pareek

Indian Journal of Research in Homoeopathy

Introduction: Reinke’s edema, also known as polypoid degeneration of vocal cords, is a bilateral, symmetrical swelling of the whole of the membranous part of the vocal cords. Surgery has been the mainstay of treatment for Reinke’s edema. Thus, patients are often left with practically no non-invasive treatment option. Case Summary: This is the case of a 40-year-old male, teacher, who presented with hoarseness of voice for 1 year and opted for homeopathic treatment when he was advised surgery. A rapid improvement in the symptoms, as well as significant objective improvement as confirmed with video laryngoscopy. The results were …


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