Physiology Commons^™

New Author Guidelines In Statistical Reporting: Embracing An Era Beyond P < .05, Samantha Johnson, Whitley J. Stone, Jennifer Bunn, Scott Lyons, James W. Navalta

International Journal of Exercise Science

International Journal of Exercise Science 13(1): 1-5, 2020. Statistical reporting of quantitative research data has been plagued by potential bias and reporting suppression due to a single numerical output: the p-value. While there is great importance in its merit, creating a pass-fail system (set at point of .05) has created a culture of researchers submitting their project’s data to a filing cabinet if it does not yield “statistical significance” based on this value. The editors of the International Journal of Exercise Science are following the American Statistical Association’s call for statistical reform by adjusting our reporting guidelines to the …

Behavioral Ecology And Physiological Health Of Managed Populations Of Juvenile Blanding's Turtles (Emydoidea Blandingii) In Urban Wetlands, Armand Andre' Cann

Master's Theses

Substantial threats to reptile species biodiversity have become apparent in the last few decades. This is partly caused by significant losses in grasslands and their associate prairie-wetland ecosystems. One Midwestern prairie-wetland species, Blanding's Turtles (Emydoidea blandingii), are at risk of extirpation due to habitat loss, fragmentation, and increased predator populations. Consequently, significant head-starting efforts, a form of reintroduction conservation using captive-reared and then released turtles, have been conducted to recover populations of E. blandingii in northeastern Illinois. However, the success of these programs both locally and range-wide have not been fully quantified. Unfortunately, many approaches to guaging success involve long-term …

Estrogen Regulation Of Mir-9-5p And Mir-9-3p Stability And Localization In The Aging Female Brain, Chun Kim

Dissertations

In females, levels of estrogens fluctuate across the lifespan and rapidly decline during menopause. Hormone replacement therapy (HRT) has been introduced as a clinical alternative to replenish systemic levels of 17β-estradiol (E2), the primary estrogen in circulation. However, studies from the Women's Health Initiative revealed a critical period immediately following the onset of menopause where HRT is efficacious. Here, we identified the differential regulation of miRNAs, small non-coding RNAs that inhibit translation, as a potential mechanism for this temporal switch in estrogen action. Specifically, early - but not late - E2 administration following ovariectomy in a rat model of menopause …

Modulation Of Epileptogenesis: A Paradigm For The Integration Of Enzyme-Based Microelectrode Arrays And Optogenetics, Corwin R. Butler, Jeffery A. Boychuk, Francois Pomerleau, Ramona Alcala, Peter Huettl, Yi Ai, Johan Jakobsson, Sidney W. Whiteheart, Greg A. Gerhardt, Bret N. Smith, John T. Slevin

Physiology Faculty Publications

BACKGROUND: Genesis of acquired epilepsy includes transformations spanning genetic-to- network-level modifications, disrupting the regional excitatory/inhibitory balance. Methodology concurrently tracking changes at multiple levels is lacking. Here, viral vectors are used to differentially express two opsin proteins in neuronal populations within dentate gyrus (DG) of hippocampus. When activated, these opsins induced excitatory or inhibitory neural output that differentially affected neural networks and epileptogenesis. In vivo measures included behavioral observation coupled to real-time measures of regional glutamate flux using ceramic-based amperometric microelectrode arrays (MEAs).

RESULTS: Using MEA technology, phasic increases of extracellular glutamate were recorded immediately upon application of blue light/488 nm …

Can The Carbon And Nitrogen Isotope Values Of Offspring Be Used As A Proxy For Their Mother's Diet? Using Foetal Physiology To Interpret Bulk Tissue And Amino Acid Δ15N Values, Nico Lübcker, John P. Whiteman, Seth D. Newsome, Robert P. Millar, P.J. Nico De Bruyn

Biological Sciences Faculty Publications

The measurement of bulk tissue nitrogen (δ¹⁵N) and carbon isotope values (δ¹³C) chronologically along biologically inert tissues sampled from offspring can provide a longitudinal record of their mothers' foraging habits. This study tested the important assumption that mother-offspring stable isotope values are positively and linearly correlated. In addition, any change in the mother-offspring bulk tissues and individual amino acids that occurred during gestation was investigated. Whiskers sampled from southern elephant seal pups (Mirounga leonina) and temporally overlapping whiskers from their mothers were analyzed. This included n = 1895 chronologically subsampled whisker segments for bulk …

An Identification Of Tgf-B'S Role In Ischemic Cholangiopathy, Courtney Chmielewski

Theses and Dissertations

Organ transplants are a necessary intervention for many diseases that result in end stage organ failure. The donation pool cannot match the demands of the transplant list, so expanding the pool to include donation after cardiac death (DCD) is desired. However, there are increased odds of graft failure and ischemic cholangiopathy leading to inferior outcomes when DCD livers are used. Ischemic cholangiopathy consists of multiple diffuse strictures and fibrosis of the bile ducts leading to a loss of epithelialization and fibrosis. The cellular mechanism is proposed to be epithelial-to-mesenchymal transition (EMT). TGF-�� is seen as a key initiator of EMT, …

Seen In Science: Lgbtq+ Inclusivity In Anatomy & Physiology Texts, Harshini Sirvisetty, Kat Ray King, Linda Catherine Fuselier

Undergraduate Arts and Research Showcase

Biology is unique from other science disciplines in that concepts taught in core classes can inform our student’s understanding of sex and gender. A biology major encounters lessons on sex determination, sexual reproduction, and sex characteristics in their courses. The language used in these units matters. It is imperative that educators consider how the language, examples, and content that we use in classrooms drive (or not) inclusivity for gender- and sexuality-diverse (GSD) (aka LGBTQ+) individuals. We chose to analyze four college-level human anatomy/physiology (AP) textbooks for GSD population inclusivity. We adopted a queer theory framework to critically examine how sex, …

Predictors Of Work Economy In Structural Firefighters, Maxwell Steele Norris

Theses and Dissertations--Kinesiology and Health Promotion

The purpose of this study was to investigate a novel work economy metric to quantify firefighter physical ability and identify physical fitness and anthropometric correlates of work economy. Physical fitness and anthropometric measurements were taken on 19 incumbent structural firefighters (Age: 35.0±7.1 yr, Body mass: 87.5±13.1 kg). Firefighters performed a timed maximal effort simulated fireground test (SFGT) in personal protective equipment. SFGT air depletion was represented by change in cylinder pressure. Work economy was quantified as: (1/(SFGT completion time x air depletion))x10⁴. Bivariate and multiple linear regression analyses were used to identify anthropometric and physical fitness predictors of …

Divergence In Neuronal Calcium Dysregulation In Brain Aging And Animal Models Of Ad, Adam Ghoweri

Theses and Dissertations--Pharmacology and Nutritional Sciences

Neuronal calcium dysregulation first garnered attention during the mid-1980’s as a key factor in brain aging, which led to the formulation of the Ca²⁺ hypothesis of brain aging and dementia. Indeed, many Ca²⁺-dependent cellular processes that change with age, including an increase in the afterhyperpolarization, a decrease in long-term potentiation, an increased susceptibility to long-term depression, and a reduction in short-term synaptic plasticity, have been identified. It was later determined that increased intracellular Ca²⁺ with age was due to increased Ca²⁺ channel density, elevated release from intracellular Ca²⁺ stores, and decreased Ca²⁺ buffering …

The Dynamics Of Life And Death: Mitochondrial Fragmentation, Mitophagy, And Swelling During Neuronal Ischemia/Reperfusion Injury, Anthony Roy Anzell

Wayne State University Dissertations

Ischemic brain injury caused by cardiac arrest or stroke continue to be leading caused of death and disability in the U.S. While restoration of blood flow is necessary to salvage ischemic tissue, reperfusion paradoxically exacerbates injury via the production of reactive oxygen species, which, damage mitochondria and induce cell death. Therefore, it is critical to have stringent quality control mechanisms to ensure a healthy mitochondrial network. Mitochondrial fragmentation has been well characterized in the progression of ischemia/reperfusion and its association with cell death. Conversely, the role of mitophagy has been controversial regarding whether upregulation of mitophagy serves as a restorative …

Causes And Potential Treatment For Altered Muscle Metaboreflex Control Of Ventricular Vascular Interactions In Heart Failure, Joseph Thomas Mannozzi

Wayne State University Dissertations

Muscle Metaboreflex Activation occurs as a result of metabolic accumulation within active skeletal muscle that stimulates type III and IV afferents. This reflex in healthy subjects causes increased ventricular contraction, tachycardia, enhanced central blood volume mobilization, and 2 mediated vasodilation as a means to increase mean arterial pressure and thereby improve perfusion pressure of active skeletal muscle. However, to date no study has evaluated the interaction between the observed changes in ventricular and vascular dynamics or how the reflex impacts contraction relaxation dynamics before and after induction of heart failure Furthermore, no study has evaluated the impact of chronic selective …

Glp-1 Mediated Diuresis And Natriuresis Are Blunted In Heart Failure And Restored By Selective Afferent Renal Denervation, Kenichi Katsurada, Shyam Sundar Nandi, Hong Zheng, Xuefei Liu, Neeru M. Sharma, Kaushik K. Patel

Journal Articles: Cellular & Integrative Physiology

BACKGROUND: Glucagon-like peptide-1 (GLP-1) induces diuresis and natriuresis. Previously we have shown that GLP-1 activates afferent renal nerve to increase efferent renal sympathetic nerve activity that negates the diuresis and natriuresis as a negative feedback mechanism in normal rats. However, renal effects of GLP-1 in heart failure (HF) has not been elucidated. The present study was designed to assess GLP-1-induced diuresis and natriuresis in rats with HF and its interactions with renal nerve activity.

METHODS: HF was induced in rats by coronary artery ligation. The direct recording of afferent renal nerve activity (ARNA) with intrapelvic injection of GLP-1 and total …

The Associations Between Socioeconomic Status And Childhood And Adult Psychosocial Experiences Among Men Living In El Paso, Texas, Sophia Marie Ornelas

Open Access Theses & Dissertations

BACKGROUND: Substantial evidence indicates that low levels of Socioeconomic Status (SES) can have adverse psychosocial health implications in early childhood that can persist into adulthood. While there is extensive research about this relationship very little is known about the relationship between SES characteristics and adult psychosocial burden among Hispanic men. OBJECTIVE: This research aims to explore the associations between SES characteristics and childhood adverse experiences, adult perceived stress burden, and depressive symptoms among Hispanic men living in El Paso, Texas. METHODS: This research used data from a cross-sectional study of 100 adult men residing in El Paso, Texas in 2018. …

The Impact Of Exercise In Spaceflight And Microgravity Environments, William Bybee

Mahurin Honors College Capstone Experience/Thesis Projects

Since mankind’s first spaceflight, a significant barricade in reaching distant planets has been the damaging effects of microgravity upon the human body. Effects range from loss in bone mineral density and severe muscle atrophy to autoimmune disorders. The most effective countermeasure of these effects to date is exercise. Implementation of exercise in microgravity is not an easy task, so various specialized equipment must be utilized to effectively administer it. Even with this equipment, exercise as it is currently used does not entirely prevent body systems from undergoing detrimental changes. New modalities and implementations are currently being investigated that may significantly …

Training And Technique Choices Predict Self-Reported Running Injuries: An International Study, Joe Warne, Allison H. Gruber, Roy Cheung, Jason Bonacci

Articles

The aim of this study was to describe the self-reported injury, training, and running technique choices of regular runners in four international regions. Design and Setting 756 participants began an expert derived self-report online survey in Ireland, USA, Hong Kong and Australia. Participants 325 participants completed the survey (age=38±10years; weight=68.0±13.1kg; height=1.70±0.10m). Main Outcome Measures Descriptive statistics are reported examining injury incidence and location; shoe and orthosis choices; and training and technique practices. A backwards logistic regression was implemented to examine associations between injury and training choices. Results 68.3% reported having an injury in the last year. 81.45% of these injuries …

Where Do We Go From Here? A Forward-Thinking Vision For Physiology Undergraduate Education, Nancy M. Aguilar-Roca, Lisa C. Anderson, Anne R. Crecelius, Michelle B. French, Katie Johnson, Jenny L. Mcfarland, Jennifer Rogers, Claudia I. Stanescu, Erica A. Wehrwein

Health and Sport Science Faculty Publications

This paper is a summary of the special collection of papers in Advances in Physiology Education dedicated to the Physiology Majors Interest Group (P-MIG). P-MIG is a new and vibrant community (1, 2) of educators and administrators who are united by the common goal of creating physiology courses, curricula and programs that will prepare our students for the future. It is an independent consortium that welcomes anyone interested in physiology education at the level of the undergraduate degree in physiology and physiology-related fields. As demonstrated by this special collection of papers of Advances in Physiology Education, P-MIG has already made …

Remodeling In The Actin Core Of The Auditory Hair Cell Stereocilia As A Novel Component Of Temporary Noise-Induced Hearing Loss, Jonathan Michael Grossheim

Theses and Dissertations--Physiology

The rigid, paracrystalline actin core of auditory hair cell stereocilia is extremely stable and after initial formation must persist for the life of the cell to preserve hearing in mammals. In healthy hair cells, turnover of actin molecules occurs only in a small region near the tips of stereocilia, while the actin filaments of the shaft are stable. For decades damage to the actin core of stereocilia from acoustic trauma has only been attributed to cases of permanent noise-induced hearing loss. Here, we show that repairable actin core damage occurs in temporary noise-induced hearing loss from moderate acoustic trauma.

We …

Impact Of Nacl Tolerance On The Stress Physiology And Fitness Of Larval Wood Frogs (Rana Sylvatica), Grascen Shidemantle, Nicholas Buss, Jessica Hua

Biological Sciences Student Scholarship

No abstract provided.

The Impact Of Mind-Body Exercises On Motor Function, Depressive Symptoms, And Quality Of Life In Parkinson’S Disease: A Systematic Review And Meta-Analysis, Xiaohu Jin, Lin Wang, Shijie Liu, Lin Zhu, Paul Dinneen Loprinzi, Xin Fan

Faculty and Student Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Purpose: To systematically evaluate the effects of mind-body exercises (Tai Chi, Yoga, and Health Qigong) on motor function (UPDRS, Timed-Up-and-Go, Balance), depressive symptoms, and quality of life (QoL) of Parkinson’s patients (PD). Methods: Through computer system search and manual retrieval, PubMed, Web of Science, The Cochrane Library, CNKI, Wanfang Database, and CQVIP were used. Articles were retrieved up to the published date of June 30, 2019. Following the Cochrane Collaboration System Evaluation Manual (version 5.1.0), two researchers independently evaluated the quality and bias risk of each article, including 22 evaluated articles. …

Evaluation Of A Cognitive Affective Model Of Physical Activity Behavior, Paul D. Loprinzi, Sara Pazirei, Gina Robinson, Briahna Dickerson, Meghan Edwards, Ryan E. Rhodes

Faculty and Student Publications

© 2020 The Author(s). Background: To empirically evaluate a cognitive affective model of physical activity. This bidirectional, cyclical model hypotheses that executive control processes directly influence habitual engagement in exercise and also directly subserve the exercise-induced affective response to acute exercise associated with future physical activity. Methods: The present study employed a one-week prospective, multi-site design. Participant recruitment and data collection occurred at two separate University sites (one in the United States and the other in Canada). Participants completed a bout of treadmill exercise, with affect and arousal assessed before, during and after the bout of exercise. Subjective and objective …