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Role Of Muscle C-Jun Nh2-Terminal Kinase 1 In Obesity-Induced Insulin Resistance, Guadalupe Sabio, Norman J. Kennedy, Julie Cavanagh-Kyros, Dae Young Jung, Hwi Jin Ko, Helena Ong, Tamera Barrett, Jason K. Kim, Roger J. Davis 2010 University of Massachusetts Medical School

Role Of Muscle C-Jun Nh2-Terminal Kinase 1 In Obesity-Induced Insulin Resistance, Guadalupe Sabio, Norman J. Kennedy, Julie Cavanagh-Kyros, Dae Young Jung, Hwi Jin Ko, Helena Ong, Tamera Barrett, Jason K. Kim, Roger J. Davis

Davis Lab Publications

Obesity caused by feeding of a high-fat diet (HFD) is associated with an increased activation of c-Jun NH(2)-terminal kinase 1 (JNK1). Activated JNK1 is implicated in the mechanism of obesity-induced insulin resistance and the development of metabolic syndrome and type 2 diabetes. Significantly, Jnk1(-)(/)(-) mice are protected against HFD-induced obesity and insulin resistance. Here we show that an ablation of the Jnk1 gene in skeletal muscle does not influence HFD-induced obesity. However, muscle-specific JNK1-deficient (M(KO)) mice exhibit improved insulin sensitivity compared with control wild-type (M(WT)) mice. Thus, insulin-stimulated AKT activation is suppressed in muscle, liver, and ...


The Differential Roles Of D-Pax2 Variants In Regulating Drosophila Eye And Bristle Development, Colin J. O’Shea 2010 Colby College

The Differential Roles Of D-Pax2 Variants In Regulating Drosophila Eye And Bristle Development, Colin J. O’Shea

Honors Theses

The ability to appropriately interact with the environment is crucial to an organism’s survival. The establishment of functional sensory systems, such as the bristles and eyes in Drosophila, is a critical event during the development of the organism. The transcription factor D Pax2 is involved in the differentiation of the shaft and glial cells in the developing bristle (Kavaler et al., Dev, 126:2261-2272, 1999) and of the cone and primary pigment cells in the developing eye (Fu and Noll, Genes Dev, 11:389-405, 1997). How D-Pax2 contributes to distinct differentiative pathways in different cell types is not known ...


Impact Of Central And Peripheral Trpv1 And Ros Levels On Proinflammatory Mediators And Nociceptive Behavior, Karin N. Westlund, Mikhail Y. Kochukov, Ying Lu, Terry A. McNearney 2010 University of Kentucky

Impact Of Central And Peripheral Trpv1 And Ros Levels On Proinflammatory Mediators And Nociceptive Behavior, Karin N. Westlund, Mikhail Y. Kochukov, Ying Lu, Terry A. Mcnearney

Physiology Faculty Publications

Background: Transient receptor potential vanilloid 1 (TRPV1) channels are important membrane sensors on peripheral nerve endings and on supportive non-neuronal synoviocytes in the knee joint. TRPV 1 ion channels respond with activation of calcium and sodium fluxes to pH, thermal, chemical, osmotic, mechanical and other stimuli abundant in inflamed joints. In the present study, the kaolin/carrageenan (k/c) induced knee joint arthritis model in rats, as well as primary and clonal human synoviocyte cultures were used to understand the reciprocal interactions between reactive nitroxidative species (ROS) and functional TRPV1 channels. ROS generation was monitored with ROS sensitive dyes using ...


Mitochondrial Physiology Of Diapausing And Developing Embryos Of The Annual Killifsh Austrofundulus Limnaeus: Implications For Extreme Anoxia Tolerance, Jeff Duerr, Jason E. Podrabsky 2010 George Fox University

Mitochondrial Physiology Of Diapausing And Developing Embryos Of The Annual Killifsh Austrofundulus Limnaeus: Implications For Extreme Anoxia Tolerance, Jeff Duerr, Jason E. Podrabsky

Faculty Publications - Department of Biology and Chemistry

Diapausing embryos of the annual killiWsh Austrofundulus limnaeus have the highest reported anoxia tolerance of any vertebrate and previous studies indicate modified mitochondrial physiology likely supports anoxic metabolism. Functional mitochondria isolated from diapausing and developing embryos of the annual killifish exhibited VO2, respiratory control ratios (RCR), and P:O ratios consistent with those obtained from other ectothermic vertebrate species. Reduced oxygen consumption associated with dormancy in whole animal respiration rates are correlated with maximal respiration rates of mitochondria isolated from diapausing versus developing embryos. P:O ratios for developing embryos were similar to those obtained from adult liver, but were ...


Relationships Between Jump Characteristics Of Collegiate Female Athletes Competing In Different Disciplines, Christopher J. MacDonalds, Hugh S. Lamont, John C. Garner, Jeremy A. Gentles, Ashley A. Kavanaugh, Michael H. Stone 2010 East Tennessee State University

Relationships Between Jump Characteristics Of Collegiate Female Athletes Competing In Different Disciplines, Christopher J. Macdonalds, Hugh S. Lamont, John C. Garner, Jeremy A. Gentles, Ashley A. Kavanaugh, Michael H. Stone

ETSU Faculty Works

No abstract provided.


Who Do You Think You Are? Constructing Self/Identity In Women's Rugby Through Aggression, Control And Unacceptable Behavior, Shannon M Baird 2010 University of Iowa

Who Do You Think You Are? Constructing Self/Identity In Women's Rugby Through Aggression, Control And Unacceptable Behavior, Shannon M Baird

Theses and Dissertations

Some behaviors in sport may be labeled: bad, unnecessary and distasteful. Sport psychologists have used concepts of aggression to understand and lessen these behaviors. To date, most research has conceptualized aggression as a product of individual cognition. Specifically, aggression is defined in the sport psychology literature as any behavior motivated by the intent to harm one's opponent (Baron, 1977; Bredemeier & Shields, 1986b; Husman & Silva, 1984; Kirker, Tenenbaum & Mattson, 2000). Consequently, sport psychology analyses of aggression tend to reproduce take-for-granted conceptions of aggression as male, physical and other-directed. To better understand sport aggression, it has been argued that symbolic interactionism has much to offer (Baird & McGannon, 2009). By utilizing symbolic interactionism we can reconceptualize aggression as a social construct given meaning in and through interaction with self and others. From this perspective, self notions and interactions with others are important "locations" of meaning making and are significant in the study of behavior.

The present study used symbolic interactionism to explore female rugby players' experiences of aggression and how they interpret, define and structure experiences relative to self development. In conjunction with participant-observation, 12 semi-structured interviews with female rugby players ages 18-45 were conducted to explore: (1) how do women define themselves as ruggers/how do they (re)produce these identities in and out of rugby, (2) how do women define and experience aggression, and (3) how are these accounts used in the construction of self/identity?

Data emerging from interviews and observations suggested that athletes defined and experienced behavior in ways challenging contemporary sport psychology conceptualizations of aggression. The participants often used the word aggression to describe forceful and physical play. In sport psychology literature, this is typically referred to as assertive behavior (Husman & Silva, 1984; Tenenbaum, Saks, Miller, Golden, & Doolin, 2000) and aggressive behavior is a label reserved for unacceptable behavior motivated by the intent to harm (Tenenbaum et al., 2000). According to the women in this study, unacceptable behavior was not defined by intent; rather, unacceptable behavior was a negotiated space that was constructed through notions of lack of control. That is, if a player was constructed as out of control, that player was seen as ...


Neural And Humoral Control Of Regional Vascular Beds Via A1 Adenosine Receptors Located In The Nucleus Of The Solitary Tract, Joseph Martin Mcclure 2010 Wayne State University

Neural And Humoral Control Of Regional Vascular Beds Via A1 Adenosine Receptors Located In The Nucleus Of The Solitary Tract, Joseph Martin Mcclure

Wayne State University Dissertations

Previous studies from our laboratory showed that activation of NTS A1 adenosine

receptors yields variable hemodynamic responses with prevailing pressor and iliac

vasoconstrictor responses. These responses are accompanied with differential

activation of regional sympathetic activity (adrenal>>renal≥lumbar) and inhibition of

baroreflex mechanisms at the level of the NTS. The variability of the hemodynamic

responses was a result of simultaneous Β-adrenergic vasodilation counteracted with

sympathetic and unknown humoral vasoconstriction. Among many potential

vasoconstrictors vasopressin, angiotensin II and circulating norepinephrine were

considered. Therefore, blood pressure and iliac vascular responses evoked by

selective stimulation of NTS A1 adenosine receptors (CPA ...


Mitochondrial Physiology Of Diapausing And Developing Embryos Of The Annual Killifish Austrofundulus Limnaeus: Implications For Extreme Anoxia Tolerance, Jeffrey M. Duerr, Jason E. Podrabsky 2010 George Fox University

Mitochondrial Physiology Of Diapausing And Developing Embryos Of The Annual Killifish Austrofundulus Limnaeus: Implications For Extreme Anoxia Tolerance, Jeffrey M. Duerr, Jason E. Podrabsky

Biology Faculty Publications and Presentations

Diapausing embryos of the annual killifish Austrofundulus limnaeus have the highest reported anoxia tolerance of any vertebrate and previous studies indicate modified mitochondrial physiology likely supports anoxic metabolism. Functional mitochondria isolated from diapausing and developing embryos of the annual killifish exhibited VO2, respiratory control ratios (RCR), and P:O ratios consistent with those obtained from other ectothermic vertebrate species. Reduced oxygen consumption associated with dormancy in whole animal respiration rates are correlated with maximal respiration rates of mitochondria isolated from diapausing versus developing embryos. P:O ratios for developing embryos were similar to those obtained from adult liver, but were ...


Afm Study Of Structural Changes In Supported Planar Dppc Bilayers Containing General Anesthetic Isofluorane (Plus Additional Afm Experiments), Chad McKell, Hiram Conley, David D. Busath 2010 Brigham Young University

Afm Study Of Structural Changes In Supported Planar Dppc Bilayers Containing General Anesthetic Isofluorane (Plus Additional Afm Experiments), Chad Mckell, Hiram Conley, David D. Busath

Faculty Publications

Atomic force microscopy (AFM) is a remarkable tool for assessing the structural properties of supported lipid planar bilayers under different physiological conditions. Previous work has shown that incorporation of anesthetics into artificial lipid bilayers results in domain formation [1], destruction of lipid aggregates and patches [2], anesthetic-lipid mixed micelle formation [2], and the development of interdigitated phases of reduced thickness compared to anesthetic-free bilayers [3]. In particular, these interdigitated phases are suspected to affect the structure and activity of membrane proteins, such as ion channels, and thus further research with proteinembedded bilayers exposed to anesthetics could reveal the mechanism responsible ...


Effect Of Exogenous Leptin On Thrombotic And Metabolic Profiles Of Fvb/B6 Lipodystrophic Mice, Hoda Chaouki Kadouh 2010 Wayne State University

Effect Of Exogenous Leptin On Thrombotic And Metabolic Profiles Of Fvb/B6 Lipodystrophic Mice, Hoda Chaouki Kadouh

Wayne State University Theses

Lipodystrophy caused by fat deficiency contributes to metabolic disease for which several treatment modalities have been implemented, with leptin therapy being the most effective to date. In addition to playing a role in energy homeostasis and metabolism, leptin was also shown to play a pro-thrombotic role in mice. This role was not examined in fatless mice, neither was thrombosis measured. The AZIP/F-1 (FVB) lipodystrophic mouse appeared to have a prolonged arterial occlusion time (p〈0.05) in a trial done in our lab, with clotting factors being normal. The present study was designed to observe the thrombotic and metabolic ...


The Impact Of Mitochondria On Preimplantation Development In The Rhesus Macaque, Tiffini Charieace Gibson 2010 Wayne State University

The Impact Of Mitochondria On Preimplantation Development In The Rhesus Macaque, Tiffini Charieace Gibson

Wayne State University Dissertations

Assisted Reproduction Technologies (ART) have been used to treat infertility since 1790. In the centuries following, dramatic advances have been made in the field of infertility research through the employment of a variety of species. Despite these advances, determination of oocyte and embryo quality remains largely subjective. Ascertainment of methods to measure oocyte and embryo quality to improve selection in ART clinics and increase pregnancy success rates is imperative. These methods are only possible with a more comprehensive understanding of the cellular and molecular properties of oocytes and preimplantation embryos. A key component of all cells, including oocytes and embryos ...


Review Of Pregnancy Diagnosis Techniques In Cattle And Small Ruminants, Brian Whitlock, Elizabeth Coffman 2009 University of Tennessee - Knoxville

Review Of Pregnancy Diagnosis Techniques In Cattle And Small Ruminants, Brian Whitlock, Elizabeth Coffman

Brian K Whitlock, PhD, DVM, DACT

Pregnancy diagnosis is a common management practice for ruminants and there are a number of methods available, with each having advantage(s) and/or disadvantage(s). A brief review of pregnancy diagnosis techniques in cattle, goats, and sheep is provided.


Pharmacology Supplement, Ahmed Mustafa, Ellioott Blumenthal 2009 Indiana University Purdue University Fort Wayne

Pharmacology Supplement, Ahmed Mustafa, Ellioott Blumenthal

Ahmed Mustafa Dr.

No abstract provided.


Update On Heritable Congenital Defects In Cattle, Brian Whitlock 2009 University of Tennessee - Knoxville

Update On Heritable Congenital Defects In Cattle, Brian Whitlock

Brian K Whitlock, PhD, DVM, DACT

Inherited congenital anomalies are probably present in all breeds of cattle and propagated as a result of specific trait selection. In some breeds, the occurrence of inherited anomalies has become frequent, and economically important. Veterinarians, animal scientists, and cattle breeders should be aware of inherited defects, and be prepared to investigate and report animals exhibiting abnormal phenotypes. This review will describe the morphologic characteristics, mode of inheritance, breeding lines affected, and the availability of testing for selected (newly described) heritable bovine fetal abnormalities.


Farm Focus - Spring 2010, Brian K. Whitlock, Matt Welborn, Maria Prado, Amy Plummer 2009 University of Tennessee - Knoxville

Farm Focus - Spring 2010, Brian K. Whitlock, Matt Welborn, Maria Prado, Amy Plummer

Brian K Whitlock, PhD, DVM, DACT

No abstract provided.


Research Review: Fun Or Fitness?, Mike Climstein 2009 Australian Catholic University

Research Review: Fun Or Fitness?, Mike Climstein

Mike Climstein

No abstract provided.


Research Review: Mixed-Method Cooling In The Heat?, Michael Climstein 2009 Australian Catholic University

Research Review: Mixed-Method Cooling In The Heat?, Michael Climstein

Mike Climstein

No abstract provided.


Research Review: Well Don’T Just Stand There!, Mike Climstein 2009 Australian Catholic University

Research Review: Well Don’T Just Stand There!, Mike Climstein

Mike Climstein

No abstract provided.


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