Histamine Production By Raoultella Ornithinolytica In Mahi-Mahi Meat At Various Storage Temperatures,
2020
Taiwan Food and Drug Administration
Histamine Production By Raoultella Ornithinolytica In Mahi-Mahi Meat At Various Storage Temperatures, C.-S. Lin, H.-F. Kung, C.-M. Lin, H.-C. Tsai, Y.-H. Tsai
Journal of Food and Drug Analysis
Mahi-mahi meat was inoculated with Raoultella ornithinolytica at 5.0 log CFU/g and stored at -20°C, 4°C, 15°C, 25°C, or 37°C to investigate bacterial growth and formation of total volatile base nitrogen and histamine in mahi-mahi meat. R. ornithinolytica grew rapidly in samples stored at temperature above 15°C. The histamine contents quickly increased to higher than 50 mg/100 g in samples stored at 25°C and 37°C within 12 hours as well as those stored at 15°C within 48 hours. The total volatile base nitrogen contents increased to higher than the index level (30 mg/100 g) for fish decomposition at 25°C within …
Analysis Of N-Nitrosodiethylamine By Ion Chromatography Coupled With Uv Photolysis Pretreatment,
2020
Taiwan Food and Drug Administration
Analysis Of N-Nitrosodiethylamine By Ion Chromatography Coupled With Uv Photolysis Pretreatment, X. Li, X. He, Y. Dong, L. Jia, Q. He
Journal of Food and Drug Analysis
Nitrosamines such as N-nitrosodiethylamine (NDEA) are commonly detected by spectrophotometry after photolysis and Griess reaction (PG) in food industries for lower cost. Results of this research indicate that NDEA decays rapidly under UV irradiation, and concentrations of the generated NO2- and NO3- ions vary with photolysis conditions. Thus, the measurement of the PG method may be inconsistent because it is based on the amount of photoproduced NO2-. In addition, more errors may be present in the PG method since NO3- cannot be measured colorimetrically using Griess reagent. In this work, the sum of the concentrations of photoproduced NO2- and NO3- …
Antioxidant Activity And Protective Effects Of Cocoa And Kola Nut Mistletoe (Globimetula Cupulata) Against Ischemia/Reperfusion Injury In Langendorff-Perfused Rat Hearts,
2020
Taiwan Food and Drug Administration
Antioxidant Activity And Protective Effects Of Cocoa And Kola Nut Mistletoe (Globimetula Cupulata) Against Ischemia/Reperfusion Injury In Langendorff-Perfused Rat Hearts, A.C. Akinmoladun, J.A. Olowe, K. Komolafe, J. Ogundele, M.T. Olaleye
Journal of Food and Drug Analysis
Protection against cardiomyocyte damage following ischemia/reperfusion (I/R) injury is highly desirable in patients with ischemic heart disease. Hydromethanol extracts of Globimetula cupulata (mistletoe) growing on cocoa (CGCE) and kola nut (KGCE) trees were assessed for antioxidant content and cardioprotective potential against I/R. Graded concentrations (1-50 μg/mL) of CGCE or KGCE were tested on Langendorff-perfused rat hearts to evaluate the effects on the flow rate, heart rate, and force of cardiac contraction, while another set of hearts were subjected to biochemical analyses. Both extracts showed good antioxidant content and activity, but KGCE (EC50: 24.8±1.8 μg/mL) showed higher hydroxyl radical scavenging activity …
Comparing The Functional Components, Sod-Like Activities, Antimutagenicity, And Nutrient Compositions Of Phellinus Igniarius And Phellinus Linteus Mushrooms,
2020
Taiwan Food and Drug Administration
Comparing The Functional Components, Sod-Like Activities, Antimutagenicity, And Nutrient Compositions Of Phellinus Igniarius And Phellinus Linteus Mushrooms, N.-C. Yang, C.-C. Wu, R.H. Liu, Y.-C. Chai, C.Y. Tseng
Journal of Food and Drug Analysis
Many species of the genus Phellinus possess beneficial properties, including antioxidant, immune-enhancing, and antimutagenic effects. Phenolic compounds and polysaccharides are two kinds of bioactive compounds; however, few studies have compared the differences between Phellinus igniarius and Phellinus linteus in their functional components, functional activities, and nutrient compositions. Herein, the proximate compositions and microelements of the fruiting body of P. igniarius and P. linteus were determined. The fruiting body of P. igniarius and P. linteus were extracted by boiling water [water extract of P. igniarius (WEPI) and P. linteus (WEPL)]. The contents of total phenolics and polysaccharides, as well as superoxide …
Determination Of Urea Content In Urea Cream By Centrifugal Partition Chromatography,
2020
Taiwan Food and Drug Administration
Determination Of Urea Content In Urea Cream By Centrifugal Partition Chromatography, Y.-Q. Wang, S.-S. Wang, J. Zhu, L. Wang, B.-H. Jiang, W.-J. Zhao
Journal of Food and Drug Analysis
The objective of this study is to establish a centrifugal partition chromatography (CPC) method for determination of the urea ingredient in urea cream. The mechanism of this method is that urea is determined by UV detector at 430 nm after being extracted from the cream and derivatized on line via Ehrlich reaction in rotor of CPC, where the reaction products dissolve in the mobile phase and the cream matrix retains in the stationary phase. The mixed solvent consisting of n-hexane, methanol, hydrochloric acid and p-dimethylaminobenzaldehyde with a ratio of 1000 mL:1000 mL:18 mL:2.0 g is used for solvent system of …
Chemical Constituents And Bioactivity Of Formosan Lauraceous Plants,
2020
Taiwan Food and Drug Administration
Chemical Constituents And Bioactivity Of Formosan Lauraceous Plants, H.-S. Chang, I.-S. Chen
Journal of Food and Drug Analysis
Taiwan is rich in lauraceous plants. A review of 197 references based on the chemical analysis and bioactivity of indigenous lauraceous plants carried out by native scientists from 1963 to 2014 has been compiled. About 303 new compounds and thousands of known compounds comprising alkaloids and non-alkaloids with diverse structures have been isolated or identified from indigenous plants belonging to the 11 lauraceous genera. The volatile components, however, have been excluded from this review. This review provides an overview of the past efforts of Taiwan scientists working on secondary metabolites and their bioactivity in native lauraceous plants. The potential of …
Anti-Inflammatory Effects, Nuclear Magnetic Resonance Identification, And High-Performance Liquid Chromatography Isolation Of The Total Flavonoids From Artemisia Frigida,
2020
Taiwan Food and Drug Administration
Anti-Inflammatory Effects, Nuclear Magnetic Resonance Identification, And High-Performance Liquid Chromatography Isolation Of The Total Flavonoids From Artemisia Frigida, Q. Wang, J. Jin, N. Dai, N. Han, J. Han, B. Bao
Journal of Food and Drug Analysis
The aerial parts of Artemisia frigida Willd. are used to treat joint swelling, renal heat, abnormal menstruation, and sore carbuncle. The anti-inflammatory effects of A. frigida have been well-known in folk medicine, suggesting that components extracted from A. frigida could potentially treat inflammatory disease. With the aim of discovering bioactive compounds, in this study, we extracted total flavonoids from the aerial parts of A. frigida and investigated their anti-inflammatory effects against inflammation induced by carrageenan and egg albumin in rats. At the doses studied, total flavonoids (100 mg/kg, 200 mg/kg, and 400 mg/kg) and some isolated compounds (30 mg/kg) showed …
Statistical Optimization Of Lovastatin And Confirmation Of Nonexistence Of Citrinin Under Solid-State Fermentation By Monascus Sanguineus,
2020
Taiwan Food and Drug Administration
Statistical Optimization Of Lovastatin And Confirmation Of Nonexistence Of Citrinin Under Solid-State Fermentation By Monascus Sanguineus, R. Dikshit, P. Tallapragada
Journal of Food and Drug Analysis
Lovastatin is a well-known natural statin, which is used for lowering plasma cholesterol levels by inhibiting 3-hydroxy-3-methyl glutaryl coenzyme A reductase. Different strains of Aspergillus and Monascus sp. have been exploited for statin production but Monascus sanguineus is still unexplored. In this study, lovastatin production from Monascus sanguineus under solid state fermentation was optimized using response surface methodology. The optimized value of the lovastatin yield was 20.04 mg/gds with soybean concentration of 20 g/L, CaCl2 concentration of 2.5 g/L, acetic acid concentration of 25 μL and inoculum size of 3.4 mL. This study also documented spectrometric characterization and fragment pattern …
Aroma Transition From Rosemary Leaves During Aromatization Of Olive Oil,
2020
Taiwan Food and Drug Administration
Aroma Transition From Rosemary Leaves During Aromatization Of Olive Oil, M. Yilmazer, Karagöz S. Göksu, G. Ozkan, E. Karacabey
Journal of Food and Drug Analysis
The aroma profile of aromatized olive oil was determined in this study. The primary objective was to investigate the transition of major aroma compounds from rosemary and olive fruit during the kneading step of olive oil production by response surface methodology. For this purpose, temperature, time, and amount of rosemary leaves were determined as independent variables. The results indicated that temperature and time did not affect the transition of target compounds, but rosemary leaves addition had a strong influence on transition, especially for characteristic aroma compounds of this herb. Adequacies of developed models were found to be high enough to …
Application Of Hollow Fiber Liquid Phase Microextraction And Dispersive Liquid-Liquid Microextraction Techniques In Analytical Toxicology,
2020
Taiwan Food and Drug Administration
Application Of Hollow Fiber Liquid Phase Microextraction And Dispersive Liquid-Liquid Microextraction Techniques In Analytical Toxicology, V. Sharifi, A. Abbasi, A. Nosrati
Journal of Food and Drug Analysis
The recent developments in hollow fiber liquid phase microextraction and dispersive liquid-liquid microextraction are reviewed. Applications of these newly emerging developments in extraction and preconcentration of a vast category of compounds including heavy metals, pesticides, pharmaceuticals and abused drugs in complex matrices (environmental and biological matrices) are reviewed and discussed. The new developments in these techniques including the use of solvents lighter than water, ionic liquids and supramolecular solvents are also considered. Applications of these new solvents reduce the use of toxic solvents and eliminate the centrifugation step, which reduces the extraction time. Copyright © 2016, Food and Drug Administration, …
Fast Separation And Quantification Of Three Anti-Glaucoma Drugs By High-Performance Liquid Chromatography Uv Detection,
2020
Taiwan Food and Drug Administration
Fast Separation And Quantification Of Three Anti-Glaucoma Drugs By High-Performance Liquid Chromatography Uv Detection, M. Walash, R. El-Shaheny
Journal of Food and Drug Analysis
In this study, a simple and accurate high-performance liquid chromatography method was developed and validated for fast separation of three anti-glaucoma drugs: timolol maleate (TM), brimonidine tartrate (BM), and latanoprost (LP). Separation of the three drugs was achieved in < 6 minutes using a BDS Hypersil phenyl column and a mobile phase consisting of acetonitrile: 25mM phosphate buffer, pH 4.0 (50: 50, v/v) at 1.2 mL/min with UV detection at 210 nm. The method was linear over the concentration ranges of 5.0-200.0 μg/mL, 2.0-80.0 μg/mL and 1.0-25.0 μg/mL with lower detection limits of 0.21 μg/mL, 0.10 μg/mL and 0.11 μg/mL for TM, BM and LP, respectively. The method was applied for the determination of two fixed-dose combination eye drops for the treatment of glaucoma, containing TM together with either BM or LP. Commercial samples of single-ingredient ophthalmic solutions containing the studied drugs were also successfully analyzed. The results obtained by the proposed method were favorably compared with those obtained by the comparison methods using Student's t test and the variance ratio F test. Copyright © 2016, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
Characterization Of Myrtle Seed (Myrtus Communis Var. Baetica) As A Source Of Lipids, Phenolics, And Antioxidant Activities,
2020
Taiwan Food and Drug Administration
Characterization Of Myrtle Seed (Myrtus Communis Var. Baetica) As A Source Of Lipids, Phenolics, And Antioxidant Activities, W.A. Wannes, B. Marzouk
Journal of Food and Drug Analysis
This study aimed to characterize the chemical composition and antioxidant activity of the oil and the methanolic extract of Myrtus communis var. baetica seed. The oil yield of myrtle seed was 8.90%, with the amount of neutral lipid, especially triacylglycerol, being the highest, followed by phospholipids and glycolipids. Total lipids and all lipid classes were rich in linoleic acid. The content of total phenols, flavonoids, tannins, and proanthocyanidins of the methanolic extract and the oil from myrtle seed was determined using spectrophotometric methods. Antioxidant activities of the oil and the methanolic extract from myrtle seed were evaluated using 1,1-diphenyl-2-picrylhydrazyl radical …
Erratum: Evaluation Of A Health-Promoting School Program To Enhance Correct Medication Use In Taiwan (Journal Of Food And Drug Analysis(2014) 22 (271-278)),
2020
Taiwan Food and Drug Administration
Erratum: Evaluation Of A Health-Promoting School Program To Enhance Correct Medication Use In Taiwan (Journal Of Food And Drug Analysis(2014) 22 (271-278)), H.-Y. Chi, F.-C. Chang, H.-J. Lin, L.-J. Huang, J.-C. Chang, M.-K. Yeh, J.-J. Kang
Journal of Food and Drug Analysis
[No abstract available]
Erratum: Flavone Glycosides From Commercially Available Lophatheri Herba And Their Chromatographic Fingerprinting And Quantitation (Journal Of Food And Drug Analysis (2015) 23 (821-827)),
2020
Taiwan Food and Drug Administration
Erratum: Flavone Glycosides From Commercially Available Lophatheri Herba And Their Chromatographic Fingerprinting And Quantitation (Journal Of Food And Drug Analysis (2015) 23 (821-827)), J.-S. Fan, I.-J. Lee, Y.-L. Lin
Journal of Food and Drug Analysis
[No abstract available]
Correlation Between Drug-Drug Interaction-Induced Stevens-Johnson Syndrome And Related Deaths In Taiwan,
2020
Taiwan Food and Drug Administration
Correlation Between Drug-Drug Interaction-Induced Stevens-Johnson Syndrome And Related Deaths In Taiwan, F.-J. Cheng, F.-K. Syu, K.-H. Lee, F.-C. Chen, C.-H. Wu, C.-C. Chen
Journal of Food and Drug Analysis
Concomitant use of some drugs can lead to interactions between them resulting in severe adverse effects. To date, there are few reports of incidences of Stevens-Johnson syndrome (SJS) associated with combination drug administration. Therefore, we studied the relationship between drug combinations and SJS-related mortality, with the hope that a retrospective study of this nature would provide information crucial for the prevention of future drug-drug interaction related deaths attributable to SJS. This retrospective longitudinal study used mortality cases from 1999 to 2008 that were diagnosed as erythema multiforme (International Classification of Diseases, Ninth Revision, Clinical Modification 695.1) from the National Health …
Phytochemical Standardization, Antioxidant, And Antibacterial Evaluations Of Leea Macrophylla: A Wild Edible Plant,
2020
Taiwan Food and Drug Administration
Phytochemical Standardization, Antioxidant, And Antibacterial Evaluations Of Leea Macrophylla: A Wild Edible Plant, A. Joshi, S.K. Prasad, V.K. Joshi, S. Hemalatha
Journal of Food and Drug Analysis
In Ayurveda, Leea macrophylla Roxb. ex Hornem. (Leeaceae) is indicated in worm infestation, dermatopathies, wounds, inflammation, and in symptoms of diabetes. The present study aims to determine the antioxidant and antibacterial potential of ethanolic extract and its different fractions of Leea macrophylla root tubers using phytochemical profiling which is still unexplored. Quantitative estimations of different phytoconstituents along with characterization of ethanol extract using high performance liquid chromatography (HPLC) were performed using chlorogenic acid as a marker compound for the first time. The extract and its successive fractions were also evaluated for in vitro antioxidant activity using different models. The extract …
Acute Pancreatitis In Patients With Type 2 Diabetes Mellitus Treated With Dipeptidyl Peptidase-4 Inhibitors,
2020
Taiwan Food and Drug Administration
Acute Pancreatitis In Patients With Type 2 Diabetes Mellitus Treated With Dipeptidyl Peptidase-4 Inhibitors, T.-L. Yang, M.-C. Shen, M.-L. Yu, Y.-B. Huang, C.-Y. Chen
Journal of Food and Drug Analysis
Dipeptidyl peptidase (DPP)-4 inhibitors are approved for use in monotherapy or in combination therapy for patients with type 2 diabetes mellitus for However, numerous reports of DPP-4 inhibitors induced acute pancreatitis were made through the US Food and Drug Administration Adverse Event Reporting System, and this led to a revision in the prescribing information for these drugs. Therefore, this study is designed to evaluate DPP-4 inhibitors induced acute pancreatitis via the spontaneous adverse drug reactions (ADRs) reporting system in a medical center. In four of 2305 ADR cases, it is suspected that DPP-4 inhibitors induced moderate to serious acute pancreatitis. …
Evaluation Of Boldenone As A Growth Promoter In Broilers: Safety And Meat Quality Aspects,
2020
Taiwan Food and Drug Administration
Evaluation Of Boldenone As A Growth Promoter In Broilers: Safety And Meat Quality Aspects, A. Elmajdoub, A. Garbaj, S. Abolghait, A. El-Mahmoudy
Journal of Food and Drug Analysis
The object of this study was to evaluate the safety and meat quality criteria in broilers following intramuscular injection of boldenone. Twenty-four broiler chicks, divided into two groups, were used in the present study. Boldenone was injected intramuscularly at a single-dose level of 5 mg/kg body weight into 12 broiler chicks at 2 weeks old; the other 12 chicks were injected with sesame oil and kept as controls. Blood samples were collected from the wing and metatarsal veins after 1, 2, and 3 weeks through the experimental course for hematological and clinic-chemical safety parameters. On the last day, chicks were …
Rapid Screening Of Toxic Salbutamol, Ractopamine, And Clenbuterol In Pork Sample By High-Performance Liquid Chromatography - Uv Method,
2020
Taiwan Food and Drug Administration
Rapid Screening Of Toxic Salbutamol, Ractopamine, And Clenbuterol In Pork Sample By High-Performance Liquid Chromatography - Uv Method, K. Yan, H. Zhang, W. Hui, H. Zhu, X. Li, F. Zhong, X. Tong, C. Chen
Journal of Food and Drug Analysis
A rapid and simple high-performance liquid chromatography–UV method was developed for the separation and quantification of salbutamol, ractopamine, and clenbuterol in pork. A mixture of acetonitrile–formic acid–ammonium acetate was used as the mobile phase to separate three β-agonists on a C18 column with gradient. The effects of the addition of formic acid and ammonium acetate to mobile phases on the separation of β-agonists were investigated. These additives can greatly improve the resolution and sensitivity. Under the optimized chromatographic condition, this separation does not need extra sample preparation. Complete baseline separation of three β-agonists was achieved in < 20 minutes; the linear range is 0.2–50 μg/L with a correlation coefficient R2 value of > 0.99. Excellent method reproducibility …
Biochemical Characterization Of A Novel Antioxidant And Angiotensin I-Converting Enzyme Inhibitory Peptide From Struthio Camelus Egg White Protein Hydrolysis,
2020
Taiwan Food and Drug Administration
Biochemical Characterization Of A Novel Antioxidant And Angiotensin I-Converting Enzyme Inhibitory Peptide From Struthio Camelus Egg White Protein Hydrolysis, A. Asoodeh, M. Homayouni-Tabrizi, H. Shabestarian, S. Emtenani, S. Emtenani
Journal of Food and Drug Analysis
A peptide from ostrich (Struthio camelus) egg white protein hydrolysate (OEWPH) was purified, characterized, and its antioxidant and enzyme inhibitory properties were evaluated. The OEWPH was prepared using pepsin and pancreatin, and then fractionated using reversed-phase high performance liquid chromatography. The antioxidant activity of the WG-9 peptide was investigated based on its scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, 2,20-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS), superoxide (O2•-), hydroxyl (OH•-), and lipid peroxidation inhibition. The angiotensin-converting enzyme (ACE) inhibitory activity and kinetic parameters of the peptide were determined using N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine (FAPGG) as a substrate. Tandem mass spectrometry analysis of the purified peptide …
