Validation Of The 40 Hz Auditory Steady State Response As A Pharmacodynamic Biomarker Of Evoked Neural Synchrony,
2022
East Tennessee State University
Validation Of The 40 Hz Auditory Steady State Response As A Pharmacodynamic Biomarker Of Evoked Neural Synchrony, Muhammad Ummear Raza
Electronic Theses and Dissertations
Schizophrenia is a troubling and severe mental illness that is only incompletely treated by currently available drugs. New drug development is hindered by a scarcity of functionally relevant pharmacodynamic biomarkers that are translatable across preclinical and human subjects. Although psychosis is a major feature of schizophrenia, cognitive and negative symptoms determine the long-term functional outcomes for patients. Stimulus-evoked neural synchrony at gamma (~ 40 Hz) frequency plays an important role in the processing and integration of sensory information. Not surprisingly, schizophrenia patients show deficits in gamma oscillations. NMDA receptor (NMDAR) activation on fast-spiking parvalbumin-positive interneurons is deemed important for the …
Pharmacological Interventions For The Treatment And Control Of Shivering In Adult Patients Undergoing Elective Surgery Under Regional Anaesthesia: A Systematic Review And Meta-Analysis,
2022
Aga Khan University
Pharmacological Interventions For The Treatment And Control Of Shivering In Adult Patients Undergoing Elective Surgery Under Regional Anaesthesia: A Systematic Review And Meta-Analysis, Malika Hameed, Naureen Akber Ali, Khalid Ahsan, Mohsin Nazir
Department of Anaesthesia
Intraoperative shivering is quite common after regional anaesthesia, which not only increases the total body oxygen requirement but also causes discomfort to the patients. The aim of this systematic review is to determine the effectiveness of pharmacological agents administered intra-operatively for treating shivering in adult patients who are undergoing elective surgery under regional (i.e., central neuraxial) anaesthesia so that an optimal choice of an agent can be recommended for clinical application. A literature search was carried out using PubMed, Cochrane Library, CINAHL databases, and hand searches to identify relevant studies. After literature screening and information extraction, a systematic review was …
Edible Mushrooms: An Emerging Therapeutic Of Diabetes,
2022
Chulalongkorn University
Edible Mushrooms: An Emerging Therapeutic Of Diabetes, Nilanjan Chakraborty, Anuron Banerjee, Sudeshna Nandi, Swagata Sarkar, Krishnendu Acharya
The Thai Journal of Pharmaceutical Sciences
Diabetes is the third most customary non-infectious disease occurring worldwide and leads to untimely disability and mortality. This metabolic disorder is characterized by impaired insulin secretions and high blood glucose levels. Among others, type 2 diabetes is the most common. Various chemical and biochemical hypoglycemic drugs are utilized to control and treat hyperglycemia but required further interventions to reduce their toxicity and side effects on the users. Edible mushrooms have been employed from ancient times to heal many diseases as it composed of anti-oxidant, alkaloids, fibers, triterpenoids, and other phytochemicals. The bioactive secondary metabolites of mushrooms can improve insulin resistance …
Determination Of Sugars And Amino Acids In Japanese Wine Using Core–Shell Liquid Chromatography Tandem Electrochemical Detection,
2022
Chulalongkorn University
Determination Of Sugars And Amino Acids In Japanese Wine Using Core–Shell Liquid Chromatography Tandem Electrochemical Detection, Kana Yoshimura, Aiko Sano, Ryuichiro Suzuki, Shun-Ichi Mitomo, Yukiko Negishi, Toshiki Mutai, Florencio Arce Jr, Gerard Lee See, Takashi Tanikawa, Yutaka Inoue
The Thai Journal of Pharmaceutical Sciences
In this study, sugars (glucose, fructose, and sucrose) and amino acids in plum and yuzu wines were quantified with a new and simple method involving an electrochemical detector (ECD) and core–shell column (S-30/70 = Styrene/divinylbenzene – 5 tetramethyldiaminohexane). Analysis was conducted under the following conditions: A column temperature (40°C), flow rate (0.3 mL/min), injection volume (20 μL), and mobile phase (0.1 mol/L NaOH). Glucose, fructose, and sucrose had retention times of 14.68 min, 16.22 min, and 19.29 min, respectively, when measured using an ECD. When the sugar content was compared among the plum wines, plum wine A had the lowest …
Formulation, Characterization, And Pharmacokinetic Study Of Methoteraxate-Quercetin Loaded Nanoparticles,
2022
Chulalongkorn University
Formulation, Characterization, And Pharmacokinetic Study Of Methoteraxate-Quercetin Loaded Nanoparticles, Gyanesh Kumar Sahu, Harish Sharma, Swarnali Das Paul, Ajazuddin, Chanchal Deep Kaur
The Thai Journal of Pharmaceutical Sciences
Objectives: Methotrexate (MTX) is a biopharmaceutics classification system Class IV drug having potential cytotoxic action against cancer cells. However, short half-life and poor bioavailability have limited its application. The object of this work was to entrap MTX and an herbal bioenhancer in a nanoparticle system to improve its bioavailability. Methods: We prepared the nanoparticles (NPs) by emulsion solvent evaporation method with Eudragit RLPO (ERLPO) polymer. Results: The result revealed good in vitro properties with 110 to 228 nm particle size range. The percentage of drugs released from all the batches in 72 h was within the range of 82.71 to …
Design, Development, And Characterization Of Brinzolamide And Brimonidine Tartrate Nanoemulsion For Ophthalmic Drug Delivery,
2022
Chulalongkorn University
Design, Development, And Characterization Of Brinzolamide And Brimonidine Tartrate Nanoemulsion For Ophthalmic Drug Delivery, Bhavin R. Choradiya, Sanjay B. Patil
The Thai Journal of Pharmaceutical Sciences
Aim: The current investigation work sums up the enumerating improvement and depiction of brinzolamide and brimonidine tartrate ophthalmic nanoemulsion giving widened helpful effect and improved visual penetration for treating glaucoma. Methodology: Nanoemulsion was formulated using polysorbate 80, castor oil and glycerol using the continuous emulsification technique. Preliminary batches were screened subject to in vitro medication release, globule size, zeta potential, and stability with regards to accelerated and long time. Nanoemulsions were evaluated for ex vivo optical irritancy using the hen’s egg chorioallantois membrane test model. Results: Screened nanoemulsion batches showed a low mean globule width (<220 nm), higher penetrability (>75%) in comparison with …
Development And Optimization Of Polyherbal Formulation For Antiurolithiatic Activity Using Box Behnken Statistical Design,
2022
Chulalongkorn University
Development And Optimization Of Polyherbal Formulation For Antiurolithiatic Activity Using Box Behnken Statistical Design, Tejal Gandhi, Vaidehi Patel, Saloni Dalwadi, Vaishali Thakkar
The Thai Journal of Pharmaceutical Sciences
Background: The objective of the present investigation was to design and evaluate the antiurolithiatic activity of extract of Tribulus terrestris, Bryophyllum pinnatum, and Cyperus rotundus on ethylene glycol-induced urolithiasis in Wistar albino rats using Box Behnken Design. To induce urolithiasis, 0.75% w/v ethylene glycol was administered orally to the rats for 28 days. Cystone 750 mg/kg was selected as the reference standard as a preventive dose. On the 28th day, urine discharged in 24 h was collected and subjected for estimation of various biochemical parameters which were evaluated using urine, serum, and kidney homogenate. The kidneys were also sectioned and …
The Successful Treatment Of Brevundimonas Diminuta Using Ceftriaxone, In A Patient On Continuous Ambulatory Peritoneal Dialysis: A Case Report And Literature Review,
2022
Chulalongkorn University
The Successful Treatment Of Brevundimonas Diminuta Using Ceftriaxone, In A Patient On Continuous Ambulatory Peritoneal Dialysis: A Case Report And Literature Review, Sukrit Kanchanasurakit, Natnicha Woranithipokin, Piyakamol Teeranaew, Natthawee Kaewrattanapatthama, Chotirat Nakaranurack
The Thai Journal of Pharmaceutical Sciences
Brevundimonas diminuta (B. diminuta) is found in the health-care environment and in the community. At present, there are few reports of infections caused by this microorganism, especially in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). A 44-year-old woman undergoing CAPD was diagnosed with a B. diminuta infection. Ceftriaxone was given both intravenously and intraperitoneally. After treatment with ceftriaxone, the peritoneal dialysis fluid white cell count, neutrophil count, and symptoms improved. To the best of our knowledge, this is the first case report of a B. diminuta infection in a patient had undergoing CAPD in Thailand
Preparation And Stability Of Fluocinolone Acetonide Premicroemulsion Concentrates And Microemulsions For Oral Lichen Planus Treatment,
2022
Chulalongkorn University
Preparation And Stability Of Fluocinolone Acetonide Premicroemulsion Concentrates And Microemulsions For Oral Lichen Planus Treatment, W. Muangsiri, P. Chukaewrungroj, Pornpen Werawatganone
The Thai Journal of Pharmaceutical Sciences
Purpose: Fluocinolone acetonide (FA) preparations were developed in the forms of premicroemulsion concentrates and microemulsions and their stabilities were evaluated. Materials and Methods: A pseudoternary diagram of clove oil, surfactant mixture (containing polysorbate80: Polyethylene glycol 400 [PEG400] at the ratio of 2:1), and water was constructed for the formulation of FA premicroemulsion concentrates and microemulsions. Physical properties and chemical stabilities of the preparations were monitored in the absence and presence of three antioxidants. Their beyond-use dates were determined. Results and Discussion: The premicroemulsion concentrates and microemulsions containing polysorbate 80, PEG400, and clove oil successfully improved FA solubility. Average diameters of …
A New Antidiabetic Polyherbal Formulation For Diabetes,
2022
Chulalongkorn University
A New Antidiabetic Polyherbal Formulation For Diabetes, Sadish Kumar Shanmugam, Praveen Kumar Gaur, Deepak Kumar
The Thai Journal of Pharmaceutical Sciences
Background: Synergism is a well-known concept in Herbal therapies. Polyherbal aqueous extract (PH-AE) containing Gymnema sylvestre (GS), Momordica charantia, Syzygium cumini, and Mangifera indica was evaluated for Antidiabetic activity. Objective: In our continuous research, an attempt has been made to explore GS aqueous extract (GS-AE) and its Polyherbal composite for diabetes to achieve greater efficacy. Methods: The antidiabetic activity was assessed in Streptozotocin induced diabetic rats and histopathological changes in Pancreas were documented after screening acute toxicity of both extracts. Results: Chromatographic separation and identification of GS-AE revealed the presence of Saponins and glycosides, which have also been confirmed in …
Silymarin And Oral Cancer: A Review On Clinical And Analytical Reports,
2022
Chulalongkorn University
Silymarin And Oral Cancer: A Review On Clinical And Analytical Reports, Ramya Jonnalagadda, C. Vinodhini
The Thai Journal of Pharmaceutical Sciences
Oral cancer is the sixth-largest kind globally of cancer and a major health issue in India as well and affects a large population that is very vulnerable to recurrences and a lower survival rate among all the other malignancies. Milk thistle is a phytochemical herb of interest that has been used as folk medicine since ancient times. Due to its potential benefits, the pharmaceutical industrial world is widely using silymarin (an active component of milk thistle) for commercial preparations. Knowing the quantity and identity of active components is of utmost importance. Therefore, robust, accurate, and precise analytical methods are needed …
Impact Of Clinical Pharmacist Intervention On Medication Adherence In Patients With Cardiovascular Disease,
2022
Chulalongkorn University
Impact Of Clinical Pharmacist Intervention On Medication Adherence In Patients With Cardiovascular Disease, S. Lavanya, Netal Patel, Arnav Purani, Kajal Patel
The Thai Journal of Pharmaceutical Sciences
Background: Cardiovascular diseases (CVDs) are a category of heart and blood vessel disorders that include coronary disorders, cerebrovascular diseases, rheumatic pain, and other conditions. One of the major risk factors for CVDs is high blood pressure (BP). Furthermore, it is poorly managed due to a lack of understanding of hypertension, a lack of proper primary care, and a lack of follow-up. The patient education improves the patient’s response to the disease and its management and their quality of life. Objectives: The objectives of this study were to evaluate the effect of clinical pharmacist intervention by the provision of patient counseling, …
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers,
2022
Chulalongkorn University
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Antioxidant Status, Antihyperlipidemic Activity, And Serum Electrolyte Levels In Dexamethasone-Induced Oxidative Stress In Wistar Rats Treated With Vitamin E,
2022
Chulalongkorn University
Antioxidant Status, Antihyperlipidemic Activity, And Serum Electrolyte Levels In Dexamethasone-Induced Oxidative Stress In Wistar Rats Treated With Vitamin E, Idara Asuquo Okon, Justin Atiang Beshel, Daniel Udofia Owu
The Thai Journal of Pharmaceutical Sciences
Objectives: Dexamethasone (Dex) is an anti-inflammatory drug with serious side effects. The aim of this study was to investigate, antioxidants status, antihyperlipidemic activity, and serum electrolyte levels of rats treated with Vitamin E in Dex-induced oxidative stress. Materials and Methods: Wistar rats of both sexes were assigned to four groups (n = 6). The control group was fed with standard rat feed and water, while Dex group received 30 μg/kg of Dex. Vitamin E group received 300 IU/kg of vitamin E, while Dex + Vitamin E group received 30 μg/kg of Dex and 300 IU/kg of vitamin E. After 14 …
Complexity Of Implementing Harm Reduction Services In Community Hospitals: A Two-Phase Qualitative Study,
2022
Chulalongkorn University
Complexity Of Implementing Harm Reduction Services In Community Hospitals: A Two-Phase Qualitative Study, Kanittha Nimsakul, Puckwipa Suwannaprom, Siritree Suttajit
The Thai Journal of Pharmaceutical Sciences
Objective: Regardless of effective harm reduction services (HRS) in Thanyarak Hospital, difficulties exist while implementing them in community hospitals. This study aimed to investigate the complexities of HRS implementation in two community hospitals in Mae Hong Son. Methods: Phase 1, in-depth interviews were conducted with 21 participants to investigate the complexity of HRS dissemination. An interview guide was developed from the seven domains of the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability framework, and thematic analysis was used. Phase 2 involved two rounds of a Delphi technique with 17 experts to evaluate the HRS’s complexity level (complex, complicated, simple). Results: Although …
A Review Of Covid-19 In Relation To Metabolic Syndrome: Obesity, Hypertension, Diabetes, And Dyslipidemia,
2022
Nova Southeastern University
A Review Of Covid-19 In Relation To Metabolic Syndrome: Obesity, Hypertension, Diabetes, And Dyslipidemia, Elias Makhoul, Joseph L. Aklinski, Jesse Miller, Cara Leonard, Sean Backer, Payal Kahar, Mayur S. Parmar, Deepesh Khanna
HPD Articles
Although severe cases and mortality of coronavirus disease 2019 (COVID-19) are proportionally infrequent, these cases are strongly linked to patients with conditions of metabolic syndrome (obesity, hypertension, diabetes, and dyslipidemia). However, the pathophysiology of COVID-19 in relation to metabolic syndrome is not well understood. Thus, the goal of this secondary literature review was to examine the relationship between severe acute respiratory syndrome (SARS-CoV-2) infection and the individual conditions of metabolic syndrome. The objective of this secondary literature review was achieved by examining primary studies, case studies, and other secondary studies, to obtain a comprehensive perspective of theories and observations of …
Knowledge And Attitudes Of Pharmacogenetics Among Canadian Nurses: Implications For Nursing Education,
2022
University of Calgary
Knowledge And Attitudes Of Pharmacogenetics Among Canadian Nurses: Implications For Nursing Education, Noopur Swadas, Sarah Dewell, Sandra J. Davidson
Quality Advancement in Nursing Education - Avancées en formation infirmière
Pharmacogenetic testing is used to tailor medication recommendations based on an individual's genetic makeup. Increased precision in prescribing medication through the use of genetics leads to a reduction in adverse drug reactions resulting in decreased morbidity and mortality. Due to the noted benefits to patient health outcomes and reduction in healthcare costs, a growing number of Canadian health centers and community pharmacies are beginning to offer pharmacogenetic testing. Previous studies indicate that Canadian nurses have minimal education in genomics; however, there has been an increase in attention to nursing roles in the implementation of genomic health practices in recent years. …
Corrigendum To “The Impact Of The Rare Disease And Orphan Drug Act In Taiwan” [J Food Drug Anal 29 (2021) 717-725],
2022
Taiwan Food and Drug Administration
Corrigendum To “The Impact Of The Rare Disease And Orphan Drug Act In Taiwan” [J Food Drug Anal 29 (2021) 717-725]
Journal of Food and Drug Analysis
No abstract provided.
The Study Of Distribution Of Ingested Terbinafine On Skin With Ambient Ionization Tandem Mass Spectrometry,
2022
Department of Cosmetic Applications and Management, Yuh-Ing Junior College of Health Care & Management, No. 15, Ln. 420, Dachang 2nd Rd. Sanmin Dist., Kaohsiung 807634, Taiwan
The Study Of Distribution Of Ingested Terbinafine On Skin With Ambient Ionization Tandem Mass Spectrometry, Yi-Tzu Cho, Hung Su, Ching-Ying Wu, Jingyueh Jeng, Chi-Wei Lee, Deng‐Chyang Wu, Tiao-Lai Huang, Jentaie Shiea
Journal of Food and Drug Analysis
We aim to develop an efficient and non-invasive strategy for monitoring of drugs and their metabolites via human skin. Probe sampling was combined with thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) to characterize trace terbinafine, which was secreted on patient’s skin after ingesting terbinafine tablets. The terbinafine ion signals were directly detected in the samples collected from different skin regions and the signals were monitored for 8 weeks. The detection and location of terbinafine via the skin suggest that the methods are useful in rapidly and noninvasively collecting the molecular information of the ingested drug on skin for pharmacokinetic studies.
Chemiluminescence Of Lucigenin-Tetracycline And Itsapplication For Sensitive Determination Of Procyanidin,
2022
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541004, China
Chemiluminescence Of Lucigenin-Tetracycline And Itsapplication For Sensitive Determination Of Procyanidin, Shuai Quan, Kaixiang Ji, Fangshuo Liu, Tesfaye Hailemariam Barkae, Mohamed Ibrahim Halawa, Saima Hanif, Baohua Lou, Jianping Li, Guobao Xu
Journal of Food and Drug Analysis
Tetracycline was reported to trigger intense lucigenin chemiluminescence (CL). Based on its significant quenching to lucigenin-tetracycline CL, procyanidin was detected. The mechanism of the lucigenin-tetracycline CL and its quenching by procyanidin were proposed. Under the optimum conditions, the calibration curve is linear in the range of 10-1000 nM for procyanidin with a detection limit of 4.4 nM. The RSD for nine replicate determinations of procyanidin was less than 1.7%. Moreover, this method was satisfactorily applied to the determination of procyanidin in human urine samples and health food capsule of grape seed.
