Web Based Services In The Library, 2010 Nigerian Nuclear Regulatory Authority
Web Based Services In The Library, Nkiru F. Opara Jarlath
Sharing knowledge is power’ as opposed to the old adage that, ‘knowledge is power
Ellagic Acid, Phenolic Acids, And Flavonoids In Malaysian Honey Extracts Demonstrate In Vitro Anti-Inflammatory Activity, 2010 Department of Pharmacology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Ellagic Acid, Phenolic Acids, And Flavonoids In Malaysian Honey Extracts Demonstrate In Vitro Anti-Inflammatory Activity, Mohd Rais Mustafa
Mohd Rais Mustafa
Natural honey has been used in traditional medicine of different cultures throughout the world. This study looked into the extraction of Malaysian honey and the evaluation of the anti-inflammatory activity of these extracts. It was hypothesized that honey extracts contain varying amounts of phenolic compounds and that they possess different in vitro anti-inflammatory activities. Honey extracts were analyzed using liquid chromatography–mass spectrometry to identify and compare phenolic compounds, whereas high-performance liquid chromatography was used for their quantification. Subsequently, honey methanol extract (HME) and honey ethyl acetate extract (HEAE) were tested in vitro for their effect on nitric oxide production ...
Virtual Field Visits To The Pearl River Delta, 2010 Hong Kong Baptist University
Virtual Field Visits To The Pearl River Delta, Ming H. Wong, Doris W S Ng, Angela W M Wong
Croucher Institute for Environmental Sciences Book Chapter
The PRD has been undergoing an economic take-off, however, at the same time, its environmental quality has been rapidly deteriorating. Field visits to the PRD would be ideal for students to explore different environmental problems. Unfortunately, organising field visits would involve lots of manpower and resources. As such, this project developed a web-based "Virtual Field Visits to the Pearl River Delta" in order to allow students to visit different field sites via the web. This teaching aid enabled students to understand the landscape, population, industries and current environmental problems of the major cities of the PRD simply by browsing through ...
Expression Of The Periplaneta Americana's Α-Adrenergic-Like Octopamine Receptor In The Yeast Saccharomyces Cerevisiae: A High-Throughput Screening System In Search Of Biorational Insecticides, 2010 Iowa State University
Expression Of The Periplaneta Americana's Α-Adrenergic-Like Octopamine Receptor In The Yeast Saccharomyces Cerevisiae: A High-Throughput Screening System In Search Of Biorational Insecticides, Aaron Donald Gross
Graduate Theses and Dissertations
The use of conventional synthetic insecticides is facing increased scrutiny due to environmental and mammalian health concerns along with resistance to target insects. This has led to an investigation of alternative control measures to combat both economically and medically important arthropods. Octopamine, a biogenic amine, has significant physiological functions in invertebrates, including insects, and signals through G-protein-coupled receptors (GPCRs). Co-evolution of plants with insects has led to plants adapting defensive mechanisms to deter herbivore, microbial, or viral attack. This is sometimes accomplished via the production of essential oils that are composed of a variety of compounds, in particular monoterpenoids, sesquiterpenoids ...
An Inventory And Condition Survey Of The Western Australian Part Of The Nullarbor Region, 2010 Department of Agriculture and Food, Western Australia
An Inventory And Condition Survey Of The Western Australian Part Of The Nullarbor Region, P A. Waddell, A K. Gardner, P Hennig
The inventory and condition survey of the Western Australian part of the Nullarbor region, undertaken by the Department of Agriculture and Food, Western Australia (DAFWA) between 2005 and 2007, describes and maps the natural resources of the region. This survey report provides a baseline record of the existence and condition of the area's natural resources, to assist with the planning and implementation of land management practices. The report identified and described the condition of soils, landforms, vegetation, habitat, ecosystems, and declared plants and animals. It also assessed the impact of pastoralism and made land management recommendations. The Nullarbor region ...
Quantitative Structure-Activity Relationships For Organophosphates Binding To Trypsin And Chymotrypsin, 2010 Wright State University
Quantitative Structure-Activity Relationships For Organophosphates Binding To Trypsin And Chymotrypsin, Christopher Daniel Ruark
Browse all Theses and Dissertations
Organophosphate (OP) nerve agents such as sarin, soman, tabun, and O-ethyl S-[2-(diisopropylamino) ethyl] methylphosphonothioate (VX) do not react solely with acetylcholinesterase (AChE). Evidence suggests that a wide range of cholinergic-independent pathways are also targeted, including serine proteases. These proteases comprise nearly one-third of all known proteases and play major roles in synaptic plasticity, learning, memory, neuroprotection, wound healing, cell signaling, inflammation, blood coagulation and protein processing. Inhibition of these proteases by OPs was found to exert a wide range of noncholinergic effects depending on the type of OP, the dose, and the duration of exposure. Consequently, in order ...
Hyperbaric Oxygen In The Prevention Of Carbon Monoxide Induced Delayed Neurological Sequelae In Male Sprague Dawley Rats (Rattus Norvegicus), Chester P. Gut Jr.
Browse all Theses and Dissertations
In Carbon Monoxide (CO) induced Delayed Neurological Sequelae (DNS) clinical signs develop 1 to 6 weeks after CO has cleared the body. The aim of this experiment was to develop a model of CO induced DNS which closely mimics "real world" conditions both in exposure and treatment. The model was challenged with hyperbaric or normobaric oxygen, or room air. Basic behaviors were measured by Open Field test on days 1, 7, 14 post exposure and treatment. No significant difference in behavior was observed between exposed and control animals or between treatment groups. Histological analyses showed no DNA or necrotic damage ...
Tissue Specific Effects Of Adipose Stem Cells (Asc) In A Melanoma Tumor Environment, 2010 Wright State University
Tissue Specific Effects Of Adipose Stem Cells (Asc) In A Melanoma Tumor Environment, Drew Michael Nedderman
Browse all Theses and Dissertations
This study determined the tissue-specific effect of adipose stem cells (ASC) within a melanoma environment for development of a cell-based melanoma therapy. Analysis included a subcutaneous B16-F1 melanoma model using thirty-one C57BL/6 wild-type mice. Melanoma xenografts were treated with cell-based therapies of CFDA-SE-labeled human fibroblasts HF20x (control), non-differentiated ndASC or hematopoietic-differentiated HdASC. No tumor regression was observed in presence of cell-based therapies, thus, the HdASC group demonstrated an increase in tumor growth accompanied with an up-regulated macrophage response, and increased angiogenesis. In addition, this group demonstrated a decrease in Melan-A tumor marker and interferon-γ expression suggesting that ASC-supported tumor ...
2,3,7,8-Tetrachlordibenzo-P-Dioxin Mediated Immune Suppression Through Interactions At The 3'Immunoglobulin Heavy Chain Regulatory Region Enhancers, David Harold Ellis
Browse all Theses and Dissertations
2,3,7,8-Tetrachlordibenzo-p-dioxin (TCDD) is a potent toxin which inhibits the antibody response of B cells. The 3'IgHRR which is involved in transcriptional regulation of the heavy-chain polypeptide of antibodies is inhibited by TCDD. The hs1,2 enhancer region, isolated from the 3'IgHRR, is also inhibited while the isolated hs4 is activated by TCDD. This project sought to determine if that dichotomy in effects results from interactions at enhancer-specific binding sites for AhR, thought to mediate transcriptional effects of TCDD, and NFκB, a transcription factor involved in B cell activation. Here, I report a difference in the ...
Cytotoxity Of Saponin-Rich Extracts From Phytolacca Americana L. (Phytolaccaceae) (Abstract), 2010 Stephen F Austin State University, Arthur Temple College of Forestry and Agriculture
Cytotoxity Of Saponin-Rich Extracts From Phytolacca Americana L. (Phytolaccaceae) (Abstract), Ping Wang, Guangrui Deng, Wei Yuan, Shiyou Li
NCPC Publications and Patents
No abstract provided.
Sesquiterpenes And Dimeric Sesquiterpenoids From Sarcandra Glabra, 2010 State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People’s Republic of China
Sesquiterpenes And Dimeric Sesquiterpenoids From Sarcandra Glabra, Xiu-Feng He, Sheng Yin, Yin-Chun Ji, Zu-Shang Su, Mei-Yu Geng, Jian-Min Yue
Two new sesquiterpenes, sarcandralactones A (1) and B (2), and five new dimeric sesquiterpenoids, sarcandrolides A-E (3-7), along with 10 known compounds were isolated from the whole plants of Sarcandra glabra. Their structures were elucidated on the basis of spectroscopic analysis. Some of the new isolates exhibit significant cytotoxicities when tested against a small panel of tumor cell lines.
Application Of The Tissue Residue Approach In Ecological Risk Assessment, 2010 Radboud University
Application Of The Tissue Residue Approach In Ecological Risk Assessment, Steven P. Bradbury, Keith G. Sappington, Todd S. Bridges, Russell J. Erickson, A. Jan Hendriks, Roman P. Lanno, James P. Meador, David R. Mount, Mike H. Salazar, Doug J. Spry
Steven P. Bradbury
The objective of this work is to present a critical review of the application of the tissue residue approach (TRA) in ecological risk and/or impact assessment (ERA) of chemical stressors and environmental criteria development. A secondary goal is to develop a framework for integrating the TRA into ecological assessments along with traditional, exposure concentration-based assessment approaches. Although widely recognized for its toxicological appeal, the utility of the TRA in specific applications will depend on numerous factors, such as chemical properties, exposure characteristics, assessment type, availability of tissue residue-response data, and ability to quantify chemical exposure. Therefore, the decision to ...
Meeting The Common Needs Of A More Effective And Efficient Testing And Assessment Paradigm For Chemical Risk Management, Steven P. Bradbury, Vicki Dellarco, Tala Henry, Phil Sayre, Jennifer Seed
Steven P. Bradbury
Significant advances have been made in human health and ecological risk assessment over the last decade. Substantial challenges, however, remain in providing credible scientific information in a timely and efficient manner to support chemical risk assessment and management decisions. A major challenge confronting risk managers is the need for critical information to address risk uncertainties in large chemical inventories such as high- and medium-production-volume industrial chemicals or pesticide inert ingredients. From a strategic and tactical viewpoint, an integrated approach that relies on all existing knowledge and uses a range of methods, including those from emerging and novel technologies, is needed ...
Spectroscopic Study Of The Inhibition Of Calcium Oxalate Calculi By Larrea Tridentata, 2010 University of Texas at El Paso
Spectroscopic Study Of The Inhibition Of Calcium Oxalate Calculi By Larrea Tridentata, Luis Alonso Pinales
Open Access Theses & Dissertations
The causes of urolithiasis include such influences as diet, metabolic disorders, and genetic factors which have been documented as sources that aggravate urinary calculi depositions and aggregations, and, implicitly, as causes of urolithiasis. This study endeavors to detail the scientific mechanisms involved in calcium oxalate calculi formation, and, more importantly, their inhibition under growth conditions imposed by the traditional medicinal approach using the herbal extract, Larrea tridentata. The calculi were synthesized without and with Larrea tridentata infusion by employing the single diffusion gel technique. A visible decrease in calcium oxalate crystal growth with increasing amounts of Larrea tridentata herbal infusion ...
Gabab Regulation Of Methamphetamine-Induced Associative Learning, 2010 Loyola University Chicago
Gabab Regulation Of Methamphetamine-Induced Associative Learning, Robin Michelle Voigt
Addiction is a chronic, relapsing disorder for which strikingly few effective therapies exist, and there are no FDA-approved pharmacotherapies for methamphetamine (Meth) addition. There is an immense need to identify the neurobiological underpinnings of psychostimulant addiction and develop efficacious drug therapies to compliment the current mainstay treatment of behavioral/cognitive therapy.
Re-exposure to cues associated with psychostimulants (e.g., drug paraphernalia) increase neuronal activity and can elicit drug-craving and -seeking; an effect which is profound and long-lasting. A mechanism to disrupt those brain processes which are necessary to maintain the association may reduce the incidence of cue-elicited relapse.
Conditioned place ...
Role Stress, Emotional Exhaustion, And Job Satisfaction In The Hotel Industry: The Moderating Role Of Supervisory Support, 2010 Eastern Mediterranean University
Role Stress, Emotional Exhaustion, And Job Satisfaction In The Hotel Industry: The Moderating Role Of Supervisory Support, Osman M. Karatepe
The purpose of this study is to investigate supervisory support as a moderator of the effects of role conflict and role ambiguity on emotional exhaustion and job satisfaction. This study also examines the moderating role of supervisory support on the relationship between emotional exhaustion and job satisfaction. Data were collected from a sample of frontline hotel employees in Northern Cyprus. The aforementioned relationships were tested based on hierarchical multiple regression analysis. The results demonstrate that supervisory support mitigates the impact of role conflict on emotional exhaustion and further reveal that supervisory support reduces the effect of emotional exhaustion on job ...
Polychlorinated Biphenyl-Induced Endothelial Cell Dysfunction And Its Modulation By Dietary Lipids, 2010 University of Kentucky
Polychlorinated Biphenyl-Induced Endothelial Cell Dysfunction And Its Modulation By Dietary Lipids, Zuzana Majkova
University of Kentucky Doctoral Dissertations
Cardiovascular diseases are the number one cause of death in Western societies. Endothelial dysfunction is an early event in the pathology of atherosclerosis, which is an underlying cause in the majority of cardiovascular events. Exposure to persistent environmental pollutants, such as polychlorinated biphenyls (PCBs), is a risk factor for the development of atherosclerosis.
First, we tested a hypothesis that coplanar PCBs, dioxin-like chemicals with affinity for aryl hydrocarbon receptor (AhR), can stimulate up-regulation of monocyte chemoattractant protein-1 (MCP-1), an endothelium-derived chemokine that attracts monocytes into sub-endothelial space in early stages of atherosclerosis. Coplanar PCBs 77 and 126 increased expression of ...
Improving The Value Of Standard Toxicity Test Data In Reach, 2010 Stockholm University
Improving The Value Of Standard Toxicity Test Data In Reach, Magnus Breitholtz, Elin Lundström, Ulrika Dahl, Valery E. Forbes
Valery Forbes Publications
Worldwide, environmental risk assessment strategies are based on the assumption that measuring direct effects of single substances, using a few single species tests, in combination with safety factors correcting for extrapolation inconsistencies, can be used to protect higher levels of biological organization, such as populations and even ecosystems. At the same time, we are currently facing a range of pollution problems (Millennium Ecosystem Assessment Series 2005), of which some could at least indirectly be linked to the fact that this assumption may not be fully valid. Consequently, there is an ongoing scientific debate on whether current chemical control protocols are ...
Investigation Of The Fate And Effects Of Acetyl Cedrene On Capitella Teleta And Sediment Bacterial Community, 2010 Copenhagen University
Investigation Of The Fate And Effects Of Acetyl Cedrene On Capitella Teleta And Sediment Bacterial Community, Lea Ellegaard-Petersen, Henriette Selck, Anders Priemé, Daniel Salvito, Valery E. Forbes
Valery Forbes Publications
The fate of the fragrance material, acetyl cedrene (AC), in sediment was examined in a 16 day laboratory experiment using the sediment microbial community subjected to the following treatments: AC (nominal concentration; 0 and 50 μg g−1 dw sediment) and macrofaunal worms (with/without Capitella teleta (formerly Capitella sp. I)). Furthermore effects of AC on microbial respiration in the system were determined by examining CO2 flux. T-RFLP (terminal restriction fragment length polymorphism) was used to analyze PCR (polymerase chain reaction) amplified 16S DNA gene fragments from the sediments to detect changes in the structure and diversity of the ...
Environmentally Sensitive Life-Cycle Traits Have Low Elasticity: Implications For Theory And Practice, 2010 University of Nebraska-Lincoln
Environmentally Sensitive Life-Cycle Traits Have Low Elasticity: Implications For Theory And Practice, Valery E. Forbes, Mette Olsen, Annemette Palmqvist, Peter Calow
Valery Forbes Publications
The relationships between population growth rate and the life-cycle traits contributing to it are nonlinear and variable. This has made it difficult for ecologists to consistently predict changes in population dynamics from observations on changes in life-cycle traits. We show that traits having a high sensitivity to chemical toxicants tend to have a low elasticity, meaning that changes in them have a relatively low impact on population growth rate, compared to other life-cycle traits. This makes evolutionary sense in that there should be selection against variability in population growth rate. In particular, we found that fecundity was generally more sensitive ...